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Items: 1 to 50 of 114

1.

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW.

Nature. 2018 Aug 8. doi: 10.1038/s41586-018-0395-5. [Epub ahead of print]

PMID:
30089902
2.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

3.

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo.

Zhang K, Riba A, Nietschke M, Torow N, Repnik U, Pütz A, Fulde M, Dupont A, Hensel M, Hornef M.

PLoS Pathog. 2018 Mar 9;14(3):e1006925. doi: 10.1371/journal.ppat.1006925. eCollection 2018 Mar.

4.

The neonatal window of opportunity-early priming for life.

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW.

J Allergy Clin Immunol. 2018 Apr;141(4):1212-1214. doi: 10.1016/j.jaci.2017.11.019. Epub 2017 Dec 14. No abstract available.

PMID:
29247715
5.

Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells.

Selvakumar TA, Bhushal S, Kalinke U, Wirth D, Hauser H, Köster M, Hornef MW.

Front Immunol. 2017 Oct 16;8:1302. doi: 10.3389/fimmu.2017.01302. eCollection 2017.

6.

Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium.

Zhang K, Griffiths G, Repnik U, Hornef M.

Int J Med Microbiol. 2017 Sep 14. pii: S1438-4221(17)30370-3. doi: 10.1016/j.ijmm.2017.09.011. [Epub ahead of print] Review.

PMID:
28939439
7.

Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice.

Ginzel M, Feng X, Kuebler JF, Klemann C, Yu Y, von Wasielewski R, Park JK, Hornef MW, Vieten G, Ure BM, Kaussen T, Gosemann JH, Mayer S, Suttkus A, Lacher M.

PLoS One. 2017 Aug 17;12(8):e0182732. doi: 10.1371/journal.pone.0182732. eCollection 2017.

8.

Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells.

Bhushal S, Wolfsmüller M, Selvakumar TA, Kemper L, Wirth D, Hornef MW, Hauser H, Köster M.

Front Immunol. 2017 Jun 12;8:671. doi: 10.3389/fimmu.2017.00671. eCollection 2017.

9.

CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.

Suwandi A, Bargen I, Pils MC, Krey M, Zur Lage S, Singh AK, Basler T, Falk CS, Seidler U, Hornef MW, Goethe R, Weiss S.

Front Cell Infect Microbiol. 2017 Mar 16;7:75. doi: 10.3389/fcimb.2017.00075. eCollection 2017.

10.

Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children.

van de Pol JA, van Best N, Mbakwa CA, Thijs C, Savelkoul PH, Arts IC, Hornef MW, Mommers M, Penders J.

Front Microbiol. 2017 Mar 10;8:355. doi: 10.3389/fmicb.2017.00355. eCollection 2017.

11.

β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.

Drescher HK, Schippers A, Clahsen T, Sahin H, Noels H, Hornef M, Wagner N, Trautwein C, Streetz KL, Kroy DC.

J Hepatol. 2017 Jun;66(6):1251-1264. doi: 10.1016/j.jhep.2017.02.001. Epub 2017 Feb 10.

PMID:
28192190
12.

Does a prenatal bacterial microbiota exist?

Hornef M, Penders J.

Mucosal Immunol. 2017 May;10(3):598-601. doi: 10.1038/mi.2016.141. Epub 2017 Jan 25. No abstract available.

PMID:
28120852
13.

c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine.

Mandić AD, Bennek E, Verdier J, Zhang K, Roubrocks S, Davis RJ, Denecke B, Gassler N, Streetz K, Kel A, Hornef M, Cubero FJ, Trautwein C, Sellge G.

Mucosal Immunol. 2017 Sep;10(5):1211-1223. doi: 10.1038/mi.2016.125. Epub 2017 Jan 18.

PMID:
28098247
14.

The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis.

Torow N, Hornef MW.

J Immunol. 2017 Jan 15;198(2):557-563. doi: 10.4049/jimmunol.1601253. Review.

15.

Reduced PICD in Monocytes Mounts Altered Neonate Immune Response to Candida albicans.

Dreschers S, Saupp P, Hornef M, Prehn A, Platen C, Morschhäuser J, Orlikowsky TW.

