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Items: 1 to 50 of 396

1.

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro.

Salomon JJ, Gausterer JC, Selo MA, Hosoya KI, Huwer H, Schneider-Daum N, Lehr CM, Ehrhardt C.

Pharmaceutics. 2019 Aug 7;11(8). pii: E396. doi: 10.3390/pharmaceutics11080396.

2.

Efficacy and safety of pembrolizumab as first-line therapy in advanced non-small cell lung cancer with at least 50% PD-L1 positivity: a multicenter retrospective cohort study (HOPE-001).

Tamiya M, Tamiya A, Hosoya K, Taniguchi Y, Yokoyama T, Fukuda Y, Hirano K, Matsumoto H, Kominami R, Suzuki H, Hirashima T, Uchida J, Morita M, Kanazu M, Sawa N, Kinoshita Y, Hara S, Kumagai T, Fujimoto D.

Invest New Drugs. 2019 Aug 7. doi: 10.1007/s10637-019-00843-y. [Epub ahead of print]

PMID:
31392549
3.

Atomic force microscopic image data of botulinum neurotoxin complexes with different molecular sizes.

Miyashita SI, Sagane Y, Uchino T, Karatsu S, Hosoya K, Huang I, Niwa K, Watanabe T, Niimura Y, Suzuki T.

Data Brief. 2019 Jun 25;25:104193. doi: 10.1016/j.dib.2019.104193. eCollection 2019 Aug.

4.

Outcomes following balloon dilation for management of urethral obstruction secondary to urothelial carcinoma in dogs: 12 cases (2010-2015).

Kim S, Hosoya K, Takagi S, Okumura M.

J Am Vet Med Assoc. 2019 Aug 1;255(3):330-335. doi: 10.2460/javma.255.3.330.

PMID:
31298635
5.

Ineligibility for the PACIFIC trial in unresectable stage III non-small cell lung cancer patients.

Hosoya K, Fujimoto D, Kawachi H, Sato Y, Kogo M, Nagata K, Nakagawa A, Tachikawa R, Hiraoka S, Kokubo M, Tomii K.

Cancer Chemother Pharmacol. 2019 Aug;84(2):275-280. doi: 10.1007/s00280-019-03885-4. Epub 2019 Jun 14.

PMID:
31201490
6.

Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.

Akanuma SI, Kida R, Tsuchiyama A, Tachikawa M, Kubo Y, Hosoya KI.

Drug Metab Pharmacokinet. 2019 Aug;34(4):239-246. doi: 10.1016/j.dmpk.2019.04.001. Epub 2019 Apr 11.

PMID:
31174976
7.

Epidemiology of massive hepatocellular carcinoma in dogs: A 4-year retrospective study.

Leela-Arporn R, Ohta H, Nagata N, Sasaoka K, Tamura M, Dermlim A, Nisa K, Morishita K, Sasaki N, Nakamura K, Takagi S, Hosoya K, Takiguchi M.

Vet J. 2019 Jun;248:74-78. doi: 10.1016/j.tvjl.2019.04.011. Epub 2019 Apr 24.

PMID:
31113567
8.

Association Between Formalin Fixation Time and Programmed Cell Death Ligand 1 Expression in Patients With Non-Small Cell Lung Cancer.

Kawachi H, Fujimoto D, Yamashita D, Fukuoka J, Kitamura Y, Hosoya K, Sato Y, Nagata K, Nakagawa A, Tachikawa R, Date N, Sakanoue I, Hamakawa H, Takahashi Y, Tomii K.

Anticancer Res. 2019 May;39(5):2561-2567. doi: 10.21873/anticanres.13378.

PMID:
31092453
9.

Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features.

Leela-Arporn R, Ohta H, Tamura M, Nagata N, Sasaoka K, Dermlim A, Nisa K, Morishita K, Sasaki N, Nakamura K, Takagi S, Hosoya K, Takiguchi M.

J Vet Med Sci. 2019 May 31;81(5):723-729. doi: 10.1292/jvms.18-0673. Epub 2019 Apr 8.

10.

Early depth of tumor shrinkage and treatment outcomes in non-small cell lung cancer treated using Nivolumab.

Kawachi H, Fujimoto D, Morimoto T, Hosoya K, Sato Y, Kogo M, Nagata K, Nakagawa A, Tachikawa R, Tomii K.

