Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 20

1.

Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.

Sachse SM, Lievens S, Ribeiro LF, Dascenco D, Masschaele D, Horré K, Misbaer A, Vanderroost N, De Smet AS, Salta E, Erfurth ML, Kise Y, Nebel S, Van Delm W, Plaisance S, Tavernier J, De Strooper B, De Wit J, Schmucker D.

EMBO J. 2019 Mar 15;38(6). pii: e99669. doi: 10.15252/embj.201899669. Epub 2019 Feb 11.

PMID:
30745319
2.

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.

Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):277-286. doi: 10.1073/pnas.1811938116. Epub 2018 Dec 21.

3.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

4.

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.

Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, Tosi S, Munck S, Salas IH, Annaert W, De Strooper B.

Mol Neurodegener. 2017 Mar 10;12(1):25. doi: 10.1186/s13024-017-0165-0.

5.

PLD3 gene and processing of APP.

Fazzari P, Horre K, Arranz AM, Frigerio CS, Saito T, Saido TC, De Strooper B.

Nature. 2017 Jan 25;541(7638):E1-E2. doi: 10.1038/nature21030. No abstract available.

PMID:
28128235
6.

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A.

Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492.

PMID:
26468326
7.

The dynamic conformational landscape of gamma-secretase.

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L.

J Cell Sci. 2015 Feb 1;128(3):589-98.

8.

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.

J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.

9.

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B.

Nat Med. 2013 Jan;19(1):43-9. doi: 10.1038/nm.3023. Epub 2012 Dec 2.

PMID:
23202293
10.

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

Nelson O, Supnet C, Tolia A, Horré K, De Strooper B, Bezprozvanny I.

J Biol Chem. 2011 Jun 24;286(25):22339-47. doi: 10.1074/jbc.M111.243063. Epub 2011 Apr 29.

11.

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.

Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.

12.

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.

Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P.

Science. 2009 Feb 13;323(5916):946-51. doi: 10.1126/science.1160649.

13.

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B.

Neurobiol Dis. 2009 Mar;33(3):422-8. doi: 10.1016/j.nbd.2008.11.009. Epub 2008 Dec 9.

PMID:
19110058
14.

Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.

Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9775-80. doi: 10.1073/pnas.0800507105. Epub 2008 Jul 14.

15.

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.

Tolia A, Horré K, De Strooper B.

J Biol Chem. 2008 Jul 11;283(28):19793-803. doi: 10.1074/jbc.M802461200. Epub 2008 May 15.

16.

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. doi: 10.1073/pnas.0710263105. Epub 2008 Apr 23.

17.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

18.

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.

Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. Epub 2005 Jan 21.

19.

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.

Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B.

Neurobiol Dis. 2004 Nov;17(2):260-72.

PMID:
15474363
20.

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.

Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B.

J Biol Chem. 2003 Oct 31;278(44):43430-6. Epub 2003 Jul 28.

Supplemental Content

Support Center