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Items: 1 to 50 of 129

1.

Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children.

Schuldt K, Ehmen C, Sievertsen J, Evans J, May J, Ansong D, Muntau B, Ruge G, Timmann C, Agbenyega T, Horstmann RD, Thye T.

G3 (Bethesda). 2017 Mar 10;7(3):859-864. doi: 10.1534/g3.116.036475.

2.

TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis.

Meyer CG, Reiling N, Ehmen C, Ruge G, Owusu-Dabo E, Horstmann RD, Thye T.

PLoS One. 2016 May 23;11(5):e0156046. doi: 10.1371/journal.pone.0156046. eCollection 2016.

3.

A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients.

Hölscher C, Heitmann L, Owusu-Dabo E, Horstmann RD, Meyer CG, Ehlers S, Thye T.

Mediators Inflamm. 2016;2016:4245028. doi: 10.1155/2016/4245028. Epub 2016 Feb 10.

4.

Beijing clades of Mycobacterium tuberculosis are associated with differential survival in HIV-negative Russian patients.

Balabanova Y, Nikolayevskyy V, Ignatyeva O, Kontsevaya I, Mironova S, Kovalyov A, Kritsky A, Rodionova Y, Fedorin I, Casali N, Hooper R, Horstmann RD, Nejentsev S, Hoffner S, Nuernberg P, Drobniewski F.

Infect Genet Evol. 2015 Dec;36:517-523. doi: 10.1016/j.meegid.2015.08.028. Epub 2015 Aug 28.

PMID:
26319998
5.

No significant impact of IFN-γ pathway gene variants on tuberculosis susceptibility in a West African population.

Meyer CG, Intemann CD, Förster B, Owusu-Dabo E, Franke A, Horstmann RD, Thye T.

Eur J Hum Genet. 2016 May;24(5):748-55. doi: 10.1038/ejhg.2015.172. Epub 2015 Aug 5.

6.

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.

Curtis J, Luo Y, Zenner HL, Cuchet-Lourenço D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S.

Nat Genet. 2015 May;47(5):523-527. doi: 10.1038/ng.3248. Epub 2015 Mar 16.

7.

Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children.

Schuldt K, Ehmen C, Evans J, May J, Ansong D, Sievertsen J, Muntau B, Ruge G, Agbenyega T, Horstmann RD.

PLoS One. 2014 Dec 26;9(12):e115770. doi: 10.1371/journal.pone.0115770. eCollection 2014.

8.

CCN1 mutation is associated with atrial septal defect.

Perrot A, Schmitt KR, Roth EM, Stiller B, Posch MG, Browne EN, Timmann C, Horstmann RD, Berger F, Özcelik C.

Pediatr Cardiol. 2015 Feb;36(2):295-9. doi: 10.1007/s00246-014-1001-8. Epub 2014 Aug 19.

PMID:
25135600
9.

Evolution and transmission of drug-resistant tuberculosis in a Russian population.

Casali N, Nikolayevskyy V, Balabanova Y, Harris SR, Ignatyeva O, Kontsevaya I, Corander J, Bryant J, Parkhill J, Nejentsev S, Horstmann RD, Brown T, Drobniewski F.

Nat Genet. 2014 Mar;46(3):279-86. doi: 10.1038/ng.2878. Epub 2014 Jan 26.

10.

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD.

Cell Microbiol. 2014 May;16(5):701-8. doi: 10.1111/cmi.12270. Epub 2014 Feb 24.

11.

The spectrum of β-thalassemia mutations in Gaza Strip, Palestine.

Sirdah MM, Sievertsen J, Al-Yazji MS, Tarazi IS, Al-Haddad RM, Horstmann RD, Timmann C.

Blood Cells Mol Dis. 2013 Apr;50(4):247-51. doi: 10.1016/j.bcmd.2012.12.004. Epub 2013 Jan 12.

PMID:
23321370
12.

Genome-wide association study indicates two novel resistance loci for severe malaria.

Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, Sievertsen J, Muntau B, Ruge G, Loag W, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Kwakye KO, Akoto AO, Sylverken J, Brendel M, Schuldt K, Loley C, Franke A, Meyer CG, Agbenyega T, Ziegler A, Horstmann RD.

