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The Association of Fever and Antipyretic Medication With Outcomes in Mechanically Ventilated Patients: A Cohort Study.

Evans EM, Doctor RJ, Gage BF, Hotchkiss RS, Fuller BM, Drewry AM.

Shock. 2019 Aug;52(2):152-159. doi: 10.1097/SHK.0000000000001368.


What Is the Skinny on Obesity During Sepsis?

Crouser ED, Caldwell CC, Hotchkiss RS.

Crit Care Med. 2019 May;47(5):735-736. doi: 10.1097/CCM.0000000000003707. No abstract available.


An Aspirin a Day Keeps the Intensivist Away?

Turnbull IR, Hotchkiss RS.

Crit Care Med. 2019 Apr;47(4):603-604. doi: 10.1097/CCM.0000000000003672. No abstract available.


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM.

Crit Care Med. 2019 May;47(5):632-642. doi: 10.1097/CCM.0000000000003685.


Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike.

Watanabe E, Thampy LK, Hotchkiss RS.

Acute Med Surg. 2018 Aug 6;5(4):309-315. doi: 10.1002/ams2.363. eCollection 2018 Oct.


Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.

Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS.

PLoS One. 2018 Jun 26;13(6):e0199497. doi: 10.1371/journal.pone.0199497. eCollection 2018.


Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.

JCI Insight. 2018 Mar 8;3(5). pii: 98960. doi: 10.1172/jci.insight.98960.


Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis.

Drewry AM, Ablordeppey EA, Murray ET, Dalton CM, Fuller BM, Kollef MH, Hotchkiss RS.

Shock. 2018 Oct;50(4):381-387. doi: 10.1097/SHK.0000000000001083.


Host-directed therapies for bacterial and viral infections.

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.

Nat Rev Drug Discov. 2018 Jan;17(1):35-56. doi: 10.1038/nrd.2017.162. Epub 2017 Sep 22. Review.


Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!

Gaudilliere B, Angst MS, Hotchkiss RS.

Crit Care Med. 2017 Sep;45(9):1577-1578. doi: 10.1097/CCM.0000000000002594. No abstract available.


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Ann Emerg Med. 2017 Sep;70(3):406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013. Epub 2017 Mar 2.


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Crit Care Med. 2017 Apr;45(4):645-652. doi: 10.1097/CCM.0000000000002268.


Sepsis and septic shock.

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL.

Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Review.


Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL.

Crit Care Med. 2017 Mar;45(3):407-414. doi: 10.1097/CCM.0000000000002207.


Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.

Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL.

Lancet Infect Dis. 2017 Jan;17(1):18. doi: 10.1016/S1473-3099(16)30541-2. No abstract available.


Anti-PD-L1 peptide improves survival in sepsis.

Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS.

J Surg Res. 2017 Feb;208:33-39. doi: 10.1016/j.jss.2016.08.099. Epub 2016 Sep 8.


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.

Crouser ED, Hotchkiss RS.

Crit Care Med. 2017 Jan;45(1):145-147. No abstract available.


Sepsis: Preventing organ failure in sepsis - the search continues.

Graetz TJ, Hotchkiss RS.

Nat Rev Nephrol. 2017 Jan;13(1):5-6. doi: 10.1038/nrneph.2016.171. Epub 2016 Nov 21. No abstract available.


Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.

Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS.

Crit Care. 2016 Oct 20;20(1):334. doi: 10.1186/s13054-016-1505-0.


Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.

Doerflinger M, Glab J, Nedeva C, Jose I, Lin A, O'Reilly L, Allison C, Pellegrini M, Hotchkiss RS, Puthalakath H.

Sci Rep. 2016 Oct 3;6:34702. doi: 10.1038/srep34702.


Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS.

J Leukoc Biol. 2016 Dec;100(6):1239-1254. Epub 2016 Sep 26.


Understanding host-pathogen interaction.

Asehnoune K, Villadangos J, Hotchkiss RS.

Intensive Care Med. 2016 Dec;42(12):2084-2086. doi: 10.1007/s00134-016-4544-8. Epub 2016 Sep 24. Review. No abstract available.


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS.

J Leukoc Biol. 2017 Feb;101(2):543-554. doi: 10.1189/jlb.4A1215-581R. Epub 2016 Sep 14.


Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.

Santos CA, Hotchkiss RS, Chapman WC, Olsen MA.

Transplant Direct. 2016 Feb 22;2(3):e67. doi: 10.1097/TXD.0000000000000573. eCollection 2016 Mar.


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

BMJ Open. 2016 Apr 11;6(4):e010991. doi: 10.1136/bmjopen-2015-010991.


Understanding why clinicians should care about danger-associated molecular patterns.

Asehnoune K, Hotchkiss RS, Monneret G.