Invest New Drugs. 2019 Apr 1. doi: 10.1007/s10637-019-00770-y. [Epub ahead of print]

PMID:
30937690
11.

Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines.

Deguchi T, Hosoya K, Murase Y, Koangyong S, Kim S, Okumura M.

Vet Comp Oncol. 2019 Jun;17(2):119-129. doi: 10.1111/vco.12452. Epub 2019 Jan 20.

PMID:
30549190
12.

Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis.

Suranji Wijekoon HM, Kim S, Bwalya EC, Fang J, Aoshima K, Hosoya K, Okumura M.

Res Vet Sci. 2019 Feb;122:179-185. doi: 10.1016/j.rvsc.2018.11.028. Epub 2018 Dec 1.

13.

Comparison of PD-L1 Assays in Non-small Cell Lung Cancer: 22C3 pharmDx and SP263.

Fujimoto D, Yamashita D, Fukuoka J, Kitamura Y, Hosoya K, Kawachi H, Sato Y, Nagata K, Nakagawa A, Tachikawa R, Date N, Sakanoue I, Hamakawa H, Takahashi Y, Tomii K.

Anticancer Res. 2018 Dec;38(12):6891-6895. doi: 10.21873/anticanres.13065.

PMID:
30504406
14.

Comparison of three mobilization protocols for peripheral blood stem cell apheresis with Spectra Optia continuous mononuclear cell protocol in healthy dogs.

Kim S, Hosoya K, Kobayashi A, Okumura M.

Vet Comp Oncol. 2019 Mar;17(1):61-68. doi: 10.1111/vco.12446. Epub 2018 Oct 11.

PMID:
30221450
15.

Independent chondrogenic potential of canine bone marrow-derived mesenchymal stem cells in monolayer expansion cultures decreases in a passage-dependent pattern.

Bwalya EC, Wijekoon HS, Fang J, Kim S, Hosoya K, Okumura M.

J Vet Med Sci. 2018 Nov 9;80(11):1681-1687. doi: 10.1292/jvms.18-0202. Epub 2018 Sep 11.

16.

Multiple Cellular Transport and Binding Processes of Unesterified Docosahexaenoic Acid in Outer Blood-Retinal Barrier Retinal Pigment Epithelial Cells.

Tachikawa M, Akanuma SI, Imai T, Okayasu S, Tomohiro T, Hatanaka Y, Hosoya KI.

Biol Pharm Bull. 2018;41(9):1384-1392. doi: 10.1248/bpb.b18-00185.

17.

Impact of Nicotine Transport across the Blood-Brain Barrier: Carrier-Mediated Transport of Nicotine and Interaction with Central Nervous System Drugs.

Tega Y, Yamazaki Y, Akanuma SI, Kubo Y, Hosoya KI.

Biol Pharm Bull. 2018;41(9):1330-1336. doi: 10.1248/bpb.b18-00134. Review.

18.

Mandibular vascular hamartoma in a cat.

Takagi S, Kagawa Y, Hanazono K, Murakami S, Deguchi T, Izumi Y, Hosoya K, Kim S, Okumura M.

J Vet Med Sci. 2018 Sep 26;80(9):1456-1458. doi: 10.1292/jvms.18-0148. Epub 2018 Jul 13.

19.

Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood-Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin.

Kinoshita Y, Nogami K, Jomura R, Akanuma SI, Abe H, Inouye M, Kubo Y, Hosoya KI.

Mol Pharm. 2018 Aug 6;15(8):3583-3594. doi: 10.1021/acs.molpharmaceut.8b00617. Epub 2018 Jul 17.

PMID:
29966424
20.

Response to neoadjuvant chemotherapy for breast cancer judged by PERCIST - multicenter study in Japan.

Kitajima K, Nakatani K, Yamaguchi K, Nakajo M, Tani A, Ishibashi M, Hosoya K, Morita T, Kinoshita T, Kaida H, Miyoshi Y.

Eur J Nucl Med Mol Imaging. 2018 Sep;45(10):1661-1671. doi: 10.1007/s00259-018-4008-1. Epub 2018 May 12.

PMID:
29754160
21.

Inhibitory effects of sodium pentosan polysulfate on formation and function of osteoclasts derived from canine bone marrow.

Wijekoon HMS, Bwalya EC, Fang J, Kim S, Hosoya K, Okumura M.

