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Items: 1 to 50 of 85


Contact guidance persists under myosin inhibition due to the local alignment of adhesions and individual protrusions.

Kubow KE, Shuklis VD, Sales DJ, Horwitz AR.

Sci Rep. 2017 Oct 30;7(1):14380. doi: 10.1038/s41598-017-14745-7.


Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.

Bachir AI, Horwitz AR, Nelson WJ, Bianchini JM.

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7). pii: a023234. doi: 10.1101/cshperspect.a023234. Review.


Chondroitin Sulfate Impairs Neural Stem Cell Migration Through ROCK Activation.

Galindo LT, Mundim MTVV, Pinto AS, Chiarantin GMD, Almeida MES, Lamers ML, Horwitz AR, Santos MF, Porcionatto M.

Mol Neurobiol. 2018 Apr;55(4):3185-3195. doi: 10.1007/s12035-017-0565-8. Epub 2017 May 5.


Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC).

Montenegro CF, Casali BC, Lino RLB, Pachane BC, Santos PK, Horwitz AR, Selistre-de-Araujo HS, Lamers ML.

PLoS One. 2017 Apr 24;12(4):e0176226. doi: 10.1371/journal.pone.0176226. eCollection 2017.


Breast cancer antiestrogen resistance 3-p130Cas interactions promote adhesion disassembly and invasion in breast cancer cells.

Cross AM, Wilson AL, Guerrero MS, Thomas KS, Bachir AI, Kubow KE, Horwitz AR, Bouton AH.

Oncogene. 2016 Nov 10;35(45):5850-5859. doi: 10.1038/onc.2016.123. Epub 2016 Apr 25.


Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma.

Ramos Gde O, Bernardi L, Lauxen I, Sant'Ana Filho M, Horwitz AR, Lamers ML.

PLoS One. 2016 Mar 15;11(3):e0151338. doi: 10.1371/journal.pone.0151338. eCollection 2016.


Sperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell Growth, Morphology, Migration and Ciliogenesis.

Li W, Mukherjee A, Wu J, Zhang L, Teves ME, Li H, Nambiar S, Henderson SC, Horwitz AR, Strauss JF III, Fang X, Zhang Z.

Sci Rep. 2015 Nov 20;5:16506. doi: 10.1038/srep16506.


Signaling networks that regulate cell migration.

Devreotes P, Horwitz AR.

Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a005959. doi: 10.1101/cshperspect.a005959. Review.


ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity.

Newell-Litwa KA, Badoual M, Asmussen H, Patel H, Whitmore L, Horwitz AR.

J Cell Biol. 2015 Jul 20;210(2):225-42. doi: 10.1083/jcb.201504046. Epub 2015 Jul 13.


A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity.

Juanes-Garcia A, Chapman JR, Aguilar-Cuenca R, Delgado-Arevalo C, Hodges J, Whitmore LA, Shabanowitz J, Hunt DF, Horwitz AR, Vicente-Manzanares M.

J Cell Biol. 2015 Apr 13;209(1):23-32. doi: 10.1083/jcb.201407059.


Involvement of calpains in adult neurogenesis: implications for stroke.

Machado VM, Morte MI, Carreira BP, Azevedo MM, Takano J, Iwata N, Saido TC, Asmussen H, Horwitz AR, Carvalho CM, Araújo IM.

Front Cell Neurosci. 2015 Feb 4;9:22. doi: 10.3389/fncel.2015.00022. eCollection 2015.


Cell Biology. Many modes of motility.

DeSimone DW, Horwitz AR.

Science. 2014 Aug 29;345(6200):1002-3. doi: 10.1126/science.1259176. No abstract available.


Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions.

Bachir AI, Zareno J, Moissoglu K, Plow EF, Gratton E, Horwitz AR.

Curr Biol. 2014 Aug 18;24(16):1845-53. doi: 10.1016/j.cub.2014.07.011. Epub 2014 Jul 31.


α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.

Hodges JL, Vilchez SM, Asmussen H, Whitmore LA, Horwitz AR.

PLoS One. 2014 Jul 9;9(7):e101770. doi: 10.1371/journal.pone.0101770. eCollection 2014.


A nu-space for ICS: characterization and application to measure protein transport in live cells.

Potvin-Trottier L, Chen L, Horwitz AR, Wiseman PW.

New J Phys. 2013 Aug;15. doi: 10.1088/1367-2630/15/8/085006.


Spatial separation benefit for unaided and aided listening.

