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Complete Genome Sequence of Vibrio campbellii DS40M4.

Colston SM, Hervey WJ 4th, Horne WC, Haygood MG, Petersen BD, van Kessel JC, Vora GJ.

Microbiol Resour Announc. 2019 Jan 24;8(4). pii: e01187-18. doi: 10.1128/MRA.01187-18. eCollection 2019 Jan.


TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.

Zhang MZ, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L, Razzaque M, Horne WC, Romero D, Tzivion G, Colland F, Baron R, Atfi A.

Cancer Cell. 2015 Apr 13;27(4):547-60. doi: 10.1016/j.ccell.2015.03.002.


Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.

Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R.

J Exp Med. 2013 May 6;210(5):969-85. doi: 10.1084/jem.20121187. Epub 2013 Apr 8.


Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.

Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Lüth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R.

J Clin Invest. 2013 Feb;123(2):666-81. doi: 10.1172/JCI64840. Epub 2013 Jan 16.


Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus.

Rowe GC, Vialou V, Sato K, Saito H, Yin M, Green TA, Lotinun S, Kveiborg M, Horne WC, Nestler EJ, Baron R.

J Bone Miner Res. 2012 Aug;27(8):1649-58. doi: 10.1002/jbmr.1618.


Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass.

Marzia M, Guaiquil V, Horne WC, Blobel CP, Baron R, Chiusaroli R.

Biol Chem. 2011 Oct;392(10):877-85. doi: 10.1515/BC.2011.080. Epub 2011 Jul 30.


Activin receptor signaling: a potential therapeutic target for osteoporosis.

Lotinun S, Pearsall RS, Horne WC, Baron R.

Curr Mol Pharmacol. 2012 Jun;5(2):195-204. Review.


Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity.

Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, Toben D, Duda G, Atfi A, Geoffroy V, Horne WC, Baron R.

J Cell Biol. 2010 Dec 27;191(7):1271-83. doi: 10.1083/jcb.201009107. Epub 2010 Dec 20.


Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.

Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R.

Dev Cell. 2010 Oct 19;19(4):533-46. doi: 10.1016/j.devcel.2010.09.008.


c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.

Purev E, Neff L, Horne WC, Baron R.

Mol Biol Cell. 2009 Sep;20(18):4021-30. doi: 10.1091/mbc.E09-03-0248. Epub 2009 Jul 29.


Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.

Bruzzaniti A, Neff L, Sandoval A, Du L, Horne WC, Baron R.

Mol Cell Biol. 2009 Jul;29(13):3644-56. doi: 10.1128/MCB.00851-08. Epub 2009 Apr 20.


Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

Nakajima A, Sanjay A, Chiusaroli R, Adapala NS, Neff L, Itzsteink C, Horne WC, Baron R.

J Bone Miner Res. 2009 Jul;24(7):1162-72. doi: 10.1359/jbmr.090205.


Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo.

Wu M, Hesse E, Morvan F, Zhang JP, Correa D, Rowe GC, Kiviranta R, Neff L, Philbrick WM, Horne WC, Baron R.

Bone. 2009 Apr;44(4):528-36. doi: 10.1016/j.bone.2008.11.011. Epub 2008 Nov 27.


Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.

Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R.

Endocrinology. 2009 Jan;150(1):135-43. doi: 10.1210/en.2008-0678. Epub 2008 Sep 4.


The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts.

Destaing O, Sanjay A, Itzstein C, Horne WC, Toomre D, De Camilli P, Baron R.

Mol Biol Cell. 2008 Jan;19(1):394-404. Epub 2007 Oct 31.


The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.

Bonaventure J, Horne WC, Baron R.

FEBS J. 2007 Jun;274(12):3078-93. Epub 2007 May 17. Erratum in: FEBS J. 2007 Aug;274(15):4008. Gibbs, Linda [removed].


Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

Sanjay A, Miyazaki T, Itzstein C, Purev E, Horne WC, Baron R.

FEBS J. 2006 Dec;273(23):5442-56. Epub 2006 Nov 9.


Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor.

Windahl SH, Galien R, Chiusaroli R, Clément-Lacroix P, Morvan F, Lepescheux L, Nique F, Horne WC, Resche-Rigon M, Baron R.

J Clin Invest. 2006 Sep;116(9):2500-9.


A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.

Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R.

J Clin Invest. 2006 Jun;116(6):1525-34. Epub 2006 May 4.


Calpain is required for normal osteoclast function and is down-regulated by calcitonin.

Marzia M, Chiusaroli R, Neff L, Kim NY, Chishti AH, Baron R, Horne WC.

J Biol Chem. 2006 Apr 7;281(14):9745-54. Epub 2006 Feb 3.


The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function.

Horne WC, Sanjay A, Bruzzaniti A, Baron R.

