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Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Paul-Friedman K, Martin M, Crofton KM, Hsu CW, Sakamuru S, Zhao J, Xia M, Huang R, Stavreva DA, Soni V, Varticovski L, Raziuddin R, Hager GL, Houck KA.

Environ Health Perspect. 2019 Sep;127(9):97009. doi: 10.1289/EHP5314. Epub 2019 Sep 30.


The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.

Thomas RS, Bahadori T, Buckley TJ, Cowden J, Deisenroth C, Dionisio KL, Frithsen JB, Grulke CM, Gwinn MR, Harrill JA, Higuchi M, Houck KA, Hughes MF, Hunter ES, Isaacs KK, Judson RS, Knudsen TB, Lambert JC, Linnenbrink M, Martin TM, Newton SR, Padilla S, Patlewicz G, Paul-Friedman K, Phillips KA, Richard AM, Sams R, Shafer TJ, Setzer RW, Shah I, Simmons JE, Simmons SO, Singh A, Sobus JR, Strynar M, Swank A, Tornero-Valez R, Ulrich EM, Villeneuve DL, Wambaugh JF, Wetmore BA, Williams AJ.

Toxicol Sci. 2019 Jun 1;169(2):317-332. doi: 10.1093/toxsci/kfz058.


Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides.

Li S, Zhao J, Huang R, Santillo MF, Houck KA, Xia M.

Toxicol In Vitro. 2019 Apr;56:93-100. doi: 10.1016/j.tiv.2019.01.002. Epub 2019 Jan 6.


Workflow for defining reference chemicals for assessing performance of in vitro assays.

Judson RS, Thomas RS, Baker N, Simha A, Howey XM, Marable C, Kleinstreuer NC, Houck KA.

ALTEX. 2019;36(2):261-276. doi: 10.14573/altex.1809281. Epub 2018 Dec 17.


Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals.

Blackwell BR, Ankley GT, Bradley PM, Houck KA, Makarov SS, Medvedev AV, Swintek J, Villeneuve DL.

Environ Sci Technol. 2019 Jan 15;53(2):973-983. doi: 10.1021/acs.est.8b05304. Epub 2018 Dec 21.


Evaluating biological activity of compounds by transcription factor activity profiling.

Medvedev A, Moeser M, Medvedeva L, Martsen E, Granick A, Raines L, Zeng M, Makarov S Jr, Houck KA, Makarov SS.

Sci Adv. 2018 Sep 26;4(9):eaar4666. doi: 10.1126/sciadv.aar4666. eCollection 2018 Sep.


Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Wetmore BA, Clewell RA, Cholewa B, Parks B, Pendse SN, Black MB, Mansouri K, Haider S, Berg EL, Judson RS, Houck KA, Martin M, Clewell HJ 3rd, Andersen ME, Thomas RS, McMullen PD.

Toxicol In Vitro. 2019 Feb;54:41-57. doi: 10.1016/j.tiv.2018.09.006. Epub 2018 Sep 12.


Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.

Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, Witt KL, DeVito M, Freedman JH, Austin CP, Houck KA, Thomas RS, Paules RS, Tice RR, Simeonov A.

Environ Health Perspect. 2018 Jul 26;126(7):077010. doi: 10.1289/EHP2589. eCollection 2018 Jul.


Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays.

Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches D, Kullman SW.

Sci Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3.


On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity.

Judson RS, Houck KA, Watt ED, Thomas RS.

Regul Toxicol Pharmacol. 2017 Dec;91:39-49. doi: 10.1016/j.yrtph.2017.09.022. Epub 2017 Oct 6.


Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

Strickland JD, Martin MT, Richard AM, Houck KA, Shafer TJ.

Arch Toxicol. 2018 Jan;92(1):487-500. doi: 10.1007/s00204-017-2035-5. Epub 2017 Aug 2.


Primary Cell Phenotypic Screening Illuminates ADRs and AOPs.

Bone AJ, Houck KA.

Cell Chem Biol. 2017 Jul 20;24(7):781-782. doi: 10.1016/j.chembiol.2017.07.001.


An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.

Blackwell BR, Ankley GT, Corsi SR, DeCicco LA, Houck KA, Judson RS, Li S, Martin MT, Murphy E, Schroeder AL, Smith ER, Swintek J, Villeneuve DL.

Environ Sci Technol. 2017 Aug 1;51(15):8713-8724. doi: 10.1021/acs.est.7b01613. Epub 2017 Jul 18.


Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.

Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.


Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

Houck KA, Judson RS, Knudsen TB, Martin MT, Richard AM, Crofton KM, Simeonov A, Paules RS, Bucher JR, Thomas RS.