Nature. 2012 Sep 20;489(7416):443-6. doi: 10.1038/nature11334. Epub 2012 Aug 15.

PMID:
22895189
13.

Common variants at 11p13 are associated with susceptibility to tuberculosis.

Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG.

Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

14.

Microevolution of extensively drug-resistant tuberculosis in Russia.

Casali N, Nikolayevskyy V, Balabanova Y, Ignatyeva O, Kontsevaya I, Harris SR, Bentley SD, Parkhill J, Nejentsev S, Hoffner SE, Horstmann RD, Brown T, Drobniewski F.

Genome Res. 2012 Apr;22(4):735-45. doi: 10.1101/gr.128678.111. Epub 2012 Jan 31.

15.

Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis.

Thye T, Niemann S, Walter K, Homolka S, Intemann CD, Chinbuah MA, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Rüsch-Gerdes S, Horstmann RD, Ehlers S, Meyer CG.

PLoS One. 2011;6(6):e20908. doi: 10.1371/journal.pone.0020908. Epub 2011 Jun 10.

16.

A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria.

Schuldt K, Kretz CC, Timmann C, Sievertsen J, Ehmen C, Esser C, Loag W, Ansong D, Dering C, Evans J, Ziegler A, May J, Krammer PH, Agbenyega T, Horstmann RD.

PLoS Genet. 2011 May;7(5):e1002066. doi: 10.1371/journal.pgen.1002066. Epub 2011 May 19.

17.

MCP1 haplotypes associated with protection from pulmonary tuberculosis.

Intemann CD, Thye T, Förster B, Owusu-Dabo E, Gyapong J, Horstmann RD, Meyer CG.

BMC Genet. 2011 Apr 19;12:34. doi: 10.1186/1471-2156-12-34.

18.

IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.

Meyer CG, Calixto Fernandes MH, Intemann CD, Kreuels B, Kobbe R, Kreuzberg C, Ayim M, Ruether A, Loag W, Ehmen C, Adjei S, Adjei O, Horstmann RD, May J.

Hum Mol Genet. 2011 Mar 15;20(6):1173-81. doi: 10.1093/hmg/ddq562. Epub 2011 Jan 10.

PMID:
21224257
19.

The new Powerplex® ESX17 and ESI17 kits in paternity and maternity analyses involving people from Africa--including allele frequencies for three African populations.

Poetsch M, Ergin Z, Bayer K, El-Mostaqim D, Rakotomavo N, Browne EN, Timmann C, Horstmann RD, Schwark T, von Wurmb-Schwark N.

Int J Legal Med. 2011 Jan;125(1):149-54. doi: 10.1007/s00414-010-0502-0. Epub 2010 Sep 9.

PMID:
20827485
20.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AVS.

Nat Genet. 2010 Sep;42(9):739-741. doi: 10.1038/ng.639. Epub 2010 Aug 8. Erratum in: Nat Genet. 2011 Oct;43(10):1040.

21.

Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana.

Homolka S, Meyer CG, Hillemann D, Owusu-Dabo E, Adjei O, Horstmann RD, Browne EN, Chinbuah A, Osei I, Gyapong J, Kubica T, Ruesch-Gerdes S, Niemann S.

Int J Med Microbiol. 2010 Nov;300(7):489-95. doi: 10.1016/j.ijmm.2010.04.019. Epub 2010 Jun 9.

PMID:
20538518
22.

Rare human IFNG variants.

Thye T, Ehmen C, Intemann CD, Chinbuah MA, Ziegler A, Horstmann RD, Meyer CG.

J Interferon Cytokine Res. 2010 Apr;30(4):219-22. doi: 10.1089/jir.2009.0042.

PMID:
20038203
23.

A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

Möller M, Flachsbart F, Till A, Thye T, Horstmann RD, Meyer CG, Osei I, van Helden PD, Hoal EG, Schreiber S, Nebel A, Franke A.

Am J Respir Crit Care Med. 2010 Feb 15;181(4):388-93. doi: 10.1164/rccm.200905-0678OC. Epub 2009 Dec 10.

24.

FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children.

Schuldt K, Esser C, Evans J, May J, Timmann C, Ehmen C, Loag W, Ansong D, Ziegler A, Agbenyega T, Meyer CG, Horstmann RD.

