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An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.

Dai S, Horton JR, Wilkinson AW, Gozani O, Zhang X, Cheng X.

J Biol Chem. 2020 Feb 28;295(9):2582-2589. doi: 10.1074/jbc.RA119.012319. Epub 2020 Jan 7.


Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å.

Horton JR, Yang J, Zhang X, Petronzio T, Fomenkov A, Wilson GG, Roberts RJ, Cheng X.

Nucleic Acids Res. 2020 Feb 20;48(3):1466-1478. doi: 10.1093/nar/gkz1195.


Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.

Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B.

Genes Dev. 2019 Dec 1;33(23-24):1702-1717. doi: 10.1101/gad.332395.119. Epub 2019 Nov 7.


The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site.

Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X.

Nat Commun. 2019 Oct 10;10(1):4600. doi: 10.1038/s41467-019-12498-7.


Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.

Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM.

J Cell Sci. 2019 Oct 9;132(19). pii: jcs231514. doi: 10.1242/jcs.231514.


Structural basis for the target specificity of actin histidine methyltransferase SETD3.

Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X.

Nat Commun. 2019 Aug 6;10(1):3541. doi: 10.1038/s41467-019-11554-6.


Structural basis of specific DNA binding by the transcription factor ZBTB24.

Ren R, Hardikar S, Horton JR, Lu Y, Zeng Y, Singh AK, Lin K, Coletta LD, Shen J, Lin Kong CS, Hashimoto H, Zhang X, Chen T, Cheng X.

Nucleic Acids Res. 2019 Sep 19;47(16):8388-8398. doi: 10.1093/nar/gkz557.


Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.

Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X.

Nucleic Acids Res. 2019 Sep 19;47(16):8375-8387. doi: 10.1093/nar/gkz381.


Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.

Milite C, Feoli A, Horton JR, Rescigno D, Cipriano A, Pisapia V, Viviano M, Pepe G, Amendola G, Novellino E, Cosconati S, Cheng X, Castellano S, Sbardella G.

J Med Chem. 2019 Mar 14;62(5):2666-2689. doi: 10.1021/acs.jmedchem.8b02008. Epub 2019 Feb 26.


SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O.

Nature. 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10.


Structural basis for effects of CpA modifications on C/EBPβ binding of DNA.

Yang J, Horton JR, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal RM, Cheng X.

Nucleic Acids Res. 2019 Feb 28;47(4):1774-1785. doi: 10.1093/nar/gky1264.


Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15.


KDM5 histone demethylases repress immune response via suppression of STING.

Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.

PLoS Biol. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. eCollection 2018 Aug.


Detecting and interpreting DNA methylation marks.

Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X.

Curr Opin Struct Biol. 2018 Dec;53:88-99. doi: 10.1016/ Epub 2018 Jul 19. Review.


DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins.

Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X.

Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 Mar 15.


Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.


Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.

Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X.

Nucleic Acids Res. 2018 May 4;46(8):3864-3877. doi: 10.1093/nar/gkx1274.


Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X.

Mol Cell. 2017 Jun 1;66(5):711-720.e3. doi: 10.1016/j.molcel.2017.05.004. Epub 2017 May 18.


Standardized Criteria for Palliative Care Consultation on a Solid Tumor Oncology Service Reduces Downstream Health Care Use.

Adelson K, Paris J, Horton JR, Hernandez-Tellez L, Ricks D, Morrison RS, Smith CB.

J Oncol Pract. 2017 May;13(5):e431-e440. doi: 10.1200/JOP.2016.016808. Epub 2017 Mar 17.


Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta.

Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X.

Nucleic Acids Res. 2017 Mar 17;45(5):2503-2515. doi: 10.1093/nar/gkx057.


State of Research on Palliative Care in Heart Failure as Evidenced by Published Literature, Conference Proceedings, and NIH Funding.

Xie K, Gelfman L, Horton JR, Goldstein NE.

J Card Fail. 2017 Feb;23(2):197-200. doi: 10.1016/j.cardfail.2016.10.013. Epub 2016 Oct 28. Review.


Developing triggers for the surgical intensive care unit for palliative care integration.

Finkelstein M, Goldstein NE, Horton JR, Eshak D, Lee EJ, Kohli-Seth R.

J Crit Care. 2016 Oct;35:7-11. doi: 10.1016/j.jcrc.2016.04.010. Epub 2016 Apr 23.


Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X.

Cell Chem Biol. 2016 Jul 21;23(7):769-781. doi: 10.1016/j.chembiol.2016.06.006. Epub 2016 Jul 14.


Evidence for Neurotoxicity Due to Morphine or Hydromorphone Use in Renal Impairment: A Systematic Review.

Lee KA, Ganta N, Horton JR, Chai E.

J Palliat Med. 2016 Nov;19(11):1179-1187. Epub 2016 Jul 11. Review.


Impact of Inpatient Palliative Care on Treatment Intensity for Patients with Serious Illness.

Horton JR, Morrison RS, Capezuti E, Hill J, Lee EJ, Kelley AS.

J Palliat Med. 2016 Sep;19(9):936-42. doi: 10.1089/jpm.2015.0240. Epub 2016 Jun 1.


Update in Hospice and Palliative Care.

Gray NA, Horton JR, Dionne-Odom JN, Smith CB, Johnson KS.

J Palliat Med. 2016 May;19(5):559-65. doi: 10.1089/jpm.2016.0034. Epub 2016 Apr 5.


Structural basis for human PRDM9 action at recombination hot spots.

Patel A, Horton JR, Wilson GG, Zhang X, Cheng X.

Genes Dev. 2016 Feb 1;30(3):257-65. doi: 10.1101/gad.274928.115.


Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X.

J Biol Chem. 2016 Feb 5;291(6):2631-46. doi: 10.1074/jbc.M115.698449. Epub 2015 Dec 8.


