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Items: 1 to 50 of 104

1.

IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.

Ritzmann F, Jungnickel C, Vella G, Kamyschnikow A, Herr C, Li D, Menger MM, Angenendt A, Hoth M, Lis A, Bals R, Beisswenger C.

Sci Rep. 2019 Jul 17;9(1):10353. doi: 10.1038/s41598-019-46759-8.

2.

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment.

Frisch J, Angenendt A, Hoth M, Prates Roma L, Lis A.

Cancers (Basel). 2019 Mar 30;11(4). pii: E457. doi: 10.3390/cancers11040457. Review.

3.

CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes.

Nickel AG, Kohlhaas M, Bertero E, Wilhelm D, Wagner M, Sequeira V, Kreusser MM, Dewenter M, Kappl R, Hoth M, Dudek J, Backs J, Maack C.

J Physiol. 2019 Feb 16. doi: 10.1113/JP276766. [Epub ahead of print]

PMID:
30770570
4.

miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.

Hart M, Walch-Rückheim B, Friedmann KS, Rheinheimer S, Tänzer T, Glombitza B, Sester M, Lenhof HP, Hoth M, Schwarz EC, Keller A, Meese E.

Cell Death Dis. 2019 Jan 18;10(2):46. doi: 10.1038/s41419-018-1295-1.

5.

Calcium signal dynamics in T lymphocytes: Comparing in vivo and in vitro measurements.

Friedmann KS, Bozem M, Hoth M.

Semin Cell Dev Biol. 2019 Oct;94:84-93. doi: 10.1016/j.semcdb.2019.01.004. Epub 2019 Jan 11. Review.

6.

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms.

Backes CS, Friedmann KS, Mang S, Knörck A, Hoth M, Kummerow C.

J Biol Chem. 2018 Oct 19;293(42):16348-16363. doi: 10.1074/jbc.RA118.004549. Epub 2018 Sep 6.

7.

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum.

Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I.

Nat Commun. 2018 Aug 28;9(1):3489. doi: 10.1038/s41467-018-06003-9.

8.

Light-sheet Microscopy for Three-dimensional Visualization of Human Immune Cells.

Schoppmeyer R, Zhao R, Hoth M, Qu B.

J Vis Exp. 2018 Jun 13;(136). doi: 10.3791/57651.

PMID:
29985362
9.

Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.

Knörck A, Marx S, Friedmann KS, Zöphel S, Lieblang L, Hässig C, Müller I, Pilch J, Sester U, Hoth M, Eichler H, Sester M, Schwarz EC.

Transfusion. 2018 Jun;58(6):1516-1526. doi: 10.1111/trf.14616. Epub 2018 May 6.

PMID:
29732580
10.

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.

Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M.

J Physiol. 2018 Jul;596(14):2681-2698. doi: 10.1113/JP274964. Epub 2018 Mar 12.

11.

NFATc1 controls the cytotoxicity of CD8+ T cells.

Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.

Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6.

12.

Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.

Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C, Zhou X, Schwarz EC, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B.

Eur J Immunol. 2017 Sep;47(9):1562-1572. doi: 10.1002/eji.201747124. Epub 2017 Jul 31.

13.

Electrochemical Quantification of Extracellular Local H2O2 Kinetics Originating from Single Cells.

Bozem M, Knapp P, Mirčeski V, Slowik EJ, Bogeski I, Kappl R, Heinemann C, Hoth M.

Antioxid Redox Signal. 2018 Aug 20;29(6):501-517. doi: 10.1089/ars.2016.6840. Epub 2017 May 15.

14.

The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes.

Eisenbeis J, Peisker H, Backes CS, Bur S, Hölters S, Thewes N, Greiner M, Junker C, Schwarz EC, Hoth M, Junker K, Preissner KT, Jacobs K, Herrmann M, Bischoff M.

Int J Med Microbiol. 2017 Feb;307(2):116-125. doi: 10.1016/j.ijmm.2017.01.002. Epub 2017 Jan 18.

PMID:
28117265
15.

Cytoskeleton rotation relocates mitochondria to the immunological synapse and increases calcium signals.

Maccari I, Zhao R, Peglow M, Schwarz K, Hornak I, Pasche M, Quintana A, Hoth M, Qu B, Rieger H.

Cell Calcium. 2016 Nov;60(5):309-321. doi: 10.1016/j.ceca.2016.06.007. Epub 2016 Jul 7.

PMID:
27451384
16.

DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.

Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B.

Oncotarget. 2016 Sep 27;7(39):64191-64202. doi: 10.18632/oncotarget.11640.

17.

Optimality of Spatially Inhomogeneous Search Strategies.

