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Items: 1 to 50 of 91

1.

Strategies for purification of the bacteriophage HK97 small and large terminase subunits that yield pure and homogeneous samples that are functional.

Weiditch SA, Seraphim TV, Houry WA, Kanelis V.

Protein Expr Purif. 2019 Aug;160:45-55. doi: 10.1016/j.pep.2019.03.017. Epub 2019 Apr 4.

PMID:
30954531
2.

The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex.

Lynham J, Houry WA.

Adv Exp Med Biol. 2018;1106:37-72. doi: 10.1007/978-3-030-00737-9_4.

PMID:
30484152
3.

Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation.

Shorter J, Houry WA.

Front Mol Biosci. 2018 Oct 2;5:85. doi: 10.3389/fmolb.2018.00085. eCollection 2018. No abstract available.

4.

Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks.

Rizzolo K, Houry WA.

J Biol Chem. 2019 Feb 8;294(6):2142-2150. doi: 10.1074/jbc.TM118.002805. Epub 2018 Sep 7. Review.

5.

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.

Wong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao YQ, Rizzolo K, Leung E, Moutaoufik MT, Hoell L, Phanse S, Goodreid J, Barbosa LRS, Ramos CHI, Babu M, Mennella V, Batey RA, Schimmer AD, Houry WA.

Cell Chem Biol. 2018 Aug 16;25(8):1017-1030.e9. doi: 10.1016/j.chembiol.2018.05.014. Epub 2018 Jun 28.

PMID:
30126533
6.

Reversible inhibition of the ClpP protease via an N-terminal conformational switch.

Vahidi S, Ripstein ZA, Bonomi M, Yuwen T, Mabanglo MF, Juravsky JB, Rizzolo K, Velyvis A, Houry WA, Vendruscolo M, Rubinstein JL, Kay LE.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6447-E6456. doi: 10.1073/pnas.1805125115. Epub 2018 Jun 25.

7.

The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases.

Bhandari V, Wong KS, Zhou JL, Mabanglo MF, Batey RA, Houry WA.

ACS Chem Biol. 2018 Jun 15;13(6):1413-1425. doi: 10.1021/acschembio.8b00124. Epub 2018 Jun 1. Review.

PMID:
29775273
8.

Systems analysis of the genetic interaction network of yeast molecular chaperones.

Rizzolo K, Kumar A, Kakihara Y, Phanse S, Minic Z, Snider J, Stagljar I, Zilles S, Babu M, Houry WA.

Mol Omics. 2018 Apr 16;14(2):82-94. doi: 10.1039/C7MO00142H.

PMID:
29659649
9.

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Houry WA, Bertrand E, Coulombe B.

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5. Review.

PMID:
29203338
10.

Computational Analysis of the Chaperone Interaction Networks.

Kumar A, Rizzolo K, Zilles S, Babu M, Houry WA.

Methods Mol Biol. 2018;1709:275-291. doi: 10.1007/978-1-4939-7477-1_20.

PMID:
29177666
11.

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA.

Cell Rep. 2017 Sep 12;20(11):2735-2748. doi: 10.1016/j.celrep.2017.08.074.

12.

The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology.

Mao YQ, Houry WA.

Front Mol Biosci. 2017 Aug 24;4:58. doi: 10.3389/fmolb.2017.00058. eCollection 2017. Review.

13.

The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex.

Wong KS, Bhandari V, Janga SC, Houry WA.

J Mol Biol. 2017 Jan 20;429(2):324-344. doi: 10.1016/j.jmb.2016.12.008. Epub 2016 Dec 12.

14.

Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.

Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pomès R, Sharpe S, Houry WA.

Structure. 2016 Jul 6;24(7):1095-109. doi: 10.1016/j.str.2016.05.002. Epub 2016 Jun 2.

15.

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.

Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR.

Structure. 2016 May 3;24(5):657-666. doi: 10.1016/j.str.2016.03.018. Epub 2016 Apr 21.

16.

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.

Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I.

Sci Rep. 2016 Apr 15;6:24601. doi: 10.1038/srep24601.

17.

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.

Goodreid JD, Janetzko J, Santa Maria JP Jr, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA.

J Med Chem. 2016 Jan 28;59(2):624-46. doi: 10.1021/acs.jmedchem.5b01451. Epub 2016 Jan 12.

PMID:
26818454
18.

Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL.

Bhandari V, Houry WA.

Adv Exp Med Biol. 2015;883:271-94. doi: 10.1007/978-3-319-23603-2_15. Review.

PMID:
26621473
19.

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD.

Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004.

20.

The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.

Matias PM, Baek SH, Bandeiras TM, Dutta A, Houry WA, Llorca O, Rosenbaum J.

