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Harmonization and Standardization of Panel-Based Tumor Mutational Burden (TMB) Measurement: Real-World Results and Recommendations of the QuIP Study.

Stenzinger A, Endris V, Budczies J, Merkelbach-Bruse S, Kazdal D, Dietmaier W, Pfarr N, Siebolts U, Hummel M, Herold S, Andreas J, Zoche M, Tögel L, Rempel E, Maas J, Merino D, Stewart M, Zaoui K, Schlesner M, Glimm H, Fröhling S, Allen J, Horst D, Baretton G, Wickenhauser C, Tiemann M, Evert M, Moch H, Kirchner T, Büttner R, Schirmacher P, Jung A, Haller F, Weichert W, Dietel M.

J Thorac Oncol. 2020 Feb 28. pii: S1556-0864(20)30135-0. doi: 10.1016/j.jtho.2020.01.023. [Epub ahead of print]


Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.

Hohenester S, Kanitz V, Kremer AE, Paulusma CC, Wimmer R, Kuehn H, Denk G, Horst D, Elferink RO, Beuers U.

Cells. 2020 Jan 23;9(2). pii: E281. doi: 10.3390/cells9020281.


Clinical Evidence on the Interaction Between MLK4, KRAS and Microsatellite Instability to Determine the Prognosis of Early-Stage Colorectal Carcinoma.

Brandl L, Horst D, Grünewald TGP, Mayerle J, Sendelhofert A, Neumann J, Kirchner T, De Toni EN.

Cell Physiol Biochem. 2019;53(5):820-831. doi: 10.33594/000000175.


Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy.

Trotsyuk I, Sparschuh H, Müller AJ, Neumann K, Kruschewski M, Horst D, Elezkurtaj S.

BMC Cancer. 2019 Nov 1;19(1):1033. doi: 10.1186/s12885-019-6261-5.


Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer.

Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W.

BMC Cancer. 2019 Nov 1;19(1):1030. doi: 10.1186/s12885-019-6270-4.


Testing NTRK testing: Wet-lab and in silico comparison of RNA-based targeted sequencing assays.

Pfarr N, Kirchner M, Lehmann U, Leichsenring J, Merkelbach-Bruse S, Glade J, Hummel M, Stögbauer F, Lehmann A, Trautmann M, Kumbrink J, Jung A, Dietmaier W, Endris V, Kazdal D, Evert M, Horst D, Kreipe H, Kirchner T, Wardelmann E, Lassen U, Büttner R, Weichert W, Dietel M, Schirmacher P, Stenzinger A.

Genes Chromosomes Cancer. 2020 Mar;59(3):178-188. doi: 10.1002/gcc.22819. Epub 2019 Nov 18.


Next generation sequencing of lung adenocarcinoma subtypes with intestinal differentiation reveals distinct molecular signatures associated with histomorphology and therapeutic options.

Jurmeister P, Vollbrecht C, Behnke A, Frost N, Arnold A, Treue D, Rückert JC, Neudecker J, Schweizer L, Klauschen F, Horst D, Hummel M, Dietel M, von Laffert M.

Lung Cancer. 2019 Dec;138:43-51. doi: 10.1016/j.lungcan.2019.10.005. Epub 2019 Oct 11.


RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer.

Elmasry M, Brandl L, Engel J, Jung A, Kirchner T, Horst D.

J Cancer. 2019 Aug 27;10(20):4883-4891. doi: 10.7150/jca.35180. eCollection 2019.


Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry.

Arnold A, Daum S, von Winterfeld M, Berg E, Hummel M, Horst D, Rau B, Stein U, Treese C.

Pathol Res Pract. 2019 Nov;215(11):152662. doi: 10.1016/j.prp.2019.152662. Epub 2019 Sep 19.


Sympathetic nerve tissue in milky spots of the human greater omentum.

Cleypool CGJ, Schurink B, van der Horst DEM, Bleys RLAW.

J Anat. 2020 Jan;236(1):156-164. doi: 10.1111/joa.13077. Epub 2019 Sep 9.


