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Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice.

Wang C, Arrington J, Ratliff AC, Chen J, Horton HE, Nie Y, Yue F, Hrycyna CA, Tao WA, Kuang S.

J Biol Chem. 2019 Sep 13;294(37):13718-13728. doi: 10.1074/jbc.RA119.008430. Epub 2019 Jul 25.


Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.

Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R.

Nat Commun. 2019 May 7;10(1):2087. doi: 10.1038/s41467-019-10097-0.


Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Leung WH, Gay J, Martin U, Garrett TE, Horton HM, Certo MT, Blazar BR, Morgan RA, Gregory PD, Jarjour J, Astrakhan A.

JCI Insight. 2019 Apr 30;5. pii: 124430. doi: 10.1172/jci.insight.124430.


Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.

McGowan DC, Herschke F, Khamlichi MD, Rosauro ML, Benedicto SMP, Pauwels F, Stoops B, Pande V, Scholliers A, Van Schoubroeck B, Mostmans W, Van Dijck K, Thoné T, Horton H, Fanning G, Jonckers THM, Raboisson P.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3216-3221. doi: 10.1016/j.bmcl.2018.08.015. Epub 2018 Aug 16.


2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.

Embrechts W, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Pande V, Pille G, Amssoms K, Smyej I, Dhuyvetter D, Scholliers A, Mostmans W, Van Dijck K, Van Schoubroeck B, Thone T, De Pooter D, Fanning G, Jonckers THM, Horton H, Raboisson P, McGowan D.

J Med Chem. 2018 Jul 26;61(14):6236-6246. doi: 10.1021/acs.jmedchem.8b00643. Epub 2018 Jul 17.


Effective Targeting of Multiple B-Cell Maturation Antigen-Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells.

Friedman KM, Garrett TE, Evans JW, Horton HM, Latimer HJ, Seidel SL, Horvath CJ, Morgan RA.

Hum Gene Ther. 2018 May;29(5):585-601. doi: 10.1089/hum.2018.001.


Precision-cut human liver slice cultures as an immunological platform.

Wu X, Roberto JB, Knupp A, Kenerson HL, Truong CD, Yuen SY, Brempelis KJ, Tuefferd M, Chen A, Horton H, Yeung RS, Crispe IN.

J Immunol Methods. 2018 Apr;455:71-79. doi: 10.1016/j.jim.2018.01.012. Epub 2018 Feb 1.


Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells.

Heffner GC, Bonner M, Christiansen L, Pierciey FJ, Campbell D, Smurnyy Y, Zhang W, Hamel A, Shaw S, Lewis G, Goss KA, Garijo O, Torbett BE, Horton H, Finer MH, Gregory PD, Veres G.

Mol Ther. 2018 Jan 3;26(1):320-328. doi: 10.1016/j.ymthe.2017.09.025. Epub 2017 Oct 5.


Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults.

Storey HL, Singa B, Naulikha J, Horton H, Richardson BA, John-Stewart G, Walson JL.

Parasite Epidemiol Control. 2017 Feb;2(1):13-20. doi: 10.1016/j.parepi.2016.12.003. Epub 2017 Jan 3.


Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.

McGowan DC, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, Pieters S, Embrechts W, Khamlichi MD, Thoné T, Van Schoubroeck B, Mostmans W, Wuyts D, Verstappen D, Scholliers A, De Pooter D, Dhuyvetter D, Borghys H, Tuefferd M, Arnoult E, Hong J, Fanning G, Bollekens J, Urmaliya V, Teisman A, Horton H, Jonckers THM, Raboisson P.

J Med Chem. 2017 Jul 27;60(14):6137-6151. doi: 10.1021/acs.jmedchem.7b00365. Epub 2017 Jul 14.


Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes.

Wang C, Liu W, Nie Y, Qaher M, Horton HE, Yue F, Asakura A, Kuang S.

EBioMedicine. 2017 Feb;16:212-223. doi: 10.1016/j.ebiom.2017.01.015. Epub 2017 Jan 13.


Kinetics of Myeloid-Derived Suppressor Cell Frequency and Function during Simian Immunodeficiency Virus Infection, Combination Antiretroviral Therapy, and Treatment Interruption.