Schwarz K, Schröder Y, Qu B, Hoth M, Rieger H.

Phys Rev Lett. 2016 Aug 5;117(6):068101. doi: 10.1103/PhysRevLett.117.068101. Epub 2016 Aug 2.

PMID:
27541477
18.

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.

Weingärtner O, Bogeski I, Kummerow C, Schirmer SH, Husche C, Vanmierlo T, Wagenpfeil G, Hoth M, Böhm M, Lütjohann D, Laufs U.

J Steroid Biochem Mol Biol. 2017 May;169:219-225. doi: 10.1016/j.jsbmb.2016.07.016. Epub 2016 Jul 27.

PMID:
27473562
19.

New insights into the chemistry of Coenzyme Q-0: A voltammetric and spectroscopic study.

Gulaboski R, Bogeski I, Kokoskarova P, Haeri HH, Mitrev S, Stefova M, Stanoeva JP, Markovski V, Mirčeski V, Hoth M, Kappl R.

Bioelectrochemistry. 2016 Oct;111:100-8. doi: 10.1016/j.bioelechem.2016.05.008. Epub 2016 May 29.

PMID:
27268099
20.

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.

Bhat SS, Friedmann KS, Knörck A, Hoxha C, Leidinger P, Backes C, Meese E, Keller A, Rettig J, Hoth M, Qu B, Schwarz EC.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1653-64. doi: 10.1016/j.bbamcr.2016.04.014. Epub 2016 Apr 17.

21.

Deep characterization of blood cell miRNomes by NGS.

Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A.

Cell Mol Life Sci. 2016 Aug;73(16):3169-81. doi: 10.1007/s00018-016-2154-9. Epub 2016 Feb 13.

PMID:
26874686
22.

CRAC channels, calcium, and cancer in light of the driver and passenger concept.

Hoth M.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1408-17. doi: 10.1016/j.bbamcr.2015.12.009. Epub 2015 Dec 17. Review.

23.

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

Nickel AG, von Hardenberg A, Hohl M, Löffler JR, Kohlhaas M, Becker J, Reil JC, Kazakov A, Bonnekoh J, Stadelmaier M, Puhl SL, Wagner M, Bogeski I, Cortassa S, Kappl R, Pasieka B, Lafontaine M, Lancaster CR, Blacker TS, Hall AR, Duchen MR, Kästner L, Lipp P, Zeller T, Müller C, Knopp A, Laufs U, Böhm M, Hoth M, Maack C.

Cell Metab. 2015 Sep 1;22(3):472-84. doi: 10.1016/j.cmet.2015.07.008. Epub 2015 Aug 6.

24.

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.

Marshall MR, Pattu V, Halimani M, Maier-Peuschel M, Müller ML, Becherer U, Hong W, Hoth M, Tschernig T, Bryceson YT, Rettig J.

J Cell Biol. 2015 Jul 6;210(1):135-51. doi: 10.1083/jcb.201411093. Epub 2015 Jun 29.

25.

Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens.

Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgórska M, Smola S, Hoth M, Zufall F.

J Biol Chem. 2015 Mar 20;290(12):7369-87. doi: 10.1074/jbc.M114.626747. Epub 2015 Jan 20.

26.

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide.

Ermakova YG, Bilan DS, Matlashov ME, Mishina NM, Markvicheva KN, Subach OM, Subach FV, Bogeski I, Hoth M, Enikolopov G, Belousov VV.

Nat Commun. 2014 Oct 21;5:5222. doi: 10.1038/ncomms6222.

27.

DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood.

Yang R, Pfütze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B.

Int J Cancer. 2015 Apr 15;136(8):1845-55. doi: 10.1002/ijc.29205. Epub 2014 Sep 24.

28.

Human T cells monitored by impedance spectrometry using field-effect transistor arrays: a novel tool for single-cell adhesion and migration studies.

Law JK, Susloparova A, Vu XT, Zhou X, Hempel F, Qu B, Hoth M, Ingebrandt S.

Biosens Bioelectron. 2015 May 15;67:170-6. doi: 10.1016/j.bios.2014.08.007. Epub 2014 Aug 13.

PMID:
25155061
29.

Patch-clamp measurement of ICRAC and ORAI channel activity.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):602-7. doi: 10.1101/pdb.top066795.

PMID:
24890214
30.

The minimal requirements to use calcium imaging to analyze ICRAC.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):638-42. doi: 10.1101/pdb.prot073262.

PMID:
24890204
31.

Measuring endogenous ICRAC and ORAI currents with the patch-clamp technique.

Alansary D, Kilch T, Holzmann C, Peinelt C, Hoth M, Lis A.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):630-7. doi: 10.1101/pdb.prot073254.