BMC Vet Res. 2018 May 2;14(1):152. doi: 10.1186/s12917-018-1466-4.

22.

Recent advances in drug and nutrient transport across the blood-retinal barrier.

Kubo Y, Akanuma SI, Hosoya KI.

Expert Opin Drug Metab Toxicol. 2018 May;14(5):513-531. doi: 10.1080/17425255.2018.1472764. Epub 2018 May 10. Review.

PMID:
29719158
23.

Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine-Urea Bifunctional Organocatalyst.

Kawaguchi M, Nakano K, Hosoya K, Orihara T, Yamanaka M, Odagi M, Nagasawa K.

Org Lett. 2018 May 18;20(10):2811-2815. doi: 10.1021/acs.orglett.8b00641. Epub 2018 May 2.

PMID:
29717876
24.

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin.

Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI.

Mol Pharm. 2018 Jun 4;15(6):2327-2337. doi: 10.1021/acs.molpharmaceut.8b00179. Epub 2018 May 2.

PMID:
29688723
25.

Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier.

Kubo Y, Nakazawa A, Akanuma SI, Hosoya KI.

Pharm Res. 2018 Mar 12;35(5):93. doi: 10.1007/s11095-018-2384-7.

PMID:
29532174
26.

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels.

Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya KI, Terasaki T.

Anat Sci Int. 2018 Sep;93(4):456-463. doi: 10.1007/s12565-018-0435-0. Epub 2018 Mar 8.

PMID:
29520568
27.
28.

Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.

Akanuma SI, Higashi H, Maruyama S, Murakami K, Tachikawa M, Kubo Y, Hosoya KI.

Exp Eye Res. 2018 Mar;168:128-137. doi: 10.1016/j.exer.2018.01.016. Epub 2018 Jan 31.

PMID:
29366904
29.

Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain.

Akanuma SI, Yamazaki Y, Kubo Y, Hosoya KI.

Fluids Barriers CNS. 2018 Jan 8;15(1):1. doi: 10.1186/s12987-017-0087-9.

30.

Evolution of the connection patterns of the cephalic lateral line canal system and its use to diagnose opsariichthyin cyprinid fishes (Teleostei, Cyprinidae).

Ito T, Fukuda T, Morimune T, Hosoya K.

Zookeys. 2017 Dec 4;(718):115-131. doi: 10.3897/zookeys.718.13574. eCollection 2017.

31.

Developmental changes of l-arginine transport at the blood-brain barrier in rats.

Tachikawa M, Hirose S, Akanuma SI, Matsuyama R, Hosoya KI.

Microvasc Res. 2018 May;117:16-21. doi: 10.1016/j.mvr.2017.12.003. Epub 2017 Dec 14.

PMID:
29247719
32.

Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain.

Tachikawa M, Watanabe M, Fukaya M, Sakai K, Terasaki T, Hosoya KI.

Neurochem Res. 2018 Feb;43(2):500-510. doi: 10.1007/s11064-017-2446-y. Epub 2017 Dec 5.

PMID:
29209878
33.

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.

Tachikawa M, Yashiki A, Akanuma SI, Matsukawa H, Ide S, Minami M, Hosoya KI.

Neurochem Int. 2018 Feb;113:1-7. doi: 10.1016/j.neuint.2017.11.013. Epub 2017 Nov 24.

PMID:
29175673
34.

Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages.

Wijekoon S, Bwalya EC, Fang J, Kim S, Hosoya K, Okumura M.

J Vet Med Sci. 2017 Dec 22;79(12):2030-2035. doi: 10.1292/jvms.17-0393. Epub 2017 Nov 3.

35.

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma SI, Hosoya KI, Urtti A, Terasaki T, Tachikawa M.

Mol Pharm. 2017 Nov 6;14(11):3729-3738. doi: 10.1021/acs.molpharmaceut.7b00493. Epub 2017 Oct 12.

PMID:
28954515
36.

Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer.

Wakahara M, Sakabe T, Kubouchi Y, Hosoya K, Hirooka Y, Yurugi Y, Nosaka K, Shiomi T, Nakamura H, Umekita Y.

Anticancer Res. 2017 Sep;37(9):5071-5077.

PMID:
28870936
37.

