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Effects of a Personalized Web-Based Decision Aid for Surrogate Decision Makers of Patients With Prolonged Mechanical Ventilation: A Randomized Clinical Trial.

Cox CE, White DB, Hough CL, Jones DM, Kahn JM, Olsen MK, Lewis CL, Hanson LC, Carson SS.

Ann Intern Med. 2019 Jan 29. doi: 10.7326/M18-2335. [Epub ahead of print]


The acute respiratory distress syndrome after out-of-hospital cardiac arrest: Incidence, risk factors, and outcomes.

Johnson NJ, Caldwell E, Carlbom DJ, Gaieski DF, Prekker ME, Rea TD, Sayre M, Hough CL.

Resuscitation. 2019 Jan 14;135:37-44. doi: 10.1016/j.resuscitation.2019.01.009. [Epub ahead of print]


Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.

Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH.

Psychiatry Res. 2019 Jan 3;273:108-113. doi: 10.1016/j.psychres.2019.01.013. [Epub ahead of print]


Emergency Department Crowding Is Associated With Delayed Antibiotics for Sepsis.

Peltan ID, Bledsoe JR, Oniki TA, Sorensen J, Jephson AR, Allen TL, Samore MH, Hough CL, Brown SM.

Ann Emerg Med. 2018 Nov 20. pii: S0196-0644(18)31361-1. doi: 10.1016/j.annemergmed.2018.10.007. [Epub ahead of print]


Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative.

McPeake J, Hirshberg EL, Christie LM, Drumright K, Haines K, Hough CL, Meyer J, Wade D, Andrews A, Bakhru R, Bates S, Barwise JA, Bastarache J, Beesley SJ, Boehm LM, Brown S, Clay AS, Firshman P, Greenberg S, Harris W, Hill C, Hodgson C, Holdsworth C, Hope AA, Hopkins RO, Howell DCJ, Janssen A, Jackson JC, Johnson A, Kross EK, Lamas D, MacLeod-Smith B, Mandel R, Marshall J, Mikkelsen ME, Nackino M, Quasim T, Sevin CM, Slack A, Spurr R, Still M, Thompson C, Weinhouse G, Wilcox ME, Iwashyna TJ.

Crit Care Med. 2019 Jan;47(1):e21-e27. doi: 10.1097/CCM.0000000000003497.


Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure.

Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR 3rd, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M; National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung injury (PETAL) Clinical Trials Network.

Ann Am Thorac Soc. 2018 Nov 8. doi: 10.1513/AnnalsATS.201807-459OC. [Epub ahead of print]


Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.

Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators.

N Engl J Med. 2018 Dec 27;379(26):2506-2516. doi: 10.1056/NEJMoa1808217. Epub 2018 Oct 22.


Prehospital Care and Emergency Department Door-to-Antibiotic Time in Sepsis.

Peltan ID, Mitchell KH, Rudd KE, Mann BA, Carlbom DJ, Rea TD, Butler AM, Hough CL, Brown SM.

Ann Am Thorac Soc. 2018 Dec;15(12):1443-1450. doi: 10.1513/AnnalsATS.201803-199OC.


N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.

Lai JD, Swystun LL, Cartier D, Nesbitt K, Zhang C, Hough C, Dennis JW, Lillicrap D.

Haematologica. 2018 Nov;103(11):1925-1936. doi: 10.3324/haematol.2018.188219. Epub 2018 Jul 12.


Effects of mindfulness training programmes delivered by a self-directed mobile app and by telephone compared with an education programme for survivors of critical illness: a pilot randomised clinical trial.

Cox CE, Hough CL, Jones DM, Ungar A, Reagan W, Key MD, Gremore T, Olsen MK, Sanders L, Greeson JM, Porter LS.

Thorax. 2019 Jan;74(1):33-42. doi: 10.1136/thoraxjnl-2017-211264. Epub 2018 May 23.


Evaluating Muscle Mass in Survivors of Acute Respiratory Distress Syndrome: A 1-Year Multicenter Longitudinal Study.

Chan KS, Mourtzakis M, Aronson Friedman L, Dinglas VD, Hough CL, Ely EW, Morris PE, Hopkins RO, Needham DM; National Institutes of Health National Heart, Lung, and Blood Institute (NHLBI) Acute Respiratory Distress Syndrome (ARDS) Network.