Environ Health Perspect. 2017 Jan 1;125(1):A8-A11. doi: 10.1289/EHP881. No abstract available.


ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology.

Richard AM, Judson RS, Houck KA, Grulke CM, Volarath P, Thillainadarajah I, Yang C, Rathman J, Martin MT, Wambaugh JF, Knudsen TB, Kancherla J, Mansouri K, Patlewicz G, Williams AJ, Little SB, Crofton KM, Thomas RS.

Chem Res Toxicol. 2016 Aug 15;29(8):1225-51. doi: 10.1021/acs.chemrestox.6b00135. Epub 2016 Jul 20.


Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program.

Karmaus AL, Filer DL, Martin MT, Houck KA.

Food Chem Toxicol. 2016 Jun;92:188-96. doi: 10.1016/j.fct.2016.04.012. Epub 2016 Apr 19.


Environmental surveillance and monitoring--The next frontiers for high-throughput toxicology.

Schroeder AL, Ankley GT, Houck KA, Villeneuve DL.

Environ Toxicol Chem. 2016 Mar;35(3):513-25. doi: 10.1002/etc.3309.


Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries.

Paul Friedman K, Watt ED, Hornung MW, Hedge JM, Judson RS, Crofton KM, Houck KA, Simmons SO.

Toxicol Sci. 2016 May;151(1):160-80. doi: 10.1093/toxsci/kfw034. Epub 2016 Feb 15.


Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.

Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ.

Environ Health Perspect. 2016 Jul;124(7):910-9. doi: 10.1289/ehp.1409029. Epub 2015 Oct 16.


Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS.

Toxicol Sci. 2015 Nov;148(1):137-54. doi: 10.1093/toxsci/kfv168. Epub 2015 Aug 13.


Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.

Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME.

Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6.


An evaluation of 25 selected ToxCast chemicals in medium-throughput assays to detect genotoxicity.

Kligerman AD, Young RR, Stankowski LF Jr, Pant K, Lawlor T, Aardema MJ, Houck KA.

Environ Mol Mutagen. 2015 Jun;56(5):468-76. doi: 10.1002/em.21934. Epub 2014 Dec 23.


Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M.

Sci Rep. 2014 Jul 11;4:5664. doi: 10.1038/srep05664.


Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Valdivia P, Martin M, LeFew WR, Ross J, Houck KA, Shafer TJ.

Neurotoxicology. 2014 Sep;44:204-17. doi: 10.1016/j.neuro.2014.06.012. Epub 2014 Jul 2.


Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.

Rotroff DM, Martin MT, Dix DJ, Filer DL, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS.

Environ Sci Technol. 2014;48(15):8706-16. doi: 10.1021/es502676e. Epub 2014 Jul 10.


Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.

Kleinstreuer NC, Yang J, Berg EL, Knudsen TB, Richard AM, Martin MT, Reif DM, Judson RS, Polokoff M, Dix DJ, Kavlock RJ, Houck KA.

Nat Biotechnol. 2014 Jun;32(6):583-91. doi: 10.1038/nbt.2914. Epub 2014 May 18.


Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate.

Wambaugh JF, Setzer RW, Pitruzzello AM, Liu J, Reif DM, Kleinstreuer NC, Wang NC, Sipes N, Martin M, Das K, DeWitt JC, Strynar M, Judson R, Houck KA, Lau C.

Toxicol Sci. 2013 Dec;136(2):308-27. doi: 10.1093/toxsci/kft204. Epub 2013 Sep 17.


Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.

Rotroff DM, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Reif DM, Richard AM, Sipes NS, Abassi YA, Jin C, Stampfl M, Judson RS.

Chem Res Toxicol. 2013 Jul 15;26(7):1097-107. doi: 10.1021/tx400117y. Epub 2013 Jun 10.


Characterization of physicochemical properties of nanomaterials and their immediate environments in high-throughput screening of nanomaterial biological activity.

Wang A, Marinakos SM, Badireddy AR, Powers CM, Houck KA.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Sep-Oct;5(5):430-48. doi: 10.1002/wnan.1229. Epub 2013 May 9.


Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.

Sipes NS, Martin MT, Kothiya P, Reif DM, Judson RS, Richard AM, Houck KA, Dix DJ, Kavlock RJ, Knudsen TB.

Chem Res Toxicol. 2013 Jun 17;26(6):878-95. doi: 10.1021/tx400021f. Epub 2013 May 16.


Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.

Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS.

Environ Health Perspect. 2013 Jan;121(1):7-14. doi: 10.1289/ehp.1205065. Epub 2012 Sep 28.


In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.

