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Items: 1 to 50 of 75

1.

Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads.

Hornemann S, Schwarz P, Rushing EJ, Connolly MD, Zuckermann RN, Yam AY, Aguzzi A.

PLoS One. 2019 Sep 12;14(9):e0216013. doi: 10.1371/journal.pone.0216013. eCollection 2019.

2.

Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial.

Markova M, Koelman L, Hornemann S, Pivovarova O, Sucher S, Machann J, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH, Aleksandrova K.

Clin Nutr. 2019 Mar 27. pii: S0261-5614(19)30132-3. doi: 10.1016/j.clnu.2019.03.019. [Epub ahead of print]

PMID:
30967307
3.

Unaltered prion disease in mice lacking developmental endothelial locus-1.

Zhu C, Li Z, Li B, Pfammatter M, Hornemann S, Aguzzi A.

Neurobiol Aging. 2019 Apr;76:208-213. doi: 10.1016/j.neurobiolaging.2019.01.003. Epub 2019 Jan 11.

PMID:
30743056
4.

Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans.

Kessler K, Hornemann S, Petzke KJ, Kemper M, Markova M, Rudovich N, Grune T, Kramer A, Pfeiffer AFH, Pivovarova-Ramich O.

Am J Clin Nutr. 2018 Dec 1;108(6):1209-1219. doi: 10.1093/ajcn/nqy224.

PMID:
30541098
5.

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

Keller A, Nuvolone M, Abakumova I, Chincisan A, Reimann R, Avar M, Heinzer D, Hornemann S, Wagner J, Kirschenbaum D, Voigt FF, Zhu C, Regli L, Helmchen F, Aguzzi A.

PLoS Pathog. 2018 Nov 29;14(11):e1007424. doi: 10.1371/journal.ppat.1007424. eCollection 2018 Nov.

6.

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

Bardelli M, Frontzek K, Simonelli L, Hornemann S, Pedotti M, Mazzola F, Carta M, Eckhardt V, D'Antuono R, Virgilio T, González SF, Aguzzi A, Varani L.

PLoS Pathog. 2018 Oct 1;14(10):e1007335. doi: 10.1371/journal.ppat.1007335. eCollection 2018 Oct.

7.

Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium (Tropaeolum majus L.)-A Pilot Study.

Kühn C, Kupke F, Baldermann S, Klopsch R, Lamy E, Hornemann S, Pfeiffer AFH, Schreiner M, Hanschen FS, Rohn S.

Mol Nutr Food Res. 2018 Oct;62(20):e1800588. doi: 10.1002/mnfr.201800588. Epub 2018 Aug 28.

PMID:
30091516
8.

Rate of appearance of amino acids after a meal regulates insulin and glucagon secretion in patients with type 2 diabetes: a randomized clinical trial.

Markova M, Hornemann S, Sucher S, Wegner K, Pivovarova O, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH.

Am J Clin Nutr. 2018 Aug 1;108(2):279-291. doi: 10.1093/ajcn/nqy100.

PMID:
29982277
9.

The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM.

Diabetologia. 2018 Sep;61(9):2054-2065. doi: 10.1007/s00125-018-4636-9. Epub 2018 May 12.

PMID:
29754289
10.

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Schüler R, Seebeck N, Osterhoff MA, Witte V, Flöel A, Busjahn A, Jais A, Brüning JC, Frahnow T, Kabisch S, Pivovarova O, Hornemann S, Kruse M, Pfeiffer AFH.

Mol Metab. 2018 May;11:129-136. doi: 10.1016/j.molmet.2018.02.004. Epub 2018 Feb 12.

11.

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH.

ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4.

PMID:
29178774
12.

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A.

PLoS Pathog. 2017 Nov 27;13(11):e1006733. doi: 10.1371/journal.ppat.1006733. eCollection 2017 Nov.

13.

Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity.

Tacke C, Aleksandrova K, Rehfeldt M, Murahovschi V, Markova M, Kemper M, Hornemann S, Kaiser U, Honig C, Gerbracht C, Kabisch S, Hörbelt T, Ouwens DM, Weickert MO, Boeing H, Pfeiffer AFH, Pivovarova O, Rudovich N.

J Cell Commun Signal. 2018 Sep;12(3):539-548. doi: 10.1007/s12079-017-0427-1. Epub 2017 Nov 11.

14.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

15.

Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes.

Schüler R, Osterhoff MA, Frahnow T, Möhlig M, Spranger J, Stefanovski D, Bergman RN, Xu L, Seltmann AC, Kabisch S, Hornemann S, Kruse M, Pfeiffer AFH.

Sci Rep. 2017 Aug 23;7(1):9234. doi: 10.1038/s41598-017-08300-7.

16.

Heritability and responses to high fat diet of plasma lipidomics in a twin study.

Frahnow T, Osterhoff MA, Hornemann S, Kruse M, Surma MA, Klose C, Simons K, Pfeiffer AFH.

