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Desiccation tolerance is associated with Staphylococcus aureus hypertransmissibility, resistance and infection development in the operating room.

Loftus RW, Dexter F, Robinson ADM, Horswill AR.

J Hosp Infect. 2018 Nov;100(3):299-308. doi: 10.1016/j.jhin.2018.06.020. Epub 2018 Jun 30.


Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.

Urbano R, Karlinsey JE, Libby SJ, Doulias PT, Ischiropoulos H, Warheit-Niemi HI, Liggitt DH, Horswill AR, Fang FC.

Cell Host Microbe. 2018 May 9;23(5):594-606.e7. doi: 10.1016/j.chom.2018.04.001.


Draft Genome Sequence of USA100 Methicillin-Resistant Staphylococcus aureus Strain 209.

Chen Y, Crosby HA, Oosthuysen WF 2nd, Diekema DJ, Kelley ST, Horswill AR.

Genome Announc. 2018 Jan 4;6(1). pii: e01399-17. doi: 10.1128/genomeA.01399-17.


Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing.

Paharik AE, Parlet CP, Chung N, Todd DA, Rodriguez EI, Van Dyke MJ, Cech NB, Horswill AR.

Cell Host Microbe. 2017 Dec 13;22(6):746-756.e5. doi: 10.1016/j.chom.2017.11.001. Epub 2017 Nov 30.


Identification of Staphylococcal Quorum Sensing Inhibitors by Quantification of õ-Hemolysin with High Performance Liquid Chromatography.

Quave CL, Horswill AR.

Methods Mol Biol. 2018;1673:363-370. doi: 10.1007/978-1-4939-7309-5_27.


Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation.

Mishra S, Horswill AR.

mSphere. 2017 Jun 21;2(3). pii: e00135-17. doi: 10.1128/mSphere.00135-17. eCollection 2017 May-Jun.


Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections.

Todd DA, Parlet CP, Crosby HA, Malone CL, Heilmann KP, Horswill AR, Cech NB.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00263-17. doi: 10.1128/AAC.00263-17. Print 2017 Aug.


The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine.

Nicholson TL, Brockmeier SL, Sukumar N, Paharik AE, Lister JL, Horswill AR, Kehrli ME Jr, Loving CL, Shore SM, Deora R.

Infect Immun. 2017 Jul 19;85(8). pii: e00261-17. doi: 10.1128/IAI.00261-17. Print 2017 Aug.


Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models.

Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL.

Sci Rep. 2017 Feb 10;7:42275. doi: 10.1038/srep42275.


The metalloprotease SepA governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in Staphylococcus epidermidis.

Paharik AE, Kotasinska M, Both A, Hoang TN, Büttner H, Roy P, Fey PD, Horswill AR, Rohde H.

Mol Microbiol. 2017 Mar;103(5):860-874. doi: 10.1111/mmi.13594. Epub 2017 Jan 26.


Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress.

Schaeffer CR, Hoang TN, Sudbeck CM, Alawi M, Tolo IE, Robinson DA, Horswill AR, Rohde H, Fey PD.

mSphere. 2016 Oct 5;1(5). pii: e00165-16. eCollection 2016 Sep-Oct.


The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia.

Paharik AE, Salgado-Pabon W, Meyerholz DK, White MJ, Schlievert PM, Horswill AR.

mSphere. 2016 Oct 12;1(5). pii: e00208-16. eCollection 2016 Sep-Oct.


Correction: Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance.

Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR.

PLoS One. 2016 Sep 22;11(9):e0163655. doi: 10.1371/journal.pone.0163655. eCollection 2016.


Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR.

J Med Chem. 2016 Oct 13;59(19):8879-8888. Epub 2016 Sep 15.


Staphylococcus aureus Aggregation and Coagulation Mechanisms, and Their Function in Host-Pathogen Interactions.

Crosby HA, Kwiecinski J, Horswill AR.

Adv Appl Microbiol. 2016;96:1-41. doi: 10.1016/bs.aambs.2016.07.018. Epub 2016 Aug 4. Review.


Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition.

Todd DA, Zich DB, Ettefagh KA, Kavanaugh JS, Horswill AR, Cech NB.

J Microbiol Methods. 2016 Aug;127:89-94. doi: 10.1016/j.mimet.2016.05.024. Epub 2016 May 26.