Immunol Rev. 2005 Dec;208:106-25. Review.


Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.

Bruzzaniti A, Neff L, Sanjay A, Horne WC, De Camilli P, Baron R.

Mol Biol Cell. 2005 Jul;16(7):3301-13. Epub 2005 May 4.


The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.

Seck T, Pellegrini M, Florea AM, Grignoux V, Baron R, Mierke DF, Horne WC.

Mol Endocrinol. 2005 Aug;19(8):2132-44. Epub 2005 Apr 28.


Molecular characterization of two novel isoforms of the human calcitonin receptor.

Beaudreuil J, Balasubramanian S, Chenais J, Taboulet J, Frenkian M, Orcel P, Jullienne A, Horne WC, de Vernejoul MC, Cressent M.

Gene. 2004 Dec 8;343(1):143-51.


DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms.

Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC, Baron R.

Mol Cell Biol. 2004 Apr;24(7):2820-30.


Src kinase activity is essential for osteoclast function.

Miyazaki T, Sanjay A, Neff L, Tanaka S, Horne WC, Baron R.

J Biol Chem. 2004 Apr 23;279(17):17660-6. Epub 2004 Jan 22.


Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.

Miyazaki T, Neff L, Tanaka S, Horne WC, Baron R.

J Cell Biol. 2003 Mar 3;160(5):709-18.


Binding of filamin to the C-terminal tail of the calcitonin receptor controls recycling.

Seck T, Baron R, Horne WC.

J Biol Chem. 2003 Mar 21;278(12):10408-16. Epub 2003 Jan 16.


The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.

Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R.

Endocrinology. 2002 Nov;143(11):4304-9.


Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts.

Zhang Z, Neff L, Bothwell AL, Baron R, Horne WC.

Bone. 2002 Sep;31(3):359-65.


Molecular complexes that contain both c-Cbl and c-Src associate with Golgi membranes.

Bard F, Patel U, Levy JB, Jurdic P, Horne WC, Baron R.

Eur J Cell Biol. 2002 Jan;81(1):26-35. Erratum in: Eur J Cell Biol 2002 Mar;81(3):174.


The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases.

Sanjay A, Horne WC, Baron R.

Sci STKE. 2001 Nov 27;2001(110):pe40. Review.


Calcitonin (CT) rapidly increases NA(+)/H(+) exchange and metabolic acid production: effects mediated selectively by the C1A CT receptor isoform.

Santhanagopal A, Chidiac P, Horne WC, Baron R, Dixon SJ.

Endocrinology. 2001 Oct;142(10):4401-13.


Carbonic anhydrase II is an AP-1 target gene in osteoclasts.

David JP, Rincon M, Neff L, Horne WC, Baron R.

J Cell Physiol. 2001 Jul;188(1):89-97.


Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility.

Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, Levy J, Gailit J, Bowtell D, Horne WC, Baron R.

J Cell Biol. 2001 Jan 8;152(1):181-95.


The presence of the alternatively spliced A2 cassette in the vacuolar H+-ATPase subunit A prevents assembly of the V1 catalytic domain.

Hernando N, David P, Tarsio M, Bartkiewicz M, Horne WC, Kane PM, Baron R.

Eur J Biochem. 1999 Nov;266(1):293-301.


Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.

Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R.

J Biol Chem. 1999 Oct 29;274(44):31707-12.


The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice.

Aoki K, Didomenico E, Sims NA, Mukhopadhyay K, Neff L, Houghton A, Amling M, Levy JB, Horne WC, Baron R.

Bone. 1999 Sep;25(3):261-7.


Biological properties of salmon calcitonin IV.

Schecroun N, Pidoux E, Horne WC, Hernandez-Lagunas L, Baron R, Cressent M.

J Bone Miner Res. 1999 Aug;14(8):1425-31.


Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.

Shyu JF, Zhang Z, Hernandez-Lagunas L, Camerino C, Chen Y, Inoue D, Baron R, Horne WC.

Eur J Biochem. 1999 May;262(1):95-101.


Calcitonin-dependent down-regulation of the mouse C1a calcitonin receptor in cells of the osteoclast lineage involves a transcriptional mechanism.

Inoue D, Shih C, Galson DL, Goldring SR, Horne WC, Baron R.

Endocrinology. 1999 Mar;140(3):1060-8.


The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium.

Chen Y, Shyu JF, Santhanagopal A, Inoue D, David JP, Dixon SJ, Horne WC, Baron R.

J Biol Chem. 1998 Jul 31;273(31):19809-16.


Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.

Insogna KL, Sahni M, Grey AB, Tanaka S, Horne WC, Neff L, Mitnick M, Levy JB, Baron R.

J Clin Invest. 1997 Nov 15;100(10):2476-85.


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