Crit Care Med. 2018 Aug;46(8):1238-1246. doi: 10.1097/CCM.0000000000003183.


Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms.

Georgescu MT, Moorehead PC, van Velzen AS, Nesbitt K, Reipert BM, Steinitz KN, Schuster M, Hough C, Lillicrap D.

Haematologica. 2018 Aug;103(8):1403-1413. doi: 10.3324/haematol.2018.189852. Epub 2018 Apr 19.


Prevalence, Risk Factors, and Outcomes of Financial Stress in Survivors of Critical Illness.

Khandelwal N, Hough CL, Downey L, Engelberg RA, Carson SS, White DB, Kahn JM, Jones DM, Key MD, Reagan W, Porter LS, Curtis JR, Cox CE.

Crit Care Med. 2018 Jun;46(6):e530-e539. doi: 10.1097/CCM.0000000000003076.


Upper arm anthropometrics versus DXA scan in survivors of acute respiratory distress syndrome.

Chan KS, Mourtzakis M, Aronson Friedman L, Dinglas VD, Hough CL, Ely EW, Morris PE, Hopkins RO, Needham DM; with the National Institutes of Health NHLBI ARDS Network.

Eur J Clin Nutr. 2018 Apr;72(4):613-617. doi: 10.1038/s41430-018-0106-1. Epub 2018 Feb 26.


Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.

Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH.

Neuropsychopharmacology. 2018 Jun;43(7):1557-1564. doi: 10.1038/s41386-017-0001-9. Epub 2018 Jan 30.


Validity of a single PTSD checklist item to screen for insomnia in survivors of critical illness.

Parsons EC, Hough CL, Vitiello MV, Palen B, Zatzick D, Davydow DS.

Heart Lung. 2018 Mar - Apr;47(2):87-92. doi: 10.1016/j.hrtlng.2017.12.006. Epub 2018 Feb 12.


H2 Receptor Antagonist Use and Mortality in Pulmonary Hypertension: Insight from the VA-CART Program.

Leary PJ, Hess E, Barón AE, Branch KR, Choudhary G, Hough CL, Maron BA, Ralph DD, Ryan JJ, Tedford RJ, Weiss NS, Zamanian RT, Lahm T.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1638-1641. doi: 10.1164/rccm.201801-0048LE. No abstract available.


Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.

Lai JD, Cartier D, Hartholt RB, Swystun LL, van Velzen AS, den Haan JMM, Hough C, Voorberg J, Lillicrap D.

J Thromb Haemost. 2018 Mar;16(3):533-545. doi: 10.1111/jth.13936. Epub 2018 Feb 2.


Three-dimensional ultrasound cranial imaging and early neurodevelopment in preterm growth-restricted infants.

McLean G, Hough C, Sehgal A, Ditchfield M, Polglase GR, Miller SL.

J Paediatr Child Health. 2018 Apr;54(4):420-425. doi: 10.1111/jpc.13808. Epub 2017 Dec 15.


Critical illness, disability, and the road home.

Denehy L, Hough CL.

Intensive Care Med. 2017 Dec;43(12):1881-1883. doi: 10.1007/s00134-017-4942-6. Epub 2017 Nov 22. No abstract available.


The authors reply.

Peltan ID, Hough CL, Brown SM.

Crit Care Med. 2017 Dec;45(12):e1298-e1299. doi: 10.1097/CCM.0000000000002741. No abstract available.


Low tidal volume ventilation use remains low in patients with acute respiratory distress syndrome at a single center.

Spece LJ, Mitchell KH, Caldwell ES, Gundel SJ, Jolley SE, Hough CL.

J Crit Care. 2018 Apr;44:72-76. doi: 10.1016/j.jcrc.2017.10.021. Epub 2017 Oct 18.


Effects of a Telephone- and Web-based Coping Skills Training Program Compared with an Education Program for Survivors of Critical Illness and Their Family Members. A Randomized Clinical Trial.

Cox CE, Hough CL, Carson SS, White DB, Kahn JM, Olsen MK, Jones DM, Somers TJ, Kelleher SA, Porter LS.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):66-78. doi: 10.1164/rccm.201704-0720OC.


Response to Alternating Electric Fields of Tubulin Dimers and Microtubule Ensembles in Electrolytic Solutions.

Santelices IB, Friesen DE, Bell C, Hough CM, Xiao J, Kalra A, Kar P, Freedman H, Rezania V, Lewis JD, Shankar K, Tuszynski JA.

