Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 137

1.

Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors.

Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW.

Neuropharmacology. 2016 Sep;108:252-63. doi: 10.1016/j.neuropharm.2016.04.042. Epub 2016 Apr 30.

PMID:
27140694
2.

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms.

Hough LB, Nalwalk JW, Ding X, Scheer N.

Drug Metab Dispos. 2015 Sep;43(9):1326-30. doi: 10.1124/dmd.115.065490. Epub 2015 Jun 24.

3.

Neuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms.

Hough LB, Nalwalk JW, Yang W, Ding X.

Brain Res. 2015 Aug 7;1616:10-8. doi: 10.1016/j.brainres.2015.04.045. Epub 2015 Apr 29.

4.

Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects.

Hough LB, Nalwalk JW, Cleary RA, Phillips JG, Fang C, Yang W, Ding X.

Eur J Pharmacol. 2014 Oct 5;740:255-62. doi: 10.1016/j.ejphar.2014.07.028. Epub 2014 Jul 22.

5.

Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia.

Hough LB, Nalwalk JW, Yang W, Ding X.

Brain Res. 2014 Aug 26;1578:30-7. doi: 10.1016/j.brainres.2014.07.007. Epub 2014 Jul 11.

6.

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

Li L, Jia K, Zhou X, McCallum SE, Hough LB, Ding X.

J Pharmacol Exp Ther. 2013 Dec;347(3):746-54. doi: 10.1124/jpet.113.208256. Epub 2013 Sep 17.

7.

Antinociceptive activity of CC44, a biotinylated improgan congener.

Hoerbelt P, Nalwalk JW, Phillips JG, Wentland MP, Shan Z, Hough LB.

Eur J Pharmacol. 2013 Aug 15;714(1-3):464-71. doi: 10.1016/j.ejphar.2013.06.041. Epub 2013 Jul 5.

8.

TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.

Agarwal JJ, Zhu Y, Zhang QY, Mongin AA, Hough LB.

PLoS One. 2013 May 7;8(5):e63028. doi: 10.1371/journal.pone.0063028. Print 2013.

9.

CC12, a P450/epoxygenase inhibitor, acts in the rat rostral, ventromedial medulla to attenuate morphine antinociception.

Conroy JL, Nalwalk JW, Phillips JG, Hough LB.

Brain Res. 2013 Mar 7;1499:1-11. doi: 10.1016/j.brainres.2012.12.030. Epub 2013 Jan 5.

10.

Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.

Phillips RS, Cleary DR, Nalwalk JW, Arttamangkul S, Hough LB, Heinricher MM.

J Neurophysiol. 2012 Nov;108(9):2393-404. doi: 10.1152/jn.00563.2012. Epub 2012 Sep 5.

11.

Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition.

Yang J, VanAlstine MA, Phillips JG, Wentland MP, Hough LB.

Acta Pharm Sin B. 2012 Apr;2(2):137-145.

12.

Histamine-gated ion channels in mammals?

Fleck MW, Thomson JL, Hough LB.

Biochem Pharmacol. 2012 May 1;83(9):1127-35. doi: 10.1016/j.bcp.2011.12.011. Epub 2011 Dec 16. Review.

PMID:
22192818
13.

Efficacy of improgan, a non-opioid analgesic, in neuropathic pain.

Albrecht PJ, Nalwalk JW, Hough LB.

Brain Res. 2011 Nov 18;1424:32-7. doi: 10.1016/j.brainres.2011.10.002. Epub 2011 Oct 8.

14.

Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s.

VanAlstine MA, Hough LB.

Drug Metab Dispos. 2011 Jul;39(7):1221-6. doi: 10.1124/dmd.110.037424. Epub 2011 Apr 1.

15.

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X.

Pain. 2011 Apr;152(4):878-87. doi: 10.1016/j.pain.2011.01.001.

16.

Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor.

Heinricher MM, Maire JJ, Lee D, Nalwalk JW, Hough LB.

J Neurophysiol. 2010 Dec;104(6):3222-30. doi: 10.1152/jn.00681.2010. Epub 2010 Oct 6.

17.

H3 receptors and pain modulation: peripheral, spinal, and brain interactions.

Hough LB, Rice FL.

J Pharmacol Exp Ther. 2011 Jan;336(1):30-7. doi: 10.1124/jpet.110.171264. Epub 2010 Sep 23. Review.

18.

Neural basis for improgan antinociception.

Heinricher MM, Martenson ME, Nalwalk JW, Hough LB.

Neuroscience. 2010 Sep 1;169(3):1414-20. doi: 10.1016/j.neuroscience.2010.05.042. Epub 2010 May 24.

19.

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.

Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB.

Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7.

20.

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.

Stadel R, Carpenter AB, Nalwalk JW, de Esch IJ, Janssen E, Hough LB.

Eur J Pharmacol. 2010 Apr 25;632(1-3):33-8. doi: 10.1016/j.ejphar.2010.01.026. Epub 2010 Feb 6.

21.

Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.

Grimberg BT, Jaworska MM, Hough LB, Zimmerman PA, Phillips JG.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5452-7. doi: 10.1016/j.bmcl.2009.07.095. Epub 2009 Jul 23.

22.

Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms.

Hough LB, Svokos K, Nalwalk JW.

Brain Res. 2009 Jan 9;1247:62-70. doi: 10.1016/j.brainres.2008.10.008. Epub 2008 Oct 21.

23.

High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain.

Stadel R, Yang J, Nalwalk JW, Phillips JG, Hough LB.

Drug Metab Dispos. 2008 Mar;36(3):614-21. Epub 2007 Dec 19.

24.

Antinociceptive activity of furan-containing congeners of improgan and ranitidine.

