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Items: 1 to 50 of 115

1.

Paramedic Disaster Health Management Competencies: A Scoping Review.

Horrocks P, Hobbs L, Tippett V, Aitken P.

Prehosp Disaster Med. 2019 May 28:1-8. doi: 10.1017/S1049023X19004357. [Epub ahead of print]

PMID:
31134873
2.

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays.

Berry SL, Hameed H, Thomason A, Maciej-Hulme ML, Saif Abou-Akkada S, Horrocks P, Price HP.

PLoS Negl Trop Dis. 2018 Jul 12;12(7):e0006639. doi: 10.1371/journal.pntd.0006639. eCollection 2018 Jul.

3.

Investigation of the antibiofilm capacity of peptide-modified stainless steel.

Cao P, Li WW, Morris AR, Horrocks PD, Yuan CQ, Yang Y.

R Soc Open Sci. 2018 Mar 7;5(3):172165. doi: 10.1098/rsos.172165. eCollection 2018 Mar.

4.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

Johnson-Ajinwo OR, Ullah I, Mbye H, Richardson A, Horrocks P, Li WW.

Bioorg Med Chem Lett. 2018 Apr 15;28(7):1219-1222. doi: 10.1016/j.bmcl.2018.02.051. Epub 2018 Feb 27.

PMID:
29519737
5.

G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets.

Harris LM, Monsell KR, Noulin F, Famodimu MT, Smargiasso N, Damblon C, Horrocks P, Merrick CJ.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01828-17. doi: 10.1128/AAC.01828-17. Print 2018 Mar.

6.

Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development.

Boyle MJ, Skidmore M, Dickerman B, Cooper L, Devlin A, Yates E, Horrocks P, Freeman C, Chai W, Beeson JG.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00709-17. doi: 10.1128/AAC.00709-17. Print 2017 Nov.

7.

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.

Aldulaimi O, Uche FI, Hameed H, Mbye H, Ullah I, Drijfhout F, Claridge TDW, Horrocks P, Li WW.

J Ethnopharmacol. 2017 Feb 23;198:221-225. doi: 10.1016/j.jep.2017.01.014. Epub 2017 Jan 9.

PMID:
28089716
8.

A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.

Ullah I, Sharma R, Biagini GA, Horrocks P.

J Antimicrob Chemother. 2017 Mar 1;72(3):717-726. doi: 10.1093/jac/dkw449.

PMID:
27999014
9.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

10.

Lemierre's Syndrome: Recognising a Typical Presentation of a Rare Condition.

Coultas JA, Bodasing N, Horrocks P, Cadwgan A.

Case Rep Infect Dis. 2015;2015:797415. doi: 10.1155/2015/797415. Epub 2015 Jan 27.

11.
12.

Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites.

Russell K, Cheng CH, Bizzaro JW, Ponts N, Emes RD, Le Roch K, Marx KA, Horrocks P.

BMC Genomics. 2014 Oct 3;15:848. doi: 10.1186/1471-2164-15-848.

13.

Enhancing paramedics procedural skills using a cadaveric model.

Lim D, Bartlett S, Horrocks P, Grant-Wakefield C, Kelly J, Tippett V.

BMC Med Educ. 2014 Jul 8;14:138. doi: 10.1186/1472-6920-14-138.

14.

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.

Horrocks P, Pickard MR, Parekh HH, Patel SP, Pathak RB.

Org Biomol Chem. 2013 Aug 7;11(29):4891-8. doi: 10.1039/c3ob27290g. Epub 2013 Jun 19.

PMID:
23779132
15.

Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum.

Russell K, Hasenkamp S, Emes R, Horrocks P.

BMC Genomics. 2013 Apr 19;14:267. doi: 10.1186/1471-2164-14-267.

16.

Functional analysis of the 5' untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum.

Hasenkamp S, Russell K, Ullah I, Horrocks P.

Acta Trop. 2013 Jul;127(1):69-74. doi: 10.1016/j.actatropica.2013.03.007. Epub 2013 Apr 6.

