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Cellular mechanisms underlying steroid-resistant asthma.

Wadhwa R, Dua K, Adcock IM, Horvat JC, Kim RY, Hansbro PM.

Eur Respir Rev. 2019 Oct 21;28(153). pii: 190096. doi: 10.1183/16000617.0096-2019. Print 2019 Sep 30. Review. Erratum in: Eur Respir Rev. 2019 Nov 13;28(154):.


Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology.

Woods JJ, Skelding KA, Martin KL, Aryal R, Sontag E, Johnstone DM, Horvat JC, Hansbro PM, Milward EA.

Brain Behav Immun. 2019 Oct 15. pii: S0889-1591(19)30454-4. doi: 10.1016/j.bbi.2019.10.014. [Epub ahead of print] Review.


Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

Liu G, Cooley MA, Jarnicki AG, Borghuis T, Nair PM, Tjin G, Hsu AC, Haw TJ, Fricker M, Harrison CL, Jones B, Hansbro NG, Wark PA, Horvat JC, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2019 Jul 25;5. pii: 124529. doi: 10.1172/jci.insight.124529.


IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM.

Eur Respir J. 2019 Jul 18;54(1). pii: 1800174. doi: 10.1183/13993003.00174-2018. Print 2019 Jul.


Polycomb repressive complex 2 is a critical mediator of allergic inflammation.

Keenan CR, Iannarella N, Garnham AL, Brown AC, Kim RY, Horvat JC, Hansbro PM, Nutt SL, Allan RS.

JCI Insight. 2019 May 16;4(10). pii: 127745. doi: 10.1172/jci.insight.127745. eCollection 2019 May 16.


Dietary Fatty Acids Amplify Inflammatory Responses to Infection through p38 MAPK Signaling.

Rutting S, Zakarya R, Bozier J, Xenaki D, Horvat JC, Wood LG, Hansbro PM, Oliver BG.

Am J Respir Cell Mol Biol. 2019 May;60(5):554-568. doi: 10.1165/rcmb.2018-0215OC.


Short-chain fatty acids increase TNFα-induced inflammation in primary human lung mesenchymal cells through the activation of p38 MAPK.

Rutting S, Xenaki D, Malouf M, Horvat JC, Wood LG, Hansbro PM, Oliver BG.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L157-L174. doi: 10.1152/ajplung.00306.2018. Epub 2018 Nov 8.


Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

Donovan C, Starkey MR, Kim RY, Rana BMJ, Barlow JL, Jones B, Haw TJ, Mono Nair P, Budden K, Cameron GJM, Horvat JC, Wark PA, Foster PS, McKenzie ANJ, Hansbro PM.

J Leukoc Biol. 2019 Jan;105(1):143-150. doi: 10.1002/JLB.3AB0518-178R. Epub 2018 Sep 27.


IL-6 Drives Neutrophil-Mediated Pulmonary Inflammation Associated with Bacteremia in Murine Models of Colitis.

Mateer SW, Mathe A, Bruce J, Liu G, Maltby S, Fricker M, Goggins BJ, Tay HL, Marks E, Burns G, Kim RY, Minahan K, Walker MM, Callister RC, Foster PS, Horvat JC, Hansbro PM, Keely S.

Am J Pathol. 2018 Jul;188(7):1625-1639. doi: 10.1016/j.ajpath.2018.03.016. Epub 2018 Apr 22.


Toll-like receptor 2 and 4 have opposing roles in the pathogenesis of cigarette smoke-induced chronic obstructive pulmonary disease.

Haw TJ, Starkey MR, Pavlidis S, Fricker M, Arthurs AL, Nair PM, Liu G, Hanish I, Kim RY, Foster PS, Horvat JC, Adcock IM, Hansbro PM.

Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L298-L317. doi: 10.1152/ajplung.00154.2017. Epub 2017 Oct 12.


Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, Haw TJ, Hansbro NG, Ge Q, Brown AC, Tay H, Foster PS, Wark PA, Horvat JC, Bourke JE, Grainge CL, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

J Pathol. 2017 Dec;243(4):510-523. doi: 10.1002/path.4979.


Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma.

Hansbro PM, Kim RY, Starkey MR, Donovan C, Dua K, Mayall JR, Liu G, Hansbro NG, Simpson JL, Wood LG, Hirota JA, Knight DA, Foster PS, Horvat JC.

Immunol Rev. 2017 Jul;278(1):41-62. doi: 10.1111/imr.12543. Review.


Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation.

Al-Kouba J, Wilkinson AN, Starkey MR, Rudraraju R, Werder RB, Liu X, Law SC, Horvat JC, Brooks JF, Hill GR, Davies JM, Phipps S, Hansbro PM, Steptoe RJ.

