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Items: 1 to 50 of 175

1.

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.

Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH, Houck KA, Kane A, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M.

Cancer Epidemiol Biomarkers Prev. 2020 Mar 9. pii: cebp.1346.2019. doi: 10.1158/1055-9965.EPI-19-1346. [Epub ahead of print]

PMID:
32152214
2.

High-Throughput Screening to Predict Chemical-Assay Interference.

Borrel A, Huang R, Sakamuru S, Xia M, Simeonov A, Mansouri K, Houck KA, Judson RS, Kleinstreuer NC.

Sci Rep. 2020 Mar 4;10(1):3986. doi: 10.1038/s41598-020-60747-3.

3.

Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity.

Zurlinden TJ, Saili KS, Rush N, Kothiya P, Judson RS, Houck KA, Hunter ES, Baker NC, Palmer JA, Thomas RS, Knudsen TB.

Toxicol Sci. 2020 Apr 1;174(2):189-209. doi: 10.1093/toxsci/kfaa014.

PMID:
32073639
4.

Drinking water improvements and rates of urinary and gastrointestinal infections in Galápagos, Ecuador: Assessing household and community factors.

Houck KM, Terán E, Ochoa J, Zapata GN, Gomez AM, Parra R, Dvorquez D, Stewart JR, Bentley ME, Thompson AL.

Am J Hum Biol. 2020 Jan;32(1):e23358. doi: 10.1002/ajhb.23358. Epub 2019 Nov 19.

PMID:
31746081
5.

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Paul-Friedman K, Martin M, Crofton KM, Hsu CW, Sakamuru S, Zhao J, Xia M, Huang R, Stavreva DA, Soni V, Varticovski L, Raziuddin R, Hager GL, Houck KA.

Environ Health Perspect. 2019 Sep;127(9):97009. doi: 10.1289/EHP5314. Epub 2019 Sep 30.

6.

Placenta-derived extracellular vesicles induce preeclampsia in mouse models.

Han C, Wang C, Chen Y, Wang J, Xu X, Hilton T, Cai W, Zhao Z, Wu Y, Li K, Houck K, Liu L, Sood AK, Wu X, Xue F, Li M, Dong JF, Zhang J.

Haematologica. 2019 Aug 22. pii: haematol.2019.226209. doi: 10.3324/haematol.2019.226209. [Epub ahead of print]

7.

Methods for evaluating variability in human health dose-response characterization.

Axelrad DA, Setzer RW, Bateson TF, DeVito M, Dzubow RC, Fitzpatrick JW, Frame AM, Hogan KA, Houck K, Stewart M.

Hum Ecol Risk Assess. 2019 Nov 6;25:1-24. doi: 10.1080/10807039.2019.1615828.

PMID:
31404325
8.

Pharmacist-driven multidisciplinary pretreatment workup process for hepatitis C care: A novel model for same-day pretreatment workup.

Houck KK, Ifeachor AP, Fleming BS, Andres AM, O'Donovan KN, Johnson AJ, Liangpunsakul S.

J Am Pharm Assoc (2003). 2019 Sep - Oct;59(5):710-716. doi: 10.1016/j.japh.2019.05.003. Epub 2019 Jun 18.

PMID:
31227418
9.

Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts.

Houck KL, Yuan H, Tian Y, Solomon M, Cramer D, Liu K, Zhou Z, Wu X, Zhang J, Oehler V, Dong JF.

J Thromb Haemost. 2019 Sep;17(9):1500-1510. doi: 10.1111/jth.14525. Epub 2019 Jun 23.

PMID:
31145836
10.

Second primary anal and oropharyngeal cancers in cervical cancer survivors.

Papatla K, Halpern MT, Hernandez E, Brown J, Benrubi D, Houck K, Chu C, Rubin S.

Am J Obstet Gynecol. 2019 Nov;221(5):478.e1-478.e6. doi: 10.1016/j.ajog.2019.05.025. Epub 2019 May 22.

PMID:
31128108
11.

Second primary uterine malignancies after radiation therapy for cervical cancer.

Papatla K, Houck KL, Hernandez E, Chu C, Rubin S.

Arch Gynecol Obstet. 2019 Aug;300(2):389-394. doi: 10.1007/s00404-019-05187-9. Epub 2019 May 8.

