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Boerhaave syndrome due to hypopharyngeal stenosis associated with chemoradiotherapy for hypopharyngeal cancer: a case report.

Tanaka H, Uemura N, Nishikawa D, Oguri K, Abe T, Higaki E, Hosoi T, An B, Hasegawa Y, Shimizu Y.

Surg Case Rep. 2018 Jun 8;4(1):54. doi: 10.1186/s40792-018-0462-z.


Development of a Tissue-Engineered Artificial Ligament: Reconstruction of Injured Rabbit Medial Collateral Ligament With Elastin-Collagen and Ligament Cell Composite Artificial Ligament.

Hirukawa M, Katayama S, Sato T, Inoue K, Niwa K, Ito N, Hattori T, Hosoi T, Unno H, Suzuki Y, Hasegawa M, Miyamoto K, Horiuchi T.

Artif Organs. 2018 Apr 16. doi: 10.1111/aor.13124. [Epub ahead of print]


TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses.

Abd El-Hafeez AA, Hosoi T, Nakatsu K, Thon M, Shimamoto A, Tahara H, Ozawa K.

Biotechnol Lett. 2018 Jun;40(6):915-922. doi: 10.1007/s10529-018-2544-1. Epub 2018 Apr 5.


Peritoneal cecal cancer metastasis to a mesh-plug prosthesis:A case report.

Shigeyoshi I, Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Higaki E, An B, Ouchi A, Tsutsuyama M, Hosoi T, Hayashi D, Tanaka H, Uchino T, Kunitomo A, Shimizu Y.

J Med Invest. 2018;65(1.2):142-146. doi: 10.2152/jmi.65.142.


Combined resection of re-recurrent lateral lymph nodes and external iliac vein:Case Report and Literature.

Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Higaki E, Ouchi A, Tsutsuyama M, Hosoi T, Shigeyoshi I, An B, Akazawa T, Hayashi D, Tanaka H, Uchino T, Kunitomo A, Shimizu Y.

J Med Invest. 2018;65(1.2):136-138. doi: 10.2152/jmi.65.136.


A case of local recurrence of T1 rectal cancer 10 years after transanal excision.

Tanaka H, Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Higaki E, Ouchi A, Tsutsuyama M, Hosoi T, Shigeyoshi I, An B, Akazawa T, Hayashi D, Uchino T, Kunitomo A, Shimizu Y.

Nagoya J Med Sci. 2018 Feb;80(1):135-140. doi: 10.18999/nagjms.80.1.135.


Identifying elderly people at risk for cognitive decline by using the 2-step test.

Maruya K, Fujita H, Arai T, Hosoi T, Ogiwara K, Moriyama S, Ishibashi H.

J Phys Ther Sci. 2018 Jan;30(1):145-149. doi: 10.1589/jpts.30.145. Epub 2018 Jan 27.


[Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance-The Need for Cooperation between the Pharmacy and the University in Genetic Testing].

Ikeda K, Kasuga M, Hosoi T, Yoshii M, Sugiyama M, Wako A, Ozawa K.

Yakugaku Zasshi. 2017;137(12):1517-1531. doi: 10.1248/yakushi.16-00243. Japanese.


Editorial: Leptin Resistance in Metabolic Disorders: Possible Mechanisms and Treatments.

Hosoi T, Maffei M.

Front Endocrinol (Lausanne). 2017 Nov 2;8:300. doi: 10.3389/fendo.2017.00300. eCollection 2017. No abstract available.


Mechanisms of the action of adenine on anti-allergic effects in mast cells.

Hosoi T, Ino S, Ohnishi F, Todoroki K, Yoshii M, Kakimoto M, Müller CE, Ozawa K.

Immun Inflamm Dis. 2018 Mar;6(1):97-105. doi: 10.1002/iid3.200. Epub 2017 Nov 1.


Thoracoscopic resection of esophageal cancer with a tracheal diverticulum.

Tanaka H, Uemura N, Abe T, Higaki E, Kawakami J, Hosoi T, An B, Komori K, Ito S, Shimizu Y.

