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Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.

Sarkar TJ, Quarta M, Mukherjee S, Colville A, Paine P, Doan L, Tran CM, Chu CR, Horvath S, Qi LS, Bhutani N, Rando TA, Sebastiano V.

Nat Commun. 2020 Mar 24;11(1):1545. doi: 10.1038/s41467-020-15174-3.


Psychosocial stress and epigenetic aging.

Palma-Gudiel H, Fañanás L, Horvath S, Zannas AS.

Int Rev Neurobiol. 2020;150:107-128. doi: 10.1016/bs.irn.2019.10.020. Epub 2019 Nov 20.


Estimating breast tissue-specific DNA methylation age using next-generation sequencing data.

Castle JR, Lin N, Liu J, Storniolo AMV, Shendre A, Hou L, Horvath S, Liu Y, Wang C, He C.

Clin Epigenetics. 2020 Mar 12;12(1):45. doi: 10.1186/s13148-020-00834-4.


Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease.

Vallerga CL, Zhang F, Fowdar J, McRae AF, Qi T, Nabais MF, Zhang Q, Kassam I, Henders AK, Wallace L, Montgomery G, Chuang YH, Horvath S, Ritz B, Halliday G, Hickie I, Kwok JB, Pearson J, Pitcher T, Kennedy M, Bentley SR, Silburn PA, Yang J, Wray NR, Lewis SJG, Anderson T, Dalrymple-Alford J, Mellick GD, Visscher PM, Gratten J.

Nat Commun. 2020 Mar 6;11(1):1238. doi: 10.1038/s41467-020-15065-7.


The concentration of fetal red blood cells in first-trimester pregnant women undergoing uterine aspiration is below the calculated threshold for Rh sensitization.

Horvath S, Tsao P, Huang ZY, Zhao L, Du Y, Sammel MD, Luning Prak ET, Schreiber CA.

Contraception. 2020 Mar 2. pii: S0010-7824(20)30064-0. doi: 10.1016/j.contraception.2020.02.011. [Epub ahead of print]


Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).

Thurston RC, Carroll JE, Levine M, Chang Y, Crandall C, Manson JE, Pal L, Hou L, Shadyab AH, Horvath S.

J Clin Endocrinol Metab. 2020 Apr 1;105(4). pii: dgaa081. doi: 10.1210/clinem/dgaa081.


An epigenetic clock for human skeletal muscle.

Voisin S, Harvey NR, Haupt LM, Griffiths LR, Ashton KJ, Coffey VG, Doering TM, Thompson JM, Benedict C, Cedernaes J, Lindholm ME, Craig JM, Rowlands DS, Sharples AP, Horvath S, Eynon N.

J Cachexia Sarcopenia Muscle. 2020 Feb 17. doi: 10.1002/jcsm.12556. [Epub ahead of print]


Immune epigenetic age in pregnancy and 1 year after birth: Associations with weight change.

Ross KM, Carroll J, Horvath S, Hobel CJ, Coussons-Read ME, Dunkel Schetter C.

Am J Reprod Immunol. 2020 Feb 15:e13229. doi: 10.1111/aji.13229. [Epub ahead of print]


Development and face validation of ultrasound-guided renal biopsy virtual trainer.

Enquobahrie A, Horvath S, Arikatla S, Rosenberg A, Cleary K, Sharma K.

Healthc Technol Lett. 2019 Nov 26;6(6):210-213. doi: 10.1049/htl.2019.0081. eCollection 2019 Dec.


Coagulation factor VIII: Relationship to cardiovascular disease risk and whole genome sequence and epigenome-wide analysis in African Americans.

Raffield LM, Lu AT, Szeto MD, Little A, Grinde KE, Shaw J, Auer PL, Cushman M, Horvath S, Irvin MR, Lange EM, Lange LA, Nickerson DA, Thornton TA, Wilson JG, Wheeler MM; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, Zakai NA, Reiner AP.

J Thromb Haemost. 2020 Jan 27. doi: 10.1111/jth.14741. [Epub ahead of print]


Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.

Gondalia R, Holliday KM, Baldassari A, Justice AE, Stewart JD, Liao D, Yanosky JD, Engel SM, Jordahl KM, Bhatti P, Horvath S, Assimes TL, Pankow JS, Demerath EW, Guan W, Fornage M, Bressler J, North KE, Conneely KN, Li Y, Hou L, Baccarelli AA, Whitsel EA.