Kleinstreuer NC, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Paul KB, Reif DM, Crofton KM, Hamilton K, Hunter R, Shah I, Judson RS.

Toxicol Sci. 2013 Jan;131(1):40-55. doi: 10.1093/toxsci/kfs285. Epub 2012 Sep 28.


Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Dix DJ, Houck KA, Judson RS, Kleinstreuer NC, Knudsen TB, Martin MT, Reif DM, Richard AM, Shah I, Sipes NS, Kavlock RJ.

Toxicol Sci. 2012 Dec;130(2):440-1; author reply 442-3. doi: 10.1093/toxsci/kfs281. Epub 2012 Sep 14. No abstract available.


Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

Padilla S, Corum D, Padnos B, Hunter DL, Beam A, Houck KA, Sipes N, Kleinstreuer N, Knudsen T, Dix DJ, Reif DM.

Reprod Toxicol. 2012 Apr;33(2):174-87. doi: 10.1016/j.reprotox.2011.10.018. Epub 2011 Dec 9.


Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.

Wetmore BA, Wambaugh JF, Ferguson SS, Sochaski MA, Rotroff DM, Freeman K, Clewell HJ 3rd, Dix DJ, Andersen ME, Houck KA, Allen B, Judson RS, Singh R, Kavlock RJ, Richard AM, Thomas RS.

Toxicol Sci. 2012 Jan;125(1):157-74. doi: 10.1093/toxsci/kfr254. Epub 2011 Sep 26.


Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential.

Gangwal S, Brown JS, Wang A, Houck KA, Dix DJ, Kavlock RJ, Hubal EA.

Environ Health Perspect. 2011 Nov;119(11):1539-46. doi: 10.1289/ehp.1103750. Epub 2011 Jul 25.


Predictive model of rat reproductive toxicity from ToxCast high throughput screening.

Martin MT, Knudsen TB, Reif DM, Houck KA, Judson RS, Kavlock RJ, Dix DJ.

Biol Reprod. 2011 Aug;85(2):327-39. doi: 10.1095/biolreprod.111.090977. Epub 2011 May 12.


Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP.

Environ Health Perspect. 2011 Aug;119(8):1142-8. doi: 10.1289/ehp.1002952. Epub 2011 May 4.


Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.

Judson RS, Kavlock RJ, Setzer RW, Hubal EA, Martin MT, Knudsen TB, Houck KA, Thomas RS, Wetmore BA, Dix DJ.

Chem Res Toxicol. 2011 Apr 18;24(4):451-62. doi: 10.1021/tx100428e. Epub 2011 Mar 8.


Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.

Knudsen TB, Houck KA, Sipes NS, Singh AV, Judson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, Kavlock RJ.

Toxicology. 2011 Mar 28;282(1-2):1-15. doi: 10.1016/j.tox.2010.12.010. Epub 2011 Jan 18.


Endocrine profiling and prioritization of environmental chemicals using ToxCast data.

Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RJ.

Environ Health Perspect. 2010 Dec;118(12):1714-20. doi: 10.1289/ehp.1002180. Epub 2010 Sep 8.


Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS.

Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Erratum in: Toxicol Sci. 2014 Feb;137(2):499. Dosage error in article text.


Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ.

Environ Sci Technol. 2010 Aug 1;44(15):5979-85. doi: 10.1021/es102150z.


Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46. doi: 10.1080/10937404.2010.483949.


In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.

Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ.

Environ Health Perspect. 2010 Apr;118(4):485-92. doi: 10.1289/ehp.0901392.


Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

Martin MT, Dix DJ, Judson RS, Kavlock RJ, Reif DM, Richard AM, Rotroff DM, Romanov S, Medvedev A, Poltoratskaya N, Gambarian M, Moeser M, Makarov SS, Houck KA.

Chem Res Toxicol. 2010 Mar 15;23(3):578-90. doi: 10.1021/tx900325g.


Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems.

Houck KA, Dix DJ, Judson RS, Kavlock RJ, Yang J, Berg EL.

J Biomol Screen. 2009 Oct;14(9):1054-66. doi: 10.1177/1087057109345525. Epub 2009 Sep 22.


Understanding mechanisms of toxicity: insights from drug discovery research.

Houck KA, Kavlock RJ.

Toxicol Appl Pharmacol. 2008 Mar 1;227(2):163-78. Epub 2007 Nov 4. Review.


Screening for activators of the wingless type/Frizzled pathway by automated fluorescent microscopy.

Borchert KM, Sells Galvin RJ, Hale LV, Trask OJ, Nickischer DR, Houck KA.

Methods Enzymol. 2006;414:140-50.


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