Involvement of Carrier-Mediated Transport at the Blood-Cerebrospinal Fluid Barrier in Spermine Clearance from Rat Brain.

Akanuma SI, Shimada H, Kubo Y, Hosoya KI.

Biol Pharm Bull. 2017;40(9):1599-1603. doi: 10.1248/bpb.b17-00394.

38.

Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants.

Kubo Y, Akanuma SI, Hosoya KI.

Biol Pharm Bull. 2017;40(8):1139-1145. doi: 10.1248/bpb.b17-00090. Review.

39.

Differentiation potential of synoviocytes derived from joints with cranial cruciate ligament rupture and medial patella luxation in dogs.

Wijekoon HMS, Toyota K, Kim S, Fang J, Bwalya EC, Hosoya K, Okumura M.

Res Vet Sci. 2017 Oct;114:370-377. doi: 10.1016/j.rvsc.2017.07.004. Epub 2017 Jul 9.

40.

Effects of pentosan polysulfate and polysulfated glycosaminoglycan on chondrogenesis of canine bone marrow-derived mesenchymal stem cells in alginate and micromass culture.

Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M.

J Vet Med Sci. 2017 Jul 7;79(7):1182-1190. doi: 10.1292/jvms.17-0084. Epub 2017 May 27.

41.

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.

Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M.

Placenta. 2017 May;53:76-82. doi: 10.1016/j.placenta.2017.04.002. Epub 2017 Apr 6.

PMID:
28487024
42.

Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.

Bwalya EC, Kim S, Fang J, Wijekoon HMS, Hosoya K, Okumura M.

PLoS One. 2017 May 4;12(5):e0177144. doi: 10.1371/journal.pone.0177144. eCollection 2017.

43.

Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier.

Kubo Y, Yamamoto M, Matsunaga K, Usui T, Akanuma SI, Hosoya KI.

J Pharm Sci. 2017 Sep;106(9):2583-2591. doi: 10.1016/j.xphs.2017.04.028. Epub 2017 Apr 25.

PMID:
28454745
44.

Impact of surgical margins on survival of 37 dogs with massive hepatocellular carcinoma.

Matsuyama A, Takagi S, Hosoya K, Kagawa Y, Nakamura K, Deguchi T, Takiguchi M.

N Z Vet J. 2017 Sep;65(5):227-231. doi: 10.1080/00480169.2017.1319304. Epub 2017 May 8.

PMID:
28441916
45.

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

Ehrhardt C, Bäckman P, Couet W, Edwards C, Forbes B, Fridén M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R.

J Pharm Sci. 2017 Sep;106(9):2234-2244. doi: 10.1016/j.xphs.2017.04.011. Epub 2017 Apr 15. Review.

PMID:
28416418
46.

An ultra-specific and sensitive sandwich ELISA for imatinib using two anti-imatinib antibodies.

Saita T, Yamamoto Y, Hosoya K, Yamamoto Y, Kimura S, Narisawa Y, Shin M.

Anal Chim Acta. 2017 May 29;969:72-78. doi: 10.1016/j.aca.2017.03.034. Epub 2017 Mar 27.

PMID:
28411632
47.

Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients.

Hosoya K, Matsusaka S, Kashiwada T, Suzuki K, Ureshino N, Sato A, Miki Y, Kitera K, Hirai M, Hatake K, Kimura S, Sueoka-Aragane N.

Pathol Oncol Res. 2017 Oct;23(4):737-744. doi: 10.1007/s12253-016-0175-1. Epub 2017 Jan 5.

PMID:
28058585
48.

Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.

Kubo Y, Yahata S, Miki S, Akanuma SI, Hosoya KI.

Drug Metab Pharmacokinet. 2017 Feb;32(1):92-99. doi: 10.1016/j.dmpk.2016.09.006. Epub 2016 Oct 8.

PMID:
27964953
49.

Impact of SLC6A Transporters in Physiological Taurine Transport at the Blood-Retinal Barrier and in the Liver.

Kubo Y, Akanuma SI, Hosoya KI.

Biol Pharm Bull. 2016;39(12):1903-1911. Review.

50.

Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).

Usui T, Nakazawa A, Okura T, Deguchi Y, Akanuma SI, Kubo Y, Hosoya KI.

J Neurochem. 2016 Nov;139(3):408-418. doi: 10.1111/jnc.13758. Epub 2016 Sep 15.

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