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Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

Horsley AR, Alrumuh A, Bianco B, Bayfield K, Tomlinson J, Jones A, Maitra A, Cunningham S, Smith J, Fullwood C, Pandyan A, Gilchrist FJ.

PLoS One. 2020 Feb 25;15(2):e0229300. doi: 10.1371/journal.pone.0229300. eCollection 2020.


Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes.

Bayfield KJ, Horsley A, Alton E, Irving S, Bush A, Davies JC.

ERJ Open Res. 2019 Nov 4;5(4). pii: 00234-2018. doi: 10.1183/23120541.00234-2018. eCollection 2019 Oct.


Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome.

Driskel M, Horsley A, Fretwell L, Clayton N, Al-Aloul M.

ERJ Open Res. 2019 Oct 15;5(4). pii: 00164-2019. doi: 10.1183/23120541.00164-2019. eCollection 2019 Oct.


Tezacaftor and ivacaftor for the treatment of cystic fibrosis.

Paterson SL, Barry PJ, Horsley AR.

Expert Rev Respir Med. 2020 Jan;14(1):15-30. doi: 10.1080/17476348.2020.1682998. Epub 2019 Oct 31.


Composition of airway bacterial community correlates with chest HRCT in adults with bronchiectasis.

O'Neill K, Einarsson GG, Rowan S, McIlreavey L, Lee AJ, Lawson J, Lynch T, Horsley A, Bradley JM, Elborn JS, Tunney MM.

Respirology. 2020 Jan;25(1):64-70. doi: 10.1111/resp.13653. Epub 2019 Jul 30.


A novel method for infant multiple breath washout: First report in clinical practice.

Shawcross A, Murray CS, Pike K, Horsley A.

Pediatr Pulmonol. 2019 Aug;54(8):1284-1290. doi: 10.1002/ppul.24384. Epub 2019 Jun 18.


Implications of fatherhood in cystic fibrosis.

Bianco B, Horsley A, Brennan A.

Paediatr Respir Rev. 2019 Aug;31:18-20. doi: 10.1016/j.prrv.2019.02.008. Epub 2019 Mar 16.


Assessing arthritis in the context of cystic fibrosis.

Clarke EA, Watson P, Freeston JE, Peckham DG, Jones AM, Horsley A.

Pediatr Pulmonol. 2019 Jun;54(6):770-777. doi: 10.1002/ppul.24290. Epub 2019 Mar 5. Review.


Comment on Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis.

Horsley A, Nissenbaum C, Guglani L, Weiner D.

J Cyst Fibros. 2019 May;18(3):e26-e27. doi: 10.1016/j.jcf.2018.12.007. Epub 2019 Mar 2. No abstract available.


Precision public health to inhibit the contagion of disease and move toward a future in which microbes spread health.

Thaler DS, Head MG, Horsley A.

BMC Infect Dis. 2019 Feb 6;19(1):120. doi: 10.1186/s12879-019-3715-y. Review.


Modelling structural determinants of ventilation heterogeneity: A perturbative approach.

Whitfield CA, Horsley A, Jensen OE.

PLoS One. 2018 Nov 29;13(11):e0208049. doi: 10.1371/journal.pone.0208049. eCollection 2018.


Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride.

Whitfield CA, Jensen OE, Horsley A.

ERJ Open Res. 2018 Oct 19;4(4). pii: 00132-2018. doi: 10.1183/23120541.00132-2018. eCollection 2018 Oct.


Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout.

Smith LJ, Collier GJ, Marshall H, Hughes PJC, Biancardi AM, Wildman M, Aldag I, West N, Horsley A, Wild JM.

Eur Respir J. 2018 Nov 8;52(5). pii: 1800821. doi: 10.1183/13993003.00821-2018. Print 2018 Nov.


VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group.

N Engl J Med. 2018 Oct 25;379(17):1599-1611. doi: 10.1056/NEJMoa1807119. Epub 2018 Oct 18.


Feasibility and challenges of using multiple breath washout in COPD.