Gen Thorac Cardiovasc Surg. 2018 Feb;66(2):116-119. doi: 10.1007/s11748-017-0852-3. Epub 2017 Oct 24.


Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells.

Thon M, Hosoi T, Chea C, Ozawa K.

Biol Pharm Bull. 2017;40(8):1161-1164. doi: 10.1248/bpb.b17-00311.


A case of metachronous left ovarian metastasis 8 years after surgery for cecal cancer and right ovarian metastasis: Report of a case.

Shigeyoshi I, Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Kawakami J, Ouchi A, Tsutsuyama M, Hosoi T, Akazawa T, Hayashi D, Tanaka H, Yatabe Y, Shimizu Y.

Nagoya J Med Sci. 2017 Feb;79(2):259-266. doi: 10.18999/nagjms.79.2.259.


Coincident Port-site and Functional End-to-end Anastomotic Recurrences after Laparoscopic Surgery for Colon Cancer: A case report and literature review.

Komori K, Kinoshita T, Taihei O, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Kawakami J, Ouchi A, Tsutsuyama M, Hosoi T, Shigeyoshi I, Akazawa T, Hayashi D, Tanaka H, Shimizu Y.

J Med Invest. 2017;64(1.2):177-180. doi: 10.2152/jmi.64.177. Review.


Clinical Impact of Intrathoracic Herniation of Gastric Tube Pull-Up via the Retrosternal Route following Esophagectomy.

Uemura N, Abe T, Kawakami J, Hosoi T, Ito S, Shimizu Y.

Dig Surg. 2017;34(6):483-488. doi: 10.1159/000456084. Epub 2017 Feb 10.


Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Dam J.

Mol Metab. 2016 Nov 3;6(1):159-172. doi: 10.1016/j.molmet.2016.10.009. eCollection 2017 Jan.


Histopathologic risk stratification of stage IIB colorectal cancer.

Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Kawakami J, Ouchi A, Tsutsuyama M, Hosoi T, Shigeyoshi I, Akazawa T, Hayashi D, Tanaka H, Shimizu Y.

Surg Today. 2017 Aug;47(8):934-939. doi: 10.1007/s00595-016-1456-8. Epub 2016 Dec 30.


Aggressive resection of frequent peritoneal recurrences in colorectal cancer contributes to long-term survival.

Komori K, Kinoshita T, Taihei O, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Kawakami J, Ouchi A, Tsutsuyama M, Hosoi T, Shigeyoshi I, Akazawa T, Hayashi D, Tanaka H, Shimizu Y.

Nagoya J Med Sci. 2016 Dec;78(4):501-506. doi: 10.18999/nagjms.78.4.501.


Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells.

Noda S, Yamada A, Tanabe R, Nakaoka K, Hosoi T, Goseki-Sone M.

Nutr Res. 2016 Nov;36(11):1269-1276. doi: 10.1016/j.nutres.2016.10.001. Epub 2016 Oct 14.


Goal-Directed Treatment for Osteoporosis: A Progress Report From the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis.

Cummings SR, Cosman F, Lewiecki EM, Schousboe JT, Bauer DC, Black DM, Brown TD, Cheung AM, Cody K, Cooper C, Diez-Perez A, Eastell R, Hadji P, Hosoi T, Jan De Beur S, Kagan R, Kiel DP, Reid IR, Solomon DH, Randall S.

J Bone Miner Res. 2017 Jan;32(1):3-10. doi: 10.1002/jbmr.3039. Epub 2016 Dec 27.


Transplantation of epidermal cell sheets by endoscopic balloon dilatation to avoid esophageal re-strictures: initial experience in a porcine model.

Kobayashi S, Kanai N, Tanaka N, Maeda M, Hosoi T, Fukai F, Eguchi S, Yamato M.

Endosc Int Open. 2016 Nov;4(11):E1116-E1123. Epub 2016 Oct 28.


Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis.

Thon M, Hosoi T, Ozawa K.

Front Endocrinol (Lausanne). 2016 Oct 20;7:138. eCollection 2016. Review.


Study protocol for a multi-center, randomized controlled trial to develop Japanese denture adhesive guidelines for patients with complete dentures: the Denture Adhesive Guideline trial: study protocol for a randomized controlled trial.