PMID:
31069490
12.

Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review.

Ackroyd SA, Goetsch L, Brown J, Houck K, Wang C, Hernandez E.

Gynecol Oncol Rep. 2019 Mar 27;28:109-115. doi: 10.1016/j.gore.2019.03.012. eCollection 2019 May. Review.

13.

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.

Thomas RS, Bahadori T, Buckley TJ, Cowden J, Deisenroth C, Dionisio KL, Frithsen JB, Grulke CM, Gwinn MR, Harrill JA, Higuchi M, Houck KA, Hughes MF, Hunter ES, Isaacs KK, Judson RS, Knudsen TB, Lambert JC, Linnenbrink M, Martin TM, Newton SR, Padilla S, Patlewicz G, Paul-Friedman K, Phillips KA, Richard AM, Sams R, Shafer TJ, Setzer RW, Shah I, Simmons JE, Simmons SO, Singh A, Sobus JR, Strynar M, Swank A, Tornero-Valez R, Ulrich EM, Villeneuve DL, Wambaugh JF, Wetmore BA, Williams AJ.

Toxicol Sci. 2019 Jun 1;169(2):317-332. doi: 10.1093/toxsci/kfz058.

PMID:
30835285
14.

Rising rates of cesarean delivery in Ecuador: Socioeconomic and institutional determinants over two decades.

Jahnke JR, Houck KM, Bentley ME, Thompson AL.

Birth. 2019 Jun;46(2):335-343. doi: 10.1111/birt.12421. Epub 2019 Feb 13.

15.

Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates.

Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2018 Aug;19(8):1020-1022. doi: 10.1016/S1470-2045(18)30491-1. Epub 2018 Jun 28. No abstract available.

PMID:
30700372
16.

Pathways linking caesarean delivery to early health in a dual burden context: Immune development and the gut microbiome in infants and children from Galápagos, Ecuador.

Thompson AL, Houck KM, Jahnke JR.

Am J Hum Biol. 2019 Jan 28:e23219. doi: 10.1002/ajhb.23219. [Epub ahead of print]

PMID:
30693586
17.

Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides.

Li S, Zhao J, Huang R, Santillo MF, Houck KA, Xia M.

Toxicol In Vitro. 2019 Apr;56:93-100. doi: 10.1016/j.tiv.2019.01.002. Epub 2019 Jan 6.

18.

Workflow for defining reference chemicals for assessing performance of in vitro assays.

Judson RS, Thomas RS, Baker N, Simha A, Howey XM, Marable C, Kleinstreuer NC, Houck KA.

ALTEX. 2019;36(2):261-276. doi: 10.14573/altex.1809281. Epub 2018 Dec 17.

19.

Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals.

Blackwell BR, Ankley GT, Bradley PM, Houck KA, Makarov SS, Medvedev AV, Swintek J, Villeneuve DL.

Environ Sci Technol. 2019 Jan 15;53(2):973-983. doi: 10.1021/acs.est.8b05304. Epub 2018 Dec 21.

20.

Evaluating biological activity of compounds by transcription factor activity profiling.

Medvedev A, Moeser M, Medvedeva L, Martsen E, Granick A, Raines L, Zeng M, Makarov S Jr, Houck KA, Makarov SS.

Sci Adv. 2018 Sep 26;4(9):eaar4666. doi: 10.1126/sciadv.aar4666. eCollection 2018 Sep.

21.

A preoperative risk score to predict red blood cell transfusion in patients undergoing hysterectomy for ovarian cancer.

Ackroyd SA, Brown J, Houck K, Chu C, Mantia-Smaldone G, Rubin S, Hernandez E.

Am J Obstet Gynecol. 2018 Dec;219(6):598.e1-598.e10. doi: 10.1016/j.ajog.2018.09.011. Epub 2018 Sep 18.

PMID:
30240655
22.

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Wetmore BA, Clewell RA, Cholewa B, Parks B, Pendse SN, Black MB, Mansouri K, Haider S, Berg EL, Judson RS, Houck KA, Martin M, Clewell HJ 3rd, Andersen ME, Thomas RS, McMullen PD.

Toxicol In Vitro. 2019 Feb;54:41-57. doi: 10.1016/j.tiv.2018.09.006. Epub 2018 Sep 12.