J Med Genet. 2010 Jul;47(7):471-5. doi: 10.1136/jmg.2009.073643. Epub 2009 Dec 3.

PMID:
19965803
25.

Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.

Intemann CD, Thye T, Niemann S, Browne EN, Amanua Chinbuah M, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Helm S, Rüsch-Gerdes S, Horstmann RD, Meyer CG.

PLoS Pathog. 2009 Sep;5(9):e1000577. doi: 10.1371/journal.ppat.1000577. Epub 2009 Sep 11.

26.

CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.

Thye T, Scarisbrick G, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rüsch-Gerdes S, Meyer CG, Horstmann RD.

PLoS One. 2009 Jul 17;4(7):e6307. doi: 10.1371/journal.pone.0006307.

27.

Genome-wide and fine-resolution association analysis of malaria in West Africa.

Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network.

Nat Genet. 2009 Jun;41(6):657-65. doi: 10.1038/ng.388. Epub 2009 May 24.

28.

IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

Thye T, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Brattig NW, Niemann S, Rüsch-Gerdes S, Horstmann RD, Meyer CG.

PLoS One. 2009;4(5):e5420. doi: 10.1371/journal.pone.0005420. Epub 2009 May 1.

29.

Genotyping of IRGM tetranucleotide promoter oligorepeats by fluorescence resonance energy transfer.

Intemann CD, Thye T, Sievertsen J, Owusu-Dabo E, Horstmann RD, Meyer CG.

Biotechniques. 2009 Jan;46(1):58-60.

30.

A structural variant of the human interferon-gamma gene.

Thye T, Intemann CD, Gyapong J, Horstmann RD, Meyer CG.

Tissue Antigens. 2009 Mar;73(3):287-8. doi: 10.1111/j.1399-0039.2008.01207.x.

PMID:
19254267
31.

MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa.

Thye T, Nejentsev S, Intemann CD, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Zeitels LR, Herb F, Horstmann RD, Meyer CG.

Hum Mol Genet. 2009 Jan 15;18(2):381-8. doi: 10.1093/hmg/ddn352. Epub 2008 Oct 20.

32.

Allele frequencies of 11 X-chromosomal loci in a population sample from Ghana.

Poetsch M, El-Mostaqim D, Tschentscher F, Browne EN, Timmann C, Horstmann RD, von Wurmb-Schwark N.

Int J Legal Med. 2009 Jan;123(1):81-3. doi: 10.1007/s00414-008-0251-5. Epub 2008 Jul 8.

PMID:
18607615
33.

Pulmonary tuberculosis: virulence of Mycobacterium africanum and relevance in HIV co-infection.

Meyer CG, Scarisbrick G, Niemann S, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Kubica T, Rüsch-Gerdes S, Thye T, Horstmann RD.

Tuberculosis (Edinb). 2008 Sep;88(5):482-9. doi: 10.1016/j.tube.2008.05.004. Epub 2008 Jun 30.

PMID:
18590979
34.

Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan.

Timmann C, van der Kamp E, Kleensang A, König IR, Thye T, Büttner DW, Hamelmann C, Marfo Y, Vens M, Brattig N, Ziegler A, Horstmann RD.

J Infect Dis. 2008 Aug 1;198(3):427-33. doi: 10.1086/589720.

PMID:
18558870
35.

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.

Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD.

Nat Genet. 2008 Mar;40(3):261-2; author reply 262-3. doi: 10.1038/ng0308-261. No abstract available.

PMID:
18305471
36.

ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.

Herb F, Thye T, Niemann S, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Werz O, Rüsch-Gerdes S, Horstmann RD, Meyer CG.

Hum Mol Genet. 2008 Apr 1;17(7):1052-60. doi: 10.1093/hmg/ddm378. Epub 2008 Jan 3.

PMID:
18174194
37.

Hemoglobin variants and disease manifestations in severe falciparum malaria.

May J, Evans JA, Timmann C, Ehmen C, Busch W, Thye T, Agbenyega T, Horstmann RD.

JAMA. 2007 May 23;297(20):2220-6.

PMID:
17519411
38.

Genome-wide linkage analysis of malaria infection intensity and mild disease.

