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Items: 31


O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.

Sharp C, Boinett C, Cain A, Housden NG, Kumar S, Turner K, Parkhill J, Kleanthous C.

J Bacteriol. 2019 Jan 28;201(4). pii: e00545-18. doi: 10.1128/JB.00545-18. Print 2019 Feb 15.


Correction to "Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm".

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Sep 4;57(35):5270. doi: 10.1021/acs.biochem.8b00864. Epub 2018 Aug 23. No abstract available.


Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm.

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Jul 24;57(29):4374-4381. doi: 10.1021/acs.biochem.8b00621. Epub 2018 Jul 6. Erratum in: Biochemistry. 2018 Sep 4;57(35):5270.


Lipid binding attenuates channel closure of the outer membrane protein OmpF.

Liko I, Degiacomi MT, Lee S, Newport TD, Gault J, Reading E, Hopper JTS, Housden NG, White P, Colledge M, Sula A, Wallace BA, Kleanthous C, Stansfeld PJ, Bayley H, Benesch JLP, Allison TM, Robinson CV.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6691-6696. doi: 10.1073/pnas.1721152115. Epub 2018 Jun 11.


Exploitation of an iron transporter for bacterial protein antibiotic import.

White P, Joshi A, Rassam P, Housden NG, Kaminska R, Goult JD, Redfield C, McCaughey LC, Walker D, Mohammed S, Kleanthous C.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12051-12056. doi: 10.1073/pnas.1713741114. Epub 2017 Oct 25.


Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces.

Ambrose S, Housden NG, Gupta K, Fan J, White P, Yen HY, Marcoux J, Kleanthous C, Hopper JTS, Robinson CV.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14463-14468. doi: 10.1002/anie.201704849. Epub 2017 Sep 18.


Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models.

Sharp C, Bray J, Housden NG, Maiden MCJ, Kleanthous C.

PLoS Comput Biol. 2017 Jul 17;13(7):e1005652. doi: 10.1371/journal.pcbi.1005652. eCollection 2017 Jul.


Orientation of the OmpF Porin in Planar Lipid Bilayers.

Ionescu SA, Lee S, Housden NG, Kaminska R, Kleanthous C, Bayley H.

Chembiochem. 2017 Mar 16;18(6):554-562. doi: 10.1002/cbic.201600644. Epub 2017 Feb 28.


Structural and biophysical analysis of nuclease protein antibiotics.

Klein A, Wojdyla JA, Joshi A, Josts I, McCaughey LC, Housden NG, Kaminska R, Byron O, Walker D, Kleanthous C.

Biochem J. 2016 Sep 15;473(18):2799-812. doi: 10.1042/BCJ20160544. Epub 2016 Jul 8.


High-resolution mass spectrometry of small molecules bound to membrane proteins.

Gault J, Donlan JA, Liko I, Hopper JT, Gupta K, Housden NG, Struwe WB, Marty MT, Mize T, Bechara C, Zhu Y, Wu B, Kleanthous C, Belov M, Damoc E, Makarov A, Robinson CV.

Nat Methods. 2016 Apr;13(4):333-6. doi: 10.1038/nmeth.3771. Epub 2016 Feb 22.


Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria.

Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, Quinn DM, Garrod TJ, Sansom MS, Piehler J, Baumann CG, Kleanthous C.

Nature. 2015 Jul 16;523(7560):333-6. doi: 10.1038/nature14461. Epub 2015 Jun 10.


Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.

Vankemmelbeke M, Housden NG, James R, Kleanthous C, Penfold CN.

Microbiologyopen. 2013 Oct;2(5):853-61. doi: 10.1002/mbo3.122. Epub 2013 Aug 28.


Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF.

Housden NG, Hopper JT, Lukoyanova N, Rodriguez-Larrea D, Wojdyla JA, Klein A, Kaminska R, Bayley H, Saibil HR, Robinson CV, Kleanthous C.

Science. 2013 Jun 28;340(6140):1570-4. doi: 10.1126/science.1237864.


A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.

Farrance OE, Hann E, Kaminska R, Housden NG, Derrington SR, Kleanthous C, Radford SE, Brockwell DJ.