23.

Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.

Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, Witt KL, DeVito M, Freedman JH, Austin CP, Houck KA, Thomas RS, Paules RS, Tice RR, Simeonov A.

Environ Health Perspect. 2018 Jul 26;126(7):077010. doi: 10.1289/EHP2589. eCollection 2018 Jul.

24.

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.

Wu Y, Liu W, Zhou Y, Hilton T, Zhao Z, Liu W, Wang M, Yeon J, Houck K, Thiagarajan P, Zhang F, Shi FD, Wu X, Li M, Dong JF, Zhang J.

Blood. 2018 Sep 6;132(10):1075-1084. doi: 10.1182/blood-2018-03-841932. Epub 2018 Jun 25.

25.

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays.

Mahapatra D, Franzosa JA, Roell K, Kuenemann MA, Houck KA, Reif DM, Fourches D, Kullman SW.

Sci Rep. 2018 Jun 11;8(1):8883. doi: 10.1038/s41598-018-27055-3.

26.

Do screening and a randomized brief intervention at a Level 1 trauma center impact acute stress reactions to prevent later development of posttraumatic stress disorder?

Manser SS, Houck K, Kramer MD, Tabas IA, Brown CVR, Coopwood B.

J Trauma Acute Care Surg. 2018 Sep;85(3):466-475. doi: 10.1097/TA.0000000000001977.

PMID:
29787532
27.

Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma.

Yang AJ, Wang M, Wang Y, Cai W, Li Q, Zhao TT, Zhang LH, Houck K, Chen X, Jin YL, Mu JY, Dong JF, Li M.

Oncogenesis. 2018 Jan 24;7(1):12. doi: 10.1038/s41389-017-0023-5.

28.

Voltage-gated Potassium Channel Antibody Autoimmune Encephalopathy Presenting With Isolated Psychosis in an Adolescent.

Pon NC, Houck KM, Muscal E, Idicula SA.

J Psychiatr Pract. 2017 Nov;23(6):441-445. doi: 10.1097/PRA.0000000000000265.

PMID:
29303952
29.

Abdominal wall reconstruction after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy.

Scholer AJ, Oliver JB, Rosado J, Patel JS, Lynch LJ, Spiegler KM, Houck K, Chokshi RJ.

J Surg Res. 2018 Jan;221:266-274. doi: 10.1016/j.jss.2017.08.002. Epub 2017 Oct 5.

PMID:
29229138
30.

On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity.

Judson RS, Houck KA, Watt ED, Thomas RS.

Regul Toxicol Pharmacol. 2017 Dec;91:39-49. doi: 10.1016/j.yrtph.2017.09.022. Epub 2017 Oct 6.

31.

The benefits of data mining.

Bone A, Houck K.

Elife. 2017 Aug 16;6. pii: e30280. doi: 10.7554/eLife.30280.

32.

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

Strickland JD, Martin MT, Richard AM, Houck KA, Shafer TJ.

Arch Toxicol. 2018 Jan;92(1):487-500. doi: 10.1007/s00204-017-2035-5. Epub 2017 Aug 2.

33.

Primary Cell Phenotypic Screening Illuminates ADRs and AOPs.

Bone AJ, Houck KA.

Cell Chem Biol. 2017 Jul 20;24(7):781-782. doi: 10.1016/j.chembiol.2017.07.001.

34.

An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.

Blackwell BR, Ankley GT, Corsi SR, DeCicco LA, Houck KA, Judson RS, Li S, Martin MT, Murphy E, Schroeder AL, Smith ER, Swintek J, Villeneuve DL.

Environ Sci Technol. 2017 Aug 1;51(15):8713-8724. doi: 10.1021/acs.est.7b01613. Epub 2017 Jul 18.

35.

Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.

Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.

36.

Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer.

Greenup RA, Blitzblau RC, Houck KL, Sosa JA, Horton J, Peppercorn JM, Taghian AG, Smith BL, Hwang ES.

J Oncol Pract. 2017 Apr;13(4):e283-e290. doi: 10.1200/JOP.2016.016683. Epub 2017 Mar 14.

37.

Age- and treatment-related associations with health behavior change among breast cancer survivors.