Timmann C, Evans JA, König IR, Kleensang A, Rüschendorf F, Lenzen J, Sievertsen J, Becker C, Enuameh Y, Kwakye KO, Opoku E, Browne EN, Ziegler A, Nürnberg P, Horstmann RD.

PLoS Genet. 2007 Mar 23;3(3):e48.

39.

Capillary refill time as an independent prognostic indicator in severe and complicated malaria.

Evans JA, May J, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Osei-Kwakye K, Akoto AO, Ofori AO, Sambian D, Sylverken J, Busch W, Timmann C, Agbenyega T, Horstmann RD.

J Pediatr. 2006 Nov;149(5):676-81.

PMID:
17095342
40.

YAC/BAC contig spanning the MHC class III region of cattle.

Gelhaus A, Hess M, Förster B, Goldammer T, Schwerin M, Horstmann RD.

Cytogenet Genome Res. 2006;115(1):45-50.

PMID:
16974083
41.

Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality.

von Kalckreuth V, Evans JA, Timmann C, Kuhn D, Agbenyega T, Horstmann RD, May J.

J Infect Dis. 2006 Oct 1;194(7):949-57. Epub 2006 Aug 30.

PMID:
16960783
42.

Hereditary periodic fever with systemic amyloidosis: is hyper-IgD syndrome really a benign disease?

Siewert R, Ferber J, Horstmann RD, Specker C, Heering PJ, Timmann C.

Am J Kidney Dis. 2006 Sep;48(3):e41-5.

PMID:
16931207
43.

Mycobacterium tuberculosis drug resistance, Ghana.

Owusu-Dabo E, Adjei O, Meyer CG, Horstmann RD, Enimil A, Kruppa TF, Bonsu F, Browne EN, Chinbuah MA, Osei I, Gyapong J, Berberich C, Kubica T, Niemann S, Ruesch-Gerdes S.

Emerg Infect Dis. 2006 Jul;12(7):1171-2. No abstract available.

44.

No associations of human pulmonary tuberculosis with Sp110 variants.

Thye T, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rüsch-Gerdes S, Horstmann RD, Meyer CG.

J Med Genet. 2006 Jul;43(7):e32.

45.

Cerebral malaria is associated with IgG2 and IgG4 antibody responses to recombinant Plasmodium falciparum RIFIN antigen.

Schreiber N, Brattig N, Evans J, Tsiri Agbenyega, Horstmann RD, May J, Klinkert MQ.

Microbes Infect. 2006 Apr;8(5):1269-76. Epub 2006 Feb 6.

PMID:
16679041
46.

Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine.

Marks F, von Kalckreuth V, Kobbe R, Adjei S, Adjei O, Horstmann RD, Meyer CG, May J.

J Infect Dis. 2005 Dec 1;192(11):1962-5. Epub 2005 Oct 20. Erratum in: J Infect Dis. 2006 May 1;193(9):1340.

PMID:
16267768
47.

Pre-treatment with chloroquine and parasite chloroquine resistance in Ghanaian children with severe malaria.

Evans JA, May J, Tominski D, Eggelte T, Marks F, Abruquah HH, Meyer CG, Timmann C, Agbenyega T, Horstmann RD.

QJM. 2005 Nov;98(11):789-96. Epub 2005 Sep 26.

PMID:
16186171
48.

Diagnosis of alpha+-thalassemias by determining the ratio of the two alpha-globin gene copies by oligonucleotide hybridization and melting curve analysis.

Timmann C, Moenkemeyer F, Evans JA, Foerster B, Tannich E, Haase S, Sievertsen J, Kohne E, Horstmann RD.

Clin Chem. 2005 Sep;51(9):1711-3. No abstract available.

49.

High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of Ghana.

Marks F, Evans J, Meyer CG, Browne EN, Flessner C, von Kalckreuth V, Eggelte TA, Horstmann RD, May J.

Antimicrob Agents Chemother. 2005 Mar;49(3):1101-5.

50.

Relevance of ex vivo blood lymphocyte assay for in vivo lymphocyte function.

Brattig NW, Timmann C, Abraha RS, Lepping B, Müller-Myhsok B, Horstmann RD.

Clin Exp Immunol. 2005 Jan;139(1):127-31.

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