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A two-way molecular dialogue between embryo and endosperm is required for seed development.

Doll NM, Royek S, Fujita S, Okuda S, Chamot S, Stintzi A, Widiez T, Hothorn M, Schaller A, Geldner N, Ingram G.

Science. 2020 Jan 24;367(6476):431-435. doi: 10.1126/science.aaz4131.


Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.

Okuda S, Fujita S, Moretti A, Hohmann U, Doblas VG, Ma Y, Pfister A, Brandt B, Geldner N, Hothorn M.

Proc Natl Acad Sci U S A. 2020 Jan 21. pii: 201911553. doi: 10.1073/pnas.1911553117. [Epub ahead of print]


Mechanistic insights into the evolution of DUF26-containing proteins in land plants.

Vaattovaara A, Brandt B, Rajaraman S, Safronov O, Veidenberg A, Luklová M, Kangasjärvi J, Löytynoja A, Hothorn M, Salojärvi J, Wrzaczek M.

Commun Biol. 2019 Feb 8;2(1):56. doi: 10.1038/s42003-019-0306-9.


A genetically validated approach for detecting inorganic polyphosphates in plants.

Zhu J, Loubéry S, Broger L, Zhang Y, Lorenzo-Orts L, Utz-Pugin A, Fernie AR, Young-Tae C, Hothorn M.

Plant J. 2019 Dec 9. doi: 10.1111/tpj.14642. [Epub ahead of print]


Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.

Zhu J, Lau K, Puschmann R, Harmel RK, Zhang Y, Pries V, Gaugler P, Broger L, Dutta AK, Jessen HJ, Schaaf G, Fernie AR, Hothorn LA, Fiedler D, Hothorn M.

Elife. 2019 Aug 22;8. pii: e43582. doi: 10.7554/eLife.43582.


Identity and functions of inorganic and inositol polyphosphates in plants.

Lorenzo-Orts L, Couto D, Hothorn M.

New Phytol. 2020 Jan;225(2):637-652. doi: 10.1111/nph.16129. Epub 2019 Sep 20. Review.


Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.

Lau K, Podolec R, Chappuis R, Ulm R, Hothorn M.

EMBO J. 2019 Sep 16;38(18):e102140. doi: 10.15252/embj.2019102140. Epub 2019 Jul 15.


Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules.

Lorenzo-Orts L, Hohmann U, Zhu J, Hothorn M.

Life Sci Alliance. 2019 May 27;2(3). pii: e201900385. doi: 10.26508/lsa.201900385. Print 2019 Jun.


Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1.

Hohmann U, Hothorn M.

Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):488-497. doi: 10.1107/S2059798319005291. Epub 2019 Apr 29.


Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse.

Robinson GC, Kaufmann M, Roux C, Martinez-Font J, Hothorn M, Thore S, Fitzpatrick TB.

Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):400-415. doi: 10.1107/S2059798319002912. Epub 2019 Apr 4.


Mechanistic insights into the evolution of DUF26-containing proteins in land plants.

Vaattovaara A, Brandt B, Rajaraman S, Safronov O, Veidenberg A, Luklová M, Kangasjärvi J, Löytynoja A, Hothorn M, Salojärvi J, Wrzaczek M.

Commun Biol. 2019 Feb 8;2:56. doi: 10.1038/s42003-019-0306-9. eCollection 2019.


Concerted expression of a cell cycle regulator and a metabolic enzyme from a bicistronic transcript in plants.

Lorenzo-Orts L, Witthoeft J, Deforges J, Martinez J, Loubéry S, Placzek A, Poirier Y, Hothorn LA, Jaillais Y, Hothorn M.

Nat Plants. 2019 Feb;5(2):184-193. doi: 10.1038/s41477-019-0358-3. Epub 2019 Feb 8.


MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.

Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M, Ladurner AG.

EMBO Rep. 2018 Oct;19(10). pii: e44445. doi: 10.15252/embr.201744445. Epub 2018 Sep 3.


Publisher Correction: The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling.

Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M.

Nat Plants. 2018 Sep;4(9):732. doi: 10.1038/s41477-018-0244-4.


CLERK is a novel receptor kinase required for sensing of root-active CLE peptides in Arabidopsis.

Anne P, Amiguet-Vercher A, Brandt B, Kalmbach L, Geldner N, Hothorn M, Hardtke CS.

Development. 2018 May 22;145(10). pii: dev162354. doi: 10.1242/dev.162354.


The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling.

Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M.

Nat Plants. 2018 Jun;4(6):345-351. doi: 10.1038/s41477-018-0150-9. Epub 2018 May 7. Erratum in: Nat Plants. 2018 Aug 14;:.


Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors.

Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, Butenko MA, Hothorn M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3488-3493. doi: 10.1073/pnas.1714972115. Epub 2018 Mar 12.


Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain.

Jung JY, Ried MK, Hothorn M, Poirier Y.

Curr Opin Biotechnol. 2018 Feb;49:156-162. doi: 10.1016/j.copbio.2017.08.012. Epub 2017 Sep 8. Review.


Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature.

Hazak O, Brandt B, Cattaneo P, Santiago J, Rodriguez-Villalon A, Hothorn M, Hardtke CS.

EMBO Rep. 2017 Aug;18(8):1367-1381. doi: 10.15252/embr.201643535. Epub 2017 Jun 12.


The Structural Basis of Ligand Perception and Signal Activation by Receptor Kinases.

Hohmann U, Lau K, Hothorn M.

Annu Rev Plant Biol. 2017 Apr 28;68:109-137. doi: 10.1146/annurev-arplant-042916-040957. Epub 2017 Jan 11. Review.


The macro domain as fusion tag for carrier-driven crystallization.

Wild R, Hothorn M.

Protein Sci. 2017 Feb;26(2):365-374. doi: 10.1002/pro.3073. Epub 2016 Nov 2.


Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A.

Science. 2016 May 20;352(6288):986-90. doi: 10.1126/science.aad9858. Epub 2016 Apr 14.


Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission.

Santiago J, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M.

Elife. 2016 Apr 8;5. pii: e15075. doi: 10.7554/eLife.15075.


SERK co-receptor kinases.

Brandt B, Hothorn M.

Curr Biol. 2016 Mar 21;26(6):R225-6. doi: 10.1016/j.cub.2015.12.014. No abstract available.


Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes.

Martinez J, Truffault V, Hothorn M.

J Biol Chem. 2015 Sep 18;290(38):23348-60. doi: 10.1074/jbc.M115.674473. Epub 2015 Jul 28.


Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.

Bojar D, Martinez J, Santiago J, Rybin V, Bayliss R, Hothorn M.

Plant J. 2014 Apr;78(1):31-43. doi: 10.1111/tpj.12445. Epub 2014 Mar 12.


Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.

Santiago J, Henzler C, Hothorn M.

Science. 2013 Aug 23;341(6148):889-92. doi: 10.1126/science.1242468. Epub 2013 Aug 8.


Tackling drought stress: receptor-like kinases present new approaches.

Marshall A, Aalen RB, Audenaert D, Beeckman T, Broadley MR, Butenko MA, Caño-Delgado AI, de Vries S, Dresselhaus T, Felix G, Graham NS, Foulkes J, Granier C, Greb T, Grossniklaus U, Hammond JP, Heidstra R, Hodgman C, Hothorn M, Inzé D, Ostergaard L, Russinova E, Simon R, Skirycz A, Stahl Y, Zipfel C, De Smet I.

Plant Cell. 2012 Jun;24(6):2262-78. doi: 10.1105/tpc.112.096677. Epub 2012 Jun 12. Review.


Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana.

Feldman-Salit A, Wirtz M, Lenherr ED, Throm C, Hothorn M, Scheffzek K, Hell R, Wade RC.

Structure. 2012 Feb 8;20(2):292-302. doi: 10.1016/j.str.2011.11.019.


Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges.

