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Items: 1 to 50 of 91

1.

Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.

Albarazanji K, Jennis M, Cavanaugh CR, Lang W, Singh B, Lanter JC, Lenhard JM, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G653-G667. doi: 10.1152/ajpgi.00404.2018. Epub 2019 Mar 28.

PMID:
30920846
2.

Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans.

Zou K, Hinkley JM, Park S, Zheng D, Jones TE, Pories WJ, Hornby PJ, Lenhard J, Dohm GL, Houmard JA.

Int J Obes (Lond). 2019 Apr;43(4):895-905. doi: 10.1038/s41366-018-0137-7. Epub 2018 Jun 11.

PMID:
29892037
3.

Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.

Du F, Hinke SA, Cavanaugh C, Polidori D, Wallace N, Kirchner T, Jennis M, Lang W, Kuo GH, Gaul MD, Lenhard J, Demarest K, Ajami NJ, Liang Y, Hornby PJ.

J Pharmacol Exp Ther. 2018 Jun;365(3):676-687. doi: 10.1124/jpet.118.248575. Epub 2018 Apr 19.

PMID:
29674332
4.

Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo.

Jennis M, Cavanaugh CR, Leo GC, Mabus JR, Lenhard J, Hornby PJ.

Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13178. Epub 2017 Aug 7.

PMID:
28782205
5.

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques.

Muzammil S, Mabus JR, Cooper PR, Brezski RJ, Bement CB, Perkinson R, Huebert ND, Thompson S, Levine D, Kliwinski C, Bradley D, Hornby PJ.

Pharmacol Res Perspect. 2016 Apr 25;4(3):e00218. doi: 10.1002/prp2.218. eCollection 2016 Jun.

6.

Intestinal SGLT1 in metabolic health and disease.

Lehmann A, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G887-98. doi: 10.1152/ajpgi.00068.2016. Epub 2016 Mar 24. Review.

7.

Drug discovery approaches to irritable bowel syndrome.

Hornby PJ.

Expert Opin Drug Discov. 2015;10(8):809-24. doi: 10.1517/17460441.2015.1049528. Review.

PMID:
26193876
8.

The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups.

Cooper PR, Kliwinski CM, Perkinson RA, Ragwan E, Mabus JR, Powers GD, Dorai H, Giles-Komar J, Hornby PJ.

Front Pharmacol. 2014 Oct 7;5:225. doi: 10.3389/fphar.2014.00225. eCollection 2014.

9.

Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis.

Hornby PJ, Cooper PR, Kliwinski C, Ragwan E, Mabus JR, Harman B, Thompson S, Kauffman AL, Yan Z, Tam SH, Dorai H, Powers GD, Giles-Komar J.

Pharm Res. 2014 Apr;31(4):908-22. doi: 10.1007/s11095-013-1212-3. Epub 2013 Sep 26.

10.

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.

Cooper PR, Ciambrone GJ, Kliwinski CM, Maze E, Johnson L, Li Q, Feng Y, Hornby PJ.

Brain Res. 2013 Oct 9;1534:13-21. doi: 10.1016/j.brainres.2013.08.035. Epub 2013 Aug 23.

11.

Alternative functional in vitro models of human intestinal epithelia.

Kauffman AL, Gyurdieva AV, Mabus JR, Ferguson C, Yan Z, Hornby PJ.

Front Pharmacol. 2013 Jul 8;4:79. doi: 10.3389/fphar.2013.00079. eCollection 2013.

12.

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.

Kliwinski C, Cooper PR, Perkinson R, Mabus JR, Tam SH, Wilkinson TM, Giles-Komar J, Scallon B, Powers GD, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G262-70. doi: 10.1152/ajpgi.00340.2012. Epub 2012 Dec 6.

13.

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).

Breslin HJ, Diamond CJ, Kavash RW, Cai C, Dyatkin AB, Miskowski TA, Zhang SP, Wade PR, Hornby PJ, He W.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4869-72. doi: 10.1016/j.bmcl.2012.05.042. Epub 2012 May 24.

PMID:
22695132
14.

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist.

Wade PR, Palmer JM, McKenney S, Kenigs V, Chevalier K, Moore BA, Mabus JR, Saunders PR, Wallace NH, Schneider CR, Kimball ES, Breslin HJ, He W, Hornby PJ.

Br J Pharmacol. 2012 Nov;167(5):1111-25. doi: 10.1111/j.1476-5381.2012.02068.x.

