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Items: 17

1.

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation.

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR.

J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1.

2.

Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.

Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do HT, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S.

Cell Metab. 2017 Mar 7;25(3):698-712. doi: 10.1016/j.cmet.2016.12.021. Epub 2017 Jan 26.

3.

CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.

Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A.

EMBO J. 2016 Dec 1;35(23):2566-2583. Epub 2016 Oct 20.

4.

Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2016 Mar 28;212(7):877. doi: 10.1083/jcb.20140414703042016c. Epub 2016 Mar 21. No abstract available.

5.

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2015 Dec 7;211(5):1057-75. doi: 10.1083/jcb.201404147. Erratum in: J Cell Biol. 2016 Mar 28;212(7):877.

6.

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

Gorman GS, Blakely EL, Hornig-Do HT, Tuppen HA, Greaves LC, He L, Baker A, Falkous G, Newman J, Trenell MI, Lecky B, Petty RK, Turnbull DM, McFarland R, Taylor RW.

Clin Sci (Lond). 2015 Jun;128(12):895-904. doi: 10.1042/CS20140705.

7.

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.

Wilson WC, Hornig-Do HT, Bruni F, Chang JH, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, Crosby AH, Chrzanowska-Lightowlers ZM, Lightowlers RN.

Hum Mol Genet. 2014 Dec 1;23(23):6345-55. doi: 10.1093/hmg/ddu352. Epub 2014 Jul 9.

8.

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.

EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016.

9.

Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations.

Hornig-Do HT, Montanari A, Rozanska A, Tuppen HA, Almalki AA, Abg-Kamaludin DP, Frontali L, Francisci S, Lightowlers RN, Chrzanowska-Lightowlers ZM.

EMBO Mol Med. 2014 Feb;6(2):183-93. doi: 10.1002/emmm.201303202. Epub 2014 Jan 10.

10.

Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.

Alston CL, Davison JE, Meloni F, van der Westhuizen FH, He L, Hornig-Do HT, Peet AC, Gissen P, Goffrini P, Ferrero I, Wassmer E, McFarland R, Taylor RW.

J Med Genet. 2012 Sep;49(9):569-77. doi: 10.1136/jmedgenet-2012-101146.

11.

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ.

EMBO J. 2012 Mar 7;31(5):1293-307. doi: 10.1038/emboj.2011.477. Epub 2012 Jan 17.

12.

Isolation of functional pure mitochondria by superparamagnetic microbeads.

Hornig-Do HT, Günther G, Bust M, Lehnartz P, Bosio A, Wiesner RJ.

Anal Biochem. 2009 Jun 1;389(1):1-5. doi: 10.1016/j.ab.2009.02.040. Epub 2009 Mar 11.

PMID:
19285029
13.

CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation.

Franko A, Mayer S, Thiel G, Mercy L, Arnould T, Hornig-Do HT, Wiesner RJ, Goffart S.

Mol Cell Biol. 2008 Apr;28(7):2446-59. doi: 10.1128/MCB.00980-07. Epub 2008 Jan 28.

14.

Altered CD45 isoform expression in C77G carriers influences cytokine responsiveness and adhesion properties of T cells.

Windhagen A, Sönmez D, Hornig-Do HT, Kalinowsky A, Schwinzer R.

Clin Exp Immunol. 2007 Dec;150(3):509-17. Epub 2007 Sep 28.

15.

Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.

von Kleist-Retzow JC, Hornig-Do HT, Schauen M, Eckertz S, Dinh TA, Stassen F, Lottmann N, Bust M, Galunska B, Wielckens K, Hein W, Beuth J, Braun JM, Fischer JH, Ganitkevich VY, Maniura-Weber K, Wiesner RJ.

Exp Cell Res. 2007 Aug 15;313(14):3076-89. Epub 2007 Apr 19.

PMID:
17509565
16.

Mitochondrial electron transport chain activity is not involved in ultraviolet A (UVA)-induced cell death.

Schauen M, Hornig-Do HT, Schomberg S, Herrmann G, Wiesner RJ.

Free Radic Biol Med. 2007 Feb 15;42(4):499-509. Epub 2006 Nov 17.

PMID:
17275682
17.

Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment.

Hornig-Do HT, von Kleist-Retzow JC, Lanz K, Wickenhauser C, Kudin AP, Kunz WS, Wiesner RJ, Schauen M.

J Invest Dermatol. 2007 May;127(5):1084-93. Epub 2006 Dec 21.

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