PMID:
24890203
32.

A simple, economic, time-resolved killing assay.

Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B.

Eur J Immunol. 2014 Jun;44(6):1870-2. doi: 10.1002/eji.201444518. Epub 2014 Apr 13. No abstract available.

33.

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry.

Stanisz H, Saul S, Müller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I.

Pigment Cell Melanoma Res. 2014 May;27(3):442-53. doi: 10.1111/pcmr.12222. Epub 2014 Mar 7.

PMID:
24472175
34.

How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.

Saul S, Stanisz H, Backes CS, Schwarz EC, Hoth M.

Eur J Pharmacol. 2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28. Review.

PMID:
24291108
35.

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes.

Halimani M, Pattu V, Marshall MR, Chang HF, Matti U, Jung M, Becherer U, Krause E, Hoth M, Schwarz EC, Rettig J.

Eur J Immunol. 2014 Feb;44(2):573-84. doi: 10.1002/eji.201344011. Epub 2013 Dec 16.

36.

The neglected CRAC proteins: Orai2, Orai3, and STIM2.

Hoth M, Niemeyer BA.

Curr Top Membr. 2013;71:237-71. doi: 10.1016/B978-0-12-407870-3.00010-X. Review.

PMID:
23890118
37.

Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.

Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M.

Cancer Cell. 2013 Jun 10;23(6):811-25. doi: 10.1016/j.ccr.2013.05.003.

38.

Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers.

Gulaboski R, Bogeski I, Mirčeski V, Saul S, Pasieka B, Haeri HH, Stefova M, Stanoeva JP, Mitrev S, Hoth M, Kappl R.

Sci Rep. 2013;3:1865. doi: 10.1038/srep01865.

39.

Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.

Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause E, Rettig J.

Traffic. 2013 Jul;14(7):798-809. doi: 10.1111/tra.12074. Epub 2013 May 9.

40.

Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.

Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X.

Curr Mol Med. 2013 Mar;13(3):417-28.

PMID:
23331014
41.

Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells.

Schwarz EC, Qu B, Hoth M.

Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. doi: 10.1016/j.bbamcr.2012.11.016. Epub 2012 Dec 3. Review.

42.

Molecular regulation of CRAC channels and their role in lymphocyte function.

Shaw PJ, Qu B, Hoth M, Feske S.

Cell Mol Life Sci. 2013 Aug;70(15):2637-56. doi: 10.1007/s00018-012-1175-2. Epub 2012 Oct 5. Review.

43.

Mitochondrial dynamics and their impact on T cell function.

Quintana A, Hoth M.

Cell Calcium. 2012 Jul;52(1):57-63. doi: 10.1016/j.ceca.2012.02.005. Epub 2012 Mar 14. Review.

PMID:
22425631
44.

Can we see PIP(3) and hydrogen peroxide with a single probe?

Mishina NM, Bogeski I, Bolotin DA, Hoth M, Niemeyer BA, Schultz C, Zagaynova EV, Lukyanov S, Belousov VV.

Antioxid Redox Signal. 2012 Aug 1;17(3):505-12. doi: 10.1089/ars.2012.4574. Epub 2012 Apr 10.

PMID:
22369174
45.

ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes.

Stanisz H, Stark A, Kilch T, Schwarz EC, Müller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I.

J Invest Dermatol. 2012 May;132(5):1443-51. doi: 10.1038/jid.2011.478. Epub 2012 Feb 9.

46.

SNARE protein expression and localization in human cytotoxic T lymphocytes.

Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M.

Eur J Immunol. 2012 Feb;42(2):470-5. doi: 10.1002/eji.201141915. Epub 2012 Jan 5.

47.

Excitable T cells: Ca(v)1.4 channel contributions and controversies.

Niemeyer BA, Hoth M.

Immunity. 2011 Sep 23;35(3):315-7. doi: 10.1016/j.immuni.2011.09.001.

48.

Redox regulation of calcium ion channels: chemical and physiological aspects.

Bogeski I, Kappl R, Kummerow C, Gulaboski R, Hoth M, Niemeyer BA.

Cell Calcium. 2011 Nov;50(5):407-23. doi: 10.1016/j.ceca.2011.07.006. Epub 2011 Sep 17. Review.

PMID:
21930299
49.

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation.

Quintana A, Pasche M, Junker C, Al-Ansary D, Rieger H, Kummerow C, Nuñez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M.

EMBO J. 2011 Aug 16;30(19):3895-912. doi: 10.1038/emboj.2011.289.

50.

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.

Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC.

Cell Calcium. 2011 Sep;50(3):261-9. doi: 10.1016/j.ceca.2011.05.015. Epub 2011 Jun 12. Review.

PMID:
21665274

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