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Items: 26


Epigenetic profiling for the molecular classification of metastatic brain tumors.

Orozco JIJ, Knijnenburg TA, Manughian-Peter AO, Salomon MP, Barkhoudarian G, Jalas JR, Wilmott JS, Hothi P, Wang X, Takasumi Y, Buckland ME, Thompson JF, Long GV, Cobbs CS, Shmulevich I, Kelly DF, Scolyer RA, Hoon DSB, Marzese DM.

Nat Commun. 2018 Nov 6;9(1):4627. doi: 10.1038/s41467-018-06715-y.


Brain metastasis DNA methylomes, a novel resource for the identification of biological and clinical features.

Salomon MP, Orozco JIJ, Wilmott JS, Hothi P, Manughian-Peter AO, Cobbs CS, Scolyer RA, Hoon DSB, Marzese DM.

Sci Data. 2018 Nov 6;5:180245. doi: 10.1038/sdata.2018.245.


Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Diaz P, Horne E, Xu C, Hamel E, Wagenbach M, Petrov RR, Uhlenbruck B, Haas B, Hothi P, Wordeman L, Gussio R, Stella N.

Eur J Med Chem. 2018 Nov 5;159:74-89. doi: 10.1016/j.ejmech.2018.09.026. Epub 2018 Sep 11.


An anatomic transcriptional atlas of human glioblastoma.

Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD.

Science. 2018 May 11;360(6389):660-663. doi: 10.1126/science.aaf2666.


Precision knockdown of EGFR gene expression using radio frequency electromagnetic energy.

Ulasov IV, Foster H, Butters M, Yoon JG, Ozawa T, Nicolaides T, Figueroa X, Hothi P, Prados M, Butters J, Cobbs C.

J Neurooncol. 2017 Jun;133(2):257-264. doi: 10.1007/s11060-017-2440-x. Epub 2017 Apr 22.


TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme.

Ghosh D, Ulasov IV, Chen L, Harkins LE, Wallenborg K, Hothi P, Rostad S, Hood L, Cobbs CS.

Stem Cells. 2016 Sep;34(9):2276-89. doi: 10.1002/stem.2411. Epub 2016 Jul 4.


Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.

Lin B, Lee H, Yoon JG, Madan A, Wayner E, Tonning S, Hothi P, Schroeder B, Ulasov I, Foltz G, Hood L, Cobbs C.

Oncotarget. 2015 Mar 10;6(7):5369-81.


Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy.

Ulasov IV, Shah N, Kaverina NV, Lee H, Lin B, Lieber A, Kadagidze ZG, Yoon JG, Schroeder B, Hothi P, Ghosh D, Baryshnikov AY, Cobbs CS.

Oncotarget. 2015 Feb 28;6(6):3977-87.


VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner.

Pham K, Luo D, Siemann DW, Law BK, Reynolds BA, Hothi P, Foltz G, Harrison JK.

Cancer Lett. 2015 Apr 28;360(1):60-7. doi: 10.1016/j.canlet.2015.02.005. Epub 2015 Feb 9.


Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells.

Liu C, Pham K, Luo D, Reynolds BA, Hothi P, Foltz G, Harrison JK.

PLoS One. 2013;8(3):e59750. doi: 10.1371/journal.pone.0059750. Epub 2013 Mar 21.


High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.

Hothi P, Martins TJ, Chen L, Deleyrolle L, Yoon JG, Reynolds B, Foltz G.

Oncotarget. 2012 Oct;3(10):1124-36.


Pressure effects on enzyme-catalyzed quantum tunneling events arise from protein-specific structural and dynamic changes.

Hay S, Johannissen LO, Hothi P, Sutcliffe MJ, Scrutton NS.

J Am Chem Soc. 2012 Jun 13;134(23):9749-54. doi: 10.1021/ja3024115. Epub 2012 Jun 5.


Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interactions with ferredoxin.

Bowsher CG, Eyres LM, Gummadova JO, Hothi P, McLean KJ, Munro AW, Scrutton NS, Hanke GT, Sakakibara Y, Hase T.

Biochemistry. 2011 Mar 22;50(11):1778-87. doi: 10.1021/bi1014562. Epub 2011 Feb 23.


Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.

Hothi P, Hay S, Roujeinikova A, Sutcliffe MJ, Lee M, Leys D, Cullis PM, Scrutton NS.

Chembiochem. 2008 Nov 24;9(17):2839-45. doi: 10.1002/cbic.200800408.


Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation.

Hay S, Pudney CR, Hothi P, Scrutton NS.

J Phys Chem A. 2008 Dec 18;112(50):13109-15. doi: 10.1021/jp805107n.


Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

Hay S, Pudney C, Hothi P, Johannissen LO, Masgrau L, Pang J, Leys D, Sutcliffe MJ, Scrutton NS.

Biochem Soc Trans. 2008 Feb;36(Pt 1):16-21. doi: 10.1042/BST0360016. Review.


Isotope effects reveal that para-substituted benzylamines are poor reactivity probes of the quinoprotein mechanism for aromatic amine dehydrogenase.

Hothi P, Roujeinikova A, Khadra KA, Lee M, Cullis P, Leys D, Scrutton NS.

Biochemistry. 2007 Aug 14;46(32):9250-9. Epub 2007 Jul 18.


New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates.

Roujeinikova A, Hothi P, Masgrau L, Sutcliffe MJ, Scrutton NS, Leys D.

J Biol Chem. 2007 Aug 17;282(33):23766-77. Epub 2007 May 1.


Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.

Sutcliffe MJ, Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Leys D, Scrutton NS.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1375-86. Review.


Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.

Combe JP, Basran J, Hothi P, Leys D, Rigby SE, Munro AW, Scrutton NS.

J Biol Chem. 2006 Jun 30;281(26):17977-88. Epub 2006 Apr 19.


Atomic description of an enzyme reaction dominated by proton tunneling.

Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Sutcliffe MJ, Scrutton NS, Leys D.

Science. 2006 Apr 14;312(5771):237-41. Erratum in: Science. 2006 Jun 16;312(5780):1600.


Kinetic isotope effects and ligand binding in PQQ-dependent methanol dehydrogenase.

Hothi P, Sutcliffe MJ, Scrutton NS.

Biochem J. 2005 May 15;388(Pt 1):123-33.


Hydrogen tunneling in quinoproteins.

Masgrau L, Basran J, Hothi P, Sutcliffe MJ, Scrutton NS.

Arch Biochem Biophys. 2004 Aug 1;428(1):41-51. Review.


Effects of multiple ligand binding on kinetic isotope effects in PQQ-dependent methanol dehydrogenase.

Hothi P, Basran J, Sutcliffe MJ, Scrutton NS.

Biochemistry. 2003 Apr 8;42(13):3966-78.


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