PLoS One. 2016 Nov 21;11(11):e0166648. doi: 10.1371/journal.pone.0166648. eCollection 2016.

16.

Corrigendum: The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota.

Lagkouvardos I, Pukall R, Abt B, Foesel BU, Meier-Kolthoff JP, Kumar N, Bresciani A, Martínez I, Just S, Ziegler C, Brugiroux S, Garzetti D, Wenning M, Bui TP, Wang J, Hugenholtz F, Plugge CM, Peterson DA, Hornef MW, Baines JF, Smidt H, Walter J, Kristiansen K, Nielsen HB, Haller D, Overmann J, Stecher B, Clavel T.

Nat Microbiol. 2016 Oct 17;1(11):16219. doi: 10.1038/nmicrobiol.2016.219. No abstract available.

PMID:
27748770
17.

The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota.

Lagkouvardos I, Pukall R, Abt B, Foesel BU, Meier-Kolthoff JP, Kumar N, Bresciani A, Martínez I, Just S, Ziegler C, Brugiroux S, Garzetti D, Wenning M, Bui TP, Wang J, Hugenholtz F, Plugge CM, Peterson DA, Hornef MW, Baines JF, Smidt H, Walter J, Kristiansen K, Nielsen HB, Haller D, Overmann J, Stecher B, Clavel T.

Nat Microbiol. 2016 Aug 8;1(10):16131. doi: 10.1038/nmicrobiol.2016.131. Erratum in: Nat Microbiol. 2016 Oct 17;1(11):16219.

PMID:
27670113
18.

Neonatal mucosal immunology.

Torow N, Marsland BJ, Hornef MW, Gollwitzer ES.

Mucosal Immunol. 2017 Jan;10(1):5-17. doi: 10.1038/mi.2016.81. Epub 2016 Sep 21. Review.

PMID:
27649929
19.

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine.

Nikiforou M, Jacobs EM, Kemp MW, Hornef MW, Payne MS, Saito M, Newnham JP, Janssen LE, Jobe AH, Kallapur SG, Kramer BW, Wolfs TG.

Sci Rep. 2016 Jul 14;6:29806. doi: 10.1038/srep29806.

20.

Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice.

Dupont A, Sommer F, Zhang K, Repnik U, Basic M, Bleich A, Kühnel M, Bäckhed F, Litvak Y, Fulde M, Rosenshine I, Hornef MW.

PLoS Pathog. 2016 May 9;12(5):e1005616. doi: 10.1371/journal.ppat.1005616. eCollection 2016 May.

21.

Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota.

Pabst O, Cerovic V, Hornef M.

Trends Immunol. 2016 May;37(5):287-296. doi: 10.1016/j.it.2016.03.002. Epub 2016 Apr 5. Review.

PMID:
27066758
22.

The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice.

Ginzel M, Yu Y, Klemann C, Feng X, von Wasielewski R, Park JK, Hornef MW, Torow N, Vieten G, Ure BM, Kuebler JF, Lacher M.

Pediatr Res. 2016 Apr;79(4):596-602. doi: 10.1038/pr.2015.261. Epub 2015 Dec 17.

PMID:
26679153
23.

On the origin of species: Factors shaping the establishment of infant's gut microbiota.

van Best N, Hornef MW, Savelkoul PH, Penders J.

Birth Defects Res C Embryo Today. 2015 Dec;105(4):240-51. doi: 10.1002/bdrc.21113. Epub 2015 Nov 26. Review.

PMID:
26607554
24.

Real friends: Faecalibacterium prausnitzii supports mucosal immune homeostasis.

Hornef MW, Pabst O.

Gut. 2016 Mar;65(3):365-7. doi: 10.1136/gutjnl-2015-310027. Epub 2015 Nov 3. No abstract available.

PMID:
26531718
25.

Transcriptional profiling of intestinal CD4(+) T cells in the neonatal and adult mice.

Torow N, Dittrich-Breiholz O, Hornef MW.

Genom Data. 2015 Jul 15;5:371-4. doi: 10.1016/j.gdata.2015.07.009. eCollection 2015 Sep.