Ahlstrom JB, Horwitz AR, Dubno JR.

Ear Hear. 2014 Jan-Feb;35(1):72-85. doi: 10.1097/AUD.0b013e3182a02274. Erratum in: Ear Hear. 2014 May-Jun;35(3):386.


Matrix microarchitecture and myosin II determine adhesion in 3D matrices.

Kubow KE, Conrad SK, Horwitz AR.

Curr Biol. 2013 Sep 9;23(17):1607-19. doi: 10.1016/j.cub.2013.06.053. Epub 2013 Aug 8.


Fluorescence fluctuation approaches to the study of adhesion and signaling.

Bachir AI, Kubow KE, Horwitz AR.

Methods Enzymol. 2013;519:167-201. doi: 10.1016/B978-0-12-405539-1.00006-3.


CD81 regulates cell migration through its association with Rac GTPase.

Tejera E, Rocha-Perugini V, López-Martín S, Pérez-Hernández D, Bachir AI, Horwitz AR, Vázquez J, Sánchez-Madrid F, Yáñez-Mo M.

Mol Biol Cell. 2013 Feb;24(3):261-73. doi: 10.1091/mbc.E12-09-0642. Epub 2012 Dec 21.


The origins of the molecular era of adhesion research.

Horwitz AR.

Nat Rev Mol Cell Biol. 2012 Dec;13(12):805-11. doi: 10.1038/nrm3473. Epub 2012 Nov 15. Review.


STICCS reveals matrix-dependent adhesion slipping and gripping in migrating cells.

Toplak T, Pandzic E, Chen L, Vicente-Manzanares M, Horwitz AR, Wiseman PW.

Biophys J. 2012 Oct 17;103(8):1672-82. doi: 10.1016/j.bpj.2012.08.060. Epub 2012 Oct 16.


Level-dependent changes in perception of speech envelope cues.

Dubno JR, Ahlstrom JB, Wang X, Horwitz AR.

J Assoc Res Otolaryngol. 2012 Dec;13(6):835-52. doi: 10.1007/s10162-012-0343-2. Epub 2012 Aug 8.


The integrin-ligand interaction regulates adhesion and migration through a molecular clutch.

Chen L, Vicente-Manzanares M, Potvin-Trottier L, Wiseman PW, Horwitz AR.

PLoS One. 2012;7(7):e40202. doi: 10.1371/journal.pone.0040202. Epub 2012 Jul 6.


Individual and level-dependent differences in masking for adults with normal and impaired hearing.

Horwitz AR, Ahlstrom JB, Dubno JR.

J Acoust Soc Am. 2012 Apr;131(4):EL323-8. doi: 10.1121/1.3693386.


The structure of cell-matrix adhesions: the new frontier.

Hanein D, Horwitz AR.

Curr Opin Cell Biol. 2012 Feb;24(1):134-40. doi: 10.1016/ Epub 2011 Dec 22. Review.


Adhesion dynamics at a glance.

Vicente-Manzanares M, Horwitz AR.

J Cell Sci. 2011 Dec 1;124(Pt 23):3923-7. doi: 10.1242/jcs.095653. No abstract available.


Level-dependent changes in detection of temporal gaps in noise markers by adults with normal and impaired hearing.

Horwitz AR, Ahlstrom JB, Dubno JR.

J Acoust Soc Am. 2011 Nov;130(5):2928-38. doi: 10.1121/1.3643829.


Individual differences in behavioral estimates of cochlear nonlinearities.

Poling GL, Horwitz AR, Ahlstrom JB, Dubno JR.

J Assoc Res Otolaryngol. 2012 Feb;13(1):91-108. doi: 10.1007/s10162-011-0291-2. Epub 2011 Sep 22.


Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.

Hodges JL, Newell-Litwa K, Asmussen H, Vicente-Manzanares M, Horwitz AR.

PLoS One. 2011;6(8):e24149. doi: 10.1371/journal.pone.0024149. Epub 2011 Aug 26.


Integrins in cell migration.

Huttenlocher A, Horwitz AR.

Cold Spring Harb Perspect Biol. 2011 Sep 1;3(9):a005074. doi: 10.1101/cshperspect.a005074. Review.


Cell migration: PKA and RhoA set the pace.

Newell-Litwa KA, Horwitz AR.

Curr Biol. 2011 Aug 9;21(15):R596-8. doi: 10.1016/j.cub.2011.06.032.


Cell migration: an overview.

