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Items: 29

1.

Ghrelin octanoylation by ghrelin O-acyltransferase: Unique protein biochemistry underlying metabolic signaling.

Hougland JL.

Biochem Soc Trans. 2019 Jan 9. pii: BST20180436. doi: 10.1042/BST20180436. [Epub ahead of print] Review.

PMID:
30626708
2.

Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus.

Berger BM, Kim JH, Hildebrandt ER, Davis IC, Morgan MC, Hougland JL, Schmidt WK.

Genetics. 2018 Dec;210(4):1301-1316. doi: 10.1534/genetics.118.301454. Epub 2018 Sep 26.

3.

Functional group and stereochemical requirements for substrate binding by ghrelin O-acyltransferase revealed by unnatural amino acid incorporation.

Cleverdon ER, Davis TR, Hougland JL.

Bioorg Chem. 2018 Sep;79:98-106. doi: 10.1016/j.bioorg.2018.04.009. Epub 2018 Apr 21.

PMID:
29738973
4.

Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.

Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL.

J Biol Chem. 2018 Feb 23;293(8):2770-2785. doi: 10.1074/jbc.M117.805770. Epub 2017 Dec 27.

PMID:
29282289
5.

Simultaneous Analysis of a Non-Lipidated Protein and Its Lipidated Counterpart: Enabling Quantitative Investigation of Protein Lipidation's Impact on Cellular Regulation.

Shala-Lawrence A, Blanden MJ, Krylova SM, Gangopadhyay SA, Beloborodov SS, Hougland JL, Krylov SN.

Anal Chem. 2017 Dec 19;89(24):13502-13507. doi: 10.1021/acs.analchem.7b03846. Epub 2017 Dec 1.

PMID:
29144728
6.

The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin's biological interactions and avenues for controlling ghrelin signaling.

Cleverdon ER, McGovern-Gooch KR, Hougland JL.

Mol Membr Biol. 2016 Sep - Dec;33(6-8):111-124. doi: 10.1080/09687688.2017.1388930. Epub 2017 Nov 16.

PMID:
29143554
7.

Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation.

McGovern-Gooch KR, Mahajani NS, Garagozzo A, Schramm AJ, Hannah LG, Sieburg MA, Chisholm JD, Hougland JL.

Biochemistry. 2017 Feb 21;56(7):919-931. doi: 10.1021/acs.biochem.6b01008. Epub 2017 Feb 7.

8.

Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates.

McGovern-Gooch KR, Rodrigues T, Darling JE, Sieburg MA, Abizaid A, Hougland JL.

Endocrinology. 2016 Nov;157(11):4330-4338. Epub 2016 Sep 13.

PMID:
27623288
9.

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases.

Zhang Y, Blanden MJ, Sudheer Ch, Gangopadhyay SA, Rashidian M, Hougland JL, Distefano MD.

Bioconjug Chem. 2015 Dec 16;26(12):2542-53. doi: 10.1021/acs.bioconjchem.5b00553. Epub 2015 Dec 4.

10.

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.

Wellman MK, Patterson ZR, MacKay H, Darling JE, Mani BK, Zigman JM, Hougland JL, Abizaid A.

Front Endocrinol (Lausanne). 2015 Sep 25;6:144. doi: 10.3389/fendo.2015.00144. eCollection 2015.

11.

Progress in Small Molecule and Biologic Therapeutics Targeting Ghrelin Signaling.

McGovern KR, Darling JE, Hougland JL.

Mini Rev Med Chem. 2016;16(6):465-80. Review.

PMID:
26202202
12.

A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups.

Zhao F, Darling JE, Gibbs RA, Hougland JL.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2800-3. doi: 10.1016/j.bmcl.2015.05.009. Epub 2015 May 15.

PMID:
26009163
13.

Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition.

Darling JE, Zhao F, Loftus RJ, Patton LM, Gibbs RA, Hougland JL.

Biochemistry. 2015 Feb 3;54(4):1100-10. doi: 10.1021/bi5010359. Epub 2015 Jan 21.