Papillary vs clear cell renal cell carcinoma. Differentiation and grading by iodine concentration using DECT-correlation with microvascular density.

Marcon J, Graser A, Horst D, Casuscelli J, Spek A, Stief CG, Reiser MF, Rübenthaler J, Buchner A, Staehler M.

Eur Radiol. 2020 Jan;30(1):1-10. doi: 10.1007/s00330-019-06298-2. Epub 2019 Jul 5.


Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.

Schulz GB, Grimm T, Sers C, Riemer P, Elmasry M, Kirchner T, Stief CG, Karl A, Horst D.

Urol Oncol. 2019 Aug;37(8):530.e9-530.e18. doi: 10.1016/j.urolonc.2019.05.011. Epub 2019 Jun 5.


In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer.

Spartalis C, Schmidt EM, Elmasry M, Schulz GB, Kirchner T, Horst D.

Cancer Sci. 2019 Aug;110(8):2529-2539. doi: 10.1111/cas.14077. Epub 2019 Jun 17.


The efficacy of treatment options for patients with gastric cancer and peritoneal metastasis.

Rau B, Brandl A, Thuss-Patience P, Bergner F, Raue W, Arnold A, Horst D, Pratschke J, Biebl M.

Gastric Cancer. 2019 Nov;22(6):1226-1237. doi: 10.1007/s10120-019-00969-1. Epub 2019 May 7.


Urinary Calprotectin loses specificity as tumour marker due to sterile leukocyturia associated with bladder cancer.

Bausch K, Roth E, Heinz S, Horst D, Mathia S, Vlajnic T, Bubendorf L, Westhoff T, Wetterauer C, Seifert HH, Ebbing J.

PLoS One. 2019 Mar 14;14(3):e0213549. doi: 10.1371/journal.pone.0213549. eCollection 2019.


DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer.

Jurmeister P, Schöler A, Arnold A, Klauschen F, Lenze D, Hummel M, Schweizer L, Bläker H, Pfitzner BM, Mamlouk S, Sers C, Denkert C, Stichel D, Frost N, Horst D, von Laffert M, Capper D.

Mod Pathol. 2019 Jun;32(6):855-865. doi: 10.1038/s41379-019-0207-y. Epub 2019 Feb 5.


Patient-Reported Experiences with a Relicensed Generic: Thioguanine for the Treatment of Inflammatory Bowel Diseases.

Simsek M, Markus-de Kwaadsteniet TML, van der Horst D, Mulder CJJ, de Boer NKH.

J Gastrointestin Liver Dis. 2018 Dec;27(4):385-389. doi: 10.15403/jgld.2014.1121.274.tor.


Cortisol, dehydroepiandrosterone sulfate, fatty acids, and their relation in recurrent depression.

Ter Horst DM, Schene AH, Figueroa CA, Assies J, Lok A, Bockting CLH, Ruhé HG, Mocking RJT.

Psychoneuroendocrinology. 2019 Feb;100:203-212. doi: 10.1016/j.psyneuen.2018.10.012. Epub 2018 Oct 19.


Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.

Jaeckel S, Kaller M, Jackstadt R, Götz U, Müller S, Boos S, Horst D, Jung P, Hermeking H.

Nat Commun. 2018 Sep 3;9(1):3573. doi: 10.1038/s41467-018-06001-x.


Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

Öner MG, Rokavec M, Kaller M, Bouznad N, Horst D, Kirchner T, Hermeking H.

Gastroenterology. 2018 Dec;155(6):1868-1882. doi: 10.1053/j.gastro.2018.08.011. Epub 2018 Aug 10.


Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.

Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.


Editorial: faecal incontinence-the hidden burden of inflammatory bowel diseases. Authors' reply.

Vollebregt PF, van Bodegraven AA, Markus-de Kwaadsteniet TML, van der Horst D, Felt-Bersma RJF.

Aliment Pharmacol Ther. 2018 Jun;47(12):1716-1717. doi: 10.1111/apt.14660. No abstract available.


Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.

Schmidt EM, Lamprecht S, Blaj C, Schaaf C, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.

J Exp Med. 2018 Jun 4;215(6):1693-1708. doi: 10.1084/jem.20171455. Epub 2018 May 16.


Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.

Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C.

Nat Commun. 2018 Apr 18;9(1):1523. doi: 10.1038/s41467-018-03925-2.


Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications.

Barth I, Schneider U, Grimm T, Karl A, Horst D, Gaisa NT, Knüchel R, Garczyk S.

Virchows Arch. 2018 May;472(5):749-758. doi: 10.1007/s00428-018-2354-9. Epub 2018 Apr 13.


Impacts of perianal disease and faecal incontinence on quality of life and employment in 1092 patients with inflammatory bowel disease.

Vollebregt PF, van Bodegraven AA, Markus-de Kwaadsteniet TML, van der Horst D, Felt-Bersma RJF.

Aliment Pharmacol Ther. 2018 May;47(9):1253-1260. doi: 10.1111/apt.14599. Epub 2018 Mar 9.


PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer.

Lamprecht S, Kaller M, Schmidt EM, Blaj C, Schiergens TS, Engel J, Jung A, Hermeking H, Grünewald TGP, Kirchner T, Horst D.

Clin Cancer Res. 2018 Apr 15;24(8):1974-1986. doi: 10.1158/1078-0432.CCR-17-2572. Epub 2018 Feb 1.


Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.

Canli Ö, Nicolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR.

Cancer Cell. 2017 Dec 11;32(6):869-883.e5. doi: 10.1016/j.ccell.2017.11.004.


Volunteer patients and small groups contribute to abdominal examination's success.

Shields HM, Fernandez-Becker NQ, Flier SN, Vaughn BP, Tukey MH, Pelletier SR, Horst DA.

Adv Med Educ Pract. 2017 Nov 1;8:721-729. doi: 10.2147/AMEP.S146500. eCollection 2017.


Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.

Lamprecht S, Schmidt EM, Blaj C, Hermeking H, Jung A, Kirchner T, Horst D.

Nat Commun. 2017 Nov 10;8(1):1406. doi: 10.1038/s41467-017-00976-9.


Bioactive Potential of 3D-Printed Oleo-Gum-Resin Disks: B. papyrifera, C. myrrha, and S. benzoin Loading Nanooxides-TiO2, P25, Cu2O, and MoO3.

Horst DJ, Tebcherani SM, Kubaski ET, de Almeida Vieira R.

Bioinorg Chem Appl. 2017;2017:6398167. doi: 10.1155/2017/6398167. Epub 2017 Jul 25.


Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.

Rokavec M, Kaller M, Horst D, Hermeking H.

Sci Rep. 2017 Jul 5;7(1):4687. doi: 10.1038/s41598-017-04234-2.


Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.

Li H, Rokavec M, Jiang L, Horst D, Hermeking H.

Gastroenterology. 2017 Aug;153(2):505-520. doi: 10.1053/j.gastro.2017.04.017. Epub 2017 Apr 20.


[Primary prostatic sarcoma - a rare malignancy].

Herlemann A, Horst D, D'Anastasi M, Kretschmer A, Stief CG, Gratzke C.

Urologe A. 2017 Jul;56(7):857-860. doi: 10.1007/s00120-017-0370-z. Review. German.


Elastofibromatous Change in Association With Pneumatosis Intestinalis.

Jiang ZG, Matthew M, Yee EU, Horst D.

Am J Gastroenterol. 2017 Mar;112(3):1514. doi: 10.1038/ajg.2016.471. No abstract available.


Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations.

Blaj C, Schmidt EM, Lamprecht S, Hermeking H, Jung A, Kirchner T, Horst D.

Cancer Res. 2017 Apr 1;77(7):1763-1774. doi: 10.1158/0008-5472.CAN-16-2821. Epub 2017 Feb 15.


Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis.

Rokavec M, Horst D, Hermeking H.