PMID:
23567550
17.

Evaluation of bioluminescence-based assays of anti-malarial drug activity.

Hasenkamp S, Sidaway A, Devine O, Roye R, Horrocks P.

Malar J. 2013 Feb 8;12:58. doi: 10.1186/1475-2875-12-58.

18.

A quantitative analysis of Plasmodium falciparum transfection using DNA-loaded erythrocytes.

Hasenkamp S, Merrick CJ, Horrocks P.

Mol Biochem Parasitol. 2013 Feb;187(2):117-20. doi: 10.1016/j.molbiopara.2013.01.001. Epub 2013 Jan 11.

PMID:
23313825
19.

Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum.

Hasenkamp S, Russell KT, Horrocks P.

Malar J. 2012 Jun 21;11:210. doi: 10.1186/1475-2875-11-210.

20.

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum.

Hasenkamp S, Wong EH, Horrocks P.

Malar J. 2012 Feb 10;11:42. doi: 10.1186/1475-2875-11-42.

21.

Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads.

Horrocks P, Fallon S, Denman L, Devine O, Duffy LJ, Harper A, Meredith EL, Hasenkamp S, Sidaway A, Monnery D, Phillips TR, Allin SM.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1770-3. doi: 10.1016/j.bmcl.2011.12.071. Epub 2011 Dec 21.

PMID:
22264480
22.

Developing novel strategies to prevent parasitic infections.

Staines HM, Croft SL, Horrocks PD.

Expert Rev Anti Infect Ther. 2011 Jul;9(7):783-5. doi: 10.1586/eri.11.62.

PMID:
21810050
23.

Analysis of the molecular mechanisms governing the stage-specific expression of a prototypical housekeeping gene during intraerythrocytic development of P. falciparum.

Wong EH, Hasenkamp S, Horrocks P.

J Mol Biol. 2011 Apr 29;408(2):205-21. doi: 10.1016/j.jmb.2011.02.043. Epub 2011 Feb 24.

24.

Control of gene expression in Plasmodium falciparum - ten years on.

Horrocks P, Wong E, Russell K, Emes RD.

Mol Biochem Parasitol. 2009 Mar;164(1):9-25. doi: 10.1016/j.molbiopara.2008.11.010. Epub 2008 Dec 6.

PMID:
19110008
25.

Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.

Ponts N, Yang J, Chung DW, Prudhomme J, Girke T, Horrocks P, Le Roch KG.

PLoS One. 2008 Jun 11;3(6):e2386. doi: 10.1371/journal.pone.0002386.

26.

Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation.

Kyes S, Christodoulou Z, Pinches R, Kriek N, Horrocks P, Newbold C.

Mol Microbiol. 2007 Feb;63(4):1237-47.

27.

LC/ESI-MS demonstrates the absence of 5-methyl-2'-deoxycytosine in Plasmodium falciparum genomic DNA.

Choi SW, Keyes MK, Horrocks P.

Mol Biochem Parasitol. 2006 Dec;150(2):350-2. Epub 2006 Jul 28. No abstract available.

PMID:
16934885
28.

Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.

Frankland S, Adisa A, Horrocks P, Taraschi TF, Schneider T, Elliott SR, Rogerson SJ, Knuepfer E, Cowman AF, Newbold CI, Tilley L.

Eukaryot Cell. 2006 May;5(5):849-60.

29.

Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays.

Carret CK, Horrocks P, Konfortov B, Winzeler E, Qureshi M, Newbold C, Ivens A.

Mol Biochem Parasitol. 2005 Dec;144(2):177-86. Epub 2005 Sep 8.

PMID:
16174539
30.

Pexel/VTS: a protein-export motif in erythrocytes infected with malaria parasites.

Horrocks P, Muhia D.

Trends Parasitol. 2005 Sep;21(9):396-9. Review.

PMID:
16046186
31.

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu AB, Fidock DA.

EMBO J. 2005 Jul 6;24(13):2294-305. Epub 2005 Jun 9.

32.

PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.

