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Items: 27


DEL-1 promotes macrophage efferocytosis and clearance of inflammation.

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T.

Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.


Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G.

Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017.


Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T.

J Clin Invest. 2017 Oct 2;127(10):3624-3639. doi: 10.1172/JCI92571. Epub 2017 Aug 28.


Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans.

Kajikawa T, Meshikhes F, Maekawa T, Hajishengallis E, Hosur KB, Abe T, Moss K, Chavakis T, Hajishengallis G.

J Clin Periodontol. 2017 May;44(5):472-483. doi: 10.1111/jcpe.12707. Epub 2017 Apr 12.


Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis.

Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G.

J Dent Res. 2017 May;96(5):571-577. doi: 10.1177/0022034516687248. Epub 2017 Jan 17.


Coordinated regulation of acid resistance in Escherichia coli.

Aquino P, Honda B, Jaini S, Lyubetskaya A, Hosur K, Chiu JG, Ekladious I, Hu D, Jin L, Sayeg MK, Stettner AI, Wang J, Wong BG, Wong WS, Alexander SL, Ba C, Bensussen SI, Bernstein DB, Braff D, Cha S, Cheng DI, Cho JH, Chou K, Chuang J, Gastler DE, Grasso DJ, Greifenberger JS, Guo C, Hawes AK, Israni DV, Jain SR, Kim J, Lei J, Li H, Li D, Li Q, Mancuso CP, Mao N, Masud SF, Meisel CL, Mi J, Nykyforchyn CS, Park M, Peterson HM, Ramirez AK, Reynolds DS, Rim NG, Saffie JC, Su H, Su WR, Su Y, Sun M, Thommes MM, Tu T, Varongchayakul N, Wagner TE, Weinberg BH, Yang R, Yaroslavsky A, Yoon C, Zhao Y, Zollinger AJ, Stringer AM, Foster JW, Wade J, Raman S, Broude N, Wong WW, Galagan JE.

BMC Syst Biol. 2017 Jan 6;11(1):1. doi: 10.1186/s12918-016-0376-y.


Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation.

Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T.

Thromb Haemost. 2016 Apr;115(4):781-8. doi: 10.1160/TH15-05-0429. Epub 2015 Dec 17.


DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

Shin J, Maekawa T, Abe T, Hajishengallis E, Hosur K, Pyaram K, Mitroulis I, Chavakis T, Hajishengallis G.

Sci Transl Med. 2015 Sep 30;7(307):307ra155. doi: 10.1126/scitranslmed.aac5380.


Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.

Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G.

Nat Commun. 2015 Sep 16;6:8272. doi: 10.1038/ncomms9272.


Sex dimorphism in periodontitis in animal models.

Duan X, Gleason RC, Li F, Hosur KB, Duan X, Huang D, Wang H, Hajishengallis G, Liang S.

J Periodontal Res. 2016 Apr;51(2):196-202. doi: 10.1111/jre.12298. Epub 2015 Jul 22.


TLR2 promoter hypermethylation creates innate immune dysbiosis.

Benakanakere M, Abdolhosseini M, Hosur K, Finoti LS, Kinane DF.

J Dent Res. 2015 Jan;94(1):183-91. doi: 10.1177/0022034514557545. Epub 2014 Nov 11.


Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.

Choi EY, Lim JH, Neuwirth A, Economopoulou M, Chatzigeorgiou A, Chung KJ, Bittner S, Lee SH, Langer H, Samus M, Kim H, Cho GS, Ziemssen T, Bdeir K, Chavakis E, Koh JY, Boon L, Hosur K, Bornstein SR, Meuth SG, Hajishengallis G, Chavakis T.

Mol Psychiatry. 2015 Jul;20(7):880-888. doi: 10.1038/mp.2014.146. Epub 2014 Nov 11.


Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.

Abe T, Shin J, Hosur K, Udey MC, Chavakis T, Hajishengallis G.