Christie JM, Arvai AS, Baxter KJ, Heilmann M, Pratt AJ, O'Hara A, Kelly SM, Hothorn M, Smith BO, Hitomi K, Jenkins GI, Getzoff ED.

Science. 2012 Mar 23;335(6075):1492-6. doi: 10.1126/science.1218091. Epub 2012 Feb 9.


Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase.

Cuyvers S, Dornez E, Abou Hachem M, Svensson B, Hothorn M, Chory J, Delcour JA, Courtin CM.

Anal Biochem. 2012 Jan 1;420(1):90-2. doi: 10.1016/j.ab.2011.09.005. Epub 2011 Sep 10.


Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.

Hothorn M, Dabi T, Chory J.

Nat Chem Biol. 2011 Oct 2;7(11):766-8. doi: 10.1038/nchembio.667.


Structural basis of steroid hormone perception by the receptor kinase BRI1.

Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel JP, Wilson IA, Chory J.

Nature. 2011 Jun 12;474(7352):467-71. doi: 10.1038/nature10153.


Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor.

Jaillais Y, Hothorn M, Belkhadir Y, Dabi T, Nimchuk ZL, Meyerowitz EM, Chory J.

Genes Dev. 2011 Feb 1;25(3):232-7. doi: 10.1101/gad.2001911.


Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein.

Hothorn M, Van den Ende W, Lammens W, Rybin V, Scheffzek K.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17427-32. doi: 10.1073/pnas.1004481107. Epub 2010 Sep 21.


Structure of the Enterococcus faecalis EIIA(gnt) PTS component.

Reinelt S, Koch B, Hothorn M, Hengstenberg W, Welti S, Scheffzek K.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):626-9. doi: 10.1016/j.bbrc.2009.08.054. Epub 2009 Aug 13.


A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.


Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A.

Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120.


Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.

Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson TJ, Sattler M.

J Biol Chem. 2009 Jan 2;284(1):630-9. doi: 10.1074/jbc.M805395200. Epub 2008 Oct 29.


Thioredoxin as a fusion tag for carrier-driven crystallization.

Corsini L, Hothorn M, Scheffzek K, Sattler M, Stier G.

Protein Sci. 2008 Dec;17(12):2070-9. doi: 10.1110/ps.037564.108. Epub 2008 Sep 9.


The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.

Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9. doi: 10.1073/pnas.0712293105. Epub 2008 Jun 25.


The redox switch of gamma-glutamylcysteine ligase via a reversible monomer-dimer transition is a mechanism unique to plants.

Gromes R, Hothorn M, Lenherr ED, Rybin V, Scheffzek K, Rausch T.

Plant J. 2008 Jun;54(6):1063-75. doi: 10.1111/j.1365-313X.2008.03477.x. Epub 2008 Mar 12.


The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K.

EMBO Rep. 2008 Apr;9(4):350-5. doi: 10.1038/embor.2008.20. Epub 2008 Mar 7.


A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.

Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG.

Nat Struct Mol Biol. 2007 Oct;14(10):897-903. Epub 2007 Sep 23.


U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M.

Nat Struct Mol Biol. 2007 Jul;14(7):620-9. Epub 2007 Jun 24. Erratum in: Nat Struct Mol Biol. 2007 Aug;14(8):785. Bonna, Sophie [corrected to Bonnal, Sophie].


Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.

Simader H, Hothorn M, Suck D.

Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1510-9. Epub 2006 Nov 23.


Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.

Simader H, Hothorn M, Köhler C, Basquin J, Simos G, Suck D.

Nucleic Acids Res. 2006;34(14):3968-79. Epub 2006 Aug 12.


Structural basis for the redox control of plant glutamate cysteine ligase.

Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K.

J Biol Chem. 2006 Sep 15;281(37):27557-65. Epub 2006 Jun 9.


Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range.

Hothorn M, Scheffzek K.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):665-70. Epub 2006 May 12.


Splicing regulates NAD metabolite binding to histone macroH2A.

Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG.

Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19.


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