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Items: 1 to 50 of 158

1.

Delivery of Apoptosis-inducing Piperine to Triple-negative Breast Cancer Cells via Co-polymeric Nanoparticles.

Rad JG, Hoskin DW.

Anticancer Res. 2020 Feb;40(2):689-694. doi: 10.21873/anticanres.13998.

PMID:
32014909
2.

Assessing the Impact of Phytochemicals on Immune Checkpoints: Implications for Cancer Immunotherapy.

Power Coombs MR, Hoskin DW.

Methods Mol Biol. 2020;2111:161-173. doi: 10.1007/978-1-0716-0266-9_14.

PMID:
31933207
3.

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest.

Rasmussen A, Murphy K, Hoskin DW.

Adv Pharm Bull. 2019 Oct;9(4):685-689. doi: 10.15171/apb.2019.080. Epub 2019 Oct 24.

4.

DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage.

Greenshields AL, Power Coombs MR, Fernando W, Holbein BE, Hoskin DW.

Biometals. 2019 Dec;32(6):909-921. doi: 10.1007/s10534-019-00222-3. Epub 2019 Oct 17.

PMID:
31624972
5.

Apple Peel Flavonoid Fraction 4 Suppresses Breast Cancer Cell Growth by Cytostatic and Cytotoxic Mechanisms.

Loung CY, Fernando W, Rupasinghe HPV, Hoskin DW.

Molecules. 2019 Sep 13;24(18). pii: E3335. doi: 10.3390/molecules24183335.

6.

Phloridzin docosahexaenoate, a novel fatty acid ester of a plant polyphenol, inhibits mammary carcinoma cell metastasis.

Fernando W, Coyle K, Marcato P, Vasantha Rupasinghe HP, Hoskin DW.

Cancer Lett. 2019 Nov 28;465:68-81. doi: 10.1016/j.canlet.2019.08.015. Epub 2019 Aug 29.

PMID:
31473253
7.

Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells.

Huynh TT, Sultan M, Vidovic D, Dean CA, Cruickshank BM, Lee K, Loung CY, Holloway RW, Hoskin DW, Waisman DM, Weaver ICG, Marcato P.

Sci Rep. 2019 Jul 1;9(1):9414. doi: 10.1038/s41598-019-45982-7.

8.

Anticancer Activities of Natural and Synthetic Peptides.

Hilchie AL, Hoskin DW, Power Coombs MR.

Adv Exp Med Biol. 2019;1117:131-147. doi: 10.1007/978-981-13-3588-4_9. Review.

PMID:
30980357
9.

Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy?

Fernando W, Rupasinghe HPV, Hoskin DW.

Cancer Lett. 2019 Jun 28;452:168-177. doi: 10.1016/j.canlet.2019.03.022. Epub 2019 Mar 22. Review.

PMID:
30910593
10.

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway.

Almasi S, Sterea AM, Fernando W, Clements DR, Marcato P, Hoskin DW, Gujar S, El Hiani Y.

Sci Rep. 2019 Mar 12;9(1):4182. doi: 10.1038/s41598-019-40330-1.

11.

The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells.

Greenshields AL, Fernando W, Hoskin DW.

Exp Mol Pathol. 2019 Apr;107:10-22. doi: 10.1016/j.yexmp.2019.01.006. Epub 2019 Jan 17.

PMID:
30660598
12.

Thy-1 (CD90) Signaling Preferentially Promotes RORγt Expression and a Th17 Response.

Furlong S, Coombs MRP, Ghassemi-Rad J, Hoskin DW.

Front Cell Dev Biol. 2018 Nov 23;6:158. doi: 10.3389/fcell.2018.00158. eCollection 2018.

13.

Myricetin-induced oxidative stress suppresses murine T lymphocyte activation.

Ghassemi-Rad J, Maleki M, Knickle AF, Hoskin DW.

Cell Biol Int. 2018 Aug;42(8):1069-1075. doi: 10.1002/cbin.10977. Epub 2018 May 10.

PMID:
29745443
14.

Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide.

Knickle A, Fernando W, Greenshields AL, Rupasinghe HPV, Hoskin DW.

Food Chem Toxicol. 2018 Aug;118:154-167. doi: 10.1016/j.fct.2018.05.005. Epub 2018 May 6.

PMID:
29742465
15.

PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata.

Parsley NC, Kirkpatrick CL, Crittenden CM, Rad JG, Hoskin DW, Brodbelt JS, Hicks LM.

Phytochemistry. 2018 Aug;152:61-70. doi: 10.1016/j.phytochem.2018.04.014. Epub 2018 May 21.

16.

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.

Warford JR, Lamport AC, Clements DR, Malone A, Kennedy BE, Kim Y, Gujar SA, Hoskin DW, Easton AS.

Acta Neuropathol Commun. 2018 Jan 4;6(1):4. doi: 10.1186/s40478-017-0506-9.

17.

Reovirus FAST Protein Enhances Vesicular Stomatitis Virus Oncolytic Virotherapy in Primary and Metastatic Tumor Models.

