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Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation.

Hopp AK, Grüter P, Hottiger MO.

Cells. 2019 Aug 13;8(8). pii: E890. doi: 10.3390/cells8080890. Review.


A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy.

Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp AK, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger MO, Shao F.

Cell. 2019 Jul 25;178(3):552-566.e20. doi: 10.1016/j.cell.2019.06.007. Epub 2019 Jul 18.


Correction: SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310 (doi:10.1242/jcs.073783).

Rothgiesser KM, Erener S, Waibel S, Lüscher B, Hottiger MO.

J Cell Sci. 2019 Apr 24;132(8). pii: jcs232801. doi: 10.1242/jcs.232801. No abstract available.


Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Pu WL, Bai RY, Zhou K, Peng YF, Zhang MY, Hottiger MO, Li WH, Gao XM, Sun LK.

Int Immunopharmacol. 2019 Jul;72:204-210. doi: 10.1016/j.intimp.2019.04.018. Epub 2019 Apr 15.


A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.

Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M.

J Proteome Res. 2019 Apr 5;18(4):1607-1622. doi: 10.1021/acs.jproteome.8b00895. Epub 2019 Mar 21.


ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer.

Kunze FA, Bauer M, Komuczki J, Lanzinger M, Gunasekera K, Hopp AK, Lehmann M, Becher B, Müller A, Hottiger MO.

J Immunol. 2019 Mar 1;202(5):1406-1416. doi: 10.4049/jimmunol.1801107. Epub 2019 Jan 23.


Regulating Immunity via ADP-Ribosylation: Therapeutic Implications and Beyond.

Kunze FA, Hottiger MO.

Trends Immunol. 2019 Feb;40(2):159-173. doi: 10.1016/ Epub 2019 Jan 16. Review.


Validation of extracellular ligand-receptor interactions by Flow-TriCEPS.

Lopez-Garcia LA, Demiray L, Ruch-Marder S, Hopp AK, Hottiger MO, Helbling PM, Pavlou MP.

BMC Res Notes. 2018 Dec 5;11(1):863. doi: 10.1186/s13104-018-3974-5.


Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells.

Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8410. doi: 10.1126/scitranslmed.aat8410.


Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.

Leutert M, Menzel S, Braren R, Rissiek B, Hopp AK, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO.

Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048.


Mono-ADP-Ribosylhydrolase Assays.

Abplanalp J, Hopp AK, Hottiger MO.

Methods Mol Biol. 2018;1813:205-213. doi: 10.1007/978-1-4939-8588-3_13.


Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.

Leslie Pedrioli DM, Leutert M, Bilan V, Nowak K, Gunasekera K, Ferrari E, Imhof R, Malmström L, Hottiger MO.

EMBO Rep. 2018 Aug;19(8). pii: e45310. doi: 10.15252/embr.201745310. Epub 2018 Jun 28.


Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.

Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO.

Nat Commun. 2017 Dec 12;8(1):2055. doi: 10.1038/s41467-017-02253-1.


Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia.

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T.

Sci Rep. 2017 Nov 28;7(1):16477. doi: 10.1038/s41598-017-16613-w.


Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment.

Pu WL, Luo YY, Bai RY, Guo AW, Zhou K, Zhang YS, Miao L, Rüegg C, Hottiger MO, Gao XM, Sun LK.

J Cell Physiol. 2018 Aug;233(8):5747-5755. doi: 10.1002/jcp.26293. Epub 2018 Mar 1.


Targeting tumor-associated macrophages by anti-tumor Chinese materia medica.

Pu WL, Sun LK, Gao XM, Rüegg C, Cuendet M, Hottiger MO, Zhou K, Miao L, Zhang YS, Gebauer M.

Chin J Integr Med. 2017 Oct;23(10):723-732. doi: 10.1007/s11655-017-2974-y. Epub 2017 Oct 8. Review.


ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation.

Bisceglie L, Bartolomei G, Hottiger MO.