15.

The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease.

Hornby PJ, Moore BA.

Expert Opin Ther Targets. 2011 May;15(5):637-46. doi: 10.1517/14728222.2011.556620. Epub 2011 Feb 11. Review.

PMID:
21314232
16.

The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing.

Redstone HA, Buie WD, Hart DA, Wallace L, Hornby PJ, Sague S, Holst JJ, Sigalet DL.

Gastroenterol Res Pract. 2010;2010. pii: 672453. doi: 10.1155/2010/672453. Epub 2010 Oct 4.

17.

Electrical stimulation of the isolated rat intestine in the presence of nutrient stimulus enhances glucagon-like peptide-1 release.

Schwartz A, Ort T, Kajekar R, Wade PR, Hornby PJ.

Physiol Meas. 2010 Sep;31(9):1147-59. doi: 10.1088/0967-3334/31/9/006. Epub 2010 Jul 28.

PMID:
20664162
18.

GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus.

Moore BA, Peffer N, Pirone A, Bassiri A, Sague S, Palmer JM, Johnson DL, Nesspor T, Kliwinski C, Hornby PJ.

J Pharmacol Exp Ther. 2010 May;333(2):574-83. doi: 10.1124/jpet.109.161497. Epub 2010 Feb 18.

PMID:
20167840
19.

Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.

Kimball ES, Wallace NH, Schneider CR, D'Andrea MR, Hornby PJ.

Front Pharmacol. 2010 Nov 19;1:132. doi: 10.3389/fphar.2010.00132. eCollection 2010.

20.

Prokineticin-1 evokes secretory and contractile activity in rat small intestine.

Wade PR, Palmer JM, Mabus J, Saunders PR, Prouty S, Chevalier K, Gareau MG, McKenney S, Hornby PJ.

Neurogastroenterol Motil. 2010 May;22(5):e152-61. doi: 10.1111/j.1365-2982.2009.01426.x. Epub 2009 Nov 25.

PMID:
19930539
21.

TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation.

Cooper PR, Lamb R, Day ND, Branigan PJ, Kajekar R, San Mateo L, Hornby PJ, Panettieri RA Jr.

Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L530-7. doi: 10.1152/ajplung.00133.2009. Epub 2009 Jun 19.

22.

Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists.

Gong Y, Barbay JK, Buntinx M, Li J, Wauwe JV, Claes C, Lommen GV, Hornby PJ, He W.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3852-5. doi: 10.1016/j.bmcl.2008.06.059. Epub 2008 Jun 20.

PMID:
18595693
23.

Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists.

Barbay JK, Gong Y, Buntinx M, Li J, Claes C, Hornby PJ, Van Lommen G, Van Wauwe J, He W.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2544-8. doi: 10.1016/j.bmcl.2008.03.049. Epub 2008 Mar 20.

PMID:
18378452
24.

Synthesis and SAR of pyridazinone-substituted phenylalanine amide alpha4 integrin antagonists.

Gong Y, Kent Barbay J, Kimball ES, Santulli RJ, Carolyn Fisher M, Dyatkin AB, Miskowski TA, Hornby PJ, He W.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1331-5. doi: 10.1016/j.bmcl.2008.01.022. Epub 2008 Jan 11.

PMID:
18226905
25.

Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis.

Kimball ES, Prouty SP, Pavlick KP, Wallace NH, Schneider CR, Hornby PJ.

Neurogastroenterol Motil. 2007 May;19(5):390-400.

PMID:
17509021
26.

Functional effects and characteristics of cecum-projecting neurons in the dorsal motor nucleus of the vagus of rats.

Cao X, Ball AJ, Partosoedarso ER, Burmeister MA, Hornby PJ.

Auton Neurosci. 2007 Jan 30;131(1-2):1-8. Epub 2006 Sep 6.

PMID:
16950660
27.

Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.

Gong Y, Barbay JK, Dyatkin AB, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Ballentine SA, Hageman WE, Masucci JA, Maryanoff BE, Damiano BP, Andrade-Gordon P, Hlasta DJ, Hornby PJ, He W.

J Med Chem. 2006 Jun 1;49(11):3402-11.

PMID:
16722660
28.

Designing Spiegelmers to antagonise ghrelin.

Hornby PJ.

Gut. 2006 Jun;55(6):754-5. No abstract available.

29.

Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.

Kimball ES, Schneider CR, Wallace NH, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G364-71. Epub 2006 Mar 30.

30.

Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.

Dyatkin AB, Gong Y, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Hornby PJ, Diamond C, Kinney WA, Maryanoff BE, Damiano BP, He W.

Bioorg Med Chem. 2005 Dec 15;13(24):6693-702. Epub 2005 Aug 19.

PMID:
16112583
31.

Age-related neurodegenerative changes and how they affect the gut.

Wade PR, Hornby PJ.

Sci Aging Knowledge Environ. 2005 Mar 23;2005(12):pe8. Review.

PMID:
15788792
32.

Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice.

Kimball ES, Palmer JM, D'Andrea MR, Hornby PJ, Wade PR.

Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1266-73. Epub 2005 Feb 3.

33.

Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice.

Kimball ES, Wallace NH, Schneider CR, D'Andrea MR, Hornby PJ.

Neurogastroenterol Motil. 2004 Dec;16(6):811-8.

PMID:
15601431
34.

Involvement of cannabinoid receptors in gut motility and visceral perception.

Hornby PJ, Prouty SM.

Br J Pharmacol. 2004 Apr;141(8):1335-45. Review.

35.

Central vagal stimulation evokes gastric volume changes in mice: a novel technique using a miniaturized barostat.

Monroe MJ, Hornby PJ, Partosoedarso ER.

Neurogastroenterol Motil. 2004 Feb;16(1):5-11.

PMID:
14764200
36.

Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.

Dyatkin AB, Hoekstra WJ, Kinney WA, Kontoyianni M, Santulli RJ, Kimball ES, Fisher MC, Prouty SM, Abraham WM, de Garavilla L, Andrade-Gordon P, Hlasta DJ, He W, Hornby PJ, Damiano BP, Maryanoff BE.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):591-6. Erratum in: Bioorg Med Chem Lett. 2004 May 3;14(9):2371.

PMID:
14741249
37.

Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets.

Partosoedarso ER, Abrahams TP, Scullion RT, Moerschbaecher JM, Hornby PJ.

J Physiol. 2003 Jul 1;550(Pt 1):149-58.

38.

Central mechanisms of lower esophageal sphincter control.

Hornby PJ, Abrahams TP, Partosoedarso ER.

Gastroenterol Clin North Am. 2002 Dec;31(4 Suppl):S11-20, v-vi. Review.

PMID:
12489467
39.

Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function.

Krowicki ZK, Burmeister MA, Berthoud HR, Scullion RT, Fuchs K, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2002 Aug;283(2):G465-72.

40.

Lower oesophageal sphincter relaxation evoked by stimulation of the dorsal motor nucleus of the vagus in ferrets.

Abrahams TP, Partosoedarso ER, Hornby PJ.

Neurogastroenterol Motil. 2002 Jun;14(3):295-304.

PMID:
12061915
41.

Central neurocircuitry associated with emesis.

Hornby PJ.

Am J Med. 2001 Dec 3;111 Suppl 8A:106S-112S. Review.

PMID:
11749934
42.

Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats.

McDermott CM, Abrahams TP, Partosoedarso E, Hyland N, Ekstrand J, Monroe M, Hornby PJ.

Gastroenterology. 2001 Jun;120(7):1749-62.

PMID:
11375956
43.

Receptors and transmission in the brain-gut axis. II. Excitatory amino acid receptors in the brain-gut axis.

Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1055-60. Review.

44.

Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets.

Hyland NP, Abrahams TP, Fuchs K, Burmeister MA, Hornby PJ.

J Comp Neurol. 2001 Feb 5;430(2):222-34.

PMID:
11135258
45.
46.
47.

Central control of lower esophageal sphincter relaxation.

Hornby PJ, Abrahams TP.

Am J Med. 2000 Mar 6;108 Suppl 4a:90S-98S. Review.

PMID:
10718459
48.

Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation.

Krowicki ZK, Sivarao DV, Abrahams TP, Hornby PJ.

J Auton Nerv Syst. 1999 Sep 24;77(2-3):83-9.

PMID:
10580290
49.

Delta9-tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors.

Krowicki ZK, Moerschbaecher JM, Winsauer PJ, Digavalli SV, Hornby PJ.

Eur J Pharmacol. 1999 Apr 29;371(2-3):187-96.

PMID:
10357256
50.

Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation.

Sivarao DV, Krowicki ZK, Abrahams TP, Hornby PJ.

Eur J Pharmacol. 1999 Mar 5;368(2-3):173-82.

PMID:
10193653

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