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Items: 49

1.

Quercetin depletes intracellular Ca2+ stores and blunts ATP-triggered Ca2+ signaling in bEnd.3 endothelial cells.

Chen CY, Hour MJ, Shiao LR, Wong KL, Leung YM, Chan P, So EC.

Fundam Clin Pharmacol. 2020 Apr;34(2):213-221. doi: 10.1111/fcp.12514. Epub 2019 Nov 4.

PMID:
31618480
2.

Antagonism of Ca2+-sensing receptors by NPS 2143 is transiently masked by p38 activation in mouse brain bEND.3 endothelial cells.

Chen CY, Hour MJ, Lin WC, Wong KL, Shiao LR, Cheng KS, Chan P, Leung YM.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul;392(7):823-832. doi: 10.1007/s00210-019-01637-y. Epub 2019 Mar 2.

PMID:
30826858
3.

Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.

You BJ, Hour MJ, Chen LY, Luo SC, Hsu PH, Lee HZ.

Sci Rep. 2019 Mar 1;9(1):3306. doi: 10.1038/s41598-019-39778-y.

4.

Cis-3-O-p-hydroxycinnamoyl Ursolic Acid Induced ROS-Dependent p53-Mediated Mitochondrial Apoptosis in Oral Cancer Cells.

Wang CY, Lin CS, Hua CH, Jou YJ, Liao CR, Chang YS, Wan L, Huang SH, Hour MJ, Lin CW.

Biomol Ther (Seoul). 2019 Jan 1;27(1):54-62. doi: 10.4062/biomolther.2017.237.

5.

Epigallocatechin-3-gallate inhibits the early stages of Japanese encephalitis virus infection.

Wang CY, Hour MJ, Lai HC, Chen CH, Chang PJ, Huang SH, Lin CW.

Virus Res. 2018 Jul 15;253:140-146. doi: 10.1016/j.virusres.2018.06.009. Epub 2018 Jun 26.

PMID:
29958923
6.

Disruption of IGF‑1R signaling by a novel quinazoline derivative, HMJ‑30, inhibits invasiveness and reverses epithelial-mesenchymal transition in osteosarcoma U‑2 OS cells.

Chiu YJ, Hour MJ, Jin YA, Lu CC, Tsai FJ, Chen TL, Ma H, Juan YN, Yang JS.

Int J Oncol. 2018 May;52(5):1465-1478. doi: 10.3892/ijo.2018.4325. Epub 2018 Mar 16.

7.

Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis.

Lu CY, Chang YC, Hua CH, Chuang C, Huang SH, Kung SH, Hour MJ, Lin CW.

Int J Mol Sci. 2017 May 1;18(5). pii: E954. doi: 10.3390/ijms18050954.

8.

SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling.

Wang CY, Lu CY, Li SW, Lai CC, Hua CH, Huang SH, Lin YJ, Hour MJ, Lin CW.

Virus Res. 2017 May 2;235:58-66. doi: 10.1016/j.virusres.2017.04.008. Epub 2017 Apr 13.

PMID:
28414040
9.

Single-Round Infectious Particle Antiviral Screening Assays for the Japanese Encephalitis Virus.

Lu CY, Hour MJ, Wang CY, Huang SH, Mu WX, Chang YC, Lin CW.

Viruses. 2017 Apr 10;9(4). pii: E76. doi: 10.3390/v9040076.

10.

Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease.

Wang CY, Huang AC, Hour MJ, Huang SH, Kung SH, Chen CH, Chen IC, Chang YS, Lien JC, Lin CW.

Viruses. 2015 Jun 17;7(6):3155-71. doi: 10.3390/v7062764.

11.

Aggravated DNA damage as a basis for enhanced glioma cell killing by MJ-66 in combination with minocycline.

Hour MJ, Liu WT, Lu IC, Kuo SC, Gean PW.

Am J Cancer Res. 2014 Sep 6;4(5):474-83. eCollection 2014.

