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Items: 46


Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma dependends on MMP9.

Wirsching HG, Arora S, Zhang H, Szulzewsky F, Cimino PJ, Quéva C, Houghton AM, Glorioso JC, Weller M, Holland EC.

Neuro Oncol. 2019 Aug 15. pii: noz145. doi: 10.1093/neuonc/noz145. [Epub ahead of print] No abstract available.


Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma.

Wirsching HG, Zhang H, Szulzewsky F, Arora S, Grandi P, Cimino PJ, Amankulor N, Campbell JS, McFerrin L, Pattwell SS, Ene C, Hicks A, Ball M, Yan J, Zhang J, Kumasaka D, Pierce RH, Weller M, Finer M, Quéva C, Glorioso JC, Houghton AM, Holland EC.

JCI Insight. 2019 Jul 11;4(13). pii: 128217. doi: 10.1172/jci.insight.128217. eCollection 2019 Jul 11.


Comparison of prediction models with radiological semantic features and radiomics in lung cancer diagnosis of the pulmonary nodules: a case-control study.

Wu W, Pierce LA, Zhang Y, Pipavath SNJ, Randolph TW, Lastwika KJ, Lampe PD, Houghton AM, Liu H, Xia L, Kinahan PE.

Eur Radiol. 2019 May 21. doi: 10.1007/s00330-019-06213-9. [Epub ahead of print]


Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations.

Veatch JR, Jesernig BL, Kargl J, Fitzgibbon M, Lee SM, Baik C, Martins R, Houghton AM, Riddell SR.

Cancer Immunol Res. 2019 Jun;7(6):910-922. doi: 10.1158/2326-6066.CIR-18-0402. Epub 2019 May 1.


S-nitrosylation of cytoskeletal proteins.

Horenberg AL, Houghton AM, Pandey S, Seshadri V, Guilford WH.

Cytoskeleton (Hoboken). 2019 Mar;76(3):243-253. doi: 10.1002/cm.21520. Epub 2019 Apr 29. Review.


Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer.

Houghton AM.

Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S273-S277. doi: 10.1513/AnnalsATS.201808-537MG.


Tumor-derived Autoantibodies Identify Malignant Pulmonary Nodules.

Lastwika KJ, Kargl J, Zhang Y, Zhu X, Lo E, Shelley D, Ladd JJ, Wu W, Kinahan P, Pipavath SNJ, Randolph TW, Shipley M, Lampe PD, Houghton AM.

Am J Respir Crit Care Med. 2019 May 15;199(10):1257-1266. doi: 10.1164/rccm.201804-0628OC.


Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.

Veatch JR, Lee SM, Fitzgibbon M, Chow IT, Jesernig B, Schmitt T, Kong YY, Kargl J, Houghton AM, Thompson JA, McIntosh M, Kwok WW, Riddell SR.

J Clin Invest. 2018 Apr 2;128(4):1563-1568. doi: 10.1172/JCI98689. Epub 2018 Mar 12.


Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.

Roh-Johnson M, Shah AN, Stonick JA, Poudel KR, Kargl J, Yang GH, di Martino J, Hernandez RE, Gast CE, Zarour LR, Antoku S, Houghton AM, Bravo-Cordero JJ, Wong MH, Condeelis J, Moens CB.

Dev Cell. 2017 Dec 4;43(5):549-562.e6. doi: 10.1016/j.devcel.2017.11.003.


Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non-Small Cell Lung Cancer.

Mark NM, Kargl J, Busch SE, Yang GHY, Metz HE, Zhang H, Hubbard JJ, Pipavath SNJ, Madtes DK, Houghton AM.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):325-336. doi: 10.1164/rccm.201704-0795OC.


Mutant IDH1 regulates the tumor-associated immune system in gliomas.

Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, Hockenbery D, Houghton AM, Holland EC.

Genes Dev. 2017 Apr 15;31(8):774-786. doi: 10.1101/gad.294991.116. Epub 2017 May 2.


Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis.

Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW, Altemeier WA, Parks WC, Houghton AM.

Am J Pathol. 2017 Jun;187(6):1288-1300. doi: 10.1016/j.ajpath.2017.02.008. Epub 2017 Apr 8.


Neutrophils dominate the immune cell composition in non-small cell lung cancer.

Kargl J, Busch SE, Yang GH, Kim KH, Hanke ML, Metz HE, Hubbard JJ, Lee SM, Madtes DK, McIntosh MW, Houghton AM.

Nat Commun. 2017 Feb 1;8:14381. doi: 10.1038/ncomms14381.


Lung Cancer Subtypes Generate Unique Immune Responses.

Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM.

J Immunol. 2016 Dec 1;197(11):4493-4503. Epub 2016 Oct 31.


Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.

Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8795-800. doi: 10.1073/pnas.1601989113. Epub 2016 Jul 20.


Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.

Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH.

J Biol Chem. 2015 Dec 11;290(50):29742-57. doi: 10.1074/jbc.M115.691253. Epub 2015 Oct 22.


Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.

Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM.

J Leukoc Biol. 2015 Aug;98(2):143-52. doi: 10.1189/jlb.3HI1014-493R. Epub 2015 Mar 5.


Matrix metalloproteinases in destructive lung disease.

Houghton AM.

Matrix Biol. 2015 May-Jul;44-46:167-74. doi: 10.1016/j.matbio.2015.02.002. Epub 2015 Feb 14. Review.


Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking.

Tsuji T, Kelly NJ, Takahashi S, Leme AS, Houghton AM, Shapiro SD.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):822-9. doi: 10.1165/rcmb.2014-0083OC.