JCI Insight. 2017 Jun 2;2(11). pii: 85742. doi: 10.1172/jci.insight.85742. eCollection 2017 Jun 2.


Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice.

Nair PM, Starkey MR, Haw TJ, Liu G, Horvat JC, Morris JC, Verrills NM, Clark AR, Ammit AJ, Hansbro PM.

Allergy. 2017 Dec;72(12):1891-1903. doi: 10.1111/all.13212. Epub 2017 Jun 21.


Role of iron in the pathogenesis of respiratory disease.

Ali MK, Kim RY, Karim R, Mayall JR, Martin KL, Shahandeh A, Abbasian F, Starkey MR, Loustaud-Ratti V, Johnstone D, Milward EA, Hansbro PM, Horvat JC.

Int J Biochem Cell Biol. 2017 Jul;88:181-195. doi: 10.1016/j.biocel.2017.05.003. Epub 2017 May 7. Review.


Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.


Inflammasomes in the lung.

Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O'Neill LAJ, Horvat JC, Hansbro PM.

Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.


Elucidating novel disease mechanisms in severe asthma.

Kim RY, Rae B, Neal R, Donovan C, Pinkerton J, Balachandran L, Starkey MR, Knight DA, Horvat JC, Hansbro PM.

Clin Transl Immunology. 2016 Jul 15;5(7):e91. doi: 10.1038/cti.2016.37. eCollection 2016 Jul. Review.


MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.

Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, Nair PM, Hansbro NG, Jones B, Haw TJ, Sunkara KP, Nguyen TH, Jarnicki AG, Keely S, Mattes J, Adcock IM, Foster PS, Hansbro PM.

J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.


Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.

Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2016 Jun 16;1(9). pii: e86380.


COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species.

Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, McDonald VM, Gibson PG, Hansbro PM.

Respirology. 2016 May;21(4):697-704. doi: 10.1111/resp.12734. Epub 2016 Jan 18.


A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease.

Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, Hsu AC, Hanish I, Kim RY, Collison AM, Inman MD, Wark PA, Foster PS, Knight DA, Mattes J, Yagita H, Adcock IM, Horvat JC, Hansbro PM.

Mucosal Immunol. 2016 Jul;9(4):859-72. doi: 10.1038/mi.2015.111. Epub 2015 Nov 11.


Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.

Gold MJ, Hiebert PR, Park HY, Stefanowicz D, Le A, Starkey MR, Deane A, Brown AC, Liu G, Horvat JC, Ibrahim ZA, Sukkar MB, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA, Hirota JA.

Mucosal Immunol. 2016 May;9(3):809-20. doi: 10.1038/mi.2015.104. Epub 2015 Oct 28.


Inflammasomes in COPD and neutrophilic asthma.

Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM.

Thorax. 2015 Dec;70(12):1199-201. doi: 10.1136/thoraxjnl-2014-206736. Epub 2015 Oct 22. No abstract available.


Programmed Death Ligand 1 Promotes Early-Life Chlamydia Respiratory Infection-Induced Severe Allergic Airway Disease.

Starkey MR, Nguyen DH, Brown AC, Essilfie AT, Kim RY, Yagita H, Horvat JC, Hansbro PM.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.


Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease.

Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, Keely S.

J Leukoc Biol. 2015 Nov;98(5):727-37. doi: 10.1189/jlb.3RU1114-563R. Epub 2015 Aug 25. Review.


Altered lung function at mid-adulthood in mice following neonatal exposure to hyperoxia.

Sozo F, Horvat JC, Essilfie AT, O'Reilly M, Hansbro PM, Harding R.

Respir Physiol Neurobiol. 2015 Nov;218:21-7. doi: 10.1016/j.resp.2015.07.004. Epub 2015 Jul 18.


A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.

Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, Horvat JC, Hansbro PM, Bartlett NW, Johnston SL.

Clin Sci (Lond). 2015 Aug;129(3):245-58. doi: 10.1042/CS20140654.


Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma.

Essilfie AT, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, Starkey MR, Simpson JL, Foster PS, Gibson PG, Hansbro PM.

Thorax. 2015 May;70(5):458-67. doi: 10.1136/thoraxjnl-2014-206067. Epub 2015 Mar 6.


Pulmonary immunity during respiratory infections in early life and the development of severe asthma.

Hansbro PM, Starkey MR, Mattes J, Horvat JC.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S297-302. doi: 10.1513/AnnalsATS.201402-086AW. Review.


Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity.

Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, Thorne RF, Jarnicki AG, Hansbro PM, Hodgson DM.