Sci Rep. 2017 Aug 29;7(1):9594. doi: 10.1038/s41598-017-09323-w.


Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.

Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM.

J Psychosom Res. 2017 Aug;99:177-180. doi: 10.1016/j.jpsychores.2017.06.009. Epub 2017 Jun 15.


Relationship between Race and the Effect of Fluids on Long-term Mortality after Acute Respiratory Distress Syndrome. Secondary Analysis of the National Heart, Lung, and Blood Institute Fluid and Catheter Treatment Trial.

Jolley SE, Hough CL, Clermont G, Hayden D, Hou S, Schoenfeld D, Smith NL, Thompson BT, Bernard GR, Angus DC; ARDS Network Investigators.

Ann Am Thorac Soc. 2017 Sep;14(9):1443-1449. doi: 10.1513/AnnalsATS.201611-906OC.


Physicians Rarely Elicit Critically Ill Patients' Previously Expressed Treatment Preferences in Intensive Care Units.

Chiarchiaro J, Ernecoff NC, Scheunemann LP, Hough CL, Carson SS, Peterson MW, Anderson WG, Steingrub JS, Arnold RM, White DB.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):242-245. doi: 10.1164/rccm.201611-2242LE. No abstract available.


Coloring by Number? Core Outcome Measures and the Canvas of Intensive Care Unit Survivorship.

Connolly B, Hough CL.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1087-1089. doi: 10.1164/rccm.201706-1239ED. No abstract available.


Reducing Portable Chest Radiography in the Intensive Care Unit.

Hippe DS, Lehnert BE, Slade IR, Dellit TH, Hough CL, Schreuder AB, Cohen W, Miklusis JA, Pergamit R, Roma H, Potter AC, Bresnahan BW.

J Am Coll Radiol. 2017 Oct;14(10):1363-1368. doi: 10.1016/j.jacr.2017.06.003. Epub 2017 Jul 8. No abstract available.


Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.

Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D.

J Affect Disord. 2017 Sep;219:193-200. doi: 10.1016/j.jad.2017.04.042. Epub 2017 May 6.


Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study.

Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, Brower RG; National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network.

Crit Care Med. 2017 Aug;45(8):1317-1324. doi: 10.1097/CCM.0000000000002514.


Biological considerations of plasma-derived and recombinant factor VIII immunogenicity.

Lai J, Hough C, Tarrant J, Lillicrap D.

Blood. 2017 Jun 15;129(24):3147-3154. doi: 10.1182/blood-2016-11-750885. Epub 2017 Apr 21. Review.


Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.

Peltan ID, Mitchell KH, Rudd KE, Mann BA, Carlbom DJ, Hough CL, Rea TD, Brown SM.

Crit Care Med. 2017 Jun;45(6):1011-1018. doi: 10.1097/CCM.0000000000002436.


The authors reply.

Jolley SE, Hough CL.

Crit Care Med. 2017 Mar;45(3):e330-e331. doi: 10.1097/CCM.0000000000002223. No abstract available.


Beyond mortality or being mortal? Challenges in understanding and improving life after ARDS.

Hough CL.

Thorax. 2017 Apr;72(4):302-303. doi: 10.1136/thoraxjnl-2016-209082. Epub 2017 Feb 9. No abstract available.


Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study.

Andrews JS, Trupin L, Yelin EH, Hough CL, Covinsky KE, Katz PP.

Clin Rheumatol. 2017 May;36(5):1031-1039. doi: 10.1007/s10067-017-3541-9. Epub 2017 Jan 23.


Are physical measures related to patient-centred outcomes in ARDS survivors?

Chan KS, Aronson Friedman L, Dinglas VD, Hough CL, Shanholtz C, Ely EW, Morris PE, Mendez-Tellez PA, Jackson JC, Hopkins RO, Needham DM.

Thorax. 2017 Oct;72(10):884-892. doi: 10.1136/thoraxjnl-2016-209400. Epub 2017 Jan 20.


Authors' response to commentaries on rosuvastatin for delirium and cognitive impairment in sepsis-associated acute respiratory distress syndrome.

Dinglas VD, Colantuoni E, Ely EW, Hough CL, Morris PE, Mendez-Tellez PA, Wozniak AW, Hopkins RO, Needham DM.

J Thorac Dis. 2016 Nov;8(11):E1534-E1536. doi: 10.21037/jtd.2016.11.53. No abstract available.


Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression.

Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH.

Psychoneuroendocrinology. 2017 Mar;77:122-130. doi: 10.1016/j.psyneuen.2016.11.035. Epub 2016 Dec 5.


Oxidative stress, inflammation and treatment response in major depression.

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH.

Psychoneuroendocrinology. 2017 Feb;76:197-205. doi: 10.1016/j.psyneuen.2016.11.031. Epub 2016 Nov 30.


Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus.

Andrews JS, Trupin L, Hough CL, Daikh DI, Yelin EH, Katz PP.

Cytokine. 2017 Feb;90:109-112. doi: 10.1016/j.cyto.2016.11.003. Epub 2016 Nov 16.


Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline: Inspiratory Pressure Augmentation During Spontaneous Breathing Trials, Protocols Minimizing Sedation, and Noninvasive Ventilation Immediately After Extubation.

Ouellette DR, Patel S, Girard TD, Morris PE, Schmidt GA, Truwit JD, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Pawlik AJ, Schweickert WD, Sessler CN, Strøm T, Kress JP.

Chest. 2017 Jan;151(1):166-180. doi: 10.1016/j.chest.2016.10.036. Epub 2016 Nov 3.


Liberation From Mechanical Ventilation in Critically Ill Adults: Executive Summary of an Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline.

Schmidt GA, Girard TD, Kress JP, Morris PE, Ouellette DR, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Schweickert WD, Sessler CN, Strøm T, Wilson KC, Truwit JD.

Chest. 2017 Jan;151(1):160-165. doi: 10.1016/j.chest.2016.10.037. Epub 2016 Nov 3.


An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cuff Leak Tests.

Girard TD, Alhazzani W, Kress JP, Ouellette DR, Schmidt GA, Truwit JD, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Schweickert WD, Sessler CN, Strøm T, Wilson KC, Morris PE; ATS/CHEST Ad Hoc Committee on Liberation from Mechanical Ventilation in Adults.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):120-133. doi: 10.1164/rccm.201610-2075ST.


Power Calculations to Select Instruments for Clinical Trial Secondary Endpoints. A Case Study of Instrument Selection for Post-Traumatic Stress Symptoms in Subjects with Acute Respiratory Distress Syndrome.

Sjoding MW, Schoenfeld DA, Brown SM, Hough CL, Yealy DM, Moss M, Angus DC, Iwashyna TJ; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network.

Ann Am Thorac Soc. 2017 Jan;14(1):110-117. doi: 10.1513/AnnalsATS.201608-585OC.


Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome.

Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu KD, Talmor DS, Yealy DM; Reevaluation of Systemic Early Neuromuscular Blockade Protocol Committee and the National Institutes of Health National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network Investigators.

Ann Am Thorac Soc. 2017 Jan;14(1):124-133. doi: 10.1513/AnnalsATS.201608-629OT.


Point Prevalence Study of Mobilization Practices for Acute Respiratory Failure Patients in the United States.

Jolley SE, Moss M, Needham DM, Caldwell E, Morris PE, Miller RR, Ringwood N, Anders M, Koo KK, Gundel SE, Parry SM, Hough CL; Acute Respiratory Distress Syndrome Network Investigators.

Crit Care Med. 2017 Feb;45(2):205-215. doi: 10.1097/CCM.0000000000002058.


Improving ICU-Based Palliative Care Delivery: A Multicenter, Multidisciplinary Survey of Critical Care Clinician Attitudes and Beliefs.

Wysham NG, Hua M, Hough CL, Gundel S, Docherty SL, Jones DM, Reagan O, Goucher H, Mcfarlin J, Cox CE.

Crit Care Med. 2017 Apr;45(4):e372-e378. doi: 10.1097/CCM.0000000000002099.


Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD.

Hough CM, Luks TL, Lai K, Vigil O, Guillory S, Nongpiur A, Fekri SM, Kupferman E, Mathalon DH, Mathews CA.

Psychiatry Res Neuroimaging. 2016 Sep 30;255:50-9. doi: 10.1016/j.pscychresns.2016.07.007. Epub 2016 Jul 12.


Argument against the Routine Use of Steroids for Pediatric Acute Respiratory Distress Syndrome.

Hartmann SM, Hough CL.

Front Pediatr. 2016 Jul 28;4:79. doi: 10.3389/fped.2016.00079. eCollection 2016. Review.

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