Environ Health Perspect. 2020 Jan;128(1):17004. doi: 10.1289/EHP5360. Epub 2020 Jan 6.


Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine.

Hsieh S, Porter NT, Donermeyer DL, Horvath S, Strout G, Saunders BT, Zhang N, Zinselmeyer B, Martens EC, Stappenbeck TS, Allen PM.

J Immunol. 2020 Feb 15;204(4):1035-1046. doi: 10.4049/jimmunol.1901206. Epub 2020 Jan 3.


DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging.

Lewis SK, Nachun D, Martin MG, Horvath S, Coppola G, Jones DL.

Cell Mol Gastroenterol Hepatol. 2020;9(3):527-541. doi: 10.1016/j.jcmgh.2019.11.013. Epub 2019 Dec 2.


An epigenetic predictor of death captures multi-modal measures of brain health.

Hillary RF, Stevenson AJ, Cox SR, McCartney DL, Harris SE, Seeboth A, Higham J, Sproul D, Taylor AM, Redmond P, Corley J, Pattie A, Hernández MDCV, Muñoz-Maniega S, Bastin ME, Wardlaw JM, Horvath S, Ritchie CW, Spires-Jones TL, McIntosh AM, Evans KL, Deary IJ, Marioni RE.

Mol Psychiatry. 2019 Dec 3. doi: 10.1038/s41380-019-0616-9. [Epub ahead of print]


From uptake to access: a decade of learning from the ACOG LARC program.

Horvath S, Bumpus M, Luchowski A.

Am J Obstet Gynecol. 2020 Apr;222(4S):S866-S868.e1. doi: 10.1016/j.ajog.2019.11.1269. Epub 2019 Nov 30.


DNA methylation aging clocks: challenges and recommendations.

Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, Christensen BC, Gladyshev VN, Heijmans BT, Horvath S, Ideker T, Issa JJ, Kelsey KT, Marioni RE, Reik W, Relton CL, Schalkwyk LC, Teschendorff AE, Wagner W, Zhang K, Rakyan VK.

Genome Biol. 2019 Nov 25;20(1):249. doi: 10.1186/s13059-019-1824-y. Review.


A meta-analysis of genome-wide association studies of epigenetic age acceleration.

Gibson J, Russ TC, Clarke TK, Howard DM, Hillary RF, Evans KL, Walker RM, Bermingham ML, Morris SW, Campbell A, Hayward C, Murray AD, Porteous DJ, Horvath S, Lu AT, McIntosh AM, Whalley HC, Marioni RE.

PLoS Genet. 2019 Nov 18;15(11):e1008104. doi: 10.1371/journal.pgen.1008104. eCollection 2019 Nov.


Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study.

Nannini DR, Joyce BT, Zheng Y, Gao T, Liu L, Yoon G, Huan T, Ma J, Jacobs DR Jr, Wilkins JT, Ren J, Zhang K, Khan SS, Allen NB, Horvath S, Lloyd-Jones DM, Greenland P, Hou L.

Clin Epigenetics. 2019 Nov 15;11(1):160. doi: 10.1186/s13148-019-0767-1.


Transthyretin Cardiac Amyloidosis as Diagnosed by 99mTc-PYP Scanning in Patients with Acute Heart Failure and Preserved Ejection Fraction.

Lo Presti S, Horvath SA, Mihos CG, Rajadhyaksha C, McCloskey V, Santana O.

Crit Pathw Cardiol. 2019 Dec;18(4):195-199. doi: 10.1097/HPC.0000000000000183.


A comparative study of three biomaterials in an ovine bone defect model.

Cheng BC, Jaffee S, Averick S, Swink I, Horvath S, Zhukauskas R.

Spine J. 2020 Mar;20(3):457-464. doi: 10.1016/j.spinee.2019.10.003. Epub 2019 Oct 15.


Gender minority stress, sleep disturbance, and sexual victimization in transgender and gender nonconforming adults.

Kolp H, Wilder S, Andersen C, Johnson E, Horvath S, Gidycz CA, Shorey R.

J Clin Psychol. 2020 Apr;76(4):688-698. doi: 10.1002/jclp.22880. Epub 2019 Oct 18.


The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.

McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201820843. doi: 10.1073/pnas.1820843116. [Epub ahead of print]


Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DTS, Kobor MS, Horvath S.

Aging Cell. 2019 Dec;18(6):e13028. doi: 10.1111/acel.13028. Epub 2019 Sep 8.