Front Mol Biosci. 2015 May 5;2:17. doi: 10.3389/fmolb.2015.00017. eCollection 2015.

21.

Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency.

Jeganathan A, Leong V, Zhao L, Huen J, Nano N, Houry WA, Ortega J.

J Mol Biol. 2015 May 22;427(10):1875-86. doi: 10.1016/j.jmb.2015.01.010. Epub 2015 Jan 28.

PMID:
25636407
22.

Novel function discovery with GeneMANIA: a new integrated resource for gene function prediction in Escherichia coli.

Vlasblom J, Zuberi K, Rodriguez H, Arnold R, Gagarinova A, Deineko V, Kumar A, Leung E, Rizzolo K, Samanfar B, Chang L, Phanse S, Golshani A, Greenblatt JF, Houry WA, Emili A, Morris Q, Bader G, Babu M.

Bioinformatics. 2015 Feb 1;31(3):306-10. doi: 10.1093/bioinformatics/btu671. Epub 2014 Oct 13.

23.

Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

Goodreid JD, Wong K, Leung E, McCaw SE, Gray-Owen SD, Lough A, Houry WA, Batey RA.

J Nat Prod. 2014 Oct 24;77(10):2170-81. doi: 10.1021/np500158q. Epub 2014 Sep 25.

PMID:
25255326
24.

Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.

Malet H, Liu K, El Bakkouri M, Chan SW, Effantin G, Bacia M, Houry WA, Gutsche I.

Elife. 2014 Aug 5;3:e03653. doi: 10.7554/eLife.03653. Erratum in: Elife. 2014;3:e05179.

25.

Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex.

Kakihara Y, Makhnevych T, Zhao L, Tang W, Houry WA.

Genome Biol. 2014 Jul 25;15(7):404. doi: 10.1186/s13059-014-0404-4.

26.

Dynamics of the ClpP serine protease: a model for self-compartmentalized proteases.

Liu K, Ologbenla A, Houry WA.

Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):400-12. doi: 10.3109/10409238.2014.925421. Epub 2014 Jun 10. Review.

PMID:
24915503
27.

Quantitative genome-wide genetic interaction screens reveal global epistatic relationships of protein complexes in Escherichia coli.

Babu M, Arnold R, Bundalovic-Torma C, Gagarinova A, Wong KS, Kumar A, Stewart G, Samanfar B, Aoki H, Wagih O, Vlasblom J, Phanse S, Lad K, Yeou Hsiung Yu A, Graham C, Jin K, Brown E, Golshani A, Kim P, Moreno-Hagelsieb G, Greenblatt J, Houry WA, Parkinson J, Emili A.

PLoS Genet. 2014 Feb 20;10(2):e1004120. doi: 10.1371/journal.pgen.1004120. eCollection 2014 Feb.

28.

The MoxR ATPase RavA and its cofactor ViaA interact with the NADH:ubiquinone oxidoreductase I in Escherichia coli.

Wong KS, Snider JD, Graham C, Greenblatt JF, Emili A, Babu M, Houry WA.

PLoS One. 2014 Jan 15;9(1):e85529. doi: 10.1371/journal.pone.0085529. eCollection 2014.

29.

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.

Kamano Y, Saeki M, Egusa H, Kakihara Y, Houry WA, Yatani H, Kamisaki Y.

FEBS Lett. 2013 Oct 11;587(20):3303-8. doi: 10.1016/j.febslet.2013.09.001. Epub 2013 Sep 11.

30.

Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.

Saeki M, Egusa H, Kamano Y, Kakihara Y, Houry WA, Yatani H, Noguchi S, Kamisaki Y.

PLoS One. 2013 Jul 3;8(7):e67326. doi: 10.1371/journal.pone.0067326. Print 2013.

31.

Mechanisms of acid resistance in Escherichia coli.

Kanjee U, Houry WA.

Annu Rev Microbiol. 2013;67:65-81. doi: 10.1146/annurev-micro-092412-155708. Epub 2013 May 20. Review.

PMID:
23701194
32.

Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes.

Nano N, Houry WA.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110399. doi: 10.1098/rstb.2011.0399. Print 2013 May 5. Review.

33.

The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.

Rosenbaum J, Baek SH, Dutta A, Houry WA, Huber O, Hupp TR, Matias PM.

Sci Signal. 2013 Mar 12;6(266):mr1. doi: 10.1126/scisignal.2003906.

34.

The control of spindle length by Hsp70 and Hsp110 molecular chaperones.

Makhnevych T, Houry WA.

FEBS Lett. 2013 Apr 17;587(8):1067-72. doi: 10.1016/j.febslet.2013.02.018. Epub 2013 Feb 19. Review.

35.

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.

El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA.

