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Items: 41

1.

Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development.

Xu P, Ganaie SS, Wang X, Wang Z, Kleiboeker S, Horton NC, Heier RF, Meyers MJ, Tavis JE, Qiu J.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01879-18. doi: 10.1128/AAC.01879-18. Print 2019 Mar.

PMID:
30530599
2.

The Need for Speed: Run-On Oligomer Filament Formation Provides Maximum Speed with Maximum Sequestration of Activity.

Barahona CJ, Basantes LE, Tompkins KJ, Heitman DM, Chukwu BI, Sanchez J, Sanchez JL, Ghadirian N, Park CK, Horton NC.

J Virol. 2019 Feb 19;93(5). pii: e01647-18. doi: 10.1128/JVI.01647-18. Print 2019 Mar 1.

PMID:
30518649
3.

The run-on oligomer filament enzyme mechanism of SgrAI: Part 1. Assembly kinetics of the run-on oligomer filament.

Park CK, Sanchez JL, Barahona C, Basantes LE, Sanchez J, Hernandez C, Horton NC.

J Biol Chem. 2018 Sep 21;293(38):14585-14598. doi: 10.1074/jbc.RA118.003680. Epub 2018 Aug 1.

PMID:
30068553
4.

The run-on oligomer filament enzyme mechanism of SgrAI: Part 2. Kinetic modeling of the full DNA cleavage pathway.

Park CK, Sanchez JL, Barahona C, Basantes LE, Sanchez J, Hernandez C, Horton NC.

J Biol Chem. 2018 Sep 21;293(38):14599-14615. doi: 10.1074/jbc.RA118.003682. Epub 2018 Jul 27.

PMID:
30054273
5.

DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain.

Sanchez JL, Romero Z, Quinones A, Torgeson KR, Horton NC.

Biochemistry. 2016 Nov 29;55(47):6577-6593. Epub 2016 Nov 17.

6.

Probing the run-on oligomer of activated SgrAI bound to DNA.

Shah S, Sanchez J, Stewart A, Piperakis MM, Cosstick R, Nichols C, Park CK, Ma X, Wysocki V, Bitinaite J, Horton NC.

PLoS One. 2015 Apr 16;10(4):e0124783. doi: 10.1371/journal.pone.0124783. eCollection 2015.

7.

NKp44 and Natural Cytotoxicity Receptors as Damage-Associated Molecular Pattern Recognition Receptors.

Horton NC, Mathew PA.

Front Immunol. 2015 Feb 2;6:31. doi: 10.3389/fimmu.2015.00031. eCollection 2015. Review.

8.

Structure and specificity of FEN-1 from Methanopyrus kandleri.

Shah S, Dunten P, Stiteler A, Park CK, Horton NC.

Proteins. 2015 Jan;83(1):188-94. doi: 10.1002/prot.24704. Epub 2014 Nov 18.

9.

Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization.

Lyumkis D, Talley H, Stewart A, Shah S, Park CK, Tama F, Potter CS, Carragher B, Horton NC.

Structure. 2013 Oct 8;21(10):1848-58. doi: 10.1016/j.str.2013.08.012. Epub 2013 Sep 19.

10.

Structural analysis of activated SgrAI-DNA oligomers using ion mobility mass spectrometry.

Ma X, Shah S, Zhou M, Park CK, Wysocki VH, Horton NC.

Biochemistry. 2013 Jun 25;52(25):4373-81. doi: 10.1021/bi3013214. Epub 2013 Jun 17.

11.

CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes.

Kim JR, Horton NC, Mathew SO, Mathew PA.

Inflamm Res. 2013 Aug;62(8):765-72. doi: 10.1007/s00011-013-0632-1. Epub 2013 May 22.

PMID:
23695528
12.

Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44.

Horton NC, Mathew SO, Mathew PA.

PLoS One. 2013;8(3):e59552. doi: 10.1371/journal.pone.0059552. Epub 2013 Mar 19.

13.

2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes.

Aldy KN, Horton NC, Mathew PA, Mathew SO.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):503-7. doi: 10.1016/j.bbrc.2011.01.062. Epub 2011 Jan 21.

14.

New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.

Little EJ, Dunten PW, Bitinaite J, Horton NC.

Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):67-74. doi: 10.1107/S0907444910047785. Epub 2010 Dec 16.

15.

Domain swapping in allosteric modulation of DNA specificity.

Park CK, Joshi HK, Agrawal A, Ghare MI, Little EJ, Dunten PW, Bitinaite J, Horton NC.

PLoS Biol. 2010 Dec 7;8(12):e1000554. doi: 10.1371/journal.pbio.1000554.