Le Boeuf F, Gebremeskel S, McMullen N, He H, Greenshields AL, Hoskin DW, Bell JC, Johnston B, Pan C, Duncan R.

Mol Ther Oncolytics. 2017 Aug 4;6:80-89. doi: 10.1016/j.omto.2017.08.001. eCollection 2017 Sep 15.

18.

Thy-1 stimulation of mouse T cells induces a delayed T cell receptor-like signal that results in Ca2+‑independent cytotoxicity.

Furlong S, Power Coombs MR, Hoskin DW.

Mol Med Rep. 2017 Oct;16(4):5683-5692. doi: 10.3892/mmr.2017.7242. Epub 2017 Aug 14.

PMID:
28849009
19.

IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.

Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J.

Oncotarget. 2017 Jun 27;8(26):43153-43168. doi: 10.18632/oncotarget.17820.

20.

[10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells.

Bernard MM, McConnery JR, Hoskin DW.

Exp Mol Pathol. 2017 Apr;102(2):370-376. doi: 10.1016/j.yexmp.2017.03.006. Epub 2017 Mar 16.

PMID:
28315687
21.

Piperine, a Pungent Alkaloid from Black Pepper, Inhibits B Lymphocyte Activation and Effector Functions.

Soutar DA, Doucette CD, Liwski RS, Hoskin DW.

Phytother Res. 2017 Mar;31(3):466-474. doi: 10.1002/ptr.5772. Epub 2017 Jan 19.

PMID:
28102026
22.

Protocols for Studying Antimicrobial Peptides (AMPs) as Anticancer Agents.

Madera L, Hoskin DW.

Methods Mol Biol. 2017;1548:331-343. doi: 10.1007/978-1-4939-6737-7_24.

PMID:
28013516
23.

The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery.

Kirkpatrick CL, Broberg CA, McCool EN, Lee WJ, Chao A, McConnell EW, Pritchard DA, Hebert M, Fleeman R, Adams J, Jamil A, Madera L, Strömstedt AA, Göransson U, Liu Y, Hoskin DW, Shaw LN, Hicks LM.

Anal Chem. 2017 Jan 17;89(2):1194-1201. doi: 10.1021/acs.analchem.6b03625. Epub 2017 Jan 4.

PMID:
27991763
24.

Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma.

Hilchie AL, Sharon AJ, Haney EF, Hoskin DW, Bally MB, Franco OL, Corcoran JA, Hancock REW.

Biochim Biophys Acta. 2016 Dec;1858(12):3195-3204. doi: 10.1016/j.bbamem.2016.09.021. Epub 2016 Oct 18.

25.

Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties.

Whitehouse S, Chen PL, Greenshields AL, Nightingale M, Hoskin DW, Bedard K.

Phytomedicine. 2016 Nov 15;23(12):1494-1503. doi: 10.1016/j.phymed.2016.08.011. Epub 2016 Aug 31.

PMID:
27765370
26.

Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells.

Fernando W, Coombs MRP, Hoskin DW, Rupasinghe HPV.

Carcinogenesis. 2016 Oct;37(10):1004-1013. doi: 10.1093/carcin/bgw087. Epub 2016 Aug 17.

PMID:
27535497
27.

Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells.

Coombs MR, Harrison ME, Hoskin DW.

Cancer Lett. 2016 Oct 1;380(2):424-33. doi: 10.1016/j.canlet.2016.06.023. Epub 2016 Jul 1.

PMID:
27378243
28.

A re-examination of the role of the acute phase protein response in innate cancer defence.

Conrad DM, Hoskin DW, Liwski R, Naugler C.

Med Hypotheses. 2016 Aug;93:93-6. doi: 10.1016/j.mehy.2016.05.025. Epub 2016 May 24.

PMID:
27372864
29.

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate.

Greenshields AL, Shepherd TG, Hoskin DW.

Mol Carcinog. 2017 Jan;56(1):75-93. doi: 10.1002/mc.22474. Epub 2016 Feb 15.

PMID:
26878598
30.

The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.

Smith ML, Murphy K, Doucette CD, Greenshields AL, Hoskin DW.

J Cell Biochem. 2016 Aug;117(8):1913-25. doi: 10.1002/jcb.25490. Epub 2016 Feb 2.

PMID:
26755433
31.

Piperine impairs the migration and T cell-activating function of dendritic cells.

Rodgers G, Doucette CD, Soutar DA, Liwski RS, Hoskin DW.

Toxicol Lett. 2016 Feb 3;242:23-33. doi: 10.1016/j.toxlet.2015.11.025. Epub 2015 Nov 27.

PMID:
26640239
32.

Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03.

Hilchie AL, Haney EF, Pinto DM, Hancock RE, Hoskin DW.

Exp Mol Pathol. 2015 Dec;99(3):426-34. doi: 10.1016/j.yexmp.2015.08.021. Epub 2015 Sep 3.

PMID:
26344617
33.

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells.

Power Coombs MR, Grant T, Greenshields AL, Arsenault DJ, Holbein BE, Hoskin DW.

