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Hepatitis C Virus: 30 Years after Its Discovery.

Houghton M.

Cold Spring Harb Perspect Med. 2019 Sep 9. pii: a037069. doi: 10.1101/cshperspect.a037069. [Epub ahead of print]


A recombinant HCV genotype 1a E1/E2 envelope glycoprotein vaccine elicits antibodies that differentially neutralize closely related 2a strains through interactions of the N-terminal hypervariable region 1 of E2 with scavenger receptor B1.

Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M.

J Virol. 2019 Aug 28. pii: JVI.00810-19. doi: 10.1128/JVI.00810-19. [Epub ahead of print]


Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.

Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K.

Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6.


Effectiveness and Safety of Ankle Arthrodesis Versus Arthroplasty: A Prospective Multicenter Study.

Norvell DC, Ledoux WR, Shofer JB, Hansen ST, Davitt J, Anderson JG, Bohay D, Coetzee JC, Maskill J, Brage M, Houghton M, Sangeorzan BJ.

J Bone Joint Surg Am. 2019 Aug 21;101(16):1485-1494. doi: 10.2106/JBJS.18.01257.


Step Activity After Surgical Treatment of Ankle Arthritis.

Shofer JB, Ledoux WR, Orendurff MS, Hansen ST, Davitt J, Anderson JG, Bohay D, Coetzee JC, Houghton M, Norvell DC, Sangeorzan BJ.

J Bone Joint Surg Am. 2019 Jul 3;101(13):1177-1184. doi: 10.2106/JBJS.18.00511.


Exploring Lesbian and Bisexual Catholic Women's Narratives of Religious and Sexual Identity Formation and Integration.

Houghton M, Tasker F.

J Homosex. 2019 Jun 12:1-23. doi: 10.1080/00918369.2019.1624455. [Epub ahead of print]


A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors.

Banda DH, Perin PM, Brown RJP, Todt D, Solodenko W, Hoffmeyer P, Kumar Sahu K, Houghton M, Meuleman P, Müller R, Kirschning A, Pietschmann T.

J Hepatol. 2019 Jun;70(6):1082-1092. doi: 10.1016/j.jhep.2019.01.033. Epub 2019 Feb 13.


Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

Khera T, Behrendt P, Bankwitz D, Brown RJP, Todt D, Doepke M, Khan AG, Schulze K, Law J, Logan M, Hockman D, Wong JAJ, Dold L, Gonzalez-Motos V, Spengler U, Viejo-Borbolla A, Ströh LJ, Krey T, Tarr AW, Steinmann E, Manns MP, Klein F, Guzman CA, Marcotrigiano J, Houghton M, Pietschmann T.

J Hepatol. 2019 Apr;70(4):593-602. doi: 10.1016/j.jhep.2018.11.003. Epub 2018 Nov 13.


Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells.

Houghton MJ, Kerimi A, Tumova S, Boyle JP, Williamson G.

Free Radic Biol Med. 2018 Dec;129:296-309. doi: 10.1016/j.freeradbiomed.2018.09.037. Epub 2018 Sep 25.


Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism.

Houghton MJ, Kerimi A, Mouly V, Tumova S, Williamson G.

FASEB J. 2019 Feb;33(2):1887-1898. doi: 10.1096/fj.201801209R. Epub 2018 Sep 5.


Tissue engineering toward temporomandibular joint disc regeneration.

Vapniarsky N, Huwe LW, Arzi B, Houghton MK, Wong ME, Wilson JW, Hatcher DC, Hu JC, Athanasiou KA.

Sci Transl Med. 2018 Jun 20;10(446). pii: eaaq1802. doi: 10.1126/scitranslmed.aaq1802.


Frequency and Impact of Adverse Events in Patients Undergoing Surgery for End-Stage Ankle Arthritis.

Norvell DC, Shofer JB, Hansen ST, Davitt J, Anderson JG, Bohay D, Coetzee JC, Maskill J, Brage M, Houghton M, Ledoux WR, Sangeorzan BJ.

Foot Ankle Int. 2018 Sep;39(9):1028-1038. doi: 10.1177/1071100718776021. Epub 2018 May 31.


A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M.

J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8.


Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine.

