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Items: 1 to 50 of 259

1.

Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor.

Pender CL, Horvitz HR.

Elife. 2018 Jul 16;7. pii: e36828. doi: 10.7554/eLife.36828. [Epub ahead of print]

2.

A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis.

Corrionero A, Horvitz HR.

Curr Biol. 2018 May 21;28(10):1522-1535.e5. doi: 10.1016/j.cub.2018.03.063. Epub 2018 May 3.

PMID:
29731301
3.

A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.

Engert CG, Droste R, van Oudenaarden A, Horvitz HR.

PLoS Genet. 2018 Apr 27;14(4):e1007295. doi: 10.1371/journal.pgen.1007295. eCollection 2018 Apr.

4.

Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans.

Van Bael S, Watteyne J, Boonen K, De Haes W, Menschaert G, Ringstad N, Horvitz HR, Schoofs L, Husson SJ, Temmerman L.

J Biol Chem. 2018 Apr 20;293(16):6052-6063. doi: 10.1074/jbc.RA117.000731. Epub 2018 Feb 27.

PMID:
29487130
5.

Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans.

Driscoll K, Stanfield GM, Droste R, Horvitz HR.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8806-8811. doi: 10.1073/pnas.1705084114. Epub 2017 Jul 31.

6.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
7.

The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage.

Luo S, Horvitz HR.

Curr Biol. 2017 Mar 6;27(5):661-672. doi: 10.1016/j.cub.2017.01.056. Epub 2017 Feb 23.

8.

Insulin-like signalling to the maternal germline controls progeny response to osmotic stress.

Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR.

Nat Cell Biol. 2017 Mar;19(3):252-257. doi: 10.1038/ncb3470. Epub 2017 Feb 6.

9.
10.

The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior.

Paquin N, Murata Y, Froehlich A, Omura DT, Ailion M, Pender CL, Constantine-Paton M, Horvitz HR.

Curr Biol. 2016 Apr 4;26(7):862-71. doi: 10.1016/j.cub.2016.01.049. Epub 2016 Mar 3.

11.

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.

Peters OM, Cabrera GT, Tran H, Gendron TF, McKeon JE, Metterville J, Weiss A, Wightman N, Salameh J, Kim J, Sun H, Boylan KB, Dickson D, Kennedy Z, Lin Z, Zhang YJ, Daughrity L, Jung C, Gao FB, Sapp PC, Horvitz HR, Bosco DA, Brown SP, de Jong P, Petrucelli L, Mueller C, Brown RH Jr.

Neuron. 2015 Dec 2;88(5):902-909. doi: 10.1016/j.neuron.2015.11.018.

12.

Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans.

Bhatla N, Droste R, Sando SR, Huang A, Horvitz HR.

Curr Biol. 2015 Aug 17;25(16):2075-89. doi: 10.1016/j.cub.2015.06.052. Epub 2015 Jul 23.

13.

Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids.

Ma DK, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR.

Cell. 2015 May 21;161(5):1152-1163. doi: 10.1016/j.cell.2015.04.026. Epub 2015 May 14.

14.

Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.

Bhatla N, Horvitz HR.

Neuron. 2015 Feb 18;85(4):804-18. doi: 10.1016/j.neuron.2014.12.061. Epub 2015 Jan 29.

15.

The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans.

Hirose T, Horvitz HR.

PLoS Genet. 2014 Aug 7;10(8):e1004512. doi: 10.1371/journal.pgen.1004512. eCollection 2014 Aug.

16.

Axons degenerate in the absence of mitochondria in C. elegans.

Rawson RL, Yam L, Weimer RM, Bend EG, Hartwieg E, Horvitz HR, Clark SG, Jorgensen EM.

Curr Biol. 2014 Mar 31;24(7):760-5. doi: 10.1016/j.cub.2014.02.025. Epub 2014 Mar 13.

17.

The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.

de la Cruz IP, Ma L, Horvitz HR.

PLoS Genet. 2014 Feb 20;10(2):e1004175. doi: 10.1371/journal.pgen.1004175. eCollection 2014 Feb.

18.

An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways.

Hirose T, Horvitz HR.

Nature. 2013 Aug 15;500(7462):354-8. doi: 10.1038/nature12329. Epub 2013 Jul 14.

19.

Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.

Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S.

Science. 2013 Jul 26;341(6144):403-6. doi: 10.1126/science.1236758. Epub 2013 Jul 11.

20.

Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans.

Ma DK, Rothe M, Zheng S, Bhatla N, Pender CL, Menzel R, Horvitz HR.

Science. 2013 Aug 2;341(6145):554-8. doi: 10.1126/science.1235753. Epub 2013 Jun 27.

21.

Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.

Denning DP, Hatch V, Horvitz HR.

PLoS Genet. 2013;9(3):e1003341. doi: 10.1371/journal.pgen.1003341. Epub 2013 Mar 7.

22.

SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function.

Anderson C, Zhou S, Sawin E, Horvitz HR, Hurwitz ME.

PLoS Genet. 2012;8(12):e1003115. doi: 10.1371/journal.pgen.1003115. Epub 2012 Dec 13.

23.

IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.

Emtage L, Aziz-Zaman S, Padovan-Merhar O, Horvitz HR, Fang-Yen C, Ringstad N.

J Neurosci. 2012 Nov 14;32(46):16285-95. doi: 10.1523/JNEUROSCI.2667-12.2012.

24.

Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.

Gürel G, Gustafson MA, Pepper JS, Horvitz HR, Koelle MR.

Genetics. 2012 Dec;192(4):1359-71. doi: 10.1534/genetics.112.142125. Epub 2012 Sep 28.

25.

The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.