Update in hospice and palliative care.

Webb JA, Horton JR, Johnson K.

J Palliat Med. 2015 Jun;18(6):545-51. doi: 10.1089/jpm.2015.0070. Epub 2015 Apr 9. Review. No abstract available.


Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.

Horton JR, Zhang X, Blumenthal RM, Cheng X.

Nucleic Acids Res. 2015 Apr 30;43(8):4296-308. doi: 10.1093/nar/gkv251. Epub 2015 Apr 6.


Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity.

Zhu XC, Sarker R, Horton JR, Chakraborty M, Chen TE, Tse CM, Cha B, Donowitz M.

Am J Physiol Cell Physiol. 2015 May 1;308(9):C758-66. doi: 10.1152/ajpcell.00421.2014. Epub 2015 Feb 25.



Daugherty AB, Horton JR, Cheng X, Lutz S.

ACS Catal. 2015 Feb 6;5(2):892-899.


Amyloid-like assembly of the low complexity domain of yeast Nab3.

O'Rourke TW, Loya TJ, Head PE, Horton JR, Reines D.

Prion. 2015;9(1):34-47. doi: 10.1080/19336896.2014.997618. Epub 2015 Jan 22.


Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix.

Horton JR, Wang H, Mabuchi MY, Zhang X, Roberts RJ, Zheng Y, Wilson GG, Cheng X.

Nucleic Acids Res. 2014 Oct 29;42(19):12092-101. doi: 10.1093/nar/gku871. Epub 2014 Sep 27.


Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease.

Piccini JP, Al-Khatib SM, Wojdyla DM, Shaw LK, Horton JR, Lokhnygina Y, Anstrom KJ, DeWald T, Allen-LaPointe N, Steinberg BA, Thomas K, Daubert JP, Peterson ED.

Am J Cardiol. 2014 Sep 1;114(5):716-22. doi: 10.1016/j.amjcard.2014.06.004. Epub 2014 Jun 18.


Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.

Horton JR, Borgaro JG, Griggs RM, Quimby A, Guan S, Zhang X, Wilson GG, Zheng Y, Zhu Z, Cheng X.

Nucleic Acids Res. 2014 Jul;42(12):7947-59. doi: 10.1093/nar/gku497. Epub 2014 Jun 3.


Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI.

Horton JR, Nugent RL, Li A, Mabuchi MY, Fomenkov A, Cohen-Karni D, Griggs RM, Zhang X, Wilson GG, Zheng Y, Xu SY, Cheng X.

Sci Rep. 2014 Mar 7;4:4246. doi: 10.1038/srep04246.


Update in hospice and palliative care.

Roza KA, Horton JR, Johnson K, Anderson WG.

J Palliat Med. 2014 Mar;17(3):351-7. doi: 10.1089/jpm.2013.0577. Epub 2014 Feb 18. Review. No abstract available.


A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.

Goswami ND, Tsalik EL, Naggie S, Miller WC, Horton JR, Pfeiffer CD, Hicks CB.

Trials. 2014 Jan 22;15:31. doi: 10.1186/1745-6215-15-31.


Update in hospital palliative care.

Anderson WG, Flint LA, Horton JR, Johnson K, Mourad M, Sharpe BA.

J Hosp Med. 2013 Dec;8(12):715-20. doi: 10.1002/jhm.2110. Epub 2013 Nov 8. Review.


The state of infectious diseases clinical trials: a systematic review of

Goswami ND, Pfeiffer CD, Horton JR, Chiswell K, Tasneem A, Tsalik EL.

PLoS One. 2013 Oct 16;8(10):e77086. doi: 10.1371/journal.pone.0077086. eCollection 2013. Review.


Extrauterine listeriosis in the gravid mouse influences embryonic growth and development.

Suyemoto MM, Hamrick TS, Spears PA, Horton JR, Washington IM, Havell EA, Borst LB, Orndorff PE.

PLoS One. 2013 Aug 14;8(8):e72601. doi: 10.1371/journal.pone.0072601. eCollection 2013.


Association between hemoglobin level and cardiopulmonary performance in heart failure: insights from the HF-ACTION study.

Cohen-Solal A, Keteyian SJ, Horton JR, Ellis SJ, Kraus WE, Kilpatrick RD.

Int J Cardiol. 2013 Oct 9;168(4):4357-9. doi: 10.1016/j.ijcard.2013.05.070. Epub 2013 Jun 2. No abstract available.


Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients.

Pun PH, Horton JR, Middleton JP.

Clin J Am Soc Nephrol. 2013 May;8(5):797-803. doi: 10.2215/CJN.10000912. Epub 2013 Jan 31.


Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease.

Horton JR, Mabuchi MY, Cohen-Karni D, Zhang X, Griggs RM, Samaranayake M, Roberts RJ, Zheng Y, Cheng X.

Nucleic Acids Res. 2012 Oct;40(19):9763-73. doi: 10.1093/nar/gks719. Epub 2012 Jul 30.


MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.

Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X.

Nat Commun. 2011 Nov 15;2:533. doi: 10.1038/ncomms1549.


Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.

Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. doi: 10.1073/pnas.1100012108. Epub 2011 Sep 9.


Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.

Upadhyay AK, Horton JR, Zhang X, Cheng X.

Curr Opin Struct Biol. 2011 Dec;21(6):750-60. doi: 10.1016/ Epub 2011 Aug 25.


Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims.

Kociol RD, Horton JR, Fonarow GC, Reyes EM, Shaw LK, O'Connor CM, Felker GM, Hernandez AF.

Circ Heart Fail. 2011 Sep;4(5):628-36. doi: 10.1161/CIRCHEARTFAILURE.111.962290. Epub 2011 Jul 8.

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