Extending Phenomenological Crystal-Field Methods to C_{1} Point-Group Symmetry: Characterization of the Optically Excited Hyperfine Structure of ^{167}Er^{3+}:Y_{2}SiO_{5}.

Horvath SP, Rakonjac JV, Chen YH, Longdell JJ, Goldner P, Wells JR, Reid MF.

Phys Rev Lett. 2019 Aug 2;123(5):057401. doi: 10.1103/PhysRevLett.123.057401.


Towards an Advanced Virtual Ultrasound-guided Renal Biopsy Trainer.

Horvath S, Arikatla S, Cleary K, Sharma K, Rosenberg A, Enquobahrie A.

Proc SPIE Int Soc Opt Eng. 2019 Feb;10951. pii: 109511W. doi: 10.1117/12.2512871. Epub 2019 Mar 12.


Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.

Luo A, Jung J, Longley M, Rosoff DB, Charlet K, Muench C, Lee J, Hodgkinson CA, Goldman D, Horvath S, Kaminsky ZA, Lohoff FW.

Neuropsychopharmacology. 2020 Jan;45(2):327-336. doi: 10.1038/s41386-019-0500-y. Epub 2019 Aug 29.


Epigenome-wide association study of leukocyte telomere length.

Lee Y, Sun D, Ori APS, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li S, Harris JR, Magnus P, Aviv A, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Aug 26;11(16):5876-5894. doi: 10.18632/aging.102230. Epub 2019 Aug 26.


In-Mold Sensors for Injection Molding: On the Way to Industry 4.0.

Ageyeva T, Horváth S, Kovács JG.

Sensors (Basel). 2019 Aug 15;19(16). pii: E3551. doi: 10.3390/s19163551. Review.


Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.

Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, Chen BH, Ligthart S, Guarrera S, Colicino E, Just AC, Wahl S, Gieger C, Vandiver AR, Tanaka T, Hernandez DG, Pilling LC, Singleton AB, Sacerdote C, Krogh V, Panico S, Tumino R, Li Y, Zhang G, Stewart JD, Floyd JS, Wiggins KL, Rotter JI, Multhaup M, Bakulski K, Horvath S, Tsao PS, Absher DM, Vokonas P, Hirschhorn J, Fallin MD, Liu C, Bandinelli S, Boerwinkle E, Dehghan A, Schwartz JD, Psaty BM, Feinberg AP, Hou L, Ferrucci L, Sotoodehnia N, Matullo G, Peters A, Fornage M, Assimes TL, Whitsel EA, Levy D, Baccarelli AA.

Circulation. 2019 Aug 20;140(8):645-657. doi: 10.1161/CIRCULATIONAHA.118.039357. Epub 2019 Aug 19.


DNA methylation-based estimator of telomere length.

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, Taylor A, Deary IJ, Stewart JD, Whitsel EA, Assimes TL, Chen W, Li S, Mangino M, Bell JT, Wilson JG, Aviv A, Marioni RE, Raj K, Horvath S.

Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. doi: 10.18632/aging.102173. Epub 2019 Aug 18.


Theoretical Analysis of Efficiency of Multi-Layer Core-Shell Stationary Phases in the High Performance Liquid Chromatography of Large Biomolecules.

Horváth S, Gritti F, Kormány R, Horváth K.

Molecules. 2019 Aug 6;24(15). pii: E2849. doi: 10.3390/molecules24152849.


Persistent left superior vena cava identified by transesophageal echocardiography.

Horvath SA, Suraci N, D'Mello J, Santana O.

Rev Cardiovasc Med. 2019 Jun 30;20(2):99-100. doi: 10.31083/j.rcm.2019.02.510.


Optimism is not associated with two indicators of DNA methylation aging.

Kim ES, Fong K, Lee L, Spiro A, Schwartz J, Whitsel E, Horvath S, Wang C, Hou L, Baccarelli AA, Li Y, Stewart J, Manson JE, Grodstein F, DeMeo DL, Kubzansky LD.

Aging (Albany NY). 2019 Jul 18;11(14):4970-4989. doi: 10.18632/aging.102090.


Inflammation-related genes are associated with epigenetic aging in HIV.

Sundermann EE, Hussain MA, Moore DJ, Horvath S, Lin DTS, Kobor MS, Levine A; HNRP Group.

J Neurovirol. 2019 Dec;25(6):853-865. doi: 10.1007/s13365-019-00777-4. Epub 2019 Jul 8.


Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels.

