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Items: 1 to 50 of 133

1.

Validation of extracellular ligand-receptor interactions by Flow-TriCEPS.

Lopez-Garcia LA, Demiray L, Ruch-Marder S, Hopp AK, Hottiger MO, Helbling PM, Pavlou MP.

BMC Res Notes. 2018 Dec 5;11(1):863. doi: 10.1186/s13104-018-3974-5.

2.

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells.

Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8410. doi: 10.1126/scitranslmed.aat8410.

PMID:
30487251
3.

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.

Leutert M, Menzel S, Braren R, Rissiek B, Hopp AK, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO.

Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048.

4.

Mono-ADP-Ribosylhydrolase Assays.

Abplanalp J, Hopp AK, Hottiger MO.

Methods Mol Biol. 2018;1813:205-213. doi: 10.1007/978-1-4939-8588-3_13.

PMID:
30097869
5.

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.

Leslie Pedrioli DM, Leutert M, Bilan V, Nowak K, Gunasekera K, Ferrari E, Imhof R, Malmström L, Hottiger MO.

EMBO Rep. 2018 Aug;19(8). pii: e45310. doi: 10.15252/embr.201745310. Epub 2018 Jun 28.

PMID:
29954836
6.

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.

Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO.

Nat Commun. 2017 Dec 12;8(1):2055. doi: 10.1038/s41467-017-02253-1.

7.

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia.

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T.

Sci Rep. 2017 Nov 28;7(1):16477. doi: 10.1038/s41598-017-16613-w.

8.

Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment.

Pu WL, Luo YY, Bai RY, Guo AW, Zhou K, Zhang YS, Miao L, Rüegg C, Hottiger MO, Gao XM, Sun LK.

J Cell Physiol. 2018 Aug;233(8):5747-5755. doi: 10.1002/jcp.26293. Epub 2018 Mar 1.

PMID:
29155449
9.

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica.

Pu WL, Sun LK, Gao XM, Rüegg C, Cuendet M, Hottiger MO, Zhou K, Miao L, Zhang YS, Gebauer M.

Chin J Integr Med. 2017 Oct;23(10):723-732. doi: 10.1007/s11655-017-2974-y. Epub 2017 Oct 8. Review.

PMID:
28988387
10.

ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation.

Bisceglie L, Bartolomei G, Hottiger MO.

Nat Protoc. 2017 Sep;12(9):1951-1961. doi: 10.1038/nprot.2017.072. Epub 2017 Aug 24.

PMID:
28837130
11.

Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry.

Larsen SC, Leutert M, Bilan V, Martello R, Jungmichel S, Young C, Hottiger MO, Nielsen ML.

Methods Mol Biol. 2017;1608:149-162. doi: 10.1007/978-1-4939-6993-7_11.

PMID:
28695509
12.

Identification of ADP-Ribose Acceptor Sites on In Vitro Modified Proteins by Liquid Chromatography-Tandem Mass Spectrometry.

Leutert M, Bilan V, Gehrig P, Hottiger MO.

Methods Mol Biol. 2017;1608:137-148. doi: 10.1007/978-1-4939-6993-7_10.

PMID:
28695508
13.

New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

Bilan V, Selevsek N, Kistemaker HAV, Abplanalp J, Feurer R, Filippov DV, Hottiger MO.

Mol Cell Proteomics. 2017 May;16(5):949-958. doi: 10.1074/mcp.O116.065623. Epub 2017 Mar 21.

14.

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage.

Buzzo CL, Medina T, Branco LM, Lage SL, Ferreira LC, Amarante-Mendes GP, Hottiger MO, De Carvalho DD, Bortoluci KR.

Sci Rep. 2017 Feb 2;7:41686. doi: 10.1038/srep41686.

15.

Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites.

Bilan V, Leutert M, Nanni P, Panse C, Hottiger MO.

Anal Chem. 2017 Feb 7;89(3):1523-1530. doi: 10.1021/acs.analchem.6b03365. Epub 2017 Jan 13.

PMID:
28035797
16.

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.

Ma B, Hottiger MO.

