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Items: 1 to 50 of 90


Equity and diversity in academic medicine: a perspective from the JCI editors.

Resar LM, Jaffee EM, Armanios M, Jackson S, Azad NS, Horton MR, Kaplan MJ, Laiho M, Maus MV, Sumner CJ, Wheelan SJ, Wills-Karp M.

J Clin Invest. 2019 Oct 1;129(10):3974-3977. doi: 10.1172/JCI130902. No abstract available.


Targeting metabolism to regulate immune responses in autoimmunity and cancer.

Patel CH, Leone RD, Horton MR, Powell JD.

Nat Rev Drug Discov. 2019 Sep;18(9):669-688. doi: 10.1038/s41573-019-0032-5. Epub 2019 Jul 30. Review.


Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.

Park JS, Oh Y, Park YJ, Park O, Yang H, Slania S, Hummers LK, Shah AA, An HT, Jang J, Horton MR, Shin J, Dietz HC, Song E, Na DH, Park EJ, Kim K, Lee KC, Roschke VV, Hanes J, Pomper MG, Lee S.

Nat Commun. 2019 Mar 8;10(1):1128. doi: 10.1038/s41467-019-09101-4.


Inhibition of glutamine metabolism accelerates resolution of acute lung injury.

Vigeland CL, Beggs HS, Collins SL, Chan-Li Y, Powell JD, Doerschuk CM, Horton MR.

Physiol Rep. 2019 Mar;7(5):e14019. doi: 10.14814/phy2.14019.


mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.

Oh MH, Collins SL, Sun IH, Tam AJ, Patel CH, Arwood ML, Chan-Li Y, Powell JD, Horton MR.

Cell Rep. 2017 Sep 5;20(10):2439-2454. doi: 10.1016/j.celrep.2017.08.046.


Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunction.

Gonzalez-Hurtado E, Lee J, Choi J, Selen Alpergin ES, Collins SL, Horton MR, Wolfgang MJ.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E381-E393. doi: 10.1152/ajpendo.00408.2016. Epub 2017 Feb 21.


Etiology and treatment of cough in idiopathic pulmonary fibrosis.

Vigeland CL, Hughes AH, Horton MR.

Respir Med. 2017 Feb;123:98-104. doi: 10.1016/j.rmed.2016.12.016. Epub 2016 Dec 24. Review.


mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis.

Hallowell RW, Collins SL, Craig JM, Zhang Y, Oh M, Illei PB, Chan-Li Y, Vigeland CL, Mitzner W, Scott AL, Powell JD, Horton MR.

Nat Commun. 2017 Jan 27;8:14208. doi: 10.1038/ncomms14208.


CNS-targeted autoimmunity leads to increased influenza mortality in mice.

Glenn JD, Smith MD, Xue P, Chan-Li Y, Collins S, Calabresi PA, Horton MR, Whartenby KA.

J Exp Med. 2017 Feb;214(2):297-307. doi: 10.1084/jem.20160517. Epub 2017 Jan 5.


Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.

Vigeland CL, Collins SL, Chan-Li Y, Hughes AH, Oh MH, Powell JD, Horton MR.

PLoS One. 2016 Sep 20;11(9):e0163288. doi: 10.1371/journal.pone.0163288. eCollection 2016.


Metabolic variations in normal and fibrotic human laryngotracheal-derived fibroblasts: A Warburg-like effect.

Ma G, Samad I, Motz K, Yin LX, Duvvuri MV, Ding D, Namba DR, Elisseeff JH, Horton MR, Hillel AT.

Laryngoscope. 2017 Mar;127(3):E107-E113. doi: 10.1002/lary.26254. Epub 2016 Sep 1.


Cough in idiopathic pulmonary fibrosis: more than just a nuisance.

Vigeland CL, Horton MR.

Lancet Respir Med. 2016 Aug;4(8):600-601. doi: 10.1016/S2213-2600(16)30150-3. Epub 2016 Jun 23. No abstract available.


Correction: Immunological Priming Requires Regulatory T Cells and IL-10-Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation.

Aggarwal NR, Tsushima K, Eto Y, Tripathi A, Mandke P, Mock JR, Garibaldi BT, Singer BD, Sidhaye VK, Horton MR, King LS, D'Alessio FR.

J Immunol. 2016 May 1;196(9):3963-5. doi: 10.4049/jimmunol.1600348. No abstract available.


Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.

Collins SL, Chan-Li Y, Oh M, Vigeland CL, Limjunyawong N, Mitzner W, Powell JD, Horton MR.

JCI Insight. 2016 Apr 7;1(4):e83116.


Dysregulated Macrophages Are Present in Bleomycin-Induced Murine Laryngotracheal Stenosis.