16.

Activation of DNA cleavage by oligomerization of DNA-bound SgrAI.

Park CK, Stiteler AP, Shah S, Ghare MI, Bitinaite J, Horton NC.

Biochemistry. 2010 Oct 19;49(41):8818-30. doi: 10.1021/bi100557v.

17.

Crystallization of zinc finger proteins bound to DNA.

Horton NC, Park CK.

Methods Mol Biol. 2010;649:457-77. doi: 10.1007/978-1-60761-753-2_28.

PMID:
20680852
18.

The restriction enzyme SgrAI: structure solution via combination of poor MIRAS and MR phases.

Dunten PW, Little EJ, Horton NC.

Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):393-8. doi: 10.1107/S0907444909003266. Epub 2009 Mar 19.

19.

Early interrogation and recognition of DNA sequence by indirect readout.

Little EJ, Babic AC, Horton NC.

Structure. 2008 Dec 10;16(12):1828-37. doi: 10.1016/j.str.2008.09.009.

20.

DNA distortion and specificity in a sequence-specific endonuclease.

Babic AC, Little EJ, Manohar VM, Bitinaite J, Horton NC.

J Mol Biol. 2008 Oct 31;383(1):186-204. doi: 10.1016/j.jmb.2008.08.032. Epub 2008 Aug 22.

21.

The structure of SgrAI bound to DNA; recognition of an 8 base pair target.

Dunten PW, Little EJ, Gregory MT, Manohar VM, Dalton M, Hough D, Bitinaite J, Horton NC.

Nucleic Acids Res. 2008 Sep;36(16):5405-16. doi: 10.1093/nar/gkn510. Epub 2008 Aug 13.

22.

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

Segal DJ, Crotty JW, Bhakta MS, Barbas CF 3rd, Horton NC.

J Mol Biol. 2006 Oct 20;363(2):405-21. Epub 2006 Aug 11.

23.

Alteration of sequence specificity of the type II restriction endonuclease HincII through an indirect readout mechanism.

Joshi HK, Etzkorn C, Chatwell L, Bitinaite J, Horton NC.

J Biol Chem. 2006 Aug 18;281(33):23852-69. Epub 2006 May 4.

24.

Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.

Crotty JW, Etzkorn C, Barbas CF 3rd, Segal DJ, Horton NC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):573-6. Epub 2005 Jun 1.

25.
26.

Ca2+ binding in the active site of HincII: implications for the catalytic mechanism.

Etzkorn C, Horton NC.

Biochemistry. 2004 Oct 26;43(42):13256-70.

PMID:
15491133
27.
28.

DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites.

Horton NC, Perona JJ.

Biochemistry. 2004 Jun 8;43(22):6841-57.

PMID:
15170321
29.

Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease.

Horton NC, Otey C, Lusetti S, Sam MD, Kohn J, Martin AM, Ananthnarayan V, Perona JJ.

Biochemistry. 2002 Sep 3;41(35):10754-63.

PMID:
12196013
30.

Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.

Horton NC, Dorner LF, Perona JJ.

Nat Struct Biol. 2002 Jan;9(1):42-7.

PMID:
11742344
31.

Making the most of metal ions.

Horton NC, Perona JJ.

Nat Struct Biol. 2001 Apr;8(4):290-3. No abstract available.

PMID:
11276242
32.
33.

Crystallographic snapshots along a protein-induced DNA-bending pathway.

Horton NC, Perona JJ.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5729-34.

34.

Crystallization and preliminary diffraction analysis of the HincII restriction endonuclease-DNA complex.

Horton NC, Dorner LF, Schildkraut I, Perona JJ.

Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1943-5.

PMID:
10531503
35.

Divalent metal dependence of site-specific DNA binding by EcoRV endonuclease.

Martin AM, Horton NC, Lusetti S, Reich NO, Perona JJ.

Biochemistry. 1999 Jun 29;38(26):8430-9.

PMID:
10387089
36.

Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases.

Horton NC, Newberry KJ, Perona JJ.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13489-94.

37.
38.

Cation binding to the integrin CD11b I domain and activation model assessment.

Baldwin ET, Sarver RW, Bryant GL Jr, Curry KA, Fairbanks MB, Finzel BC, Garlick RL, Heinrikson RL, Horton NC, Kelley LL, Mildner AM, Moon JB, Mott JE, Mutchler VT, Tomich CS, Watenpaugh KD, Wiley VH.

Structure. 1998 Jul 15;6(7):923-35.

40.
41.

Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P.

Science. 1996 Mar 1;271(5253):1247-54.

PMID:
8638105

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