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A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22).

Moon Y, Horsman DE, Humphries RK, Park G.

Immune Netw. 2013 Oct;13(5):222-6. doi: 10.4110/in.2013.13.5.222. Epub 2013 Oct 26.


SNP analysis of minimally evolved t(14;18)(q32;q21)-positive follicular lymphomas reveals a common copy-neutral loss of heterozygosity pattern.

Cheung KJ, Rogic S, Ben-Neriah S, Boyle M, Connors JM, Gascoyne RD, Horsman DE.

Cytogenet Genome Res. 2012;136(1):38-43. doi: 10.1159/000334265. Epub 2011 Nov 18.


Identification of a novel non-immunoglobulin/MYC translocation t(8;12)(q24;p12) involving the LRMP gene in a primary B-cell lymphoma. A case report.

Singh RR, Ben-Neriah S, Johnson NN, Connors JM, Gascoyne RD, Horsman DE.

Leuk Res. 2012 Jan;36(1):e22-4. doi: 10.1016/j.leukres.2011.09.020. Epub 2011 Oct 11. No abstract available.


Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.

Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA.

Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351.


Utility of array comparative genomic hybridization in cytogenetic analysis.

Singh RR, Cheung KJ, Horsman DE.

Methods Mol Biol. 2011;730:219-34. doi: 10.1007/978-1-61779-074-4_16.


MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD.

Nature. 2011 Mar 17;471(7338):377-81. doi: 10.1038/nature09754. Epub 2011 Mar 2.


Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.

Cheung KJ, Johnson NA, Affleck JG, Severson T, Steidl C, Ben-Neriah S, Schein J, Morin RD, Moore R, Shah SP, Qian H, Paul JE, Telenius A, Relander T, Lam W, Savage K, Connors JM, Brown C, Marra MA, Gascoyne RD, Horsman DE.

Cancer Res. 2010 Nov 15;70(22):9166-74. doi: 10.1158/0008-5472.CAN-10-2460. Epub 2010 Sep 30.


Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report.

Pacheco M, Horsman DE, Hayes MM, Clarkson PW, Huwait H, Nielsen TO.

Mol Cytogenet. 2010 Jul 2;3:12. doi: 10.1186/1755-8166-3-12.


Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.

Vercauteren SM, Sung S, Starczynowski DT, Lam WL, Bruyere H, Horsman DE, Tsang P, Leitch H, Karsan A.

Am J Clin Pathol. 2010 Jul;134(1):119-26. doi: 10.1309/AJCPH27ZIZEJLORF.


High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy-neutral loss of heterozygosity and copy number alterations that target single genes.

Cheung KJ, Delaney A, Ben-Neriah S, Schein J, Lee T, Shah SP, Cheung D, Johnson NA, Mungall AJ, Telenius A, Lai B, Boyle M, Connors JM, Gascoyne RD, Marra MA, Horsman DE.

Genes Chromosomes Cancer. 2010 Aug;49(8):669-81. doi: 10.1002/gcc.20780.


Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome.

Steidl C, Telenius A, Shah SP, Farinha P, Barclay L, Boyle M, Connors JM, Horsman DE, Gascoyne RD.

Blood. 2010 Jul 22;116(3):418-27. doi: 10.1182/blood-2009-12-257345. Epub 2010 Mar 25.


Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW, Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD, Marra MA.

Nat Genet. 2010 Feb;42(2):181-5. doi: 10.1038/ng.518. Epub 2010 Jan 17.


Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP.

Shustik J, Han G, Farinha P, Johnson NA, Ben Neriah S, Connors JM, Sehn LH, Horsman DE, Gascoyne RD, Steidl C.

Haematologica. 2010 Jan;95(1):96-101. doi: 10.3324/haematol.2009.007203. Epub 2009 Oct 1.


MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy.

Savage KJ, Johnson NA, Ben-Neriah S, Connors JM, Sehn LH, Farinha P, Horsman DE, Gascoyne RD.

Blood. 2009 Oct 22;114(17):3533-7. doi: 10.1182/blood-2009-05-220095. Epub 2009 Aug 24.


Validation of predictive models for germline mutations in DNA mismatch repair genes in colorectal cancer.

Monzon JG, Cremin C, Armstrong L, Nuk J, Young S, Horsman DE, Garbutt K, Bajdik CD, Gill S.

Int J Cancer. 2010 Feb 15;126(4):930-9. doi: 10.1002/ijc.24808.


Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival.

Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, Dyer MJ, Siebert R, Kuruvilla J, Klasa R, Connors JM, Gascoyne RD, Horsman DE.

Blood. 2009 Sep 10;114(11):2273-9. doi: 10.1182/blood-2009-03-212191. Epub 2009 Jul 13.


De novo transcriptome assembly with ABySS.

Birol I, Jackman SD, Nielsen CB, Qian JQ, Varhol R, Stazyk G, Morin RD, Zhao Y, Hirst M, Schein JE, Horsman DE, Connors JM, Gascoyne RD, Marra MA, Jones SJ.