Lee Y, Choufani S, Weksberg R, Wilson SL, Yuan V, Burt A, Marsit C, Lu AT, Ritz B, Bohlin J, Gjessing HK, Harris JR, Magnus P, Binder AM, Robinson WP, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Jun 24;11(12):4238-4253. doi: 10.18632/aging.102049.


Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation.

Gondalia R, Baldassari A, Holliday KM, Justice AE, Méndez-Giráldez R, Stewart JD, Liao D, Yanosky JD, Brennan KJM, Engel SM, Jordahl KM, Kennedy E, Ward-Caviness CK, Wolf K, Waldenberger M, Cyrys J, Peters A, Bhatti P, Horvath S, Assimes TL, Pankow JS, Demerath EW, Guan W, Fornage M, Bressler J, North KE, Conneely KN, Li Y, Hou L, Baccarelli AA, Whitsel EA.

Environ Int. 2019 Nov;132:104723. doi: 10.1016/j.envint.2019.03.071. Epub 2019 Jun 14.


Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts.

Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M.

Epigenetics. 2019 Oct;14(10):961-976. doi: 10.1080/15592294.2019.1626651. Epub 2019 Jun 12.


Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.

Horvath S, Lu AT, Cohen H, Raj K.

Aging (Albany NY). 2019 May 26;11(10):3238-3249. doi: 10.18632/aging.101976.


The effects of physical activity on cancer prevention, treatment and prognosis: A review of the literature.

Lugo D, Pulido AL, Mihos CG, Issa O, Cusnir M, Horvath SA, Lin J, Santana O.

Complement Ther Med. 2019 Jun;44:9-13. doi: 10.1016/j.ctim.2019.03.013. Epub 2019 Mar 20. Review.


Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT.

Matsuyama M, WuWong DJ, Horvath S, Matsuyama S.

Aging (Albany NY). 2019 May 21;11(10):3012-3022. doi: 10.18632/aging.101955.


Tumor-Associated Disialylated Glycosphingolipid Antigen-Revealing Antibodies Found in Melanoma Patients' Immunoglobulin Repertoire Suggest a Two-Direction Regulation Mechanism Between Immune B Cells and the Tumor.

Kotlan B, Horvath S, Eles K, Plotar VK, Naszados G, Czirbesz K, Blank M, Farkas E, Toth L, Tovari J, Szekacs A, Shoenfeld Y, Godeny M, Kasler M, Liszkay G.

Front Immunol. 2019 Apr 5;10:650. doi: 10.3389/fimmu.2019.00650. eCollection 2019.


Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease.

Chuang YH, Lu AT, Paul KC, Folle AD, Bronstein JM, Bordelon Y, Horvath S, Ritz B.

J Parkinsons Dis. 2019;9(2):389-400. doi: 10.3233/JPD-181549.


The Pleiotropic Effects of Statins in Endocrine Disorders.

De La Cruz JA, Mihos CG, Horvath SA, Santana O.

Endocr Metab Immune Disord Drug Targets. 2019;19(6):787-793. doi: 10.2174/1871530319666190329115003.


Synchrony and asynchrony between an epigenetic clock and developmental timing.

Hoshino A, Horvath S, Sridhar A, Chitsazan A, Reh TA.

Sci Rep. 2019 Mar 6;9(1):3770. doi: 10.1038/s41598-019-39919-3.


Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice.

Horváth S, Komlódi R, Perkecz A, Pintér E, Gyulai R, Kemény Á.

Sci Rep. 2019 Mar 6;9(1):3685. doi: 10.1038/s41598-019-39903-x.


Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M.

PLoS Med. 2019 Feb 25;16(2):e1002760. doi: 10.1371/journal.pmed.1002760. eCollection 2019 Feb.


The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Liu Z, Chen BH, Assimes TL, Ferrucci L, Horvath S, Levine ME.

Psychoneuroendocrinology. 2019 Jun;104:18-24. doi: 10.1016/j.psyneuen.2019.01.028. Epub 2019 Feb 6.


Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen.

Wegorzewska MM, Glowacki RWP, Hsieh SA, Donermeyer DL, Hickey CA, Horvath SC, Martens EC, Stappenbeck TS, Allen PM.

Sci Immunol. 2019 Feb 8;4(32). pii: eaau9079. doi: 10.1126/sciimmunol.aau9079.


Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells.

Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S.

Aging Cell. 2019 Apr;18(2):e12897. doi: 10.1111/acel.12897. Epub 2019 Feb 2.


DNA methylation GrimAge strongly predicts lifespan and healthspan.

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S.

Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684.

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