Hillel AT, Samad I, Ma G, Ding D, Sadtler K, Powell JD, Lane AP, Horton MR.

Otolaryngol Head Neck Surg. 2015 Aug;153(2):244-50. doi: 10.1177/0194599815589106. Epub 2015 Jun 17.


Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.

Leone RD, Horton MR, Powell JD.

Cancer Cell. 2015 Apr 13;27(4):435-6. doi: 10.1016/j.ccell.2015.03.014.


Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro.

Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, Horton MR, Hillel AT.

Otolaryngol Head Neck Surg. 2015 May;152(5):881-8. doi: 10.1177/0194599815573708. Epub 2015 Mar 9.


Measurement of the pressure-volume curve in mouse lungs.

Limjunyawong N, Fallica J, Horton MR, Mitzner W.

J Vis Exp. 2015 Jan 27;(95):52376. doi: 10.3791/52376.


Lovastatin Inhibits Low Molecular Weight Hyaluronan Induced Chemokine Expression via LFA-1 and Decreases Bleomycin-Induced Pulmonary Fibrosis.

Hamblin MJ, Eberlein M, Black K, Hallowell R, Collins S, Chan-Li Y, Horton MR.

Int J Biomed Sci. 2014 Sep;10(3):146-57.


An in situ, in vivo murine model for the study of laryngotracheal stenosis.

Hillel AT, Namba D, Ding D, Pandian V, Elisseeff JH, Horton MR.

JAMA Otolaryngol Head Neck Surg. 2014 Oct;140(10):961-6. doi: 10.1001/jamaoto.2014.1663.


A mouse model of chronic idiopathic pulmonary fibrosis.

Limjunyawong N, Mitzner W, Horton MR.

Physiol Rep. 2014 Feb 25;2(2):e00249. doi: 10.1002/phy2.249. eCollection 2014 Feb 1.


Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis.

Zhao H, Chan-Li Y, Collins SL, Zhang Y, Hallowell RW, Mitzner W, Horton MR.

BMC Pulm Med. 2014 Apr 18;14:64. doi: 10.1186/1471-2466-14-64.


The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.

Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD.

Nat Immunol. 2014 May;15(5):457-64. doi: 10.1038/ni.2867. Epub 2014 Apr 6.


Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.

Aggarwal NR, Tsushima K, Eto Y, Tripathi A, Mandke P, Mock JR, Garibaldi BT, Singer BD, Sidhaye VK, Horton MR, King LS, D'Alessio FR.

J Immunol. 2014 May 1;192(9):4453-4464. doi: 10.4049/jimmunol.1400146. Epub 2014 Mar 31. Erratum in: J Immunol. 2016 May 1;196(9):3963-5.


H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.

Fitzgerald R, DeSantiago B, Lee DY, Yang G, Kim JY, Foster DB, Chan-Li Y, Horton MR, Panettieri RA, Wang R, An SS.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):393-8. doi: 10.1016/j.bbrc.2014.02.129. Epub 2014 Mar 12.


Interstitial lung disease in patients with rheumatoid arthritis: spontaneous and drug induced.

Hallowell RW, Horton MR.

Drugs. 2014 Mar;74(4):443-50. doi: 10.1007/s40265-014-0190-z. Review.


An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.

Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA.

J Am Chem Soc. 2014 Mar 5;136(9):3370-3. doi: 10.1021/ja5006674. Epub 2014 Feb 24.


Egr3 induces a Th17 response by promoting the development of γδ T cells.

Parkinson RM, Collins SL, Horton MR, Powell JD.

PLoS One. 2014 Jan 24;9(1):e87265. doi: 10.1371/journal.pone.0087265. eCollection 2014.


Source of biomass cooking fuel determines pulmonary response to household air pollution.

Sussan TE, Ingole V, Kim JH, McCormick S, Negherbon J, Fallica J, Akulian J, Yarmus L, Feller-Kopman D, Wills-Karp M, Horton MR, Breysse PN, Agrawal A, Juvekar S, Salvi S, Biswal S.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):538-48. doi: 10.1165/rcmb.2013-0201OC.


Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway.

Black KE, Collins SL, Hagan RS, Hamblin MJ, Chan-Li Y, Hallowell RW, Powell JD, Horton MR.

J Inflamm (Lond). 2013 May 30;10(1):23. doi: 10.1186/1476-9255-10-23.


Author reply: To PMID 22986377.

Lechtzin N, Horton MR.

Ann Intern Med. 2013 Mar 19;158(6):498-9. doi: 10.7326/0003-4819-158-6-201303190-00016. No abstract available.