J Immunol. 2014 Aug 1;193(3):1383-91. doi: 10.4049/jimmunol.1400970. Epub 2014 Jun 23.


Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis.

Maekawa T, Abe T, Hajishengallis E, Hosur KB, DeAngelis RA, Ricklin D, Lambris JD, Hajishengallis G.

J Immunol. 2014 Jun 15;192(12):6020-7. doi: 10.4049/jimmunol.1400569. Epub 2014 May 7.


Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss.

Moutsopoulos NM, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G.

Sci Transl Med. 2014 Mar 26;6(229):229ra40. doi: 10.1126/scitranslmed.3007696.


Expression and function of the homeostatic molecule Del-1 in endothelial cells and the periodontal tissue.

Shin J, Hosur KB, Pyaram K, Jotwani R, Liang S, Chavakis T, Hajishengallis G.

Clin Dev Immunol. 2013;2013:617809. doi: 10.1155/2013/617809. Epub 2013 Dec 12.


Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.

Abe T, Hosur KB, Hajishengallis E, Reis ES, Ricklin D, Lambris JD, Hajishengallis G.

J Immunol. 2012 Dec 1;189(11):5442-8. doi: 10.4049/jimmunol.1202339. Epub 2012 Oct 22.


Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis.

Morgan EF, Hussein AI, Al-Awadhi BA, Hogan DE, Matsubara H, Al-Alq Z, Fitch J, Andre B, Hosur K, Gerstenfeld LC.

Bone. 2012 Sep;51(3):535-45. doi: 10.1016/j.bone.2012.05.008. Epub 2012 May 19.


Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis.

Kinane JA, Benakanakere MR, Zhao J, Hosur KB, Kinane DF.

Cell Microbiol. 2012 Jul;14(7):1085-96. doi: 10.1111/j.1462-5822.2012.01780.x. Epub 2012 Mar 28.


The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss.

Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G.

J Immunol. 2011 Jan 15;186(2):869-77. doi: 10.4049/jimmunol.1003252. Epub 2010 Dec 13.


Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes.

Zhao J, Benakanakere MR, Hosur KB, Galicia JC, Martin M, Kinane DF.

Mol Immunol. 2010 Nov-Dec;48(1-3):294-304. doi: 10.1016/j.molimm.2010.07.014. Epub 2010 Aug 21.


Periodontal inflammation and bone loss in aged mice.

Liang S, Hosur KB, Domon H, Hajishengallis G.

J Periodontal Res. 2010 Aug;45(4):574-8. doi: 10.1111/j.1600-0765.2009.01245.x. Epub 2010 Mar 9.


Microbial hijacking of complement-toll-like receptor crosstalk.

Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, Hajishengallis G.

Sci Signal. 2010 Feb 16;3(109):ra11. doi: 10.1126/scisignal.2000697.


Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis.

Wang M, Liang S, Hosur KB, Domon H, Yoshimura F, Amano A, Hajishengallis G.

Oral Microbiol Immunol. 2009 Dec;24(6):478-84. doi: 10.1111/j.1399-302X.2009.00545.x.


Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.

Liang S, Domon H, Hosur KB, Wang M, Hajishengallis G.

Mech Ageing Dev. 2009 Aug;130(8):538-46. doi: 10.1016/j.mad.2009.06.006. Epub 2009 Jun 25.


In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli.

Liang S, Hosur KB, Nawar HF, Russell MW, Connell TD, Hajishengallis G.

Vaccine. 2009 Jul 9;27(32):4302-8. doi: 10.1016/j.vaccine.2009.05.027. Epub 2009 May 29.


Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer.

Liang S, Hosur KB, Lu S, Nawar HF, Weber BR, Tapping RI, Connell TD, Hajishengallis G.

J Immunol. 2009 Mar 1;182(5):2978-85. doi: 10.4049/jimmunol.0803737.

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