12.

5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts.

Lin HC, Lin TH, Wu MY, Chiu YC, Tang CH, Hour MJ, Liou HC, Tu HJ, Yang RS, Fu WM.

PLoS One. 2014 Sep 17;9(9):e107890. doi: 10.1371/journal.pone.0107890. eCollection 2014.

13.

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex.

Liu WT, Chen C, Lu IC, Kuo SC, Lee KH, Chen TL, Song TS, Lu YL, Gean PW, Hour MJ.

Neuropharmacology. 2014 Nov;86:219-27. doi: 10.1016/j.neuropharm.2014.07.014. Epub 2014 Aug 5.

14.

Combined versus monotherapy or concurrent therapy for treatment of thalassaemia.

Song TS, Hsieh YW, Peng CT, Chen TL, Lee HZ, Chung JG, Hour MJ.

In Vivo. 2014 Jul-Aug;28(4):645-9.

PMID:
24982236
15.

Quinazoline analog HMJ-30 inhibits angiogenesis: involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling.

Lu CC, Chen HP, Chiang JH, Jin YA, Kuo SC, Wu TS, Hour MJ, Yang JS, Chiu YJ.

Oncol Rep. 2014 Aug;32(2):597-606. doi: 10.3892/or.2014.3250. Epub 2014 Jun 12.

PMID:
24919794
16.

Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts.

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lee TH, Chung JG.

Biochim Biophys Acta. 2014 Jul;1840(7):2310-20. doi: 10.1016/j.bbagen.2014.02.022. Epub 2014 Mar 1.

PMID:
24594224
17.

Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.

Peng SF, Lee CY, Hour MJ, Tsai SC, Kuo DH, Chen FA, Shieh PC, Yang JS.

Int J Oncol. 2014 Jan;44(1):238-46. doi: 10.3892/ijo.2013.2175. Epub 2013 Nov 14.

PMID:
24247158
18.

Application of proteomics to identify the target molecules involved in Lonicera japonica-induced photokilling in human lung cancer CH27 cells.

Liao JC, Chang WT, Lan YH, Hour MJ, Lee HZ.

BMC Complement Altern Med. 2013 Oct 1;13:244. doi: 10.1186/1472-6882-13-244.

19.

Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: evidence for γH2A.X and DNA-PK-dependent pathway.

Chiang JH, Yang JS, Lu CC, Hour MJ, Liu KC, Lin JH, Lee TH, Chung JG.

Hum Exp Toxicol. 2014 Jun;33(6):590-601. doi: 10.1177/0960327113504791. Epub 2013 Sep 23.

PMID:
24064905
20.

Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer.

Ting WC, Chen LM, Huang LC, Hour MJ, Lan YH, Lee HZ, You BJ, Chang TY, Bao BY.

J Korean Med Sci. 2013 Sep;28(9):1302-6. doi: 10.3346/jkms.2013.28.9.1302. Epub 2013 Aug 28.

21.

Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.

Hour MJ, Huang SH, Chang CY, Lin YK, Wang CY, Chang YS, Lin CW.

Evid Based Complement Alternat Med. 2013;2013:750803. doi: 10.1155/2013/750803. Epub 2013 Jun 20.

22.

Protection of dopaminergic neurons by 5-lipoxygenase inhibitor.

Kang KH, Liou HH, Hour MJ, Liou HC, Fu WM.

Neuropharmacology. 2013 Oct;73:380-7. doi: 10.1016/j.neuropharm.2013.06.014. Epub 2013 Jun 22.

PMID:
23800665
23.

Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.

Chen HJ, Jiang YL, Lin CM, Tsai SC, Peng SF, Fushiya S, Hour MJ, Yang JS.

Int J Oncol. 2013 Jul;43(1):141-50. doi: 10.3892/ijo.2013.1941. Epub 2013 May 16.

PMID:
23677180
24.