Vicente-Manzanares M, Horwitz AR.

Methods Mol Biol. 2011;769:1-24. doi: 10.1007/978-1-61779-207-6_1. Review.


Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells.

Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore LA, Horwitz AR.

J Cell Biol. 2011 Apr 18;193(2):381-96. doi: 10.1083/jcb.201012159. Epub 2011 Apr 11.


Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions.

Choi CK, Zareno J, Digman MA, Gratton E, Horwitz AR.

Biophys J. 2011 Feb 2;100(3):583-592. doi: 10.1016/j.bpj.2010.12.3719. Erratum in: Biophys J. 2011 Jul 20;101(2):517.


Reducing background fluorescence reveals adhesions in 3D matrices.

Kubow KE, Horwitz AR.

Nat Cell Biol. 2011 Jan;13(1):3-5; author reply 5-7. doi: 10.1038/ncb0111-3. No abstract available. Erratum in: Nat Cell Biol. 2012 Dec;14(12):1344.


Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells.

Vicente-Manzanares M, Horwitz AR.

Biochem Biophys Res Commun. 2010 Nov 19;402(3):537-42. doi: 10.1016/j.bbrc.2010.10.071. Epub 2010 Oct 28.


Cell adhesion: integrating cytoskeletal dynamics and cellular tension.

Parsons JT, Horwitz AR, Schwartz MA.

Nat Rev Mol Cell Biol. 2010 Sep;11(9):633-43. doi: 10.1038/nrm2957. Review.


Non-muscle myosin II takes centre stage in cell adhesion and migration.

Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR.

Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90. doi: 10.1038/nrm2786. Review.


The matrix revolutions.

Horwitz AR.

Nat Rev Mol Cell Biol. 2009 Oct;10(10):653. doi: 10.1038/nrm2769. No abstract available.


Kinetic model for lamellipodal actin-integrin 'clutch' dynamics.

Macdonald A, Horwitz AR, Lauffenburger DA.

Cell Adh Migr. 2008 Apr-May;2(2):95-105. Epub 2008 Apr 29.


Spatial benefit of bilateral hearing AIDS.

Ahlstrom JB, Horwitz AR, Dubno JR.

Ear Hear. 2009 Apr;30(2):203-18. doi: 10.1097/AUD.0b013e31819769c1.


Stoichiometry of molecular complexes at adhesions in living cells.

Digman MA, Wiseman PW, Choi C, Horwitz AR, Gratton E.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2170-5. doi: 10.1073/pnas.0806036106. Epub 2009 Jan 23.


Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method.

Digman MA, Wiseman PW, Horwitz AR, Gratton E.

Biophys J. 2009 Jan;96(2):707-16. doi: 10.1016/j.bpj.2008.09.051.


Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.

Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, Horwitz AR.

Nat Cell Biol. 2008 Sep;10(9):1039-50. doi: 10.1038/ncb1763.


Integrins in cell migration--the actin connection.

Vicente-Manzanares M, Choi CK, Horwitz AR.

J Cell Sci. 2009 Jan 15;122(Pt 2):199-206. doi: 10.1242/jcs.018564. Review. Erratum in: J Cell Sci. 2009 May 1;122(Pt 9):1473.


Dendritic Spines: Similarities with Protrusions and Adhesions in Migrating Cells.

Vicente-Manzanares M, Hodges J, Horwitz AR.

Open Neurosci J. 2009 Jan 1;3:87-96.


Factors affecting the benefits of high-frequency amplification.

Horwitz AR, Ahlstrom JB, Dubno JR.

J Speech Lang Hear Res. 2008 Jun;51(3):798-813. doi: 10.1044/1092-4388(2008/057).


Binaural advantage for younger and older adults with normal hearing.

Dubno JR, Ahlstrom JB, Horwitz AR.

J Speech Lang Hear Res. 2008 Apr;51(2):539-56. doi: 10.1044/1092-4388(2008/039).


Longitudinal changes in speech recognition in older persons.

Dubno JR, Lee FS, Matthews LJ, Ahlstrom JB, Horwitz AR, Mills JH.

J Acoust Soc Am. 2008 Jan;123(1):462-75. doi: 10.1121/1.2817362.


Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope.

Brown CM, Dalal RB, Hebert B, Digman MA, Horwitz AR, Gratton E.

J Microsc. 2008 Jan;229(Pt 1):78-91. doi: 10.1111/j.1365-2818.2007.01871.x.

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