J Biol Chem. 2013 Jan 11;288(2):1022-31. doi: 10.1074/jbc.M112.416560. Epub 2012 Nov 28.

36.

The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus.

Paci A, Liu XH, Huang H, Lim A, Houry WA, Zhao R.

J Biol Chem. 2012 Dec 21;287(52):43205-14. doi: 10.1074/jbc.M112.408849. Epub 2012 Nov 8.

37.

Hsp110 is required for spindle length control.

Makhnevych T, Wong P, Pogoutse O, Vizeacoumar FJ, Greenblatt JF, Emili A, Houry WA.

J Cell Biol. 2012 Aug 20;198(4):623-36. doi: 10.1083/jcb.201111105.

38.

Direct binding targets of the stringent response alarmone (p)ppGpp.

Kanjee U, Ogata K, Houry WA.

Mol Microbiol. 2012 Sep;85(6):1029-43. doi: 10.1111/j.1365-2958.2012.08177.x. Epub 2012 Aug 2. Review.

39.

Novel structural and functional insights into the MoxR family of AAA+ ATPases.

Wong KS, Houry WA.

J Struct Biol. 2012 Aug;179(2):211-21. doi: 10.1016/j.jsb.2012.03.010. Epub 2012 Apr 3. Review.

PMID:
22491058
40.

Role of the N-terminal domain of the chaperone ClpX in the recognition and degradation of lambda phage protein O.

Thibault G, Houry WA.

J Phys Chem B. 2012 Jun 14;116(23):6717-24. doi: 10.1021/jp212024b. Epub 2012 Mar 6.

PMID:
22360725
41.

Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90.

Jiménez B, Ugwu F, Zhao R, Ortí L, Makhnevych T, Pineda-Lucena A, Houry WA.

J Biol Chem. 2012 Feb 17;287(8):5698-709. doi: 10.1074/jbc.M111.287458. Epub 2011 Dec 16.

42.

The enzymatic activities of the Escherichia coli basic aliphatic amino acid decarboxylases exhibit a pH zone of inhibition.

Kanjee U, Gutsche I, Ramachandran S, Houry WA.

Biochemistry. 2011 Nov 1;50(43):9388-98. doi: 10.1021/bi201161k. Epub 2011 Oct 5.

PMID:
21957966
43.

The role of Hsp90 in protein complex assembly.

Makhnevych T, Houry WA.

Biochim Biophys Acta. 2012 Mar;1823(3):674-82. doi: 10.1016/j.bbamcr.2011.09.001. Epub 2011 Sep 16. Review.

44.

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease.

Leung E, Datti A, Cossette M, Goodreid J, McCaw SE, Mah M, Nakhamchik A, Ogata K, El Bakkouri M, Cheng YQ, Wodak SJ, Eger BT, Pai EF, Liu J, Gray-Owen S, Batey RA, Houry WA.

Chem Biol. 2011 Sep 23;18(9):1167-78. doi: 10.1016/j.chembiol.2011.07.023.

45.

The R2TP complex: discovery and functions.

Kakihara Y, Houry WA.

Biochim Biophys Acta. 2012 Jan;1823(1):101-7. doi: 10.1016/j.bbamcr.2011.08.016. Epub 2011 Sep 8. Review.

46.

Bioinformatic approach to identify chaperone pathway relationship from large-scale interaction networks.

Gong Y, Zhang Z, Houry WA.

Methods Mol Biol. 2011;787:189-203. doi: 10.1007/978-1-61779-295-3_15.

PMID:
21898237
47.

Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.

Kanjee U, Gutsche I, Alexopoulos E, Zhao B, El Bakkouri M, Thibault G, Liu K, Ramachandran S, Snider J, Pai EF, Houry WA.

EMBO J. 2011 Mar 2;30(5):931-44. doi: 10.1038/emboj.2011.5. Epub 2011 Jan 28.

48.

Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.

El Bakkouri M, Gutsche I, Kanjee U, Zhao B, Yu M, Goret G, Schoehn G, Burmeister WP, Houry WA.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22499-504. doi: 10.1073/pnas.1009092107. Epub 2010 Dec 9.

49.

Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags.

Cheung KL, Huen J, Kakihara Y, Houry WA, Ortega J.

J Mol Biol. 2010 Dec 3;404(3):478-92. doi: 10.1016/j.jmb.2010.10.003. Epub 2010 Oct 8.

50.

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.

El Bakkouri M, Pow A, Mulichak A, Cheung KL, Artz JD, Amani M, Fell S, de Koning-Ward TF, Goodman CD, McFadden GI, Ortega J, Hui R, Houry WA.

J Mol Biol. 2010 Dec 3;404(3):456-77. doi: 10.1016/j.jmb.2010.09.051. Epub 2010 Sep 29.

PMID:
20887733

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