26.

Pathogens, Commensal Symbionts, and Pathobionts: Discovery and Functional Effects on the Host.

Hornef M.

ILAR J. 2015;56(2):159-62. doi: 10.1093/ilar/ilv007. Review.

PMID:
26323625
27.

The intestinal epithelium as guardian of gut barrier integrity.

Zhang K, Hornef MW, Dupont A.

Cell Microbiol. 2015 Nov;17(11):1561-9. doi: 10.1111/cmi.12501. Epub 2015 Sep 15. Review.

PMID:
26294173
28.

An unusual cause of ventriculoperitoneal shunt infection.

Esmaeilzadeh M, Islamian AP, Lang JM, Hornef M, Suerbaum S, Krauss JK.

JAAPA. 2015 Aug;28(8):39-42. doi: 10.1097/01.JAA.0000469445.49635.b6.

PMID:
26208014
29.

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Förster R, Pabst O, Hornef MW.

Nat Commun. 2015 Jul 21;6:7725. doi: 10.1038/ncomms8725.

30.

The deadly bite of Salmonella Typhi.

Zhang K, Hornef M, Fulde M.

EMBO Rep. 2015 Aug;16(8):887-8. doi: 10.15252/embr.201540748. Epub 2015 Jun 22. No abstract available.

31.

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence.

Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N, Basic M, Dupont A, Hornef M, von Bergen M, Bleich A, Haller D.

Gut. 2016 Feb;65(2):225-37. doi: 10.1136/gutjnl-2015-309333. Epub 2015 Apr 17.

32.

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.

Dupont A, Heinbockel L, Brandenburg K, Hornef MW.

Gut Microbes. 2014;5(6):761-5. doi: 10.4161/19490976.2014.972238.

33.

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways.

Günther C, Buchen B, He GW, Hornef M, Torow N, Neumann H, Wittkopf N, Martini E, Basic M, Bleich A, Watson AJ, Neurath MF, Becker C.

Gut. 2015 Apr;64(4):601-10. doi: 10.1136/gutjnl-2014-307226. Epub 2014 Jun 24.

34.

Ontogeny of intestinal epithelial innate immune responses.

Hornef MW, Fulde M.

Front Immunol. 2014 Oct 9;5:474. doi: 10.3389/fimmu.2014.00474. eCollection 2014. Review.

35.

Gut microbiota: a natural adjuvant for vaccination.

Pabst O, Hornef M.

Immunity. 2014 Sep 18;41(3):349-351. doi: 10.1016/j.immuni.2014.09.002.

36.

Age-dependent enterocyte invasion and microcolony formation by Salmonella.

Zhang K, Dupont A, Torow N, Gohde F, Leschner S, Lienenklaus S, Weiss S, Brinkmann MM, Kühnel M, Hensel M, Fulde M, Hornef MW.

PLoS Pathog. 2014 Sep 11;10(9):e1004385. doi: 10.1371/journal.ppat.1004385. eCollection 2014 Sep. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004476. Gohde, Fredrik [corrected to Gohde, Frederik].

37.

TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression.

Stockinger S, Duerr CU, Fulde M, Dolowschiak T, Pott J, Yang I, Eibach D, Bäckhed F, Akira S, Suerbaum S, Brugman M, Hornef MW.

J Immunol. 2014 Oct 15;193(8):4223-34. doi: 10.4049/jimmunol.1302708. Epub 2014 Sep 10.

38.

Experimental colitis is exacerbated by concomitant infection with Mycobacterium avium ssp. paratuberculosis.

Suwandi A, Bargen I, Roy B, Pils MC, Krey M, Zur Lage S, Basler T, Rohde M, Falk CS, Hornef MW, Goethe R, Weiss S.

Inflamm Bowel Dis. 2014 Nov;20(11):1962-71. doi: 10.1097/MIB.0000000000000157.

PMID:
25144571
39.

Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis.

Atreya R, Bülte M, Gerlach GF, Goethe R, Hornef MW, Köhler H, Meens J, Möbius P, Roeb E, Weiss S; ZooMAP Consortium.