Enhancement role of host 12/15-lipoxygenase in melanoma progression.

Kang KH, Ling TY, Liou HH, Huang YK, Hour MJ, Liou HC, Fu WM.

Eur J Cancer. 2013 Aug;49(12):2747-59. doi: 10.1016/j.ejca.2013.03.030. Epub 2013 May 8.

PMID:
23664097
25.

Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents.

Hour MJ, Lee KH, Chen TL, Lee KT, Zhao Y, Lee HZ.

Br J Pharmacol. 2013 Aug;169(7):1574-86. doi: 10.1111/bph.12233.

26.

Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.

Chiang JH, Yang JS, Lu CC, Hour MJ, Chang SJ, Lee TH, Chung JG.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):150-62. doi: 10.1016/j.taap.2013.03.007. Epub 2013 Mar 22.

PMID:
23523585
27.

A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.

Hour MJ, Lee KT, Wu YC, Wu CY, You BJ, Chen TL, Lee HZ.

Arch Toxicol. 2013 May;87(5):835-46. doi: 10.1007/s00204-012-0991-3. Epub 2012 Dec 5.

PMID:
23212307
28.

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.

Wang XF, Tian XT, Ohkoshi E, Qin B, Liu YN, Wu PC, Hour MJ, Hung HY, Qian K, Huang R, Bastow KF, Janzen WP, Jin J, Morris-Natschke SL, Lee KH, Xie L.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6224-8. doi: 10.1016/j.bmcl.2012.08.014. Epub 2012 Aug 9.

PMID:
22932313
29.

Antitumor effects of the novel quinazolinone MJ-33: inhibition of metastasis through the MAPK, AKT, NF-κB and AP-1 signaling pathways in DU145 human prostate cancer cells.

Hour MJ, Tsai SC, Wu HC, Lin MW, Chung JG, Wu JB, Chiang JH, Tsuzuki M, Yang JS.

Int J Oncol. 2012 Oct;41(4):1513-9. doi: 10.3892/ijo.2012.1560. Epub 2012 Jul 18.

PMID:
22825655
30.
31.

Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice.

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lin JJ, Huang WW, Tsuzuki M, Lee TH, Chung JG.

PLoS One. 2012;7(5):e36831. doi: 10.1371/journal.pone.0036831. Epub 2012 May 25.

32.

Development of a fast LC-MS/MS assay for the determination of deferiprone in human plasma and application to pharmacokinetics.

Song TS, Hsieh YW, Peng CT, Liu CH, Chen TL, Hour MJ.

Biomed Chromatogr. 2012 Dec;26(12):1575-81. doi: 10.1002/bmc.2734. Epub 2012 Mar 27.

PMID:
22457166
33.

The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.

Chen KT, Hour MJ, Tsai SC, Chung JG, Kuo SC, Lu CC, Chiu YJ, Chuang YH, Yang JS.

Int J Oncol. 2011 Sep;39(3):611-9. doi: 10.3892/ijo.2011.1071. Epub 2011 Jun 8.

PMID:
21667022
34.

2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubules and the cell cycle.

Wu YC, Hour MJ, Leung WC, Wu CY, Liu WZ, Chang YH, Lee HZ.

J Pharmacol Exp Ther. 2011 Sep;338(3):942-51. doi: 10.1124/jpet.110.176115. Epub 2011 Jun 7.

PMID:
21652781
35.

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells.

Hour MJ, Yang JS, Chen TL, Chen KT, Kuo SC, Chung JG, Lu CC, Chen CY, Chuang YH.

Eur J Med Chem. 2011 Jul;46(7):2709-21. doi: 10.1016/j.ejmech.2011.03.059. Epub 2011 Apr 3.

PMID:
21514013
36.

Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.

Chiu YJ, Hour MJ, Lu CC, Chung JG, Kuo SC, Huang WW, Chen HJ, Jin YA, Yang JS.