Brain Behav Immun. 2015 Feb;44:235-46. doi: 10.1016/j.bbi.2014.10.014. Epub 2014 Oct 31.


Bronchiolar remodeling in adult mice following neonatal exposure to hyperoxia: relation to growth.

O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F.

Anat Rec (Hoboken). 2014 Apr;297(4):758-69. doi: 10.1002/ar.22867. Epub 2014 Jan 17.


Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.

Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S.

Front Immunol. 2013 Sep 11;4:272. doi: 10.3389/fimmu.2013.00272. Review.


Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.

Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, Yagita H, Foster PS, Horvat JC, Mattes J, Hansbro PM.

Mucosal Immunol. 2014 May;7(3):478-88. doi: 10.1038/mi.2013.65. Epub 2013 Sep 18.


Programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease.

Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie AT, Horvat JC, Hansbro PM.

Clin Obstet Gynecol. 2013 Sep;56(3):566-76. doi: 10.1097/GRF.0b013e3182993a0c.


Murine models of infectious exacerbations of airway inflammation.

Starkey MR, Jarnicki AG, Essilfie AT, Gellatly SL, Kim RY, Brown AC, Foster PS, Horvat JC, Hansbro PM.

Curr Opin Pharmacol. 2013 Jun;13(3):337-44. doi: 10.1016/j.coph.2013.03.005. Epub 2013 Apr 6. Review.


Interferon-ε protects the female reproductive tract from viral and bacterial infection.

Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, De Weerd N, Roisman LC, Rossjohn J, Robertson SA, Schjenken JE, Parker B, Gargett CE, Nguyen HP, Carr DJ, Hansbro PM, Hertzog PJ.

Science. 2013 Mar 1;339(6123):1088-92. doi: 10.1126/science.1233321.


A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.

Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM.

J Allergy Clin Immunol. 2013 Mar;131(3):752-62. doi: 10.1016/j.jaci.2012.11.053. Epub 2013 Feb 4.


Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease.

Starkey MR, Essilfie AT, Horvat JC, Kim RY, Nguyen DH, Beagley KW, Mattes J, Foster PS, Hansbro PM.

Mucosal Immunol. 2013 May;6(3):569-79. doi: 10.1038/mi.2012.99. Epub 2012 Nov 7.


Th2 cytokine antagonists: potential treatments for severe asthma.

Hansbro PM, Scott GV, Essilfie AT, Kim RY, Starkey MR, Nguyen DH, Allen PD, Kaiko GE, Yang M, Horvat JC, Foster PS.

Expert Opin Investig Drugs. 2013 Jan;22(1):49-69. doi: 10.1517/13543784.2013.732997. Epub 2012 Nov 5. Review.


Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice.

Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie AT, Nguyen DH, Beagley KW, Mattes J, Mackay CR, Horvat JC, Hansbro PM.

PLoS One. 2012;7(8):e42588. doi: 10.1371/journal.pone.0042588. Epub 2012 Aug 1.


TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life.

Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM.

PLoS One. 2012;7(6):e39460. doi: 10.1371/journal.pone.0039460. Epub 2012 Jun 19.


Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors.

Wynne O, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM.

Dev Psychobiol. 2012 Jul;54(5):568-75. doi: 10.1002/dev.20615. Epub 2011 Oct 17.


Programming of the lung by early-life infection.

Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC.

J Dev Orig Health Dis. 2012 Jun;3(3):153-8. doi: 10.1017/S2040174412000050.


Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease.

Essilfie AT, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, Gibson PG, Hansbro PM.

PLoS Pathog. 2011 Oct;7(10):e1002244. doi: 10.1371/journal.ppat.1002244. Epub 2011 Oct 6.


Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts.

Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS.

PLoS Pathog. 2011 May;7(5):e1001339. doi: 10.1371/journal.ppat.1001339. Epub 2011 May 5.


Neonatal respiratory infection and adult re-infection: effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice.

Wynne O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, Clifton VL, Hodgson DM.

Brain Behav Immun. 2011 Aug;25(6):1214-22. doi: 10.1016/j.bbi.2011.03.014. Epub 2011 Apr 2.


Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner.

Wynne O, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM.

Stress. 2011 May;14(3):247-61. doi: 10.3109/10253890.2010.532576. Epub 2011 Feb 6.


Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells.

Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, O'Sullivan BJ, Thomas R, Beagley KW, Gibson PG, Foster PS, Hansbro PM.

Eur Respir J. 2011 Jan;37(1):53-64. doi: 10.1183/09031936.00049510. Epub 2010 Jun 4.


Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.

Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM.

J Immunol. 2010 Apr 15;184(8):4159-69. doi: 10.4049/jimmunol.0902287. Epub 2010 Mar 12.

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