Horrocks P, Pinches RA, Chakravorty SJ, Papakrivos J, Christodoulou Z, Kyes SA, Urban BC, Ferguson DJ, Newbold CI.

J Cell Sci. 2005 Jun 1;118(Pt 11):2507-18.

33.

Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria.

Makanga M, Bray PG, Horrocks P, Ward SA.

Proteomics. 2005 May;5(7):1849-58.

PMID:
15832369
34.

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

Smith KJ, Carter PS, Bridges A, Horrocks P, Lewis C, Pettman G, Clarke A, Brown M, Hughes J, Wilkinson M, Bax B, Reith A.

Structure. 2004 Jun;12(6):1067-77.

35.

Variable var transition rates underlie antigenic variation in malaria.

Horrocks P, Pinches R, Christodoulou Z, Kyes SA, Newbold CI.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11129-34. Epub 2004 Jul 15.

36.

Transcription of subtelomerically located var gene variant in Plasmodium falciparum appears to require the truncation of an adjacent var gene.

Horrocks P, Kyes S, Pinches R, Christodoulou Z, Newbold C.

Mol Biochem Parasitol. 2004 Apr;134(2):193-9.

PMID:
15003839
37.

Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes.

Kriek N, Tilley L, Horrocks P, Pinches R, Elford BC, Ferguson DJ, Lingelbach K, Newbold CI.

Mol Microbiol. 2003 Nov;50(4):1215-27.

38.

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA.

J Biol Chem. 2003 Aug 29;278(35):33593-601. Epub 2003 Jun 17.

39.

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.

Kyes SA, Christodoulou Z, Raza A, Horrocks P, Pinches R, Rowe JA, Newbold CI.

Mol Microbiol. 2003 Jun;48(5):1339-48.

40.

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG.

Nature. 2002 Oct 3;419(6906):527-31.

PMID:
12368867
41.

Stage-specific promoter activity from stably maintained episomes in Plasmodium falciparum.

Horrocks P, Pinches R, Kriek N, Newbold C.

Int J Parasitol. 2002 Sep;32(10):1203-6.

PMID:
12204219
42.

Effect of var gene disruption on switching in Plasmodium falciparum.

Horrocks P, Pinches R, Kyes S, Kriek N, Lee S, Christodoulou Z, Newbold CI.

Mol Microbiol. 2002 Aug;45(4):1131-41.

43.

Purification of chromosomes from Plasmodium falciparum.

Carucci DJ, Horrocks P, Gardner MJ.

Methods Mol Med. 2002;72:235-40. No abstract available.

PMID:
12125120
44.

Antigenic variation at the infected red cell surface in malaria.

Kyes S, Horrocks P, Newbold C.

Annu Rev Microbiol. 2001;55:673-707. Review.

PMID:
11544371
46.

Entering the post-genomic era of malaria research.

Horrocks P, Bowman S, Kyes S, Waters AP, Craig A.

Bull World Health Organ. 2000;78(12):1424-37. Epub 2003 Nov 17. Review.

47.

Assessing the impact of Plasmodium falciparum genome sequencing.

Bowman S, Horrocks P.

Microbes Infect. 2000 Oct;2(12):1479-87. Review.

PMID:
11099934
48.
49.

The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.

Bowman S, Lawson D, Basham D, Brown D, Chillingworth T, Churcher CM, Craig A, Davies RM, Devlin K, Feltwell T, Gentles S, Gwilliam R, Hamlin N, Harris D, Holroyd S, Hornsby T, Horrocks P, Jagels K, Jassal B, Kyes S, McLean J, Moule S, Mungall K, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutter S, Skelton J, Squares R, Squares S, Sulston JE, Whitehead S, Woodward JR, Newbold C, Barrell BG.

Nature. 1999 Aug 5;400(6744):532-8.

PMID:
10448855
50.

Single-cell measurements of ion concentrations within the intracellular parasite.

Wünsch S, Horrocks P, Gekle M, Lanzer M.

Parasitol Today. 1999 May;15(5):198-200. Review.

PMID:
10322354

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