Sci Rep. 2017 Jun 16;7(1):3750. doi: 10.1038/s41598-017-03965-6.

17.

Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate.

Weitkunat K, Schumann S, Nickel D, Hornemann S, Petzke KJ, Schulze MB, Pfeiffer AF, Klaus S.

Am J Clin Nutr. 2017 Jun;105(6):1544-1551. doi: 10.3945/ajcn.117.152702. Epub 2017 Apr 19.

PMID:
28424190
18.

Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.

Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A.

J Biol Chem. 2017 May 19;292(20):8356-8368. doi: 10.1074/jbc.M116.773283. Epub 2017 Mar 24.

19.

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial.

Kessler K, Hornemann S, Petzke KJ, Kemper M, Kramer A, Pfeiffer AF, Pivovarova O, Rudovich N.

Sci Rep. 2017 Mar 8;7:44170. doi: 10.1038/srep44170.

20.

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.

21.

Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial.

Sucher S, Markova M, Hornemann S, Pivovarova O, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH.

Diabetes Obes Metab. 2017 Jul;19(7):944-952. doi: 10.1111/dom.12901. Epub 2017 Mar 8.

PMID:
28181738
22.

High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.

Schüler R, Osterhoff MA, Frahnow T, Seltmann AC, Busjahn A, Kabisch S, Xu L, Mosig AS, Spranger J, Möhlig M, Hornemann S, Kruse M, Pfeiffer AF.

J Am Heart Assoc. 2017 Jan 17;6(1). pii: e004465. doi: 10.1161/JAHA.116.004465.

23.

Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes.

Markova M, Pivovarova O, Hornemann S, Sucher S, Frahnow T, Wegner K, Machann J, Petzke KJ, Hierholzer J, Lichtinghagen R, Herder C, Carstensen-Kirberg M, Roden M, Rudovich N, Klaus S, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AF.

Gastroenterology. 2017 Feb;152(3):571-585.e8. doi: 10.1053/j.gastro.2016.10.007. Epub 2016 Oct 17.

PMID:
27765690
24.

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.

Frontzek K, Pfammatter M, Sorce S, Senatore A, Schwarz P, Moos R, Frauenknecht K, Hornemann S, Aguzzi A.

PLoS One. 2016 Sep 29;11(9):e0163601. doi: 10.1371/journal.pone.0163601. eCollection 2016.

25.

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A.

Nature. 2016 Aug 25;536(7617):464-8. Epub 2016 Aug 8.

26.

Differential Toxicity of Antibodies to the Prion Protein.

Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A.

PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan.

27.

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.

Vanlandewijck M, Lebouvier T, Andaloussi Mäe M, Nahar K, Hornemann S, Kenkel D, Cunha SI, Lennartsson J, Boss A, Heldin CH, Keller A, Betsholtz C.

PLoS One. 2015 Nov 23;10(11):e0143407. doi: 10.1371/journal.pone.0143407. eCollection 2015.

28.

Structure-based drug design identifies polythiophenes as antiprion compounds.

Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, Caflisch A, Meier BH, Nilsson KP, Hornemann S, Aguzzi A.

Sci Transl Med. 2015 Aug 5;7(299):299ra123. doi: 10.1126/scitranslmed.aab1923.

PMID:
26246168
29.

Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans.

Pivovarova O, Jürchott K, Rudovich N, Hornemann S, Ye L, Möckel S, Murahovschi V, Kessler K, Seltmann AC, Maser-Gluth C, Mazuch J, Kruse M, Busjahn A, Kramer A, Pfeiffer AF.

J Clin Endocrinol Metab. 2015 Jun;100(6):2291-302. doi: 10.1210/jc.2014-3868. Epub 2015 Mar 30.

PMID:
25822100
30.

Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.

Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A.

PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004808.

31.

Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humans.

Pivovarova O, Hornemann S, Weimer S, Lu Y, Murahovschi V, Zhuk S, Seltmann AC, Malashicheva A, Kostareva A, Kruse M, Busjahn A, Rudovich N, Pfeiffer AF.

Peptides. 2015 Mar;65:12-9. doi: 10.1016/j.peptides.2014.11.009. Epub 2015 Jan 22.

PMID:
25620618
32.

Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men.

Kruse M, von Loeffelholz C, Hoffmann D, Pohlmann A, Seltmann AC, Osterhoff M, Hornemann S, Pivovarova O, Rohn S, Jahreis G, Pfeiffer AF.

Mol Nutr Food Res. 2015 Mar;59(3):507-19. doi: 10.1002/mnfr.201400446. Epub 2014 Dec 22.

PMID:
25403327
33.

WISP1 is a novel adipokine linked to inflammation in obesity.

Murahovschi V, Pivovarova O, Ilkavets I, Dmitrieva RM, Döcke S, Keyhani-Nejad F, Gögebakan Ö, Osterhoff M, Kemper M, Hornemann S, Markova M, Klöting N, Stockmann M, Weickert MO, Lamounier-Zepter V, Neuhaus P, Konradi A, Dooley S, von Loeffelholz C, Blüher M, Pfeiffer AF, Rudovich N.