Nat Protoc. 2017 Sep;12(9):1951-1961. doi: 10.1038/nprot.2017.072. Epub 2017 Aug 24.


Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry.

Larsen SC, Leutert M, Bilan V, Martello R, Jungmichel S, Young C, Hottiger MO, Nielsen ML.

Methods Mol Biol. 2017;1608:149-162. doi: 10.1007/978-1-4939-6993-7_11.


Identification of ADP-Ribose Acceptor Sites on In Vitro Modified Proteins by Liquid Chromatography-Tandem Mass Spectrometry.

Leutert M, Bilan V, Gehrig P, Hottiger MO.

Methods Mol Biol. 2017;1608:137-148. doi: 10.1007/978-1-4939-6993-7_10.


New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

Bilan V, Selevsek N, Kistemaker HAV, Abplanalp J, Feurer R, Filippov DV, Hottiger MO.

Mol Cell Proteomics. 2017 May;16(5):949-958. doi: 10.1074/mcp.O116.065623. Epub 2017 Mar 21.


Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage.

Buzzo CL, Medina T, Branco LM, Lage SL, Ferreira LC, Amarante-Mendes GP, Hottiger MO, De Carvalho DD, Bortoluci KR.

Sci Rep. 2017 Feb 2;7:41686. doi: 10.1038/srep41686.


Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites.

Bilan V, Leutert M, Nanni P, Panse C, Hottiger MO.

Anal Chem. 2017 Feb 7;89(3):1523-1530. doi: 10.1021/acs.analchem.6b03365. Epub 2017 Jan 13.


Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.

Ma B, Hottiger MO.

Front Immunol. 2016 Sep 22;7:378. eCollection 2016. Review.


Cell fate regulation by chromatin ADP-ribosylation.

Abplanalp J, Hottiger MO.

Semin Cell Dev Biol. 2017 Mar;63:114-122. doi: 10.1016/j.semcdb.2016.09.010. Epub 2016 Sep 28. Review.


Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.

Martello R, Leutert M, Jungmichel S, Bilan V, Larsen SC, Young C, Hottiger MO, Nielsen ML.

Nat Commun. 2016 Sep 30;7:12917. doi: 10.1038/ncomms12917.


Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation.

Leutert M, Pedrioli DML, Hottiger MO.

Mol Cell. 2016 Jul 21;63(2):181-183. doi: 10.1016/j.molcel.2016.07.006.


Chemoselective Dimerization of Phosphates.

Hofer A, Marques E, Kieliger N, Gatter SK, Jordi S, Ferrari E, Hofmann M, Fitzpatrick TB, Hottiger MO, Jessen HJ.

Org Lett. 2016 Jul 1;18(13):3222-5. doi: 10.1021/acs.orglett.6b01466. Epub 2016 Jun 16.


ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

Léger K, Hopp AK, Fey M, Hottiger MO.

Cell Cycle. 2016 Aug 2;15(15):2042-52. doi: 10.1080/15384101.2016.1195530. Epub 2016 Jun 13.


PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO.

Nucleic Acids Res. 2016 Sep 19;44(16):7630-45. doi: 10.1093/nar/gkw442. Epub 2016 May 19.


SnapShot: ADP-Ribosylation Signaling.

Hottiger MO.

Mol Cell. 2016 May 5;62(3):472. doi: 10.1016/j.molcel.2016.04.019. Epub 2016 May 5. No abstract available.


Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation.

Furrer A, Hottiger MO, Valaperti A.

Mol Immunol. 2016 Jun;74:47-58. doi: 10.1016/j.molimm.2016.04.009. Epub 2016 May 2.


Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.

Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A.

J Biol Chem. 2016 Jun 10;291(24):12706-23. doi: 10.1074/jbc.M116.729699. Epub 2016 Apr 21.


Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Apr 22;291(17):9382. doi: 10.1074/jbc.A115.698357. No abstract available.


Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

Wang C, Qu C, Alippe Y, Bonar SL, Civitelli R, Abu-Amer Y, Hottiger MO, Mbalaviele G.

Cell Death Dis. 2016 Mar 24;7:e2153. doi: 10.1038/cddis.2016.58.


A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.

Schuster S, Roessler C, Meleshin M, Zimmermann P, Simic Z, Kambach C, Schiene-Fischer C, Steegborn C, Hottiger MO, Schutkowski M.

Sci Rep. 2016 Mar 4;6:22643. doi: 10.1038/srep22643.


ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO.

Sci Rep. 2016 Feb 17;6:21131. doi: 10.1038/srep21131.


Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

Bartolomei G, Leutert M, Manzo M, Baubec T, Hottiger MO.

Mol Cell. 2016 Feb 4;61(3):474-485. doi: 10.1016/j.molcel.2015.12.025. Epub 2016 Jan 28.


Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Mar 4;291(10):4873-81. doi: 10.1074/jbc.M115.698357. Epub 2016 Jan 15. Erratum in: J Biol Chem. 2016 Apr 22;291(17):9382.


Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

Hottiger MO.

Expert Opin Ther Targets. 2015;19(9):1149-52. doi: 10.1517/14728222.2015.1073262. Epub 2015 Jul 27.


Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites.

Rosenthal F, Nanni P, Barkow-Oesterreicher S, Hottiger MO.

J Proteome Res. 2015 Sep 4;14(9):4072-9. doi: 10.1021/acs.jproteome.5b00432. Epub 2015 Aug 10.


ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.

Minotti R, Andersson A, Hottiger MO.

Mol Cell Biol. 2015 Sep;35(18):3189-99. doi: 10.1128/MCB.00196-15. Epub 2015 Jul 6.


SnapShot: ADP-Ribosylation Signaling.

Hottiger MO.

Mol Cell. 2015 Jun 18;58(6):1134-1134.e1. doi: 10.1016/j.molcel.2015.06.001. Erratum in: Mol Cell. 2016 May 5;62(3):472.


WNT/β-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-κB target genes.

Ma B, Fey M, Hottiger MO.

J Cell Sci. 2015 Jul 15;128(14):2430-6. doi: 10.1242/jcs.168542. Epub 2015 May 28.


Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB.

Müller-Edenborn K, Léger K, Glaus Garzon JF, Oertli C, Mirsaidi A, Richards PJ, Rehrauer H, Spielmann P, Hoogewijs D, Borsig L, Hottiger MO, Wenger RH.

Oncotarget. 2015 Aug 21;6(24):20288-301.


Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

Hottiger MO.

Annu Rev Biochem. 2015;84:227-63. doi: 10.1146/annurev-biochem-060614-034506. Epub 2015 Feb 26. Review.


ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange.

Lehmann M, Pirinen E, Mirsaidi A, Kunze FA, Richards PJ, Auwerx J, Hottiger MO.

Nucleic Acids Res. 2015 Jan;43(1):129-42. doi: 10.1093/nar/gku1260. Epub 2014 Dec 1.


A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.

Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J.

Cell Metab. 2014 Nov 4;20(5):856-869. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4.


Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.

Dahl M, Maturi V, Lönn P, Papoutsoglou P, Zieba A, Vanlandewijck M, van der Heide LP, Watanabe Y, Söderberg O, Hottiger MO, Heldin CH, Moustakas A.

PLoS One. 2014 Aug 18;9(8):e103651. doi: 10.1371/journal.pone.0103651. eCollection 2014.


Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Lo Sasso G, Ryu D, Mouchiroud L, Fernando SC, Anderson CL, Katsyuba E, Piersigilli A, Hottiger MO, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 11;9(7):e102495. doi: 10.1371/journal.pone.0102495. eCollection 2014.


Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites.

Rosenthal F, Hottiger MO.

Front Biosci (Landmark Ed). 2014 Jun 1;19:1041-56. Review.


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