PMID:
25562443
14.

Quantitative determination of cellular farnesyltransferase activity: towards defining the minimum substrate reactivity for biologically relevant protein farnesylation.

Flynn SC, Lindgren DE, Hougland JL.

Chembiochem. 2014 Oct 13;15(15):2205-10. doi: 10.1002/cbic.201402239. Epub 2014 Sep 2.

PMID:
25182009
15.

Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition.

Gangopadhyay SA, Losito EL, Hougland JL.

Biochemistry. 2014 Jan 21;53(2):434-46. doi: 10.1021/bi4011732. Epub 2014 Jan 6.

PMID:
24344934
16.

A fluorescent peptide substrate facilitates investigation of ghrelin recognition and acylation by ghrelin O-acyltransferase.

Darling JE, Prybolsky EP, Sieburg M, Hougland JL.

Anal Biochem. 2013 Jun 1;437(1):68-76. doi: 10.1016/j.ab.2013.02.013. Epub 2013 Feb 27.

PMID:
23453974
17.

Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.

Hougland JL, Gangopadhyay SA, Fierke CA.

J Biol Chem. 2012 Nov 2;287(45):38090-100. doi: 10.1074/jbc.M112.404954. Epub 2012 Sep 19.

18.

Synthesis of frame-shifted farnesyl diphosphate analogs.

Placzek AT, Hougland JL, Gibbs RA.

Org Lett. 2012 Aug 17;14(16):4038-41. doi: 10.1021/ol300683r. Epub 2012 Aug 2.

PMID:
22857735
19.

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity.

London N, Lamphear CL, Hougland JL, Fierke CA, Schueler-Furman O.

PLoS Comput Biol. 2011 Oct;7(10):e1002170. doi: 10.1371/journal.pcbi.1002170. Epub 2011 Oct 6.

20.

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.

Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):767-70. doi: 10.1016/j.bmcl.2009.11.011. Epub 2009 Nov 12.

21.

Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.

Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA.

J Mol Biol. 2010 Jan 8;395(1):176-90. doi: 10.1016/j.jmb.2009.10.038. Epub 2009 Oct 28.

22.

Getting a handle on protein prenylation.

Hougland JL, Fierke CA.

Nat Chem Biol. 2009 Apr;5(4):197-8. doi: 10.1038/nchembio0409-197. No abstract available.

PMID:
19295521
23.

Context-dependent substrate recognition by protein farnesyltransferase.

Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA.

Biochemistry. 2009 Mar 3;48(8):1691-701. doi: 10.1021/bi801710g.

24.

2'-amino-modified ribonucleotides as probes for local interactions within RNA.

Hougland JL, Piccirilli JA.

Methods Enzymol. 2009;468:107-25. doi: 10.1016/S0076-6879(09)68006-X. Epub 2009 Nov 17.

PMID:
20946767
25.

The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.

Hougland JL, Sengupta RN, Dai Q, Deb SK, Piccirilli JA.

Biochemistry. 2008 Jul 22;47(29):7684-94. doi: 10.1021/bi8000648. Epub 2008 Jun 24.

PMID:
18572927
26.

Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite.

Dai Q, Deb SK, Hougland JL, Piccirilli JA.

Bioorg Med Chem. 2006 Feb 1;14(3):705-13. Epub 2005 Oct 3.

PMID:
16202607
27.

Functional identification of catalytic metal ion binding sites within RNA.

Hougland JL, Kravchuk AV, Herschlag D, Piccirilli JA.

PLoS Biol. 2005 Sep;3(9):e277. Epub 2005 Aug 16.

28.

An atomic mutation cycle for exploring RNA's 2'-hydroxyl group.

Hougland JL, Deb SK, Maric D, Piccirilli JA.

J Am Chem Soc. 2004 Oct 27;126(42):13578-9.

PMID:
15493890
29.

Using selective withdrawal to coat microparticles.

Cohen I, Li H, Hougland JL, Mrksich M, Nagel SR.

Science. 2001 Apr 13;292(5515):265-7.

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