PLoS Biol. 2013;11(2):e1001489. doi: 10.1371/journal.pbio.1001489. Epub 2013 Feb 19.


Colicin translocation across the Escherichia coli outer membrane.

Housden NG, Kleanthous C.

Biochem Soc Trans. 2012 Dec 1;40(6):1475-9. doi: 10.1042/BST20120255. Review.


Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9.

Papadakos G, Housden NG, Lilly KJ, Kaminska R, Kleanthous C.

J Mol Biol. 2012 May 18;418(5):269-80. doi: 10.1016/j.jmb.2012.01.039. Epub 2012 Jan 30.


Thermodynamic dissection of colicin interactions.

Housden NG, Kleanthous C.

Methods Enzymol. 2011;488:123-45. doi: 10.1016/B978-0-12-381268-1.00006-9. Review.


Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF.

Housden NG, Wojdyla JA, Korczynska J, Grishkovskaya I, Kirkpatrick N, Brzozowski AM, Kleanthous C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21412-7. doi: 10.1073/pnas.1010780107. Epub 2010 Nov 22.


Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C.

EMBO J. 2009 Sep 16;28(18):2846-57. doi: 10.1038/emboj.2009.224. Epub 2009 Aug 20. Erratum in: EMBO J. 2009 Sep 16;28(18):2858.


Intermolecular sensitization of a terbium-containing amphiphile by an integral membrane protein.

Davies CL, Housden NG, Duhme-Klair AK.

Angew Chem Int Ed Engl. 2008;47(46):8856-8. doi: 10.1002/anie.200803828. No abstract available.


Generation and expression of a minimal hybrid Ig-receptor formed between single domains from proteins L and G.

Harrison SL, Housden NG, Bottomley SP, Cossins AJ, Gore MG.

Protein Expr Purif. 2008 Mar;58(1):12-22. Epub 2007 Nov 22.


Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding.

Housden NG, Loftus SR, Moore GR, James R, Kleanthous C.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13849-54. Epub 2005 Sep 15.


Comparison of the crystallization and crystal packing of two Fab single-site mutant protein L complexes.

Granata V, Housden NG, Harrison S, Jolivet-Reynaud C, Gore MG, Stura EA.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):750-4. Epub 2005 May 26.


Different crystal packing in Fab-protein L semi-disordered peptide complex.

Ménez R, Housden NG, Harrison S, Jolivet-Reynaud C, Gore MG, Stura EA.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):744-9. Epub 2005 May 26.


Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells.

Penfold CN, Healy B, Housden NG, Boetzel R, Vankemmelbeke M, Moore GR, Kleanthous C, James R.

J Bacteriol. 2004 Jul;186(14):4520-7.


Observation and characterization of the interaction between a single immunoglobulin binding domain of protein L and two equivalents of human kappa light chains.

Housden NG, Harrison S, Housden HR, Thomas KA, Beckingham JA, Roberts SE, Bottomley SP, Graille M, Stura E, Gore MG.

J Biol Chem. 2004 Mar 5;279(10):9370-8. Epub 2003 Dec 10.


Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus.

Housden NG, Harrison S, Roberts SE, Beckingham JA, Graille M, Stura E, Gore MG.

Biochem Soc Trans. 2003 Jun;31(Pt 3):716-8. Review.


Protein L mutants for the crystallization of antibody fragments.

Stura EA, Graille M, Housden NG, Gore MG.

Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 1):1744-8. Epub 2002 Sep 26.


Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface.

Graille M, Harrison S, Crump MP, Findlow SC, Housden NG, Muller BH, Battail-Poirot N, Sibaï G, Sutton BJ, Taussig MJ, Jolivet-Reynaud C, Gore MG, Stura EA.

J Biol Chem. 2002 Dec 6;277(49):47500-6. Epub 2002 Sep 8.


Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins.

Graille M, Stura EA, Housden NG, Beckingham JA, Bottomley SP, Beale D, Taussig MJ, Sutton BJ, Gore MG, Charbonnier JB.

Structure. 2001 Aug;9(8):679-87.


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