The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response.

Paharik AE, Horswill AR.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0022-2015. Review.


Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation.

Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE.

ACS Chem Biol. 2016 Jul 15;11(7):1982-91. doi: 10.1021/acschembio.6b00120. Epub 2016 May 18.


The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression.

Crosby HA, Schlievert PM, Merriman JA, King JM, Salgado-Pabón W, Horswill AR.

PLoS Pathog. 2016 May 4;12(5):e1005604. doi: 10.1371/journal.ppat.1005604. eCollection 2016 May.


Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development.

Kavanaugh JS, Horswill AR.

J Biol Chem. 2016 Jun 10;291(24):12556-64. doi: 10.1074/jbc.R116.722710. Epub 2016 Apr 21. Review.


Hyaluronan Modulation Impacts Staphylococcus aureus Biofilm Infection.

Ibberson CB, Parlet CP, Kwiecinski J, Crosby HA, Meyerholz DK, Horswill AR.

Infect Immun. 2016 May 24;84(6):1917-1929. doi: 10.1128/IAI.01418-15. Print 2016 Jun.


Staphylococcus aureus β-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis.

Herrera A, Vu BG, Stach CS, Merriman JA, Horswill AR, Salgado-Pabón W, Schlievert PM.

Biochemistry. 2016 May 3;55(17):2510-7. doi: 10.1021/acs.biochem.6b00083. Epub 2016 Apr 15.


Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms.

Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, Kaplan JB.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2639-51. doi: 10.1128/AAC.02070-15. Print 2016 May.


Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia.

Kiedrowski MR, Paharik AE, Ackermann LW, Shelton AU, Singh SB, Starner TD, Horswill AR.

Cell Microbiol. 2016 May;18(5):720-32. doi: 10.1111/cmi.12543. Epub 2016 Jan 12.


A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition.

Britton ER, Ibberson CB, Horswill AR, Cech NB.

J Microbiol Methods. 2015 Dec;119:163-7. doi: 10.1016/j.mimet.2015.10.019. Epub 2015 Oct 28.


Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.

Scherr TD, Hanke ML, Huang O, James DB, Horswill AR, Bayles KW, Fey PD, Torres VJ, Kielian T.

MBio. 2015 Aug 25;6(4). pii: e01021-15. doi: 10.1128/mBio.01021-15.


Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance.

Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR.

PLoS One. 2015 Aug 21;10(8):e0136486. doi: 10.1371/journal.pone.0136486. eCollection 2015. Erratum in: PLoS One. 2016;11(9):e0163655.


An 18 kDa scaffold protein is critical for Staphylococcus epidermidis biofilm formation.

Decker R, Burdelski C, Zobiak M, Büttner H, Franke G, Christner M, Saß K, Zobiak B, Henke HA, Horswill AR, Bischoff M, Bur S, Hartmann T, Schaeffer CR, Fey PD, Rohde H.

PLoS Pathog. 2015 Mar 23;11(3):e1004735. doi: 10.1371/journal.ppat.1004735. eCollection 2015 Mar.


ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR.

Antimicrob Agents Chemother. 2015 Apr;59(4):2223-35. doi: 10.1128/AAC.04564-14. Epub 2015 Feb 2.


Rot is a key regulator of Staphylococcus aureus biofilm formation.

Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR.

Mol Microbiol. 2015 Apr;96(2):388-404. doi: 10.1111/mmi.12943. Epub 2015 Feb 26.


Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses.

Parlet CP, Kavanaugh JS, Horswill AR, Schlueter AJ.

J Leukoc Biol. 2015 Apr;97(4):769-78. doi: 10.1189/jlb.4A0214-092R. Epub 2015 Jan 20.


Staphylococcus aureus biofilms: recent developments in biofilm dispersal.

Lister JL, Horswill AR.

Front Cell Infect Microbiol. 2014 Dec 23;4:178. doi: 10.3389/fcimb.2014.00178. eCollection 2014. Review.


Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence.

Quave CL, Horswill AR.

Front Microbiol. 2014 Dec 12;5:706. doi: 10.3389/fmicb.2014.00706. eCollection 2014. Review.


pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.

Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18703-8. doi: 10.1073/pnas.1422091112. Epub 2014 Dec 15.


Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model.

Schaeffer CR, Woods KM, Longo GM, Kiedrowski MR, Paharik AE, Büttner H, Christner M, Boissy RJ, Horswill AR, Rohde H, Fey PD.

Infect Immun. 2015 Jan;83(1):214-26. doi: 10.1128/IAI.02177-14. Epub 2014 Oct 20.


Temporal and stochastic control of Staphylococcus aureus biofilm development.

Moormeier DE, Bose JL, Horswill AR, Bayles KW.

MBio. 2014 Oct 14;5(5):e01341-14. doi: 10.1128/mBio.01341-14.


Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model.

DeLeon S, Clinton A, Fowler H, Everett J, Horswill AR, Rumbaugh KP.

Infect Immun. 2014 Nov;82(11):4718-28. doi: 10.1128/IAI.02198-14. Epub 2014 Aug 25.


Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization.

Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, Büttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR.

J Bacteriol. 2014 Oct;196(19):3482-93. doi: 10.1128/JB.01882-14. Epub 2014 Jul 28.


Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor.

Ibberson CB, Jones CL, Singh S, Wise MC, Hart ME, Zurawski DV, Horswill AR.

Infect Immun. 2014 Oct;82(10):4253-64. doi: 10.1128/IAI.01710-14. Epub 2014 Jul 28.


Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.

Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD.

PLoS Pathog. 2014 Jun 12;10(6):e1004174. doi: 10.1371/journal.ppat.1004174. eCollection 2014 Jun.


Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.

Figueroa M, Jarmusch AK, Raja HA, El-Elimat T, Kavanaugh JS, Horswill AR, Cooks RG, Cech NB, Oberlies NH.

J Nat Prod. 2014 Jun 27;77(6):1351-8. doi: 10.1021/np5000704. Epub 2014 Jun 9.


Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli.

Flack CE, Zurek OW, Meishery DD, Pallister KB, Malone CL, Horswill AR, Voyich JM.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2037-45. doi: 10.1073/pnas.1322125111. Epub 2014 Apr 29.


Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease.

Kiedrowski MR, Crosby HA, Hernandez FJ, Malone CL, McNamara JO 2nd, Horswill AR.

PLoS One. 2014 Apr 21;9(4):e95574. doi: 10.1371/journal.pone.0095574. eCollection 2014.


Quantification of confocal images of biofilms grown on irregular surfaces.

Sommerfeld Ross S, Tu MH, Falsetta ML, Ketterer MR, Kiedrowski MR, Horswill AR, Apicella MA, Reinhardt JM, Fiegel J.

J Microbiol Methods. 2014 May;100:111-20. doi: 10.1016/j.mimet.2014.02.020. Epub 2014 Mar 13.


Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.

Hernandez FJ, Huang L, Olson ME, Powers KM, Hernandez LI, Meyerholz DK, Thedens DR, Behlke MA, Horswill AR, McNamara JO 2nd.

Nat Med. 2014 Mar;20(3):301-6. doi: 10.1038/nm.3460. Epub 2014 Feb 2.


Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.

White MJ, Boyd JM, Horswill AR, Nauseef WM.

Infect Immun. 2014 Apr;82(4):1559-71. doi: 10.1128/IAI.01168-13. Epub 2014 Jan 22.


Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.

Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T.

PLoS One. 2013 Dec 30;8(12):e84089. doi: 10.1371/journal.pone.0084089. eCollection 2013.


The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis.

Walker JN, Crosby HA, Spaulding AR, Salgado-Pabón W, Malone CL, Rosenthal CB, Schlievert PM, Boyd JM, Horswill AR.

PLoS Pathog. 2013;9(12):e1003819. doi: 10.1371/journal.ppat.1003819. Epub 2013 Dec 19.


Small-molecule quorum quenchers to prevent Staphylococcus aureus infection.

Cech NB, Horswill AR.

Future Microbiol. 2013 Dec;8(12):1511-4. doi: 10.2217/fmb.13.134. No abstract available.


Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils.

Pang YY, Schwartz J, Bloomberg S, Boyd JM, Horswill AR, Nauseef WM.

J Innate Immun. 2014;6(3):353-64. doi: 10.1159/000355915. Epub 2013 Nov 15.

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