Kimoto S, Kawai Y, Gunji A, Kondo H, Nomura T, Murakami T, Tsuboi A, Hong G, Minakuchi S, Sato Y, Ohwada G, Suzuki T, Kimoto K, Hoshi N, Saita M, Yoneyama Y, Sato Y, Morokuma M, Okazaki J, Maeda T, Nakai K, Ichikawa T, Nagao K, Fujimoto K, Murata H, Kurogi T, Yoshida K, Nishimura M, Nishi Y, Murakami M, Hosoi T, Hamada T.

Trials. 2016 Oct 18;17(1):506.


Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance.

Hosoi T, Suyama Y, Kayano T, Ozawa K.

Front Pharmacol. 2016 Sep 30;7:354. eCollection 2016.


Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78.

Thon M, Hosoi T, Ozawa K.

Sci Rep. 2016 Sep 28;6:34312. doi: 10.1038/srep34312.


Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death.

Hosoi T, Kakimoto M, Tanaka K, Nomura J, Ozawa K.

J Pharmacol Sci. 2016 Aug;131(4):292-5. doi: 10.1016/j.jphs.2016.08.003. Epub 2016 Aug 12.


Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer's and Parkinson's Disease.

Nomura J, Hosoi T, Kaneko M, Ozawa K, Nishi A, Nomura Y.

Med Sci (Basel). 2016 Aug 18;4(3). pii: E14. doi: 10.3390/medsci4030014. Review.


Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells.

Thon M, Hosoi T, Ozawa K.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):716-20. doi: 10.1016/j.bbrc.2016.08.013. Epub 2016 Aug 4.


Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.

Tanaka S, Miyazaki T, Uemura Y, Miyakawa N, Gorai I, Nakamura T, Fukunaga M, Ohashi Y, Ohta H, Mori S, Hagino H, Hosoi T, Sugimoto T, Itoi E, Orimo H, Shiraki M.

J Bone Miner Metab. 2017 Jul;35(4):385-395. doi: 10.1007/s00774-016-0768-5. Epub 2016 Aug 2.


Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death.

Hosoi T, Nakatsu K, Shimamoto A, Tahara H, Ozawa K.

Neurosci Lett. 2016 Aug 26;629:241-244. doi: 10.1016/j.neulet.2016.07.027. Epub 2016 Jul 18.


Immobilization stress-induced anorexia is mediated independent of MyD88.

Hosoi T, Yamawaki Y, Kimura H, Ozawa K.

Neuroreport. 2016 Sep 7;27(13):974-7. doi: 10.1097/WNR.0000000000000641.


First Isolation and Characterization of the Highly Coordinated Group 14 Enolates: Effects of the Coordination Controls on the Geometry and Tautomerization of Germyl Enolates.

Konishi A, Minami Y, Hosoi T, Chiba K, Yasuda M.

Chemistry. 2016 Aug 26;22(36):12688-91. doi: 10.1002/chem.201603147. Epub 2016 Jul 28.


Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity.

Hosoi T, Ozawa K.

Front Endocrinol (Lausanne). 2016 Jun 8;7:59. doi: 10.3389/fendo.2016.00059. eCollection 2016. Review.


The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome.

Hosoi T, Ozawa K.

Yakugaku Zasshi. 2016;136(6):827-30. doi: 10.1248/yakushi.15-00292-5. Review. Japanese.


Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation.

Hosoi T, Kohda T, Matsuzaki S, Ishiguchi M, Kuwamura A, Akita T, Tanaka J, Ozawa K.

Br J Pharmacol. 2016 Aug;173(15):2434-45. doi: 10.1111/bph.13520. Epub 2016 Jun 23.


[Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students].

Ikeda K, Hosoi T, Yoshii M, Sugiyama M, Ozawa K.

Yakugaku Zasshi. 2016;136(2):337-50. doi: 10.1248/yakushi.15-00170. Japanese.


Hip fracture incidence in Japan: Estimates of new patients in 2012 and 25-year trends.

Orimo H, Yaegashi Y, Hosoi T, Fukushima Y, Onoda T, Hashimoto T, Sakata K.