Law JLM, Logan M, Wong J, Kundu J, Hockman D, Landi A, Chen C, Crawford K, Wininger M, Johnson J, Mesa Prince C, Dudek E, Mehta N, Tyrrell DL, Houghton M.

J Virol. 2018 May 14;92(11). pii: e02141-17. doi: 10.1128/JVI.02141-17. Print 2018 Jun 1.


Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T.

Virus Res. 2018 Mar 15;248:53-62. doi: 10.1016/j.virusres.2018.02.016. Epub 2018 Mar 2. Review.


Global Demand for Natural Resources Eliminated More Than 100,000 Bornean Orangutans.

Voigt M, Wich SA, Ancrenaz M, Meijaard E, Abram N, Banes GL, Campbell-Smith G, d'Arcy LJ, Delgado RA, Erman A, Gaveau D, Goossens B, Heinicke S, Houghton M, Husson SJ, Leiman A, Sanchez KL, Makinuddin N, Marshall AJ, Meididit A, Miettinen J, Mundry R, Musnanda, Nardiyono, Nurcahyo A, Odom K, Panda A, Prasetyo D, Priadjati A, Purnomo, Rafiastanto A, Russon AE, Santika T, Sihite J, Spehar S, Struebig M, Sulbaran-Romero E, Tjiu A, Wells J, Wilson KA, Kühl HS.

Curr Biol. 2018 Mar 5;28(5):761-769.e5. doi: 10.1016/j.cub.2018.01.053. Epub 2018 Feb 15.


Acute geriatrics at the front door.

Houghton MP.

Clin Med (Lond). 2017 Dec;17(6):590. doi: 10.7861/clinmedicine.17-6-590. No abstract available.


Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-di-AMP, a STING activator or archaeosomes.

Landi A, Law J, Hockman D, Logan M, Crawford K, Chen C, Kundu J, Ebensen T, Guzman CA, Deschatelets L, Krishnan L, Tyrrell DLJ, Houghton M.

Vaccine. 2017 Dec 15;35(50):6949-6956. doi: 10.1016/j.vaccine.2017.10.072. Epub 2017 Oct 28.


Comparison of Treatment Outcomes of Arthrodesis and Two Generations of Ankle Replacement Implants.

Benich MR, Ledoux WR, Orendurff MS, Shofer JB, Hansen ST, Davitt J, Anderson JG, Bohay D, Coetzee JC, Maskill J, Brage M, Houghton M, Sangeorzan BJ.

J Bone Joint Surg Am. 2017 Nov 1;99(21):1792-1800. doi: 10.2106/JBJS.16.01471.


Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.

Okoye IS, Houghton M, Tyrrell L, Barakat K, Elahi S.

Front Immunol. 2017 Sep 29;8:1215. doi: 10.3389/fimmu.2017.01215. eCollection 2017. Review.


Light therapy for multiple sclerosis-associated fatigue: Study protocol for a randomized controlled trial.

Mateen FJ, Manalo NC, Grundy SJ, Houghton MA, Hotan GC, Erickson H, Videnovic A.

Medicine (Baltimore). 2017 Sep;96(36):e8037. doi: 10.1097/MD.0000000000008037.


Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade.

Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K.

Drug Des Devel Ther. 2017 Aug 4;11:2301-2324. doi: 10.2147/DDDT.S133944. eCollection 2017.


First integrative trend analysis for a great ape species in Borneo.

Santika T, Ancrenaz M, Wilson KA, Spehar S, Abram N, Banes GL, Campbell-Smith G, Curran L, d'Arcy L, Delgado RA, Erman A, Goossens B, Hartanto H, Houghton M, Husson SJ, Kühl HS, Lackman I, Leiman A, Llano Sanchez K, Makinuddin N, Marshall AJ, Meididit A, Mengersen K, Musnanda, Nardiyono, Nurcahyo A, Odom K, Panda A, Prasetyo D, Purnomo, Rafiastanto A, Raharjo S, Ratnasari D, Russon AE, Santana AH, Santoso E, Sapari I, Sihite J, Suyoko A, Tjiu A, Utami-Atmoko SS, van Schaik CP, Voigt M, Wells J, Wich SA, Willems EP, Meijaard E.