Diabetes. 2015 Mar;64(3):856-66. doi: 10.2337/db14-0444. Epub 2014 Oct 3.

34.

Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content.

Hattersley JG, Pfeiffer AF, Roden M, Petzke KJ, Hoffmann D, Rudovich NN, Randeva HS, Vatish M, Osterhoff M, Goegebakan Ö, Hornemann S, Nowotny P, Machann J, Hierholzer J, von Loeffelholz C, Möhlig M, Arafat AM, Weickert MO.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2599-609. doi: 10.1210/jc.2014-2302.

PMID:
25157543
35.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

36.

Inhibition of 11β-HSD1 with RO5093151 for non-alcoholic fatty liver disease: a multicentre, randomised, double-blind, placebo-controlled trial.

Stefan N, Ramsauer M, Jordan P, Nowotny B, Kantartzis K, Machann J, Hwang JH, Nowotny P, Kahl S, Harreiter J, Hornemann S, Sanyal AJ, Stewart PM, Pfeiffer AF, Kautzky-Willer A, Roden M, Häring HU, Fürst-Recktenwald S.

Lancet Diabetes Endocrinol. 2014 May;2(5):406-16. doi: 10.1016/S2213-8587(13)70170-0. Epub 2014 Feb 17.

PMID:
24795254
37.

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.

Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ.

J Neurosci. 2014 Jan 15;34(3):1022-7. doi: 10.1523/JNEUROSCI.4636-13.2014.

38.

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.

Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A.

Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31.

PMID:
23903654
39.

Structural plasticity of the cellular prion protein and implications in health and disease.

Christen B, Damberger FF, Pérez DR, Hornemann S, Wüthrich K.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8549-54. doi: 10.1073/pnas.1306178110. Epub 2013 May 6.

40.

Superresolution imaging of amyloid fibrils with binding-activated probes.

Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L.

ACS Chem Neurosci. 2013 Jul 17;4(7):1057-61. doi: 10.1021/cn400091m. Epub 2013 Apr 22.

41.

Prion protein mPrP[F175A](121-231): structure and stability in solution.

Christen B, Hornemann S, Damberger FF, Wüthrich K.

J Mol Biol. 2012 Nov 2;423(4):496-502. doi: 10.1016/j.jmb.2012.08.011. Epub 2012 Aug 24.

PMID:
22922482
42.

Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.

Nyström S, Mishra R, Hornemann S, Aguzzi A, Nilsson KP, Hammarström P.

J Biol Chem. 2012 Jul 27;287(31):25975-84. doi: 10.1074/jbc.M112.372136. Epub 2012 Jun 5.

43.

Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.

Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A.

J Biol Chem. 2012 Jun 1;287(23):18872-87. doi: 10.1074/jbc.M112.355958. Epub 2012 Apr 6.

44.

Cellular prion protein conformation and function.

Damberger FF, Christen B, Pérez DR, Hornemann S, Wüthrich K.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17308-13. doi: 10.1073/pnas.1106325108. Epub 2011 Oct 10.

45.

Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein.

Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A.

J Neurosci. 2011 Sep 28;31(39):13840-7. doi: 10.1523/JNEUROSCI.3504-11.2011.

46.

Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans.

Weickert MO, Roden M, Isken F, Hoffmann D, Nowotny P, Osterhoff M, Blaut M, Alpert C, Gögebakan O, Bumke-Vogt C, Mueller F, Machann J, Barber TM, Petzke KJ, Hierholzer J, Hornemann S, Kruse M, Illner AK, Kohl A, Loeffelholz CV, Arafat AM, Möhlig M, Pfeiffer AF.

Am J Clin Nutr. 2011 Aug;94(2):459-71. doi: 10.3945/ajcn.110.004374. Epub 2011 Jun 1.

PMID:
21633074
47.

The amyloid-Congo red interface at atomic resolution.

Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH.

Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5956-60. doi: 10.1002/anie.201008276. Epub 2011 May 17. No abstract available.

PMID:
21591034
48.

A molecular switch controls interspecies prion disease transmission in mice.

Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A.

J Clin Invest. 2010 Jul;120(7):2590-9. doi: 10.1172/JCI42051. Epub 2010 Jun 14.

49.

Prion protein-detergent micelle interactions studied by NMR in solution.

Hornemann S, von Schroetter C, Damberger FF, Wüthrich K.

J Biol Chem. 2009 Aug 21;284(34):22713-21. doi: 10.1074/jbc.M109.000430. Epub 2009 Jun 22.

50.

Prion protein NMR structure from tammar wallaby (Macropus eugenii) shows that the beta2-alpha2 loop is modulated by long-range sequence effects.

Christen B, Hornemann S, Damberger FF, Wüthrich K.

J Mol Biol. 2009 Jun 26;389(5):833-45. doi: 10.1016/j.jmb.2009.04.040. Epub 2009 Apr 23.

PMID:
19393664

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