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IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients.

Mazer M, Unsinger J, Drewry A, Walton A, Osborne D, Blood T, Hotchkiss R, Remy KE.

J Immunol. 2019 Sep 9. pii: ji1900637. doi: 10.4049/jimmunol.1900637. [Epub ahead of print]


T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer.

Washburn ML, Wang Z, Walton AH, Goedegebuure SP, Figueroa DJ, Van Horn S, Grossman J, Remlinger K, Madsen H, Brown J, Srinivasan R, Wolf AI, Berger SB, Yi VN, Hawkins WG, Fields RC, Hotchkiss RS.

J Immunol. 2019 Sep 4. pii: ji1900560. doi: 10.4049/jimmunol.1900560. [Epub ahead of print]


The authors reply.

Hotchkiss RS, Yende S, Angus DC, Moldawer LL, Crouser E, Martin G, Coopersmith CM, Brakenridge S, Mayr FB, Park PK.

Crit Care Med. 2019 Sep;47(9):e788-e789. doi: 10.1097/CCM.0000000000003887. No abstract available.


Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy?

Levy JH, Ghadimi K, Faraoni D, van Diepen S, Levy B, Hotchkiss R, Connors JM, Iba T, Warkentin TE.

J Thromb Haemost. 2019 Jul 13. doi: 10.1111/jth.14566. [Epub ahead of print] No abstract available.


The Association of Fever and Antipyretic Medication With Outcomes in Mechanically Ventilated Patients: A Cohort Study.

Evans EM, Doctor RJ, Gage BF, Hotchkiss RS, Fuller BM, Drewry AM.

Shock. 2019 Aug;52(2):152-159. doi: 10.1097/SHK.0000000000001368.


What Is the Skinny on Obesity During Sepsis?

Crouser ED, Caldwell CC, Hotchkiss RS.

Crit Care Med. 2019 May;47(5):735-736. doi: 10.1097/CCM.0000000000003707. No abstract available.


An Aspirin a Day Keeps the Intensivist Away?

Turnbull IR, Hotchkiss RS.

Crit Care Med. 2019 Apr;47(4):603-604. doi: 10.1097/CCM.0000000000003672. No abstract available.


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM.

Crit Care Med. 2019 May;47(5):632-642. doi: 10.1097/CCM.0000000000003685.


Deep neural network improves fracture detection by clinicians.

Lindsey R, Daluiski A, Chopra S, Lachapelle A, Mozer M, Sicular S, Hanel D, Gardner M, Gupta A, Hotchkiss R, Potter H.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11591-11596. doi: 10.1073/pnas.1806905115. Epub 2018 Oct 22.


Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike.

Watanabe E, Thampy LK, Hotchkiss RS.

Acute Med Surg. 2018 Aug 6;5(4):309-315. doi: 10.1002/ams2.363. eCollection 2018 Oct.


Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.

Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS.

PLoS One. 2018 Jun 26;13(6):e0199497. doi: 10.1371/journal.pone.0199497. eCollection 2018.


A matched quantitative computed tomography analysis of 3 surgical approaches for osteochondral reconstruction of the capitellum.

Johnson CC, Roberts SM, Mintz D, Fabricant PD, Hotchkiss R, Daluiski A.

J Shoulder Elbow Surg. 2018 Oct;27(10):1762-1769. doi: 10.1016/j.jse.2018.03.029. Epub 2018 Jun 22.


Location of Osteochondritis Dissecans Lesions of the Capitellum.

Johnson CC, Roberts S, Mintz D, Fabricant PD, Hotchkiss RN, Daluiski A.

J Hand Surg Am. 2018 Nov;43(11):1039.e1-1039.e7. doi: 10.1016/j.jhsa.2018.03.017. Epub 2018 Apr 17.


Nonspanning Total Wrist Arthrodesis with a Low-Profile Locking Plate.

Rancy SK, Ek ET, Paul S, Hotchkiss RN, Wolfe SW.

J Wrist Surg. 2018 Apr;7(2):127-132. doi: 10.1055/s-0037-1606257. Epub 2017 Aug 24.


Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.

JCI Insight. 2018 Mar 8;3(5). pii: 98960. doi: 10.1172/jci.insight.98960.


Immunotherapy: It is not just for cancer anymore.

Moldawer LL, Hotchkiss R.

J Leukoc Biol. 2018 Jan;103(1):9-11. doi: 10.1002/JLB.4CE1117-447. Epub 2018 Jan 3. No abstract available.


Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis.

Drewry AM, Ablordeppey EA, Murray ET, Dalton CM, Fuller BM, Kollef MH, Hotchkiss RS.

Shock. 2018 Oct;50(4):381-387. doi: 10.1097/SHK.0000000000001083.


Host-directed therapies for bacterial and viral infections.

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.

Nat Rev Drug Discov. 2018 Jan;17(1):35-56. doi: 10.1038/nrd.2017.162. Epub 2017 Sep 22. Review.


Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!

Gaudilliere B, Angst MS, Hotchkiss RS.

Crit Care Med. 2017 Sep;45(9):1577-1578. doi: 10.1097/CCM.0000000000002594. No abstract available.


A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.


Prevalence of Os Styloideum in National Hockey League Players.

Greditzer HG 4th, Hutchinson ID, Geannette CS, Hotchkiss RN, Kelly BT, Potter HG.

Sports Health. 2017 Sep/Oct;9(5):469-473. doi: 10.1177/1941738117707914. Epub 2017 May 15.