Bioinformatics. 2009 Nov 1;25(21):2872-7. doi: 10.1093/bioinformatics/btp367. Epub 2009 Jun 15.


The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target.

Cheung KJ, Horsman DE, Gascoyne RD.

Br J Haematol. 2009 Aug;146(3):257-69. doi: 10.1111/j.1365-2141.2009.07739.x. Epub 2009 Jun 3. Review.


Model-based clustering of array CGH data.

Shah SP, Cheung KJ Jr, Johnson NA, Alain G, Gascoyne RD, Horsman DE, Ng RT, Murphy KP.

Bioinformatics. 2009 Jun 15;25(12):i30-8. doi: 10.1093/bioinformatics/btp205.


Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13.

Reece D, Song KW, Fu T, Roland B, Chang H, Horsman DE, Mansoor A, Chen C, Masih-Khan E, Trieu Y, Bruyere H, Stewart DA, Bahlis NJ.

Blood. 2009 Jul 16;114(3):522-5. doi: 10.1182/blood-2008-12-193458. Epub 2009 Mar 30.


The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A.

Blood. 2009 May 28;113(22):5536-48. doi: 10.1182/blood-2008-12-193037. Epub 2009 Mar 23.


Prognostic significance of secondary cytogenetic alterations in follicular lymphomas.

Johnson NA, Al-Tourah A, Brown CJ, Connors JM, Gascoyne RD, Horsman DE.

Genes Chromosomes Cancer. 2008 Dec;47(12):1038-48. doi: 10.1002/gcc.20606.


Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances.

Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, Telenius A, Lai B, Murphy KP, Lam W, Al-Tourah AJ, Connors JM, Ng RT, Gascoyne RD, Horsman DE.

Blood. 2009 Jan 1;113(1):137-48. doi: 10.1182/blood-2008-02-140616. Epub 2008 Aug 14.


High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.

Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A.

Blood. 2008 Oct 15;112(8):3412-24. doi: 10.1182/blood-2007-11-122028. Epub 2008 Jul 28.


Chromosomal alterations in oligodendroglial tumours over multiple surgeries: is tumour progression associated with change in 1p/19q status?

Campbell BA, Horsman DE, Maguire J, Young S, Curman D, Ma R, Thiessen B.

J Neurooncol. 2008 Aug;89(1):37-45. doi: 10.1007/s11060-008-9597-2. Epub 2008 May 6.


Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma.

Nelson M, Horsman DE, Weisenburger DD, Gascoyne RD, Dave BJ, Loberiza FR, Ludkovski O, Savage KJ, Armitage JO, Sanger WG.

Br J Haematol. 2008 May;141(4):461-9. doi: 10.1111/j.1365-2141.2008.07042.x. Epub 2008 Mar 12.


Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders.

Gallagher G, Horsman DE, Tsang P, Forrest DL.

Cancer Genet Cytogenet. 2008 Feb;181(1):46-51. doi: 10.1016/j.cancergencyto.2007.10.021.


Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.

Iqbal J, Greiner TC, Patel K, Dave BJ, Smith L, Ji J, Wright G, Sanger WG, Pickering DL, Jain S, Horsman DE, Shen Y, Fu K, Weisenburger DD, Hans CP, Campo E, Gascoyne RD, Rosenwald A, Jaffe ES, Delabie J, Rimsza L, Ott G, Müller-Hermelink HK, Connors JM, Vose JM, McKeithan T, Staudt LM, Chan WC; Leukemia/Lymphoma Molecular Profiling Project.

Leukemia. 2007 Nov;21(11):2332-43. Epub 2007 Jul 12.


Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

Ng TL, O'Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE.

J Mol Diagn. 2007 Sep;9(4):459-63. Epub 2007 Jul 9.


A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.

Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Küppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Solé F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R.

Leukemia. 2007 Jul;21(7):1532-44. Epub 2007 May 10.


A comprehensive analysis of common copy-number variations in the human genome.

Wong KK, deLeeuw RJ, Dosanjh NS, Kimm LR, Cheng Z, Horsman DE, MacAulay C, Ng RT, Brown CJ, Eichler EE, Lam WL.

Am J Hum Genet. 2007 Jan;80(1):91-104. Epub 2006 Dec 5.


Imatinib mesylate responsiveness in aggressive systemic mastocytosis: novel association with a platelet derived growth factor receptor beta mutation.

Dalal BI, Horsman DE, Bruyèrè H, Forrest DL.

Am J Hematol. 2007 Jan;82(1):77-9. No abstract available.


Cytogenetically balanced translocations are associated with focal copy number alterations.

Watson SK, deLeeuw RJ, Horsman DE, Squire JA, Lam WL.

Hum Genet. 2007 Feb;120(6):795-805. Epub 2006 Oct 19.


Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors.

Lin Y, Bruyère H, Horsman DE, Pantzar T, Barnett MJ, Hogge DE, Nevill TJ, Nantel SH, Sutherland HJ, Toze CL, Shepherd JD, Lavoie JC, Song KW, Smith CA, Forrest DL.

Cancer Genet Cytogenet. 2006 Oct 1;170(1):16-23.