Dross SE, Munson PV, Kim SE, Bratt DL, Tunggal HC, Gervassi AL, Fuller DH, Horton H.

J Immunol. 2017 Jan 15;198(2):757-766. doi: 10.4049/jimmunol.1600759. Epub 2016 Dec 14.


Power and pollutant exposure in the context of American Indian health and survival.

Schell LM, Gallo MV, Horton HD.

Ann Hum Biol. 2016;43(2):107-14. doi: 10.3109/03014460.2016.1146333. Epub 2016 Feb 24. Review.


A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.

Siegel CA, Horton H, Siegel LS, Thompson KD, Mackenzie T, Stewart SK, Rice PW, Stempak JM, Dezfoli S, Haritunians T, Levy A, Baek M, Milgrom R, Dulai PS, Targan SR, Silverberg MS, Dubinsky MC, McGovern DP.

Aliment Pharmacol Ther. 2016 Jan;43(2):262-71. doi: 10.1111/apt.13460. Epub 2015 Nov 15.


Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease.

Dezfoli S, Horton HA, Thepyasuwan N, Berel D, Targan SR, Vasiliauskas EA, Dubinsky M, Shih DQ, Kaur M, McGovern DP, Ippoliti A, Feldman EJ, Melmed GY.

Inflamm Bowel Dis. 2015 Aug;21(8):1754-60. doi: 10.1097/MIB.0000000000000448.


Is Infant Immunity Actively Suppressed or Immature?

Gervassi AL, Horton H.

Virology (Auckl). 2014;2014(5):1-9.


Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses.

Gervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, Gantt S, Jaspan H, Horton H.

PLoS One. 2014 Sep 23;9(9):e107816. doi: 10.1371/journal.pone.0107816. eCollection 2014.


The role of myeloid-derived suppressor cells in immune ontogeny.

Gantt S, Gervassi A, Jaspan H, Horton H.

Front Immunol. 2014 Aug 13;5:387. doi: 10.3389/fimmu.2014.00387. eCollection 2014. Review.


Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease.

Horton HA, Dezfoli S, Berel D, Hirsch J, Ippoliti A, McGovern D, Kaur M, Shih D, Dubinsky M, Targan SR, Fleshner P, Vasiliauskas EA, Grein J, Murthy R, Melmed GY.

Antimicrob Agents Chemother. 2014 Sep;58(9):5054-9. doi: 10.1128/AAC.02606-13. Epub 2014 Jun 9.


Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.

Gasper MA, Kunwar P, Itaya G, Lejarcegui N, Bosire R, Maleche-Obimbo E, Wamalwa D, Slyker J, Overbaugh J, Horton H, Sodora DL, John-Stewart G, Lohman-Payne B.

AIDS. 2014 May 15;28(8):1115-24. doi: 10.1097/QAD.0000000000000263.


Vaccinations in older adults with gastrointestinal diseases.

Horton HA, Kim H, Melmed GY.

Clin Geriatr Med. 2014 Feb;30(1):17-28. doi: 10.1016/j.cger.2013.10.002. Review.


Use of principal components analysis and protein microarray to explore the association of HIV-1-specific IgG responses with disease progression.

Gerns Storey HL, Richardson BA, Singa B, Naulikha J, Prindle VC, Diaz-Ochoa VE, Felgner PL, Camerini D, Horton H, John-Stewart G, Walson JL.

AIDS Res Hum Retroviruses. 2014 Jan;30(1):37-44. doi: 10.1089/AID.2013.0088. Epub 2013 Dec 9.


Vaccine-induced gag-specific T cells are associated with reduced viremia after HIV-1 infection.

Janes H, Friedrich DP, Krambrink A, Smith RJ, Kallas EG, Horton H, Casimiro DR, Carrington M, Geraghty DE, Gilbert PB, McElrath MJ, Frahm N.

J Infect Dis. 2013 Oct 15;208(8):1231-9. doi: 10.1093/infdis/jit322. Epub 2013 Jul 21.


HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

Hertz T, Ahmed H, Friedrich DP, Casimiro DR, Self SG, Corey L, McElrath MJ, Buchbinder S, Horton H, Frahm N, Robertson MN, Graham BS, Gilbert P.

PLoS Pathog. 2013;9(6):e1003404. doi: 10.1371/journal.ppat.1003404. Epub 2013 Jun 20.


Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity.

Jacobson A, Bell F, Lejarcegui N, Mitchell C, Frenkel L, Horton H.

PLoS One. 2013 Jun 21;8(6):e67700. doi: 10.1371/journal.pone.0067700. Print 2013.


The role of phosphatase and tensin homolog in drug-induced gingival overgrowth.

Cetinkaya BO, Pamuk F, Keles GC, Ayas B, Ozfidan GK, Kayisli U, Arik N, Horton H.

J Periodontal Res. 2014 Jun;49(3):307-13. doi: 10.1111/jre.12108. Epub 2013 Jun 19.


Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine design.

Kunwar P, Hawkins N, Dinges WL, Liu Y, Gabriel EE, Swan DA, Stevens CE, Maenza J, Collier AC, Mullins JI, Hertz T, Yu X, Horton H.

PLoS One. 2013 May 31;8(5):e64405. doi: 10.1371/journal.pone.0064405. Print 2013.


Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.

Bernett MJ, Chu SY, Leung I, Moore GL, Lee SH, Pong E, Chen H, Phung S, Muchhal US, Horton HM, Lazar GA, Desjarlais JR, Szymkowski DE.

MAbs. 2013 May-Jun;5(3):384-96. doi: 10.4161/mabs.23976. Epub 2013 Apr 2.


Lactoferrin moderates LPS-induced hypotensive response and gut injury in rats.

Doursout MF, Horton H, Hoang L, Liang Y, Hwang SA, Boyd S, Actor JK, Kruzel ML.

Int Immunopharmacol. 2013 Feb;15(2):227-31. doi: 10.1016/j.intimp.2012.12.009. Epub 2012 Dec 23.


Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.

McClure J, Lovelace ES, Elahi S, Maurice NJ, Wagoner J, Dragavon J, Mittler JE, Kraft Z, Stamatatos L, Horton H, De Rosa SC, Coombs RW, Polyak SJ.

PLoS One. 2012;7(7):e41832. doi: 10.1371/journal.pone.0041832. Epub 2012 Jul 25. Erratum in: PLoS One. 2012;7(10). doi: 10.1371/annotation/78ba072a-6b7a-430a-8fcd-ef020e4fc458. Stamatatos, Leonidis [corrected to Stamatatos, Leonidas].


Association of HLA-alleles with the immune regulation of chronic viral infections.

Elahi S, Horton H.

Int J Biochem Cell Biol. 2012 Aug;44(8):1361-5. doi: 10.1016/j.biocel.2012.05.003. Epub 2012 May 14. Review.


Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection.

Elahi S, Niki T, Hirashima M, Horton H.

Blood. 2012 May 3;119(18):4192-204. doi: 10.1182/blood-2011-11-389585. Epub 2012 Mar 21.


Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.

Chu SY, Horton HM, Pong E, Leung IW, Chen H, Nguyen DH, Bautista C, Muchhal US, Bernett MJ, Moore GL, Szymkowski DE, Desjarlais JR.

J Allergy Clin Immunol. 2012 Apr;129(4):1102-15. doi: 10.1016/j.jaci.2011.11.029. Epub 2012 Jan 16.


Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.

Tai YT, Horton HM, Kong SY, Pong E, Chen H, Cemerski S, Bernett MJ, Nguyen DH, Karki S, Chu SY, Lazar GA, Munshi NC, Desjarlais JR, Anderson KC, Muchhal US.

Blood. 2012 Mar 1;119(9):2074-82. doi: 10.1182/blood-2011-06-364521. Epub 2012 Jan 13.


Protective HIV-specific CD8+ T cells evade Treg cell suppression.

Elahi S, Dinges WL, Lejarcegui N, Laing KJ, Collier AC, Koelle DM, McElrath MJ, Horton H.

Nat Med. 2011 Jul 17;17(8):989-95. doi: 10.1038/nm.2422. Erratum in: Nat Med. 2011 Sep;17(9):1153.


