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Items: 36


Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.

Koca Y, Housden BE, Gault WJ, Bray SJ, Mlodzik M.

Sci Rep. 2019 Dec 9;9(1):18628. doi: 10.1038/s41598-019-55203-w.


HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.

Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.

Sci Signal. 2019 Oct 1;12(601). pii: eaay0482. doi: 10.1126/scisignal.aay0482.


The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.

Xu C, Tang HW, Hung RJ, Hu Y, Ni X, Housden BE, Perrimon N.

Cell Rep. 2019 Jan 15;26(3):670-688.e6. doi: 10.1016/j.celrep.2018.12.079.


A gene-specific T2A-GAL4 library for Drosophila.

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ.

Elife. 2018 Mar 22;7. pii: e35574. doi: 10.7554/eLife.35574.


Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells.

Mohr SE, Rudd K, Hu Y, Song WR, Gilly Q, Buckner M, Housden BE, Kelley C, Zirin J, Tao R, Amador G, Sierzputowska K, Comjean A, Perrimon N.

G3 (Bethesda). 2018 Feb 2;8(2):631-641. doi: 10.1534/g3.117.300447.


Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden BE, Li Z, Kelley C, Wang Y, Hu Y, Valvezan AJ, Manning BD, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10755-E10762. doi: 10.1073/pnas.1713362114. Epub 2017 Nov 28.


mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.

Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.


A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.

Rajan A, Housden BE, Wirtz-Peitz F, Holderbaum L, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):83-98.e6. doi: 10.1016/j.devcel.2017.09.007.


Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells.

Housden BE, Nicholson HE, Perrimon N.

Bio Protoc. 2017 Feb 5;7(3). pii: e2119. doi: 10.21769/BioProtoc.2119.


Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Housden BE, Muhar M, Gemberling M, Gersbach CA, Stainier DY, Seydoux G, Mohr SE, Zuber J, Perrimon N.

Nat Rev Genet. 2017 Jan;18(1):24-40. doi: 10.1038/nrg.2016.118. Epub 2016 Oct 31. Review.


Cas9-Mediated Genome Engineering in Drosophila melanogaster.

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top086843.


Detection of Indel Mutations in Drosophila by High-Resolution Melt Analysis (HRMA).

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090795.


Design and Generation of Donor Constructs for Genome Engineering in Drosophila.

Housden BE, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090787.


Design and Generation of Drosophila Single Guide RNA Expression Constructs.

Housden BE, Hu Y, Perrimon N.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot090779.


Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.

Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582.


Mapping signaling pathway cross-talk in Drosophila cells.

Ammeux N, Housden BE, Georgiadis A, Hu Y, Perrimon N.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9940-5. doi: 10.1073/pnas.1610432113. Epub 2016 Aug 15.


Comparing CRISPR and RNAi-based screening technologies.

Housden BE, Perrimon N.

Nat Biotechnol. 2016 Jun 9;34(6):621-3. doi: 10.1038/nbt.3599. No abstract available.


CRISPR guide RNA design for research applications.

Mohr SE, Hu Y, Ewen-Campen B, Housden BE, Viswanatha R, Perrimon N.

FEBS J. 2016 Sep;283(17):3232-8. doi: 10.1111/febs.13777. Epub 2016 Jun 22. Review.


Comparison of Cas9 activators in multiple species.

Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJK, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G.

Nat Methods. 2016 Jul;13(7):563-567. doi: 10.1038/nmeth.3871. Epub 2016 May 23.


Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours.

Zacharioudaki E, Housden BE, Garinis G, Stojnic R, Delidakis C, Bray SJ.

Development. 2016 Jan 15;143(2):219-31. doi: 10.1242/dev.126326. Epub 2015 Dec 10.


Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.

Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N.

Sci Signal. 2015 Sep 8;8(393):rs9. doi: 10.1126/scisignal.aab3729.


In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila.

Lin S, Ewen-Campen B, Ni X, Housden BE, Perrimon N.

Genetics. 2015 Oct;201(2):433-42. doi: 10.1534/genetics.115.181065. Epub 2015 Aug 5. Erratum in: Genetics. 2015 Dec;201(4):1615.


Highly efficient Cas9-mediated transcriptional programming.

Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.

Nat Methods. 2015 Apr;12(4):326-8. doi: 10.1038/nmeth.3312. Epub 2015 Mar 2.


Cas9-based genome editing in Drosophila.

Housden BE, Lin S, Perrimon N.

Methods Enzymol. 2014;546:415-39. doi: 10.1016/B978-0-12-801185-0.00019-2.


Spatial and temporal organization of signaling pathways.

Housden BE, Perrimon N.

Trends Biochem Sci. 2014 Oct;39(10):457-64. doi: 10.1016/j.tibs.2014.07.008. Epub 2014 Aug 22. Review.


Notch signaling assays in Drosophila cultured cell lines.

Li J, Housden BE, Bray SJ.

Methods Mol Biol. 2014;1187:131-41. doi: 10.1007/978-1-4939-1139-4_10.


Visualizing Notch signaling in vivo in Drosophila tissues.

Housden BE, Li J, Bray SJ.

Methods Mol Biol. 2014;1187:101-13. doi: 10.1007/978-1-4939-1139-4_8.


Drosophila p53 controls Notch expression and balances apoptosis and proliferation.

Simón R, Aparicio R, Housden BE, Bray S, Busturia A.

Apoptosis. 2014 Oct;19(10):1430-43. doi: 10.1007/s10495-014-1000-5.


Resources for functional genomics studies in Drosophila melanogaster.

Mohr SE, Hu Y, Kim K, Housden BE, Perrimon N.

Genetics. 2014 May;197(1):1-18. doi: 10.1534/genetics.113.154344. Epub 2014 Mar 20. Review.


Context-dependent enhancer selection confers alternate modes of notch regulation on argos.

Housden BE, Terriente-Felix A, Bray SJ.

Mol Cell Biol. 2014 Feb;34(4):664-72. doi: 10.1128/MCB.01045-13. Epub 2013 Dec 9.


Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9.

Ren X, Sun J, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19012-7. doi: 10.1073/pnas.1318481110. Epub 2013 Nov 4.


Deadpan contributes to the robustness of the notch response.

Babaoğlan AB, Housden BE, Furriols M, Bray SJ.

PLoS One. 2013 Sep 24;8(9):e75632. doi: 10.1371/journal.pone.0075632. eCollection 2013.


Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes.

Housden BE, Fu AQ, Krejci A, Bernard F, Fischer B, Tavaré S, Russell S, Bray SJ.

PLoS Genet. 2013;9(1):e1003162. doi: 10.1371/journal.pgen.1003162. Epub 2013 Jan 3.


Drosophila Reporter Vectors Compatible with ΦC31 Integrase Transgenesis Techniques and Their Use to Generate New Notch Reporter Fly Lines.

Housden BE, Millen K, Bray SJ.

G3 (Bethesda). 2012 Jan;2(1):79-82. doi: 10.1534/g3.111.001321. Epub 2012 Jan 1.


The cytolinker Pigs is a direct target and a negative regulator of Notch signalling.

Pines MK, Housden BE, Bernard F, Bray SJ, Röper K.

Development. 2010 Mar;137(6):913-22. doi: 10.1242/dev.043224. Epub 2010 Feb 11.


Direct response to Notch activation: signaling crosstalk and incoherent logic.

Krejcí A, Bernard F, Housden BE, Collins S, Bray SJ.

Sci Signal. 2009 Jan 27;2(55):ra1. doi: 10.1126/scisignal.2000140. Erratum in: Sci Signal. 2009;2(58):er3.

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