Osteoporos Int. 2016 May;27(5):1777-84. doi: 10.1007/s00198-015-3464-8. Epub 2016 Jan 5.


Design and demonstration of phase gratings for 2D single grating interferometer.

Morimoto N, Fujino S, Ito Y, Yamazaki A, Sano I, Hosoi T, Watanabe H, Shimura T.

Opt Express. 2015 Nov 16;23(23):29399-412. doi: 10.1364/OE.23.029399.


Two dimensional x-ray phase imaging using single grating interferometer with embedded x-ray targets.

Morimoto N, Fujino S, Yamazaki A, Ito Y, Hosoi T, Watanabe H, Shimura T.

Opt Express. 2015 Jun 29;23(13):16582-8. doi: 10.1364/OE.23.016582.


Estrogen and cancers of the colorectum, breast, and lung in postmenopausal women.

Honma N, Hosoi T, Arai T, Takubo K.

Pathol Int. 2015 Sep;65(9):451-9. doi: 10.1111/pin.12326. Epub 2015 Jul 1. Review.


Effects of Fok-I polymorphism in vitamin D receptor gene on serum 25-hydroxyvitamin D, bone-specific alkaline phosphatase and calcaneal quantitative ultrasound parameters in young adults.

Tanabe R, Kawamura Y, Tsugawa N, Haraikawa M, Sogabe N, Okano T, Hosoi T, Goseki-Sone M.

Asia Pac J Clin Nutr. 2015;24(2):329-35. doi: 10.6133/apjcn.2015.24.2.01.


Endoscopic cell sheet transplantation device developed by using a 3-dimensional printer and its feasibility evaluation in a porcine model.

Maeda M, Kanai N, Kobayashi S, Hosoi T, Takagi R, Ohki T, Muragaki Y, Yamato M, Eguchi S, Fukai F, Okano T.

Gastrointest Endosc. 2015 Jul;82(1):147-52. doi: 10.1016/j.gie.2015.01.062. Epub 2015 Apr 17.


Synthesis of a peptide that can translocate to the endoplasmic reticulum.

Nakatsu K, Hosoi T, Toyoda K, Ozawa K.

Biochem Biophys Res Commun. 2015 May 8;460(3):628-32. doi: 10.1016/j.bbrc.2015.03.080. Epub 2015 Mar 21.


Stress-induced neuroprotective effects of epiregulin and amphiregulin.

Zhan L, Zheng L, Hosoi T, Okuma Y, Nomura Y.

PLoS One. 2015 Feb 12;10(2):e0118280. doi: 10.1371/journal.pone.0118280. eCollection 2015.


Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance.

Hosoi T, Matsuzaki S, Miyahara T, Shimizu K, Hasegawa Y, Ozawa K.

J Neurochem. 2015 May;133(3):343-51. doi: 10.1111/jnc.13057. Epub 2015 Mar 2.


Influence of Occlusal Force on Electroencephalograms in Edentulous Patients.

Morokuma M, Yoneyama Y, Matsuda R, Hosoi T, Ohkubo C.

J Prosthodont. 2015 Oct;24(7):532-537. doi: 10.1111/jopr.12263. Epub 2015 Jan 15.


Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT).

Sugimoto T, Matsumoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Fukunaga M, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Okubo N, Shiraki M, Nakamura T.

Osteoporos Int. 2015 Feb;26(2):765-74. doi: 10.1007/s00198-014-2964-2. Epub 2014 Nov 18.


Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells.

Thon M, Hosoi T, Yoshii M, Ozawa K.

Sci Rep. 2014 Nov 18;4:7096. doi: 10.1038/srep07096.


Prevention of esophageal strictures after endoscopic submucosal dissection.

Kobayashi S, Kanai N, Ohki T, Takagi R, Yamaguchi N, Isomoto H, Kasai Y, Hosoi T, Nakao K, Eguchi S, Yamamoto M, Yamato M, Okano T.

World J Gastroenterol. 2014 Nov 7;20(41):15098-109. doi: 10.3748/wjg.v20.i41.15098. Review.

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