Sci Rep. 2017 Jul 7;7(1):4839. doi: 10.1038/s41598-017-04435-9.


Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.

Sarhan MA, Abdel-Hakeem MS, Mason AL, Tyrrell DL, Houghton M.

Sci Rep. 2017 May 31;7(1):2495. doi: 10.1038/s41598-017-02648-6.


Thermal QST Phenotypes Associated with Response to Lumbar Epidural Steroid Injections: A Pilot Study.

Maher DP, Ding W, Singh S, Opalacz A, Fishman C, Houghton M, Ahmed S, Chen L, Mao J, Zhang Y.

Pain Med. 2017 Aug 1;18(8):1455-1463. doi: 10.1093/pm/pnw364.


A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression.

Santer DM, Minty GES, Mohamed A, Baldwin L, Bhat R, Joyce M, Egli A, Tyrrell DLJ, Houghton M.

J Immunol Methods. 2017 Jun;445:15-22. doi: 10.1016/j.jim.2017.03.001. Epub 2017 Mar 6.


Computational Prediction of the Heterodimeric and Higher-Order Structure of gpE1/gpE2 Envelope Glycoproteins Encoded by Hepatitis C Virus.

Freedman H, Logan MR, Hockman D, Koehler Leman J, Law JLM, Houghton M.

J Virol. 2017 Mar 29;91(8). pii: e02309-16. doi: 10.1128/JVI.02309-16. Print 2017 Apr 15.


Bad medicine: clinical examination.

Houghton M.

Br J Gen Pract. 2017 Feb;67(655):60-61. doi: 10.3399/bjgp17X688969. No abstract available.


A Comprehensive Computational Analysis for the Binding Modes of Hepatitis C Virus NS5A Inhibitors: The Question of Symmetry.

Ahmed M, Pal A, Houghton M, Barakat K.

ACS Infect Dis. 2016 Nov 11;2(11):872-881. Epub 2016 Aug 3.


Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets.

Freedman H, Logan MR, Law JL, Houghton M.

ACS Infect Dis. 2016 Nov 11;2(11):749-762. Epub 2016 Aug 16. Review.


Native Folding of a Recombinant gpE1/gpE2 Heterodimer Vaccine Antigen from a Precursor Protein Fused with Fc IgG.

Logan M, Law J, Wong JAJ, Hockman D, Landi A, Chen C, Crawford K, Kundu J, Baldwin L, Johnson J, Dahiya A, LaChance G, Marcotrigiano J, Law M, Foung S, Tyrrell L, Houghton M.

J Virol. 2016 Dec 16;91(1). pii: e01552-16. doi: 10.1128/JVI.01552-16. Print 2017 Jan 1.


Lithium Enolates Derived from Weinreb Amides: Insights into Five-Membered Chelate Rings.

Houghton MJ, Collum DB.

J Org Chem. 2016 Nov 18;81(22):11057-11064. Epub 2016 Oct 17.


Lithium Enolates Derived from Pyroglutaminol: Mechanism and Stereoselectivity of an Azaaldol Addition.

Houghton MJ, Huck CJ, Wright SW, Collum DB.

J Am Chem Soc. 2016 Aug 17;138(32):10276-83. doi: 10.1021/jacs.6b05481. Epub 2016 Aug 8.


Fabrication of flexible self-standing all-cellulose nanofibrous composite membranes for virus removal.

Huang W, Wang Y, Chen C, Law JL, Houghton M, Chen L.

Carbohydr Polym. 2016 Jun 5;143:9-17. doi: 10.1016/j.carbpol.2016.02.011. Epub 2016 Feb 4.


Lithium Enolates Derived from Pyroglutaminol: Aggregation, Solvation, and Atropisomerism.

Houghton MJ, Biok NA, Huck CJ, Algera RF, Keresztes I, Wright SW, Collum DB.

J Org Chem. 2016 May 20;81(10):4149-57. doi: 10.1021/acs.joc.6b00459. Epub 2016 Apr 25.


An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions.

Syedbasha M, Linnik J, Santer D, O'Shea D, Barakat K, Joyce M, Khanna N, Tyrrell DL, Houghton M, Egli A.

J Vis Exp. 2016 Mar 14;(109). doi: 10.3791/53575.


Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

Landi A, Broadhurst D, Vernon SD, Tyrrell DL, Houghton M.

Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.


Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate.

O'Shea D, Law J, Egli A, Douglas D, Lund G, Forester S, Lambert J, Law M, Burton DR, Tyrrell DL, Houghton M, Humar A, Kneteman N.

Liver Transpl. 2016 Mar;22(3):324-32. doi: 10.1002/lt.24344. Epub 2016 Jan 29.


The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.

Egli A, Santer DM, O'Shea D, Tyrrell DL, Houghton M.

Emerg Microbes Infect. 2014 Jul;3(7):e51. doi: 10.1038/emi.2014.51. Epub 2014 Jul 16. Review.


Effects of Spinal Cord Stimulation on Pain Thresholds and Sensory Perceptions in Chronic Pain Patients.

Ahmed SU, Zhang Y, Chen L, St Hillary K, Cohen A, Vo T, Houghton M, Mao J.

Neuromodulation. 2015 Jul;18(5):355-60. doi: 10.1111/ner.12316. Epub 2015 Jun 1.


Effect of 1.5% Topical Diclofenac on Clinical Neuropathic Pain.

Ahmed SU, Zhang Y, Chen L, Cohen A, St Hillary K, Vo T, Houghton M, Mao J.

Anesthesiology. 2015 Jul;123(1):191-8. doi: 10.1097/ALN.0000000000000693.


Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.

Ahmed M, Wang F, Levin A, Le C, Eltayebi Y, Houghton M, Tyrrell L, Barakat K.

Drug Discov Today. 2015 May;20(5):548-61. doi: 10.1016/j.drudis.2015.01.008. Epub 2015 Jan 24. Review.


Effect of Immunosuppression on T-Helper 2 and B-Cell Responses to Influenza Vaccination.

Egli A, Humar A, Widmer LA, Lisboa LF, Santer DM, Mueller T, Stelling J, Baluch A, O'Shea D, Houghton M, Kumar D.

J Infect Dis. 2015 Jul 1;212(1):137-46. doi: 10.1093/infdis/jiv015. Epub 2015 Jan 14.


Clinical interpretation of opioid tolerance versus opioid-induced hyperalgesia.

Chen L, Sein M, Vo T, Amhmed S, Zhang Y, Hilaire KS, Houghton M, Mao J.

J Opioid Manag. 2014 Nov-Dec;10(6):383-93. doi: 10.5055/jom.2014.0235.


IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.

Egli A, Santer DM, O'Shea D, Barakat K, Syedbasha M, Vollmer M, Baluch A, Bhat R, Groenendyk J, Joyce MA, Lisboa LF, Thomas BS, Battegay M, Khanna N, Mueller T, Tyrrell DL, Houghton M, Humar A, Kumar D.

PLoS Pathog. 2014 Dec 11;10(12):e1004556. doi: 10.1371/journal.ppat.1004556. eCollection 2014 Dec.


The future NHS: time for another change?

Houghton M.

Br J Gen Pract. 2014 Dec;64(629):614. doi: 10.3399/bjgp14X682633. No abstract available.


Increased pain sensitivity in chronic pain subjects on opioid therapy: a cross-sectional study using quantitative sensory testing.

Zhang Y, Ahmed S, Vo T, St Hilaire K, Houghton M, Cohen AS, Mao J, Chen L.

Pain Med. 2015 May;16(5):911-22. doi: 10.1111/pme.12606. Epub 2014 Nov 6.


The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era.

MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, Klein M, Sagan S, Choucha N, Balfour L, Bialystok F, Krajden M, Raven J, Roberts E, Russell R, Houghton M, Tyrrell DL, Feld JJ; National CIHR Research Training Program in Hepatitis C.

Can J Gastroenterol Hepatol. 2014 Oct;28(9):481-7.


Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization.

Wong JA, Bhat R, Hockman D, Logan M, Chen C, Levin A, Frey SE, Belshe RB, Tyrrell DL, Law JL, Houghton M.

J Virol. 2014 Dec;88(24):14278-88. doi: 10.1128/JVI.01911-14. Epub 2014 Oct 1.


A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M.

Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007. Epub 2014 Aug 13.


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