Validation of the Cough Quality-of-Life Questionnaire in patients with idiopathic pulmonary fibrosis.

Lechtzin N, Hilliard ME, Horton MR.

Chest. 2013 Jun;143(6):1745-1749. doi: 10.1378/chest.12-2870.


Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD.

PLoS One. 2012;7(11):e49801. doi: 10.1371/journal.pone.0049801. Epub 2012 Nov 15.


Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis.

Horton MR, Hallowell RW.

Drugs Today (Barc). 2012 Oct;48(10):661-71. doi: 10.1358/dot.2012.48.10.1855760. Review.


Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial.

Horton MR, Santopietro V, Mathew L, Horton KM, Polito AJ, Liu MC, Danoff SK, Lechtzin N.

Ann Intern Med. 2012 Sep 18;157(6):398-406. doi: 10.7326/0003-4819-157-6-201209180-00003.


Severe pulmonary hypertension in idiopathic nonspecific interstitial pneumonia.

Hallowell RW, Reed RM, Fraig M, Horton MR, Girgis RE.

Pulm Circ. 2012 Jan-Mar;2(1):101-6. doi: 10.4103/2045-8932.94842.


Pulmonary vaccination as a novel treatment for lung fibrosis.

Collins SL, Chan-Li Y, Hallowell RW, Powell JD, Horton MR.

PLoS One. 2012;7(2):e31299. doi: 10.1371/journal.pone.0031299. Epub 2012 Feb 17.


Regulation of immune responses by mTOR.

Powell JD, Pollizzi KN, Heikamp EB, Horton MR.

Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29. Review.


Rheumatoid arthritis-associated interstitial lung disease: diagnostic dilemma.

Hamblin MJ, Horton MR.

Pulm Med. 2011;2011:872120. doi: 10.1155/2011/872120. Epub 2011 Jun 4.


The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD.

Nat Immunol. 2011 Apr;12(4):295-303. doi: 10.1038/ni.2005. Epub 2011 Feb 27.


Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.

Collins SL, Black KE, Chan-Li Y, Ahn YH, Cole PA, Powell JD, Horton MR.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):675-83. doi: 10.1165/rcmb.2010-0387OC. Epub 2011 Jan 21.


Quieting T cells with Slfn2.

Horton MR, Powell JD.

Nat Immunol. 2010 Apr;11(4):281-2. doi: 10.1038/ni0410-281. Review. No abstract available.


Controlled nanometric phase transitions of phospholipid membranes by plasmonic heating of single gold nanoparticles.

Urban AS, Fedoruk M, Horton MR, Rädler JO, Stefani FD, Feldmann J.

Nano Lett. 2009 Aug;9(8):2903-8. doi: 10.1021/nl901201h.


Ascertainment of collagen vascular disease in patients presenting with interstitial lung disease.

Mittoo S, Gelber AC, Christopher-Stine L, Horton MR, Lechtzin N, Danoff SK.

Respir Med. 2009 Aug;103(8):1152-8. doi: 10.1016/j.rmed.2009.02.009. Epub 2009 Mar 21.


Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression.

Eberlein M, Scheibner KA, Black KE, Collins SL, Chan-Li Y, Powell JD, Horton MR.

J Inflamm (Lond). 2008 Nov 5;5:20. doi: 10.1186/1476-9255-5-20.


The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.

Scheibner KA, Boodoo S, Collins S, Black KE, Chan-Li Y, Zarek P, Powell JD, Horton MR.

Am J Respir Cell Mol Biol. 2009 Mar;40(3):251-9. doi: 10.1165/rcmb.2008-0168OC. Epub 2008 Aug 14.


Thalidomide inhibits the intractable cough of idiopathic pulmonary fibrosis.

Horton MR, Danoff SK, Lechtzin N.

Thorax. 2008 Aug;63(8):749. doi: 10.1136/thx.2008.098699. No abstract available.


Sleep quality and health-related quality of life in idiopathic pulmonary fibrosis.

Krishnan V, McCormack MC, Mathai SC, Agarwal S, Richardson B, Horton MR, Polito AJ, Collop NA, Danoff SK.

Chest. 2008 Oct;134(4):693-8. doi: 10.1378/chest.08-0173. Epub 2008 Jul 14.


Sorting of streptavidin protein coats on phase-separating model membranes.

Manley S, Horton MR, Lecszynski S, Gast AP.

Biophys J. 2008 Sep;95(5):2301-7. doi: 10.1529/biophysj.107.124024. Epub 2008 May 23.


Respiratory CSI: diagnosing occupationally related lung disease.

Horton MR.

South Med J. 2008 May;101(5):466. doi: 10.1097/SMJ.0b013e31816beaec. No abstract available.


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