Moving towards a culture of inquiry.

Ender D, Adams W, Horton H, Hobbs LA, McLaurin R, Prasnikar MK.

J Cult Divers. 2011 Summer;18(2):55-9.


Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1.

Friedrich D, Jalbert E, Dinges WL, Sidney J, Sette A, Huang Y, McElrath MJ, Horton H.

J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):248-52. doi: 10.1097/QAI.0b013e318228f992.


Visual context processing deficits in schizophrenia: effects of deafness and disorganization.

Horton HK, Silverstein SM.

Schizophr Bull. 2011 Jul;37(4):716-26. doi: 10.1093/schbul/sbr055.


Factor structure of the BPRS in deaf people with schizophrenia: correlates to language and thought.

Horton HK, Silverstein SM.

Cogn Neuropsychiatry. 2011 May;16(3):256-83. doi: 10.1080/13546805.2010.538231. Epub 2011 Apr 8.


Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.

Horton HM, Chu SY, Ortiz EC, Pong E, Cemerski S, Leung IW, Jacob N, Zalevsky J, Desjarlais JR, Stohl W, Szymkowski DE.

J Immunol. 2011 Apr 1;186(7):4223-33. doi: 10.4049/jimmunol.1003412. Epub 2011 Feb 28.


Public health preparedness laws and policies: where do we go after pandemic 2009 H1N1 influenza?

O'Connor J, Jarris P, Vogt R, Horton H.

J Law Med Ethics. 2011 Mar;39 Suppl 1:51-5. doi: 10.1111/j.1748-720X.2011.00566.x. No abstract available.


Effects of workers' compensation on the diagnosis and surgical treatment of patients with hand and wrist disorders.

Day CS, Alexander M, Lal S, Horton H, Ahn CS, Pauyo T, Rozental TD.

J Bone Joint Surg Am. 2010 Oct 6;92(13):2294-9. doi: 10.2106/JBJS.I.00158.


Linguistic ability and mental health outcomes among deaf people with schizophrenia.

Horton HK.

J Nerv Ment Dis. 2010 Sep;198(9):634-42. doi: 10.1097/NMD.0b013e3181e9dd23.


Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies.

Horton HM, Bernett MJ, Peipp M, Pong E, Karki S, Chu SY, Richards JO, Chen H, Repp R, Desjarlais JR, Zhukovsky EA.

Blood. 2010 Oct 21;116(16):3004-12. doi: 10.1182/blood-2010-01-265280. Epub 2010 Jul 8.


Virus-specific CD8+ T-cell responses better define HIV disease progression than HLA genotype.

Dinges WL, Richardt J, Friedrich D, Jalbert E, Liu Y, Stevens CE, Maenza J, Collier AC, Geraghty DE, Smith J, Moodie Z, Mullins JI, McElrath MJ, Horton H.

J Virol. 2010 May;84(9):4461-8. doi: 10.1128/JVI.02438-09. Epub 2010 Feb 10.


Enhanced antibody half-life improves in vivo activity.

Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR.

Nat Biotechnol. 2010 Feb;28(2):157-9. doi: 10.1038/nbt.1601. Epub 2010 Jan 17.


Technique comparison for efficient orthodontic tooth measurements using digital models.

Horton HM, Miller JR, Gaillard PR, Larson BE.

Angle Orthod. 2010 Mar;80(2):254-61. doi: 10.2319/041709-219.1.


Functional properties and epitope characteristics of T-cells recognizing natural HIV-1 variants.

Malhotra U, Nolin J, Horton H, Li F, Corey L, Mullins JI, McElrath MJ.

Vaccine. 2009 Nov 12;27(48):6678-87. doi: 10.1016/j.vaccine.2009.08.093. Epub 2009 Sep 9.


Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia.

Horton HM, Bernett MJ, Pong E, Peipp M, Karki S, Chu SY, Richards JO, Vostiar I, Joyce PF, Repp R, Desjarlais JR, Zhukovsky EA.

Cancer Res. 2008 Oct 1;68(19):8049-57. doi: 10.1158/0008-5472.CAN-08-2268.

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