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Ann Emerg Med. 2017 Sep;70(3):406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013. Epub 2017 Mar 2.


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Crit Care Med. 2017 Apr;45(4):645-652. doi: 10.1097/CCM.0000000000002268.


Sepsis and septic shock.

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL.

Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Review.


Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL.

Crit Care Med. 2017 Mar;45(3):407-414. doi: 10.1097/CCM.0000000000002207.


Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.

Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL.

Lancet Infect Dis. 2017 Jan;17(1):18. doi: 10.1016/S1473-3099(16)30541-2. No abstract available.


Anti-PD-L1 peptide improves survival in sepsis.

Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS.

J Surg Res. 2017 Feb;208:33-39. doi: 10.1016/j.jss.2016.08.099. Epub 2016 Sep 8.


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.

Crouser ED, Hotchkiss RS.

Crit Care Med. 2017 Jan;45(1):145-147. No abstract available.


Sepsis: Preventing organ failure in sepsis - the search continues.

Graetz TJ, Hotchkiss RS.

Nat Rev Nephrol. 2017 Jan;13(1):5-6. doi: 10.1038/nrneph.2016.171. Epub 2016 Nov 21. No abstract available.


Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.

Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS.

Crit Care. 2016 Oct 20;20(1):334. doi: 10.1186/s13054-016-1505-0.


Outcomes after operative treatment of elbow contractures in the pediatric and adolescent population.

Ek ET, Paul SK, Hotchkiss RN.

J Shoulder Elbow Surg. 2016 Dec;25(12):2066-2070. doi: 10.1016/j.jse.2016.09.008. Epub 2016 Oct 14.


Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.

Doerflinger M, Glab J, Nedeva C, Jose I, Lin A, O'Reilly L, Allison C, Pellegrini M, Hotchkiss RS, Puthalakath H.

Sci Rep. 2016 Oct 3;6:34702. doi: 10.1038/srep34702.


Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS.

J Leukoc Biol. 2016 Dec;100(6):1239-1254. Epub 2016 Sep 26.


Understanding host-pathogen interaction.

Asehnoune K, Villadangos J, Hotchkiss RS.

Intensive Care Med. 2016 Dec;42(12):2084-2086. doi: 10.1007/s00134-016-4544-8. Epub 2016 Sep 24. Review. No abstract available.


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS.

J Leukoc Biol. 2017 Feb;101(2):543-554. doi: 10.1189/jlb.4A1215-581R. Epub 2016 Sep 14.


Injuries to the Collateral Ligaments of the Metacarpophalangeal Joint of the Thumb, Including Simultaneous Combined Thumb Ulnar and Radial Collateral Ligament Injuries, in National Football League Athletes.

Werner BC, Belkin NS, Kennelly S, Weiss L, Barnes RP, Rodeo SA, Warren RF, Hotchkiss RN.

Am J Sports Med. 2017 Jan;45(1):195-200. doi: 10.1177/0363546516660979. Epub 2016 Oct 1.


Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.

Santos CA, Hotchkiss RS, Chapman WC, Olsen MA.

Transplant Direct. 2016 Feb 22;2(3):e67. doi: 10.1097/TXD.0000000000000573. eCollection 2016 Mar.


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

BMJ Open. 2016 Apr 11;6(4):e010991. doi: 10.1136/bmjopen-2015-010991.


Capitellum Fracture Fragment Excision: a Case Series.

Garner MR, Schottel PC, Hotchkiss RN, Daluiski A, Lorich DG.

HSS J. 2015 Oct;11(3):204-8. doi: 10.1007/s11420-015-9452-x. Epub 2015 Aug 1.


Understanding why clinicians should care about danger-associated molecular patterns.

Asehnoune K, Hotchkiss RS, Monneret G.

Intensive Care Med. 2016 Apr;42(4):611-614. doi: 10.1007/s00134-015-4198-y. Epub 2016 Feb 24. No abstract available.


The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC.

JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.


Erratum to: Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS.

Intensive Care Med. 2016 Jun;42(6):1106. No abstract available.


T cells from patients with Candida sepsis display a suppressive immunophenotype.

Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS.

Crit Care. 2016 Jan 20;20:15. doi: 10.1186/s13054-016-1182-z.


Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS.

Intensive Care Med. 2016 Jun;42(6):1051-4. doi: 10.1007/s00134-015-4161-y. Epub 2015 Dec 2. No abstract available. Erratum in: Intensive Care Med. 2016 Jun;42(6):1106.


The authors reply.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS.

Crit Care Med. 2015 Nov;43(11):e529-30. doi: 10.1097/CCM.0000000000001235. No abstract available.


Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Hotchkiss RS, Crouser E.

Crit Care Med. 2015 Nov;43(11):2506-8. doi: 10.1097/CCM.0000000000001289. No abstract available.


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED.

PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.


Sepsis: Revising definitions of sepsis.

Drewry AM, Hotchkiss RS.

Nat Rev Nephrol. 2015 Jun;11(6):326-8. doi: 10.1038/nrneph.2015.66. Epub 2015 Apr 28. No abstract available.


The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS.

Crit Care Med. 2015 Jun;43(6):1165-9. doi: 10.1097/CCM.0000000000000940.


Immunology. Getting sepsis therapy right.

Hotchkiss RS, Sherwood ER.

Science. 2015 Mar 13;347(6227):1201-2. doi: 10.1126/science.aaa8334. No abstract available.

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