Bell AS, Lawrence PJ, Singh D, Horsley A.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 10;13:2113-2119. doi: 10.2147/COPD.S164285. eCollection 2018.


Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.

Robinson PD, Latzin P, Ramsey KA, Stanojevic S, Aurora P, Davis SD, Gappa M, Hall GL, Horsley A, Jensen R, Lum S, Milla C, Nielsen KG, Pittman JE, Rosenfeld M, Singer F, Subbarao P, Gustafsson PM, Ratjen F; ATS Assembly on Pediatrics.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):e1-e19. doi: 10.1164/rccm.201801-0074ST.


Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis.

Smith LJ, Macleod KA, Collier GJ, Horn FC, Sheridan H, Aldag I, Taylor CJ, Cunningham S, Wild JM, Horsley A.

PLoS One. 2017 Nov 27;12(11):e0188275. doi: 10.1371/journal.pone.0188275. eCollection 2017.


Simple Atomic Quantum Memory Suitable for Semiconductor Quantum Dot Single Photons.

Wolters J, Buser G, Horsley A, Béguin L, Jöckel A, Jahn JP, Warburton RJ, Treutlein P.

Phys Rev Lett. 2017 Aug 11;119(6):060502. doi: 10.1103/PhysRevLett.119.060502. Epub 2017 Aug 8.


Longitudinal Assessment of Children with Mild Cystic Fibrosis Using Hyperpolarized Gas Lung Magnetic Resonance Imaging and Lung Clearance Index.

Smith L, Marshall H, Aldag I, Horn F, Collier G, Hughes D, West N, Horsley A, Taylor CJ, Wild J.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):397-400. doi: 10.1164/rccm.201705-0894LE. No abstract available.


'Our Care through Our Eyes'. Impact of a co-produced digital educational programme on nurses' knowledge, confidence and attitudes in providing care for children and young people who have self-harmed: a mixed-methods study in the UK.

Manning JC, Carter T, Latif A, Horsley A, Cooper J, Armstrong M, Crew J, Wood D, Callaghan P, Wharrad H.

BMJ Open. 2017 May 4;7(4):e014750. doi: 10.1136/bmjopen-2016-014750.


Orkambi in patients with severe disease - Bumps in the road to CFTR modulation.

Horsley A, Barry P.

J Cyst Fibros. 2017 May;16(3):311-312. doi: 10.1016/j.jcf.2017.04.008. Epub 2017 Apr 20. No abstract available.


Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.

Marshall H, Horsley A, Taylor CJ, Smith L, Hughes D, Horn FC, Swift AJ, Parra-Robles J, Hughes PJ, Norquay G, Stewart NJ, Collier GJ, Teare D, Cunningham S, Aldag I, Wild JM.

Thorax. 2017 Aug;72(8):760-762. doi: 10.1136/thoraxjnl-2016-208948. Epub 2017 Mar 6.


Aspergillosis and the role of mucins in cystic fibrosis.

Cowley AC, Thornton DJ, Denning DW, Horsley A.

Pediatr Pulmonol. 2017 Apr;52(4):548-555. doi: 10.1002/ppul.23618. Epub 2016 Nov 21. Review.


Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis.

Elborn JS, Horsley A, MacGregor G, Bilton D, Grosswald R, Ahuja S, Springman EB.

Clin Transl Sci. 2017 Jan;10(1):28-34. doi: 10.1111/cts.12428. Epub 2016 Nov 2.


Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out.

Horsley AR, O'Neill K, Downey DG, Elborn JS, Bell NJ, Smith J, Owers-Bradley J.

ERJ Open Res. 2016 Jan 22;2(1). pii: 00042-2015. eCollection 2016 Jan.


Using social media to improve communication with people with cystic fibrosis.

Dale C, Reid N, Cox K, Jones A, Williams H, Shawcross A, Horsley A.

ERJ Open Res. 2016 Mar 29;2(1). pii: 00015-2016. eCollection 2016 Jan.


Challenge for a new era-importance of ensuring accuracy of genotype in cystic fibrosis registries.