Hough LB, Menge WM, van de Stolpe AC, Nalwalk JW, Leurs R, de Esch IJ.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5715-9. Epub 2007 Aug 19.

25.

Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively.

Cannon KE, Leurs R, Hough LB.

Pharmacol Biochem Behav. 2007 Nov;88(1):122-9. Epub 2007 Jul 25.

26.

Significance of cannabinoid CB1 receptors in improgan antinociception.

Gehani NC, Nalwalk JW, Razdan RK, Martin BR, Sun X, Wentland M, Abood ME, Hough LB.

J Pain. 2007 Nov;8(11):850-60. Epub 2007 Jul 23.

27.
28.

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.

Hough LB, Nalwalk JW, Phillips JG, Kern B, Shan Z, Wentland MP, de Esch IJ, Janssen E, Barr T, Stadel R.

Neuropharmacology. 2007 Apr;52(5):1244-55. Epub 2007 Jan 20.

29.
30.

Cannabinoid-improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor.

Nalwalk JW, Svokos K, Hough LB.

Eur J Pharmacol. 2006 Nov 7;549(1-3):79-83. Epub 2006 Aug 26.

PMID:
16989809
31.

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.

Hough LB, de Esch IJ, Janssen E, Phillips J, Svokos K, Kern B, Trachler J, Abood ME, Leurs R, Nalwalk JW.

Neuropharmacology. 2006 Sep;51(3):447-56. Epub 2006 Jun 23.

PMID:
16806300
32.

Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.

Hough LB, Nalwalk JW, Lu Q, Shan Z, Svokos K, Wentland MP, Montero MJ.

Eur J Pharmacol. 2005 Oct 17;522(1-3):38-46. Epub 2005 Oct 10.

PMID:
16216240
33.

Actions of tacrine and galanthamine on histamine-N-methyltransferase.

Taraschenko OD, Barnes WG, Herrick-Davis K, Yokoyama Y, Boyd DL, Hough LB.

Methods Find Exp Clin Pharmacol. 2005 Apr;27(3):161-5.

PMID:
15834447
34.
35.

Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception.

Nalwalk JW, Svokos K, Leurs R, Hough LB.

Pharmacol Biochem Behav. 2005 Mar;80(3):505-10.

PMID:
15740793
36.

Effects of cimetidine-like drugs on recombinant GABAA receptors.

Cannon KE, Fleck MW, Hough LB.

Life Sci. 2004 Oct 8;75(21):2551-8.

PMID:
15363660
37.

Activation of brain stem nuclei by improgan, a non-opioid analgesic.

Nalwalk JW, Svokos K, Taraschenko O, Leurs R, Timmerman H, Hough LB.

Brain Res. 2004 Sep 24;1021(2):248-55.

PMID:
15342273
38.

Pain-relieving drugs and the brain histaminergic system: multiple analgesic mechanisms from histamine, improgan and cimetidine.

Hough LB, Nalwalk JW, Svokos K, Leurs R, Timmermann H.

Inflamm Res. 2004 Mar;53 Suppl 1:S43-4. Epub 2004 Mar 5. No abstract available.

PMID:
15054611
39.

Characterization of a new mRNA species from the human histamine N-methyltransferase gene.

Barnes WG, Grinde E, Crawford DR, Herrick-Davis K, Hough LB.

Genomics. 2004 Jan;83(1):168-71.

PMID:
14667820
40.

Activation of spinal histamine H3 receptors inhibits mechanical nociception.

Cannon KE, Nalwalk JW, Stadel R, Ge P, Lawson D, Silos-Santiago I, Hough LB.

Eur J Pharmacol. 2003 Jun 6;470(3):139-47.

PMID:
12798951
41.

Improgan antinociception does not require neuronal histamine or histamine receptors.

Izadi Mobarakeh J, Nalwalk JW, Watanabe T, Sakurada S, Hoffman M, Leurs R, Timmerman H, Silos-Santiago I, Yanai K, Hough LB.

Brain Res. 2003 Jun 6;974(1-2):146-52.

PMID:
12742632
43.

Depletion of brain histamine produces regionally selective protection against thiamine deficiency-induced lesions in the rat.

Langlais PJ, McRee RC, Nalwalk JA, Hough LB.

Metab Brain Dis. 2002 Sep;17(3):199-210.

PMID:
12322789
45.

Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study.

Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V, Hough LB, McCarley RW.

Neuroscience. 2002;113(3):663-70.

PMID:
12150786
46.

A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic.

Svokos K, Nalwalk JW, Leurs R, Menge WM, Timmerman H, Hough LB.

Brain Res. 2001 Dec 27;923(1-2):12-9.

PMID:
11743967
47.

Significance of GABAergic systems in the action of improgan, a non-opioid analgesic.

Hough LB, Nalwalk JW, Leurs R, Menge WM, Timmerman H.

Life Sci. 2001 May 4;68(24):2751-7.

PMID:
11400917
48.

Genomics meets histamine receptors: new subtypes, new receptors.

Hough LB.

Mol Pharmacol. 2001 Mar;59(3):415-9. Review. No abstract available.

PMID:
11179433
49.

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

Hough LB, Nalwalk JW, Chen Y, Schuller A, Zhu Y, Zhang J, Menge WM, Leurs R, Timmerman H, Pintar JE.

Brain Res. 2000 Oct 13;880(1-2):102-8.

PMID:
11032994
50.

A third life for burimamide. Discovery and characterization of a novel class of non-opioid analgesics derived from histamine antagonists.

Hough LB, Nalwalk JW, Barnes WG, Leurs R, Menge WM, Timmerman H, Wentland M.

Ann N Y Acad Sci. 2000;909:25-40. Review.

PMID:
10911922

Supplemental Content

Loading ...
Support Center