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Items: 12


Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

Fong L, Hotson A, Powderly JD, Sznol M, Heist RS, Choueiri TK, George S, Hughes BGM, Hellmann MD, Shepard DR, Rini BI, Kummar S, Weise AM, Riese MJ, Markman B, Emens LA, Mahadevan D, Luke JJ, Laport G, Brody JD, Hernandez-Aya L, Bonomi P, Goldman JW, Berim L, Renouf DJ, Goodwin RA, Munneke B, Ho PY, Hsieh J, McCaffery I, Kwei L, Willingham SB, Miller RA.

Cancer Discov. 2020 Jan;10(1):40-53. doi: 10.1158/2159-8290.CD-19-0980. Epub 2019 Nov 15.


A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models.

Willingham SB, Ho PY, Hotson A, Hill C, Piccione EC, Hsieh J, Liu L, Buggy JJ, McCaffery I, Miller RA.

Cancer Immunol Res. 2018 Oct;6(10):1136-1149. doi: 10.1158/2326-6066.CIR-18-0056. Epub 2018 Aug 21.


How Many Parameters Does It Take to Describe Disease Tolerance?

Louie A, Song KH, Hotson A, Thomas Tate A, Schneider DS.

PLoS Biol. 2016 Apr 18;14(4):e1002435. doi: 10.1371/journal.pbio.1002435. eCollection 2016 Apr. Erratum in: PLoS Biol. 2016 Jun;14(6):e1002485.


Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice.

Hotson AN, Gopinath S, Nicolau M, Khasanova A, Finck R, Monack D, Nolan GP.

Sci Signal. 2016 Jan 12;9(410):ra4. doi: 10.1126/scisignal.aaa9303.


Drosophila melanogaster Natural Variation Affects Growth Dynamics of Infecting Listeria monocytogenes.

Hotson AG, Schneider DS.

G3 (Bethesda). 2015 Oct 4;5(12):2593-600. doi: 10.1534/g3.115.022558.


IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system.

Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP.

Science. 2015 Jul 10;349(6244):1259425. doi: 10.1126/science.1259425.


The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses.

Gopinath S, Hotson A, Johns J, Nolan G, Monack D.

PLoS Pathog. 2013;9(6):e1003408. doi: 10.1371/journal.ppat.1003408. Epub 2013 Jun 6.


The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals.

Hotson AN, Hardy JW, Hale MB, Contag CH, Nolan GP.

J Immunol. 2009 Jun 15;182(12):7558-68. doi: 10.4049/jimmunol.0803666.


XopD SUMO protease affects host transcription, promotes pathogen growth, and delays symptom development in xanthomonas-infected tomato leaves.

Kim JG, Taylor KW, Hotson A, Keegan M, Schmelz EA, Mudgett MB.

Plant Cell. 2008 Jul;20(7):1915-29. doi: 10.1105/tpc.108.058529. Epub 2008 Jul 29.


Cysteine proteases in phytopathogenic bacteria: identification of plant targets and activation of innate immunity.

Hotson A, Mudgett MB.

Curr Opin Plant Biol. 2004 Aug;7(4):384-90. Review.


Characterization of the Xanthomonas AvrXv4 effector, a SUMO protease translocated into plant cells.

Roden J, Eardley L, Hotson A, Cao Y, Mudgett MB.

Mol Plant Microbe Interact. 2004 Jun;17(6):633-43.


Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.

Hotson A, Chosed R, Shu H, Orth K, Mudgett MB.

Mol Microbiol. 2003 Oct;50(2):377-89.

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