Intensive Care Med. 2016 Apr;42(4):611-614. doi: 10.1007/s00134-015-4198-y. Epub 2016 Feb 24. No abstract available.


The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC.

JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.


Erratum to: Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS.

Intensive Care Med. 2016 Jun;42(6):1106. No abstract available.


T cells from patients with Candida sepsis display a suppressive immunophenotype.

Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS.

Crit Care. 2016 Jan 20;20:15. doi: 10.1186/s13054-016-1182-z.


Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS.

Intensive Care Med. 2016 Jun;42(6):1051-4. doi: 10.1007/s00134-015-4161-y. Epub 2015 Dec 2. No abstract available. Erratum in: Intensive Care Med. 2016 Jun;42(6):1106.


The authors reply.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS.

Crit Care Med. 2015 Nov;43(11):e529-30. doi: 10.1097/CCM.0000000000001235. No abstract available.


Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Hotchkiss RS, Crouser E.

Crit Care Med. 2015 Nov;43(11):2506-8. doi: 10.1097/CCM.0000000000001289. No abstract available.


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED.

PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.


Sepsis: Revising definitions of sepsis.

Drewry AM, Hotchkiss RS.

Nat Rev Nephrol. 2015 Jun;11(6):326-8. doi: 10.1038/nrneph.2015.66. Epub 2015 Apr 28. No abstract available.


The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS.

Crit Care Med. 2015 Jun;43(6):1165-9. doi: 10.1097/CCM.0000000000000940.


Immunology. Getting sepsis therapy right.

Hotchkiss RS, Sherwood ER.

Science. 2015 Mar 13;347(6227):1201-2. doi: 10.1126/science.aaa8334. No abstract available.


Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

Shindo Y, Unsinger J, Burnham CA, Green JM, Hotchkiss RS.

Shock. 2015 Apr;43(4):334-43. doi: 10.1097/SHK.0000000000000317.


Probiotics for preventing ventilator-associated pneumonia.

Bo L, Li J, Tao T, Bai Y, Ye X, Hotchkiss RS, Kollef MH, Crooks NH, Deng X.

Cochrane Database Syst Rev. 2014 Oct 25;(10):CD009066. doi: 10.1002/14651858.CD009066.pub2. Review.


Parallels between cancer and infectious disease.

Hotchkiss RS, Moldawer LL.

N Engl J Med. 2014 Jul 24;371(4):380-3. doi: 10.1056/NEJMcibr1404664. No abstract available.


Persistent lymphopenia after diagnosis of sepsis predicts mortality.

Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS.

Shock. 2014 Nov;42(5):383-91. doi: 10.1097/SHK.0000000000000234.


Reactivation of multiple viruses in patients with sepsis.

Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS.

PLoS One. 2014 Jun 11;9(2):e98819. doi: 10.1371/journal.pone.0098819. eCollection 2014.


Abandon the mouse research ship? Not just yet!

Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH.

Shock. 2014 Jun;41(6):463-75. doi: 10.1097/SHK.0000000000000153.


Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury.

Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH.

Clin Chem. 2014 May;60(5):747-57. doi: 10.1373/clinchem.2013.212993. Epub 2014 Jan 31.


The new normal: immunomodulatory agents against sepsis immune suppression.

Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A.

Trends Mol Med. 2014 Apr;20(4):224-33. doi: 10.1016/j.molmed.2014.01.002. Epub 2014 Jan 30. Review.


Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department.

Fuller BM, Mohr NM, Hotchkiss RS, Kollef MH.

Shock. 2014 May;41(5):378-87. doi: 10.1097/SHK.0000000000000142. Review.


BTLA as a biomarker and mediator of sepsis-induced immunosuppression.

Sherwood ER, Hotchkiss RS.

Crit Care. 2013 Dec 9;17(6):1022. doi: 10.1186/cc13143.


Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.

Hotchkiss RS, Monneret G, Payen D.

Nat Rev Immunol. 2013 Dec;13(12):862-74. doi: 10.1038/nri3552. Epub 2013 Nov 15. Review.


Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.

Jung E, Perrone EE, Brahmamdan P, McDonough JS, Leathersich AM, Dominguez JA, Clark AT, Fox AC, Dunne WM, Hotchkiss RS, Coopersmith CM.

PLoS One. 2013 Oct 28;8(10):e77203. doi: 10.1371/journal.pone.0077203. eCollection 2013.


Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No.

Drewry AM, Hotchkiss RS.

Chest. 2013 Oct;144(4):1098-1101. doi: 10.1378/chest.13-0918. No abstract available.


Rebuttal From Drs Drewry and Hotchkiss.

Drewry AM, Hotchkiss RS.

Chest. 2013 Oct;144(4):1102-1103. doi: 10.1378/chest.13-0919. Epub 2013 Oct 12. No abstract available.

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