Anderson C, Sandler DP, Weinberg CR, Houck K, Chunduri M, Hodgson ME, Sabatino SA, White MC, Rodriguez JL, Nichols HB.

Breast. 2017 Jun;33:1-7. doi: 10.1016/j.breast.2017.02.013. Epub 2017 Feb 27.

38.

Impact of the elimination of cost sharing for mammographic breast cancer screening among rural US women: A natural experiment.

Peppercorn J, Horick N, Houck K, Rabin J, Villagra V, Lyman GH, Wheeler SB.

Cancer. 2017 Jul 1;123(13):2506-2515. doi: 10.1002/cncr.30629. Epub 2017 Feb 14.

39.

Water quality at points-of-use in the Galapagos Islands.

Gerhard WA, Choi WS, Houck KM, Stewart JR.

Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):485-493. doi: 10.1016/j.ijheh.2017.01.010. Epub 2017 Jan 30.

PMID:
28185880
40.

Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

Houck KA, Judson RS, Knudsen TB, Martin MT, Richard AM, Crofton KM, Simeonov A, Paules RS, Bucher JR, Thomas RS.

Environ Health Perspect. 2017 Jan 1;125(1):A8-A11. doi: 10.1289/EHP881. No abstract available.

41.

Development and Validation of a Computational Model for Androgen Receptor Activity.

Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.

Chem Res Toxicol. 2017 Apr 17;30(4):946-964. doi: 10.1021/acs.chemrestox.6b00347. Epub 2016 Dec 9.

42.

The Effect of Hospital Volume on Breast Cancer Mortality.

Greenup RA, Obeng-Gyasi S, Thomas S, Houck K, Lane WO, Blitzblau RC, Hyslop T, Hwang ES.

Ann Surg. 2018 Feb;267(2):375-381. doi: 10.1097/SLA.0000000000002095.

43.

PTSD in those who care for the injured.

Luftman K, Aydelotte J, Rix K, Ali S, Houck K, Coopwood TB, Teixeira P, Eastman A, Eastridge B, Brown CV, Davis M.

Injury. 2017 Feb;48(2):293-296. doi: 10.1016/j.injury.2016.11.001. Epub 2016 Nov 10.

PMID:
27871770
44.

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Setzer RW, Kothiya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS.

Toxicol Sci. 2016 Oct;153(2):409. doi: 10.1093/toxsci/kfw148. Epub 2016 Sep 7. No abstract available.

PMID:
27605417
45.

Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.

Song J, Xue C, Preisser JS, Cramer DW, Houck KL, Liu G, Folsom AR, Couper D, Yu F, Dong JF.

PLoS One. 2016 Sep 1;11(9):e0160757. doi: 10.1371/journal.pone.0160757. eCollection 2016.

46.

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology.

Richard AM, Judson RS, Houck KA, Grulke CM, Volarath P, Thillainadarajah I, Yang C, Rathman J, Martin MT, Wambaugh JF, Knudsen TB, Kancherla J, Mansouri K, Patlewicz G, Williams AJ, Little SB, Crofton KM, Thomas RS.

Chem Res Toxicol. 2016 Aug 15;29(8):1225-51. doi: 10.1021/acs.chemrestox.6b00135. Epub 2016 Jul 20.

47.

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Woodrow Setzer R, Kothiya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS.

Toxicol Sci. 2016 Aug;152(2):323-39. doi: 10.1093/toxsci/kfw092. Epub 2016 May 20. Erratum in: Toxicol Sci. 2016 Oct;153(2):409.

48.

Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program.

Karmaus AL, Filer DL, Martin MT, Houck KA.

Food Chem Toxicol. 2016 Jun;92:188-96. doi: 10.1016/j.fct.2016.04.012. Epub 2016 Apr 19.

49.

Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis.

Deal S, Wambaugh J, Judson R, Mosher S, Radio N, Houck K, Padilla S.

J Appl Toxicol. 2016 Sep;36(9):1214-22. doi: 10.1002/jat.3290. Epub 2016 Feb 29.

PMID:
26924781
50.

Environmental surveillance and monitoring--The next frontiers for high-throughput toxicology.

Schroeder AL, Ankley GT, Houck KA, Villeneuve DL.

Environ Toxicol Chem. 2016 Mar;35(3):513-25. doi: 10.1002/etc.3309.

PMID:
26923854

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