Mechanistic links between COPD and lung cancer.

Houghton AM.

Nat Rev Cancer. 2013 Apr;13(4):233-45. doi: 10.1038/nrc3477. Epub 2013 Mar 7. Review.


Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.

Gregory AD, Hale P, Perlmutter DH, Houghton AM.

J Biol Chem. 2012 Oct 12;287(42):35341-50. doi: 10.1074/jbc.M112.385617. Epub 2012 Aug 22.


Abortion reform's lessons for assisted dying.

Houghton AM.

BMJ. 2012 Jul 9;345:e4539. doi: 10.1136/bmj.e4539. No abstract available.


Endogenous modifiers of cigarette smoke exposure within the lung.

Houghton AM.

Proc Am Thorac Soc. 2012 May;9(2):66-8. doi: 10.1513/pats.201108-046MS.


Spine degeneration in a murine model of chronic human tobacco smokers.

Wang D, Nasto LA, Roughley P, Leme AS, Houghton AM, Usas A, Sowa G, Lee J, Niedernhofer L, Shapiro S, Kang J, Vo N.

Osteoarthritis Cartilage. 2012 Aug;20(8):896-905. doi: 10.1016/j.joca.2012.04.010. Epub 2012 Apr 21.


Does the BMJ have a particular ideology to pursue in assisted dying?

Houghton AM.

BMJ. 2012 Jan 31;344:e731. doi: 10.1136/bmj.e731. No abstract available.


IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.

Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M.

PLoS One. 2011;6(5):e20333. doi: 10.1371/journal.pone.0020333. Epub 2011 May 27.


Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality.

Wang D, Wang W, Dawkins P, Paterson T, Kalsheker N, Sallenave JM, Houghton AM.

Exp Lung Res. 2011 Jun;37(5):291-300. doi: 10.3109/01902148.2011.554599. Epub 2011 May 16.


Tumor-associated neutrophils: new targets for cancer therapy.

Gregory AD, Houghton AM.

Cancer Res. 2011 Apr 1;71(7):2411-6. doi: 10.1158/0008-5472.CAN-10-2583. Epub 2011 Mar 22. Review.


Insulin receptor substrate regulation of phosphoinositide 3-kinase.

Metz HE, Houghton AM.

Clin Cancer Res. 2011 Jan 15;17(2):206-11. doi: 10.1158/1078-0432.CCR-10-0434. Epub 2010 Oct 21.


The paradox of tumor-associated neutrophils: fueling tumor growth with cytotoxic substances.

Houghton AM.

Cell Cycle. 2010 May;9(9):1732-7. Epub 2010 May 25. Review.


Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD.

Nat Med. 2010 Feb;16(2):219-23. doi: 10.1038/nm.2084. Epub 2010 Jan 17.


Macrophage elastase kills bacteria within murine macrophages.

Houghton AM, Hartzell WO, Robbins CS, Gomis-Rüth FX, Shapiro SD.

Nature. 2009 Jul 30;460(7255):637-41. doi: 10.1038/nature08181. Epub 2009 Jun 17.


Epithelial cell apoptosis causes acute lung injury masquerading as emphysema.

Mouded M, Egea EE, Brown MJ, Hanlon SM, Houghton AM, Tsai LW, Ingenito EP, Shapiro SD.

Am J Respir Cell Mol Biol. 2009 Oct;41(4):407-14. doi: 10.1165/rcmb.2008-0137OC. Epub 2009 Feb 2.


Common origins of lung cancer and COPD.

Houghton AM, Mouded M, Shapiro SD.

Nat Med. 2008 Oct;14(10):1023-4. doi: 10.1038/nm1008-1023. No abstract available.


Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury.

Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD.

Am J Respir Cell Mol Biol. 2008 Jul;39(1):53-60. doi: 10.1165/rcmb.2007-0315OC. Epub 2008 Feb 14.


CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.

Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD.

J Immunol. 2007 Jun 15;178(12):8090-6.


Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.

Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, Cornelius LA, Shapiro SD.

Cancer Res. 2006 Jun 15;66(12):6149-55.


Elastin fragments drive disease progression in a murine model of emphysema.

Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD.

J Clin Invest. 2006 Mar;116(3):753-9. Epub 2006 Feb 9.


K-ras activation generates an inflammatory response in lung tumors.

Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK.

Oncogene. 2006 Mar 30;25(14):2105-12.


The GMC: expediency before principle: doctors and patients have shared interests.

Houghton AM.

BMJ. 2005 Jan 29;330(7485):253; discussion 254. No abstract available.


Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.

Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A.

Am J Pathol. 2003 Dec;163(6):2329-35.


Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D3 in human malignant melanoma cell lines.

Evans SR, Houghton AM, Schumaker L, Brenner RV, Buras RR, Davoodi F, Nauta RJ, Shabahang M.

J Surg Res. 1996 Feb 15;61(1):127-33.


Breastfeeding and intelligence.

Houghton AM.

Lancet. 1992 Mar 7;339(8793):613. No abstract available.


Pre-employment screening: use or ornament?

Houghton AM, Edmondson-Jones JP, Harris LA.

J Soc Occup Med. 1989 Summer;39(2):51-5.


Hazard with Penlon Intermed humidifier.

Houghton AM.

Anaesthesia. 1985 Aug;40(8):817-8. No abstract available.


Phase II study of AMSA in patients with metastatic malignant melanoma.

Houghton AM, Camacho F, Wittes R, Young CW.

Cancer Treat Rep. 1981 Jan-Feb;65(1-2):170-1. No abstract available.


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