Hartley CL, Barry PJ, Green H, Henchliffe J, Brock J, Tobi SE, Ramsden SC, Horsley AR.

J Cyst Fibros. 2016 Sep;15(5):e50-1. doi: 10.1016/j.jcf.2016.03.003. Epub 2016 Apr 9. No abstract available.


Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.

Horsley A, Jones AM, Lord R.

Cochrane Database Syst Rev. 2016 Jan 20;(1):CD009529. doi: 10.1002/14651858.CD009529.pub3. Review.


A benchmark survey of the common plants of South Northumberland and Durham, United Kingdom.

Groom QJ, Durkin JL, O'Reilly J, Mclay A, Richards AJ, Angel J, Horsley A, Rogers M, Young G.

Biodivers Data J. 2015 Dec 29;(3):e7318. doi: 10.3897/BDJ.3.e7318. eCollection 2015.


'Our Care through Our Eyes': a mixed-methods, evaluative study of a service-user, co-produced education programme to improve inpatient care of children and young people admitted following self-harm.

Manning JC, Latif A, Carter T, Cooper J, Horsley A, Armstrong M, Wharrad H.

BMJ Open. 2015 Dec 29;5(12):e009680. doi: 10.1136/bmjopen-2015-009680.


Commentaries on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate.

Zuo L, Pannell BK, Horsley A, Bell N, Kane M, Ratjen F, Thompson BR, Nilsen K.

J Appl Physiol (1985). 2015 Dec 15;119(12):1513-4. doi: 10.1152/japplphysiol.00747.2015. No abstract available.


Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants.

Shawcross A, Murray CS, Goddard N, Gupta R, Watson S, Horsley A.

Pediatr Pulmonol. 2016 May;51(5):491-7. doi: 10.1002/ppul.23348. Epub 2015 Dec 1.


Ventilation heterogeneity and the benefits and challenges of multiple breath washout testing in patients with cystic fibrosis.

Horsley A, Wild JM.

Paediatr Respir Rev. 2015 Oct;16 Suppl 1:15-8. doi: 10.1016/j.prrv.2015.07.010. Epub 2015 Sep 26. Review.


Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations.

Sonneveld N, Stanojevic S, Amin R, Aurora P, Davies J, Elborn JS, Horsley A, Latzin P, O'Neill K, Robinson P, Scrase E, Selvadurai H, Subbarao P, Welsh L, Yammine S, Ratjen F.

Eur Respir J. 2015 Oct;46(4):1055-64. doi: 10.1183/09031936.00211914. Epub 2015 Jul 9.


Discordance between clinical, physiological, and radiological measures in cystic fibrosis.

Barry PJ, Horsley AR.

Respirol Case Rep. 2014 Dec;2(4):129-31. doi: 10.1002/rcr2.69. Epub 2014 Sep 15.


Putting lung function and physiology into perspective: cystic fibrosis in adults.

Horsley A, Siddiqui S.

Respirology. 2015 Jan;20(1):33-45. doi: 10.1111/resp.12382. Epub 2014 Sep 15. Review.


Enhanced photoacoustic gas analyser response time and impact on accuracy at fast ventilation rates during multiple breath washout.

Horsley A, Macleod K, Gupta R, Goddard N, Bell N.

PLoS One. 2014 Jun 3;9(6):e98487. doi: 10.1371/journal.pone.0098487. eCollection 2014.


Lung clearance index in adults with non-cystic fibrosis bronchiectasis.

Gonem S, Scadding A, Soares M, Singapuri A, Gustafsson P, Ohri C, Range S, Brightling CE, Pavord I, Horsley A, Siddiqui S.

Respir Res. 2014 May 18;15:59. doi: 10.1186/1465-9921-15-59.


What is the importance of classifying Aspergillus disease in cystic fibrosis patients?

Jones AM, Horsley A, Denning DW.

Expert Rev Respir Med. 2014 Aug;8(4):389-92. doi: 10.1586/17476348.2014.915751. Epub 2014 May 29.