Int J Med Microbiol. 2014 Oct;304(7):858-67. doi: 10.1016/j.ijmm.2014.07.006. Epub 2014 Jul 25. Review.

PMID:
25128370
40.

Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors.

Leibelt S, Friede ME, Rohe C, Gütle D, Rutkowski E, Weigert A, Kveberg L, Vaage JT, Hornef MW, Steinle A.

Mucosal Immunol. 2015 Mar;8(2):232-42. doi: 10.1038/mi.2014.60. Epub 2014 Jul 2.

PMID:
24985083
41.

Maturation of the enteric mucosal innate immune system during the postnatal period.

Fulde M, Hornef MW.

Immunol Rev. 2014 Jul;260(1):21-34. doi: 10.1111/imr.12190. Review.

PMID:
24942679
42.

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide.

Dupont A, Kaconis Y, Yang I, Albers T, Woltemate S, Heinbockel L, Andersson M, Suerbaum S, Brandenburg K, Hornef MW.

Gut. 2015 Feb;64(2):222-32. doi: 10.1136/gutjnl-2014-307150. Epub 2014 May 7.

PMID:
24811998
43.

Systemic and mucosal immune reactivity upon Mycobacterium avium ssp. paratuberculosis infection in mice.

Koc A, Bargen I, Suwandi A, Roderfeld M, Tschuschner A, Rath T, Gerlach GF, Hornef M, Goethe R, Weiss S, Roeb E.

PLoS One. 2014 Apr 11;9(4):e94624. doi: 10.1371/journal.pone.0094624. eCollection 2014.

44.

Outer ear canal infection with Rhabditis sp. nematodes in a human.

Teschner M, Würfel W, Sedlacek L, Suerbaum S, Tappe D, Hornef MW.

J Clin Microbiol. 2014 May;52(5):1793-5. doi: 10.1128/JCM.00115-14. Epub 2014 Mar 5.

45.

Interleukin-13-mediated paneth cell degranulation and antimicrobial peptide release.

Stockinger S, Albers T, Duerr CU, Ménard S, Pütsep K, Andersson M, Hornef MW.

J Innate Immun. 2014;6(4):530-41. doi: 10.1159/000357644. Epub 2014 Feb 19.

PMID:
24556597
46.

Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice.

Basic M, Keubler LM, Buettner M, Achard M, Breves G, Schröder B, Smoczek A, Jörns A, Wedekind D, Zschemisch NH, Günther C, Neumann D, Lienenklaus S, Weiss S, Hornef MW, Mähler M, Bleich A.

Inflamm Bowel Dis. 2014 Mar;20(3):431-43. doi: 10.1097/01.MIB.0000441346.86827.ed.

PMID:
24487272
47.

Handle energy resources with care.

Fulde M, Hornef M.

Trends Microbiol. 2014 Jan;22(1):5-6. doi: 10.1016/j.tim.2013.12.001. Epub 2013 Dec 11.

PMID:
24332793
48.

IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock.

Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, Weber M, Kalinke U, Hofer MJ, Hatesuer B, Schughart K, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Weber F, Hornef MW, Autenrieth IB, Bohn E.

J Immunol. 2013 Oct 1;191(7):3913-21. doi: 10.4049/jimmunol.1203305. Epub 2013 Sep 6.

49.

Generation of mouse small intestinal epithelial cell lines that allow the analysis of specific innate immune functions.

Schwerk J, Köster M, Hauser H, Rohde M, Fulde M, Hornef MW, May T.

PLoS One. 2013 Aug 5;8(8):e72700. doi: 10.1371/journal.pone.0072700. Print 2013.

50.

Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors.

Heinbockel L, Sánchez-Gómez S, Martinez de Tejada G, Dömming S, Brandenburg J, Kaconis Y, Hornef M, Dupont A, Marwitz S, Goldmann T, Ernst M, Gutsmann T, Schürholz T, Brandenburg K.

Antimicrob Agents Chemother. 2013 Mar;57(3):1480-7. doi: 10.1128/AAC.02066-12. Epub 2013 Jan 14.

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