Front Immunol. 2016 Sep 22;7:378. eCollection 2016. Review.

17.

Cell fate regulation by chromatin ADP-ribosylation.

Abplanalp J, Hottiger MO.

Semin Cell Dev Biol. 2017 Mar;63:114-122. doi: 10.1016/j.semcdb.2016.09.010. Epub 2016 Sep 28. Review.

PMID:
27693398
18.

Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.

Martello R, Leutert M, Jungmichel S, Bilan V, Larsen SC, Young C, Hottiger MO, Nielsen ML.

Nat Commun. 2016 Sep 30;7:12917. doi: 10.1038/ncomms12917.

19.

Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation.

Leutert M, Pedrioli DML, Hottiger MO.

Mol Cell. 2016 Jul 21;63(2):181-183. doi: 10.1016/j.molcel.2016.07.006.

20.

Chemoselective Dimerization of Phosphates.

Hofer A, Marques E, Kieliger N, Gatter SK, Jordi S, Ferrari E, Hofmann M, Fitzpatrick TB, Hottiger MO, Jessen HJ.

Org Lett. 2016 Jul 1;18(13):3222-5. doi: 10.1021/acs.orglett.6b01466. Epub 2016 Jun 16.

PMID:
27308921
21.

ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

Léger K, Hopp AK, Fey M, Hottiger MO.

Cell Cycle. 2016 Aug 2;15(15):2042-52. doi: 10.1080/15384101.2016.1195530. Epub 2016 Jun 13.

22.

PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO.

Nucleic Acids Res. 2016 Sep 19;44(16):7630-45. doi: 10.1093/nar/gkw442. Epub 2016 May 19.

23.

SnapShot: ADP-Ribosylation Signaling.

Hottiger MO.

Mol Cell. 2016 May 5;62(3):472. doi: 10.1016/j.molcel.2016.04.019. Epub 2016 May 5. No abstract available.

24.

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation.

Furrer A, Hottiger MO, Valaperti A.

Mol Immunol. 2016 Jun;74:47-58. doi: 10.1016/j.molimm.2016.04.009. Epub 2016 May 2.

PMID:
27148820
25.

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.

Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A.

J Biol Chem. 2016 Jun 10;291(24):12706-23. doi: 10.1074/jbc.M116.729699. Epub 2016 Apr 21.

26.

Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Apr 22;291(17):9382. doi: 10.1074/jbc.A115.698357. No abstract available.

27.

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

Wang C, Qu C, Alippe Y, Bonar SL, Civitelli R, Abu-Amer Y, Hottiger MO, Mbalaviele G.

Cell Death Dis. 2016 Mar 24;7:e2153. doi: 10.1038/cddis.2016.58.

28.

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.

Schuster S, Roessler C, Meleshin M, Zimmermann P, Simic Z, Kambach C, Schiene-Fischer C, Steegborn C, Hottiger MO, Schutkowski M.

Sci Rep. 2016 Mar 4;6:22643. doi: 10.1038/srep22643.

29.

ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO.

Sci Rep. 2016 Feb 17;6:21131. doi: 10.1038/srep21131.

30.

Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

Bartolomei G, Leutert M, Manzo M, Baubec T, Hottiger MO.

Mol Cell. 2016 Feb 4;61(3):474-485. doi: 10.1016/j.molcel.2015.12.025. Epub 2016 Jan 28.

31.

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Mar 4;291(10):4873-81. doi: 10.1074/jbc.M115.698357. Epub 2016 Jan 15. Erratum in: J Biol Chem. 2016 Apr 22;291(17):9382.

32.

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

Hottiger MO.

Expert Opin Ther Targets. 2015;19(9):1149-52. doi: 10.1517/14728222.2015.1073262. Epub 2015 Jul 27.

PMID:
26212149
33.

Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites.

Rosenthal F, Nanni P, Barkow-Oesterreicher S, Hottiger MO.

J Proteome Res. 2015 Sep 4;14(9):4072-9. doi: 10.1021/acs.jproteome.5b00432. Epub 2015 Aug 10.