Leukocyte count as a predictor of death during remission induction in acute myeloid leukemia.

Greenwood MJ, Seftel MD, Richardson C, Barbaric D, Barnett MJ, Bruyere H, Forrest DL, Horsman DE, Smith C, Song K, Sutherland HJ, Toze CL, Nevill TJ, Nantel SH, Hogge DE.

Leuk Lymphoma. 2006 Jul;47(7):1245-52.


Haematopoietic stem cell transplantation as primary therapy of sporadic adult Burkitt lymphoma.

Song KW, Barnett MJ, Gascoyne RD, Horsman DE, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Voss NJ, Toze CL, Connors JM.

Br J Haematol. 2006 Jun;133(6):634-7.


Genetic risk assessment and BRCA mutation testing.

Eisinger F, Horsman DE.

Ann Intern Med. 2006 Mar 7;144(5):376; author reply 376-7. No abstract available.


BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma.

Iqbal J, Neppalli VT, Wright G, Dave BJ, Horsman DE, Rosenwald A, Lynch J, Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Campo E, Ott G, Müller-Hermelink HK, Delabie J, Jaffe ES, Grogan TM, Connors JM, Vose JM, Armitage JO, Staudt LM, Chan WC.

J Clin Oncol. 2006 Feb 20;24(6):961-8. Epub 2006 Jan 17.


Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of Mantle Cell Lymphoma.

Tucker CA, Bebb G, Klasa RJ, Chhanabhai M, Lestou V, Horsman DE, Gascoyne RD, Wiestner A, Masin D, Bally M, Williams ME.

Leuk Res. 2006 Apr;30(4):449-57. Epub 2005 Sep 23.


Anaplastic large-cell lymphoma presenting as acute leukemia.

Dalal BI, Chhanabhai M, Horsman DE, LeHuquet J, Coupland R.

Am J Hematol. 2005 Jun;79(2):164-5. No abstract available.


Fluorescence in situ hybridization for the detection of t(X;18)(p11.2;q11.2) in a synovial sarcoma tissue microarray using a breakapart-style probe.

Terry J, Barry TS, Horsman DE, Hsu FD, Gown AM, Huntsman DG, Nielsen TO.

Diagn Mol Pathol. 2005 Jun;14(2):77-82.


Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas.

Knezevich S, Ludkovski O, Salski C, Lestou V, Chhanabhai M, Lam W, Klasa R, Connors JM, Dyer MJ, Gascoyne RD, Horsman DE.

Leukemia. 2005 Apr;19(4):659-63.


Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.

Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G, Farinha P, Horsman DE, Gascoyne RD.

Clin Cancer Res. 2005 Feb 1;11(3):1065-72.


Rapid determination of Epstein-Barr virus latent or lytic infection in single human cells using in situ hybridization.

Leenman EE, Panzer-Grümayer RE, Fischer S, Leitch HA, Horsman DE, Lion T, Gadner H, Ambros PF, Lestou VS.

Mod Pathol. 2004 Dec;17(12):1564-72.


BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.

Iqbal J, Sanger WG, Horsman DE, Rosenwald A, Pickering DL, Dave B, Dave S, Xiao L, Cao K, Zhu Q, Sherman S, Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Ott G, Müller-Hermelink HK, Delabie J, Braziel RM, Jaffe ES, Campo E, Lynch JC, Connors JM, Vose JM, Armitage JO, Grogan TM, Staudt LM, Chan WC.

Am J Pathol. 2004 Jul;165(1):159-66.


Correlation between karyotype and quantitative immunophenotype in acute myelogenous leukemia with t(8;21).

Khoury H, Dalal BI, Nantel SH, Horsman DE, Lavoie JC, Shepherd JD, Hogge DE, Toze CL, Song KW, Forrest DL, Sutherland HJ, Nevill TJ.

Mod Pathol. 2004 Oct;17(10):1211-6.


The spectrum of lymphoma with 8q24 aberrations: a clinical, pathological and cytogenetic study of 87 consecutive cases.

Au WY, Horsman DE, Gascoyne RD, Viswanatha DS, Klasa RJ, Connors JM.

Leuk Lymphoma. 2004 Mar;45(3):519-28.


A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma.

Makretsov N, He M, Hayes M, Chia S, Horsman DE, Sorensen PH, Huntsman DG.

Genes Chromosomes Cancer. 2004 Jun;40(2):152-7.


Delineation of a minimal region of deletion at 6q16.3 in follicular lymphoma and construction of a bacterial artificial chromosome contig spanning a 6-megabase region of 6q16-q21.

Henderson LJ, Okamoto I, Lestou VS, Ludkovski O, Robichaud M, Chhanabhai M, Gascoyne RD, Klasa RJ, Connors JM, Marra MA, Horsman DE, Lam WL.

Genes Chromosomes Cancer. 2004 May;40(1):60-5.


Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas.

Höglund M, Sehn L, Connors JM, Gascoyne RD, Siebert R, Säll T, Mitelman F, Horsman DE.

Genes Chromosomes Cancer. 2004 Mar;39(3):195-204.


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