Cancer Res. 2017 Apr 15;77(8):1854-1867. doi: 10.1158/0008-5472.CAN-16-3236. Epub 2017 Jan 27.


ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer.

Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich T, Arnold GJ, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.

Clin Cancer Res. 2017 Jun 1;23(11):2769-2780. doi: 10.1158/1078-0432.CCR-16-1604. Epub 2016 Nov 30.


Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.

Cejas P, Cavazza A, Yandava CN, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA.

Cancer Res. 2017 Feb 1;77(3):766-779. doi: 10.1158/0008-5472.CAN-16-1346. Epub 2016 Nov 29.


Identification of recurrent mutational events in anorectal melanoma.

Yang HM, Hsiao SJ, Schaeffer DF, Lai C, Remotti HE, Horst D, Mansukhani MM, Horst BA.

Mod Pathol. 2017 Feb;30(2):286-296. doi: 10.1038/modpathol.2016.179. Epub 2016 Oct 14.


In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.

Woischke C, Schaaf CW, Yang HM, Vieth M, Veits L, Geddert H, Märkl B, Stömmer P, Schaeffer DF, Frölich M, Blum H, Vosberg S, Greif PA, Jung A, Kirchner T, Horst D.

Mod Pathol. 2017 Jan;30(1):95-103. doi: 10.1038/modpathol.2016.150. Epub 2016 Sep 2.


A systematic quality assessment of Environmental Impact Statements in the oil and gas industry.

Anifowose B, Lawler DM, van der Horst D, Chapman L.

Sci Total Environ. 2016 Dec 1;572:570-585. doi: 10.1016/j.scitotenv.2016.07.083. Epub 2016 Aug 24.


CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.

Woischke C, Blaj C, Schmidt EM, Lamprecht S, Engel J, Hermeking H, Kirchner T, Horst D.

Oncotarget. 2016 May 24;7(21):31350-60. doi: 10.18632/oncotarget.8912.


Inflammatory pseudotumor (IPT)-surgical cure of an inflammatory syndrome.

Rack A, Belohradsky BH, Grantzow R, Schweinitz DV, Pfluger T, Kammer B, Girschick H, Horst D, Wintergerst U.

Eur J Pediatr. 2016 Jul;175(7):903-8. doi: 10.1007/s00431-016-2718-6. Epub 2016 Apr 12.


Pancreatic CSCs and microenvironment.

Ilmer M, Horst D.

Genes Cancer. 2015 Sep;6(9-10):365-6. No abstract available.


Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.

Ormanns S, Altendorf-Hofmann A, Jackstadt R, Horst D, Assmann G, Zhao Y, Bruns C, Kirchner T, Knösel T.

Br J Cancer. 2015 Nov 17;113(10):1460-6. doi: 10.1038/bjc.2015.362. Epub 2015 Oct 15.


ITF-2B protein levels are correlated with favorable prognosis in patients with colorectal carcinomas.

Brandl L, Horst D, de Toni E, Kirchner T, Herbst A, Kolligs FT.

Am J Cancer Res. 2015 Jun 15;5(7):2241-8. eCollection 2015.


Giant Cystic Arteriovenous Malformation of the Mesentery and the Role of Cross-Sectional Imaging in Occult Gastrointestinal Bleeding.

Thaker AM, Allard F, Goldsmith J, Smith M, Horst D, Tapper EB.

ACG Case Rep J. 2015 Apr 10;2(3):158-60. doi: 10.14309/crj.2015.40. eCollection 2015 Apr.


Viral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolution.

Verweij MC, Horst D, Griffin BD, Luteijn RD, Davison AJ, Ressing ME, Wiertz EJ.

PLoS Pathog. 2015 Apr 16;11(4):e1004743. doi: 10.1371/journal.ppat.1004743. eCollection 2015 Apr. Review.


Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.

J Clin Invest. 2015 Mar 2;125(3):1362. doi: 10.1172/JCI81340. Epub 2015 Mar 2. No abstract available.

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