PMID:
26211397
34.

ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.

Minotti R, Andersson A, Hottiger MO.

Mol Cell Biol. 2015 Sep;35(18):3189-99. doi: 10.1128/MCB.00196-15. Epub 2015 Jul 6.

35.

SnapShot: ADP-Ribosylation Signaling.

Hottiger MO.

Mol Cell. 2015 Jun 18;58(6):1134-1134.e1. doi: 10.1016/j.molcel.2015.06.001. Erratum in: Mol Cell. 2016 May 5;62(3):472.

36.

WNT/β-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-κB target genes.

Ma B, Fey M, Hottiger MO.

J Cell Sci. 2015 Jul 15;128(14):2430-6. doi: 10.1242/jcs.168542. Epub 2015 May 28.

37.

Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB.

Müller-Edenborn K, Léger K, Glaus Garzon JF, Oertli C, Mirsaidi A, Richards PJ, Rehrauer H, Spielmann P, Hoogewijs D, Borsig L, Hottiger MO, Wenger RH.

Oncotarget. 2015 Aug 21;6(24):20288-301.

38.

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

Hottiger MO.

Annu Rev Biochem. 2015;84:227-63. doi: 10.1146/annurev-biochem-060614-034506. Epub 2015 Feb 26. Review.

PMID:
25747399
39.

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange.

Lehmann M, Pirinen E, Mirsaidi A, Kunze FA, Richards PJ, Auwerx J, Hottiger MO.

Nucleic Acids Res. 2015 Jan;43(1):129-42. doi: 10.1093/nar/gku1260. Epub 2014 Dec 1.

40.

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.

Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J.

Cell Metab. 2014 Nov 4;20(5):856-869. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4.

41.

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.

Dahl M, Maturi V, Lönn P, Papoutsoglou P, Zieba A, Vanlandewijck M, van der Heide LP, Watanabe Y, Söderberg O, Hottiger MO, Heldin CH, Moustakas A.

PLoS One. 2014 Aug 18;9(8):e103651. doi: 10.1371/journal.pone.0103651. eCollection 2014.

42.

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Lo Sasso G, Ryu D, Mouchiroud L, Fernando SC, Anderson CL, Katsyuba E, Piersigilli A, Hottiger MO, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 11;9(7):e102495. doi: 10.1371/journal.pone.0102495. eCollection 2014.

43.

Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites.

Rosenthal F, Hottiger MO.

Front Biosci (Landmark Ed). 2014 Jun 1;19:1041-56. Review.

PMID:
24896335
44.

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM.

Eur Heart J. 2015 Jan 1;36(1):51-9. doi: 10.1093/eurheartj/ehu095. Epub 2014 Mar 6.

45.

ARTD2 activity is stimulated by RNA.

Léger K, Bär D, Savić N, Santoro R, Hottiger MO.

Nucleic Acids Res. 2014 Apr;42(8):5072-82. doi: 10.1093/nar/gku131. Epub 2014 Feb 8.

46.

SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress.

Kassner I, Andersson A, Fey M, Tomas M, Ferrando-May E, Hottiger MO.

Open Biol. 2013 Oct 2;3(10):120173. doi: 10.1098/rsob.120173.

47.

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses.

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML.

Mol Cell. 2013 Oct 24;52(2):272-85. doi: 10.1016/j.molcel.2013.08.026. Epub 2013 Sep 19.

48.

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.

Quero L, Klawitter M, Schmaus A, Rothley M, Sleeman J, Tiaden AN, Klasen J, Boos N, Hottiger MO, Wuertz K, Richards PJ.

Arthritis Res Ther. 2013 Aug 22;15(4):R94. doi: 10.1186/ar4274.

49.

Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation.

Weber FA, Bartolomei G, Hottiger MO, Cinelli P.

Stem Cells. 2013 Nov;31(11):2364-73. doi: 10.1002/stem.1507.

50.

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.

Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H.

ACS Chem Biol. 2013 Aug 16;8(8):1698-703. doi: 10.1021/cb4002014. Epub 2013 Jun 25.

PMID:
23742272

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