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Items: 19


Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.

Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG.

Nat Commun. 2019 Dec 6;10(1):5604. doi: 10.1038/s41467-019-13419-4.


Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.

Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG.

FEBS Lett. 2020 Feb;594(4):646-664. doi: 10.1002/1873-3468.13648. Epub 2019 Nov 16.


Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.

Dexter JP, Ward PS, Dasgupta T, Hosios AM, Gunawardena J, Vander Heiden MG.

J Biol Chem. 2018 Dec 28;293(52):20051-20061. doi: 10.1074/jbc.RA118.004278. Epub 2018 Oct 31.


Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.

Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W.

EMBO J. 2018 Nov 15;37(22). pii: e100294. doi: 10.15252/embj.2018100294. Epub 2018 Oct 22.


Lysosomal catch-and-release controls mTORC1.

Hosios AM, Manning BD.

Nat Cell Biol. 2018 Sep;20(9):996-997. doi: 10.1038/s41556-018-0188-y. No abstract available.


Aspartate is an endogenous metabolic limitation for tumour growth.

Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.

Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25.


The redox requirements of proliferating mammalian cells.

Hosios AM, Vander Heiden MG.

J Biol Chem. 2018 May 18;293(20):7490-7498. doi: 10.1074/jbc.TM117.000239. Epub 2018 Jan 16. Review.


Endothelial Cells Get ╬▓-ox-ed In to Support Lymphangiogenesis.

Hosios AM, Vander Heiden MG.

Dev Cell. 2017 Jan 23;40(2):118-119. doi: 10.1016/j.devcel.2017.01.004.


Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG.

Cell Metab. 2016 Nov 8;24(5):716-727. doi: 10.1016/j.cmet.2016.09.006. Epub 2016 Oct 13.


Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.


Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG.

Dev Cell. 2016 Mar 7;36(5):540-9. doi: 10.1016/j.devcel.2016.02.012.


Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR.

J Cell Biol. 2016 Feb 15;212(4):439-47. doi: 10.1083/jcb.201506118.


Cooperative nutrient accumulation sustains growth of mammalian cells.

Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S.

Sci Rep. 2015 Dec 1;5:17401. doi: 10.1038/srep17401.


Lack of Evidence for PKM2 Protein Kinase Activity.

Hosios AM, Fiske BP, Gui DY, Vander Heiden MG.

Mol Cell. 2015 Sep 3;59(5):850-7. doi: 10.1016/j.molcel.2015.07.013. Epub 2015 Aug 20.


Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG.

Cell. 2015 Jul 30;162(3):552-63. doi: 10.1016/j.cell.2015.07.017.


Acetate metabolism in cancer cells.

Hosios AM, Vander Heiden MG.

Cancer Metab. 2014 Dec 11;2(1):27. doi: 10.1186/s40170-014-0027-y. eCollection 2014. No abstract available.


Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG.

Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4.


PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.

Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025.


Pyrimidine homeostasis is accomplished by directed overflow metabolism.

Reaves ML, Young BD, Hosios AM, Xu YF, Rabinowitz JD.

Nature. 2013 Aug 8;500(7461):237-41. doi: 10.1038/nature12445. Epub 2013 Jul 31.

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