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Items: 20


Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge.

Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF.

J Infect Dis. 2020 Feb 10. pii: jiz630. doi: 10.1093/infdis/jiz630. [Epub ahead of print]


A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function.

Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO.

Structure. 2019 Apr 2;27(4):660-668.e4. doi: 10.1016/j.str.2019.01.012. Epub 2019 Feb 21.


Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

Tian D, Battles MB, Moin SM, Chen M, Modjarrad K, Kumar A, Kanekiyo M, Graepel KW, Taher NM, Hotard AL, Moore ML, Zhao M, Zheng ZZ, Xia NS, McLellan JS, Graham BS.

Nat Commun. 2017 Nov 30;8(1):1877. doi: 10.1038/s41467-017-01858-w.


4'-Azidocytidine (R1479) inhibits henipaviruses and other paramyxoviruses with high potency.

Hotard AL, He B, Nichol ST, Spiropoulou CF, Lo MK.

Antiviral Res. 2017 Aug;144:147-152. doi: 10.1016/j.antiviral.2017.06.011. Epub 2017 Jun 17.


BAC-Based Recovery of Recombinant Respiratory Syncytial Virus (RSV).

Stobart CC, Hotard AL, Meng J, Moore ML.

Methods Mol Biol. 2017;1602:111-124. doi: 10.1007/978-1-4939-6964-7_8.


Antibody-Induced Internalization of the Human Respiratory Syncytial Virus Fusion Protein.

Leemans A, De Schryver M, Van der Gucht W, Heykers A, Pintelon I, Hotard AL, Moore ML, Melero JA, McLellan JS, Graham BS, Broadbent L, Power UF, Caljon G, Cos P, Maes L, Delputte P.

J Virol. 2017 Jun 26;91(14). pii: e00184-17. doi: 10.1128/JVI.00184-17. Print 2017 Jul 15.


GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Lo MK, Jordan R, Arvey A, Sudhamsu J, Shrivastava-Ranjan P, Hotard AL, Flint M, McMullan LK, Siegel D, Clarke MO, Mackman RL, Hui HC, Perron M, Ray AS, Cihlar T, Nichol ST, Spiropoulou CF.

Sci Rep. 2017 Mar 6;7:43395. doi: 10.1038/srep43395.


A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.

Stobart CC, Rostad CA, Ke Z, Dillard RS, Hampton CM, Strauss JD, Yi H, Hotard AL, Meng J, Pickles RJ, Sakamoto K, Lee S, Currier MG, Moin SM, Graham BS, Boukhvalova MS, Gilbert BE, Blanco JC, Piedra PA, Wright ER, Moore ML.

Nat Commun. 2016 Dec 21;7:13916. doi: 10.1038/ncomms13916.


Reverse Genetics of Respiratory Syncytial Virus.

Stobart CC, Hotard AL, Meng J, Moore ML.

Methods Mol Biol. 2016;1442:141-53. doi: 10.1007/978-1-4939-3687-8_10.


A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats.

Rostad CA, Stobart CC, Gilbert BE, Pickles RJ, Hotard AL, Meng J, Blanco JCG, Moin SM, Graham BS, Piedra PA, Moore ML.

J Virol. 2016 Jul 27;90(16):7508-7518. doi: 10.1128/JVI.00012-16. Print 2016 Aug 15.


Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS Jr.

J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.


EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS Jr, Power UF, Moore ML.

PLoS Pathog. 2016 May 6;12(5):e1005622. doi: 10.1371/journal.ppat.1005622. eCollection 2016 May.


Respiratory Syncytial Virus Attachment Glycoprotein Contribution to Infection Depends on the Specific Fusion Protein.

Meng J, Hotard AL, Currier MG, Lee S, Stobart CC, Moore ML.

J Virol. 2015 Oct 14;90(1):245-53. doi: 10.1128/JVI.02140-15. Print 2016 Jan 1.


Functional Analysis of the 60-Nucleotide Duplication in the Respiratory Syncytial Virus Buenos Aires Strain Attachment Glycoprotein.

Hotard AL, Laikhter E, Brooks K, Hartert TV, Moore ML.

J Virol. 2015 Aug;89(16):8258-66. doi: 10.1128/JVI.01045-15. Epub 2015 May 27.


Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.

Hotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML.

J Virol. 2015 Jan;89(1):512-22. doi: 10.1128/JVI.02472-14. Epub 2014 Oct 22.


An overview of respiratory syncytial virus.

Meng J, Stobart CC, Hotard AL, Moore ML.

PLoS Pathog. 2014 Apr 24;10(4):e1004016. doi: 10.1371/journal.ppat.1004016. eCollection 2014 Apr. Review. No abstract available.


The respiratory syncytial virus fusion protein targets to the perimeter of inclusion bodies and facilitates filament formation by a cytoplasmic tail-dependent mechanism.

Baviskar PS, Hotard AL, Moore ML, Oomens AG.

J Virol. 2013 Oct;87(19):10730-41. doi: 10.1128/JVI.03086-12. Epub 2013 Jul 31.


A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis.

Hotard AL, Shaikh FY, Lee S, Yan D, Teng MN, Plemper RK, Crowe JE Jr, Moore ML.

Virology. 2012 Dec 5;434(1):129-36. doi: 10.1016/j.virol.2012.09.022. Epub 2012 Oct 11.


A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles.

Shaikh FY, Cox RG, Lifland AW, Hotard AL, Williams JV, Moore ML, Santangelo PJ, Crowe JE Jr.

mBio. 2012 Feb 7;3(1). pii: e00270-11. doi: 10.1128/mBio.00270-11. Print 2012.

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