J Orthop Res. 2011 Sep;29(9):1448-56. doi: 10.1002/jor.21398. Epub 2011 Mar 21.

37.

Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis.

Lee HZ, Yang WH, Hour MJ, Wu CY, Peng WH, Bao BY, Han PH, Bau DT.

Eur J Pharmacol. 2010 Dec 1;648(1-3):50-8. doi: 10.1016/j.ejphar.2010.08.033. Epub 2010 Sep 16.

PMID:
20840846
38.

Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels.

Leung YM, Tsou YH, Kuo CS, Lin SY, Wu PY, Hour MJ, Kuo YH.

Phytomedicine. 2010 Dec 15;18(1):46-51. doi: 10.1016/j.phymed.2010.04.001. Epub 2010 Jun 1.

PMID:
20684875
39.

MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.

Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC, Chung JG.

J Pharmacol Exp Ther. 2010 Aug;334(2):477-88. doi: 10.1124/jpet.109.165415. Epub 2010 May 12.

PMID:
20463006
40.

P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells.

Leung HW, Hour MJ, Chang WT, Wu YC, Lai MY, Wang MY, Lee HZ.

Food Chem Toxicol. 2008 Nov;46(11):3389-400. doi: 10.1016/j.fct.2008.08.022. Epub 2008 Aug 30.

PMID:
18796326
41.

Synthesis of 2,3-disubstituted 1,4-naphthoquinones as antiplatelet agents.

Lien JC, Wu CR, Hour MJ, Huang LJ, Huang TF, Kuo SC.

Arch Pharm (Weinheim). 2008 Oct;341(10):639-44. doi: 10.1002/ardp.200800024.

PMID:
18720342
42.

HMJ-53A accelerates slow inactivation gating of voltage-gated K+ channels in mouse neuroblastoma N2A cells.

Chao CC, Shieh J, Kuo SC, Wu BT, Hour MJ, Leung YM.

Neuropharmacology. 2008 Jun;54(7):1128-35. doi: 10.1016/j.neuropharm.2008.03.006. Epub 2008 Mar 18.

PMID:
18406431
43.

Chaperones are the target in aloe-emodin-induced human lung nonsmall carcinoma H460 cell apoptosis.

Lai MY, Hour MJ, Wing-Cheung Leung H, Yang WH, Lee HZ.

Eur J Pharmacol. 2007 Nov 14;573(1-3):1-10. Epub 2007 Jul 12.

PMID:
17643413
44.

Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes.

Leung HW, Lin CJ, Hour MJ, Yang WH, Wang MY, Lee HZ.

Food Chem Toxicol. 2007 Oct;45(10):2005-13. Epub 2007 May 18.

PMID:
17583406
45.

Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.

Yang JS, Hour MJ, Kuo SC, Huang LJ, Lee MR.

Anticancer Res. 2004 May-Jun;24(3a):1769-78.

46.

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

Xia Y, Yang ZY, Hour MJ, Kuo SC, Xia P, Bastow KF, Nakanishi Y, Namrpoothiri P, Hackl T, Hamel E, Lee HK.

Bioorg Med Chem Lett. 2001 May 7;11(9):1193-6.

PMID:
11354375
47.

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

Ko TC, Hour MJ, Lien JC, Teng CM, Lee KH, Kuo SC, Huang LJ.

Bioorg Med Chem Lett. 2001 Feb 12;11(3):279-82.

PMID:
11212091
48.

6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Hour MJ, Huang LJ, Kuo SC, Xia Y, Bastow K, Nakanishi Y, Hamel E, Lee KH.

J Med Chem. 2000 Nov 16;43(23):4479-87.

PMID:
11087572
49.

Synthesis and antiplatelet activities of N-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives.

Huang LJ, Hour MJ, Teng CM, Kuo SC.

Chem Pharm Bull (Tokyo). 1992 Sep;40(9):2547-51.

PMID:
1446375

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