Exp Mol Pathol. 2015 Oct;99(2):262-70. doi: 10.1016/j.yexmp.2015.07.008. Epub 2015 Jul 22.

PMID:
26210486
34.

Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol.

Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW.

Phytother Res. 2015 Nov;29(11):1707-13. doi: 10.1002/ptr.5414. Epub 2015 Jul 14.

PMID:
26178781
35.

4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses.

Madera L, Greenshields A, Coombs MR, Hoskin DW.

PLoS One. 2015 Jul 15;10(7):e0133385. doi: 10.1371/journal.pone.0133385. eCollection 2015.

36.

Piperine from black pepper inhibits activation-induced proliferation and effector function of T lymphocytes.

Doucette CD, Rodgers G, Liwski RS, Hoskin DW.

J Cell Biochem. 2015 Nov;116(11):2577-88. doi: 10.1002/jcb.25202.

PMID:
25900378
37.

Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids.

Fernando W, Rupasinghe HP, Hoskin DW.

Mini Rev Med Chem. 2015;15(6):479-89. Review.

PMID:
25873069
38.

Structure-function relationships in histidine-rich antimicrobial peptides from Atlantic cod.

McDonald M, Mannion M, Pike D, Lewis K, Flynn A, Brannan AM, Browne MJ, Jackman D, Madera L, Power Coombs MR, Hoskin DW, Rise ML, Booth V.

Biochim Biophys Acta. 2015 Jul;1848(7):1451-61. doi: 10.1016/j.bbamem.2015.03.030. Epub 2015 Apr 1.

39.

Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways.

Doucette CD, Greenshields AL, Liwski RS, Hoskin DW.

Toxicol Lett. 2015 Apr 2;234(1):1-12. doi: 10.1016/j.toxlet.2015.01.020. Epub 2015 Feb 2.

PMID:
25655587
40.

Piperine inhibits the growth and motility of triple-negative breast cancer cells.

Greenshields AL, Doucette CD, Sutton KM, Madera L, Annan H, Yaffe PB, Knickle AF, Dong Z, Hoskin DW.

Cancer Lett. 2015 Feb 1;357(1):129-140. doi: 10.1016/j.canlet.2014.11.017. Epub 2014 Nov 13.

PMID:
25444919
41.

Regulation of cytokine polarization and T cell recruitment to inflamed paws in mouse collagen-induced arthritis by the chemokine receptor CXCR6.

Slauenwhite D, Gebremeskel S, Doucette CD, Hoskin DW, Johnston B.

Arthritis Rheumatol. 2014 Nov;66(11):3001-12. doi: 10.1002/art.38816.

42.

Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt.

Harrison ME, Power Coombs MR, Delaney LM, Hoskin DW.

Exp Mol Pathol. 2014 Oct;97(2):211-7. doi: 10.1016/j.yexmp.2014.07.006. Epub 2014 Jul 12.

PMID:
25019465
43.

Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress.

Yaffe PB, Power Coombs MR, Doucette CD, Walsh M, Hoskin DW.

Mol Carcinog. 2015 Oct;54(10):1070-85. doi: 10.1002/mc.22176. Epub 2014 May 13.

PMID:
24819444
44.

Murine experimental autoimmune encephalomyelitis is diminished by treatment with the angiogenesis inhibitors B20-4.1.1 and angiostatin (K1-3).

MacMillan CJ, Doucette CD, Warford J, Furlong SJ, Hoskin DW, Easton AS.

PLoS One. 2014 Feb 26;9(2):e89770. doi: 10.1371/journal.pone.0089770. eCollection 2014.

45.

Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53.

Sutton KM, Greenshields AL, Hoskin DW.

Nutr Cancer. 2014;66(3):408-18. doi: 10.1080/01635581.2013.878739. Epub 2014 Feb 28.

PMID:
24579801
46.

Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide).

Warford J, Doucette CD, Hoskin DW, Easton AS.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):524-30. doi: 10.1016/j.bbrc.2013.11.119. Epub 2013 Dec 6.

PMID:
24315874
47.

Assessment of antimicrobial (host defense) peptides as anti-cancer agents.

Douglas S, Hoskin DW, Hilchie AL.

Methods Mol Biol. 2014;1088:159-70. doi: 10.1007/978-1-62703-673-3_11.

PMID:
24146403
48.

Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin.

Hilchie AL, Vale R, Zemlak TS, Hoskin DW.

Exp Mol Pathol. 2013 Oct;95(2):192-8. doi: 10.1016/j.yexmp.2013.07.006. Epub 2013 Jul 26.

PMID:
23892223
49.

Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc.

Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Szabo G, Hoskin DW, Buechter DD, Van Wijnen AJ, Im HJ.

J Cell Physiol. 2013 Sep;228(9):1884-96. doi: 10.1002/jcp.24350.

50.

Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts.

Hilchie AL, Conrad DM, Coombs MR, Zemlak T, Doucette CD, Liwski RS, Hoskin DW.

Leuk Lymphoma. 2013 Oct;54(10):2255-62. doi: 10.3109/10428194.2013.770847. Epub 2013 Mar 4.

PMID:
23350892

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