Reply: lung clearance index in primary ciliary dyskinesia and bronchiectasis.

Rowan S, Horsley A, Bradley J, Elborn JS.

Am J Respir Crit Care Med. 2014 May 1;189(9):1148-9. doi: 10.1164/rccm.201402-0328LE. No abstract available.


Effects of ivacaftor in patients with cystic fibrosis who carry the G551D mutation and have severe lung disease.

Barry PJ, Plant BJ, Nair A, Bicknell S, Simmonds NJ, Bell NJ, Shafi NT, Daniels T, Shelmerdine S, Felton I, Gunaratnam C, Jones AM, Horsley AR.

Chest. 2014 Jul;146(1):152-158. doi: 10.1378/chest.13-2397.


Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis.

Rowan SA, Bradley JM, Bradbury I, Lawson J, Lynch T, Gustafsson P, Horsley A, O'Neill K, Ennis M, Elborn JS.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):586-92. doi: 10.1164/rccm.201310-1747OC.


Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.

Horsley A, Rousseau K, Ridley C, Flight W, Jones A, Waigh TA, Thornton DJ.

J Cyst Fibros. 2014 May;13(3):260-6. doi: 10.1016/j.jcf.2013.11.002. Epub 2013 Dec 12.


Sweat chloride is not a useful marker of clinical response to Ivacaftor.

Barry PJ, Jones AM, Webb AK, Horsley AR.

Thorax. 2014 Jun;69(6):586-7. doi: 10.1136/thoraxjnl-2013-204532. Epub 2013 Nov 20.


Evaluation of the impact of alveolar nitrogen excretion on indices derived from multiple breath nitrogen washout.

Nielsen N, Nielsen JG, Horsley AR.

PLoS One. 2013 Sep 9;8(9):e73335. doi: 10.1371/journal.pone.0073335. eCollection 2013.


Author's response: heterogeneity of change in LCI in patients with cystic fibrosis following antibiotic treatment.

Horsley A.

Thorax. 2014 Feb;69(2):184. doi: 10.1136/thoraxjnl-2013-204359. Epub 2013 Sep 5. No abstract available.


Consensus statement for inert gas washout measurement using multiple- and single- breath tests.

Robinson PD, Latzin P, Verbanck S, Hall GL, Horsley A, Gappa M, Thamrin C, Arets HG, Aurora P, Fuchs SI, King GG, Lum S, Macleod K, Paiva M, Pillow JJ, Ranganathan S, Ratjen F, Singer F, Sonnappa S, Stocks J, Subbarao P, Thompson BR, Gustafsson PM.

Eur Respir J. 2013 Mar;41(3):507-22. doi: 10.1183/09031936.00069712. Epub 2013 Feb 8. Erratum in: Eur Respir J. 2013 Nov;42(5):1432. Ranganathan, Sarah [corrected to Ranganathan, Sarath].


Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation.

Horsley AR, Davies JC, Gray RD, Macleod KA, Donovan J, Aziz ZA, Bell NJ, Rainer M, Mt-Isa S, Voase N, Dewar MH, Saunders C, Gibson JS, Parra-Leiton J, Larsen MD, Jeswiet S, Soussi S, Bakar Y, Meister MG, Tyler P, Doherty A, Hansell DM, Ashby D, Hyde SC, Gill DR, Greening AP, Porteous DJ, Innes JA, Boyd AC, Griesenbach U, Cunningham S, Alton EW.

Thorax. 2013 Jun;68(6):532-9. doi: 10.1136/thoraxjnl-2012-202538. Epub 2013 Feb 9.


Itraconazole and inhaled fluticasone causing hypothalamic-pituitary-adrenal axis suppression in adults with cystic fibrosis.

Gilchrist FJ, Cox KJ, Rowe R, Horsley A, Webb AK, Jones AM, Bright-Thomas RJ.

J Cyst Fibros. 2013 Jul;12(4):399-402. doi: 10.1016/j.jcf.2012.10.007. Epub 2012 Dec 28.

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