Ma L, Gao X, Luo J, Huang L, Teng Y, Horvitz HR.

PLoS Genet. 2012;8(7):e1002827. doi: 10.1371/journal.pgen.1002827. Epub 2012 Jul 19.

26.

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.

Denning DP, Hatch V, Horvitz HR.

Nature. 2012 Aug 9;488(7410):226-30. doi: 10.1038/nature11240.

27.

Dopamine signaling is essential for precise rates of locomotion by C. elegans.

Omura DT, Clark DA, Samuel AD, Horvitz HR.

PLoS One. 2012;7(6):e38649. doi: 10.1371/journal.pone.0038649. Epub 2012 Jun 13.

28.

The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.

Boulias K, Horvitz HR.

Cell Metab. 2012 Apr 4;15(4):439-50. doi: 10.1016/j.cmet.2012.02.014.

29.

CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.

Ma DK, Vozdek R, Bhatla N, Horvitz HR.

Neuron. 2012 Mar 8;73(5):925-40. doi: 10.1016/j.neuron.2011.12.037.

30.

The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.

Saffer AM, Kim DH, van Oudenaarden A, Horvitz HR.

PLoS Genet. 2011 Dec;7(12):e1002418. doi: 10.1371/journal.pgen.1002418. Epub 2011 Dec 29.

31.

Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans.

Nakano S, Stillman B, Horvitz HR.

Cell. 2011 Dec 23;147(7):1525-36. doi: 10.1016/j.cell.2011.11.053. Epub 2011 Dec 15.

32.

In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans.

Ma L, Tan Z, Teng Y, Hoersch S, Horvitz HR.

RNA. 2011 Dec;17(12):2201-11. doi: 10.1261/rna.027458.111. Epub 2011 Oct 27.

33.
34.

Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex.

Tabuchi TM, Deplancke B, Osato N, Zhu LJ, Barrasa MI, Harrison MM, Horvitz HR, Walhout AJ, Hagstrom KA.

PLoS Genet. 2011 May;7(5):e1002074. doi: 10.1371/journal.pgen.1002074. Epub 2011 May 12.

35.

SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans.

Galvin BD, Denning DP, Horvitz HR.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1998-2003. doi: 10.1073/pnas.1018805108. Epub 2011 Jan 18.

36.

The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination.

Davison EM, Saffer AM, Huang LS, DeModena J, Sternberg PW, Horvitz HR.

Genetics. 2011 Mar;187(3):803-15. doi: 10.1534/genetics.110.124487. Epub 2010 Dec 31.

37.

Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.

Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM 3rd, Horvitz HR, Sternberg PW, Ringstad N.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):254-9. doi: 10.1073/pnas.1017354108. Epub 2010 Dec 20.

38.

C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.

Korzelius J, The I, Ruijtenberg S, Portegijs V, Xu H, Horvitz HR, van den Heuvel S.

Dev Biol. 2011 Feb 15;350(2):358-69. doi: 10.1016/j.ydbio.2010.12.009. Epub 2010 Dec 10.

39.

Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.

Nakano S, Ellis RE, Horvitz HR.

Development. 2010 Dec;137(23):4017-27. doi: 10.1242/dev.058834. Epub 2010 Nov 1.

40.

3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.

Berdichevsky A, Nedelcu S, Boulias K, Bishop NA, Guarente L, Horvitz HR.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18927-32. doi: 10.1073/pnas.1013854107. Epub 2010 Oct 18.

41.

Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.

Hirose T, Galvin BD, Horvitz HR.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15479-84. doi: 10.1073/pnas.1010023107. Epub 2010 Aug 16.

42.

Many families of C. elegans microRNAs are not essential for development or viability.

Alvarez-Saavedra E, Horvitz HR.

Curr Biol. 2010 Feb 23;20(4):367-73. doi: 10.1016/j.cub.2009.12.051. Epub 2010 Jan 21.

43.

A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.

Jospin M, Qi YB, Stawicki TM, Boulin T, Schuske KR, Horvitz HR, Bessereau JL, Jorgensen EM, Jin Y.

PLoS Biol. 2009 Dec;7(12):e1000265. doi: 10.1371/journal.pbio.1000265. Epub 2009 Dec 22.

44.

Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo.

Ma L, Horvitz HR.

PLoS Genet. 2009 Nov;5(11):e1000708. doi: 10.1371/journal.pgen.1000708. Epub 2009 Nov 6.

45.

Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.

Ringstad N, Abe N, Horvitz HR.

Science. 2009 Jul 3;325(5936):96-100. doi: 10.1126/science.1169243.

46.

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.

Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr, Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL, Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9004-9. doi: 10.1073/pnas.0812937106. Epub 2009 May 18.

47.

Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans.

Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, Horvitz HR.

PLoS Biol. 2009 Apr 28;7(4):e99. doi: 10.1371/journal.pbio.1000099. Erratum in: PLoS Biol. 2009 Jun;7(6). doi: 10.1371/annotation/2259f958-a68e-4e57-92b5-2ef003070cf1.

48.

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.

Science. 2009 Feb 27;323(5918):1205-8. doi: 10.1126/science.1166066.

49.

C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development.

Vanderzalm PJ, Pandey A, Hurwitz ME, Bloom L, Horvitz HR, Garriga G.

Development. 2009 Apr;136(7):1201-10. doi: 10.1242/dev.026666. Epub 2009 Feb 25.

50.

Wnt and EGF pathways act together to induce C. elegans male hook development.

Yu H, Seah A, Herman MA, Ferguson EL, Horvitz HR, Sternberg PW.

Dev Biol. 2009 Mar 15;327(2):419-32. doi: 10.1016/j.ydbio.2008.12.023. Epub 2008 Dec 30.

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