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Items: 27

1.

A mass spectrometry guided approach for the identification of novel vaccine candidates in gram-negative pathogens.

Hornburg D, Kruse T, Anderl F, Daschkin C, Semper RP, Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F, Gerhard M.

Sci Rep. 2019 Nov 22;9(1):17401. doi: 10.1038/s41598-019-53493-8.

2.

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M.

Cell. 2019 Aug 22;178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050.

PMID:
31442403
3.

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TDB, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SMS, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M.

Nature. 2019 May;569(7758):663-671. doi: 10.1038/s41586-019-1236-x. Epub 2019 May 29.

4.

A longitudinal big data approach for precision health.

Schüssler-Fiorenza Rose SM, Contrepois K, Moneghetti KJ, Zhou W, Mishra T, Mataraso S, Dagan-Rosenfeld O, Ganz AB, Dunn J, Hornburg D, Rego S, Perelman D, Ahadi S, Sailani MR, Zhou Y, Leopold SR, Chen J, Ashland M, Christle JW, Avina M, Limcaoco P, Ruiz C, Tan M, Butte AJ, Weinstock GM, Slavich GM, Sodergren E, McLaughlin TL, Haddad F, Snyder MP.

Nat Med. 2019 May;25(5):792-804. doi: 10.1038/s41591-019-0414-6. Epub 2019 May 8.

5.

Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma.

Contrepois K, Mahmoudi S, Ubhi BK, Papsdorf K, Hornburg D, Brunet A, Snyder M.

Sci Rep. 2018 Dec 10;8(1):17747. doi: 10.1038/s41598-018-35807-4.

6.

Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity.

Hartmann H, Hornburg D, Czuppa M, Bader J, Michaelsen M, Farny D, Arzberger T, Mann M, Meissner F, Edbauer D.

Life Sci Alliance. 2018 May 16;1(2):e201800070. doi: 10.26508/lsa.201800070. eCollection 2018 May.

7.

The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases.

Broeker J, Mechelke M, Baudrexl M, Mennerich D, Hornburg D, Mann M, Schwarz WH, Liebl W, Zverlov VV.

Biotechnol Biofuels. 2018 Aug 23;11:229. doi: 10.1186/s13068-018-1228-3. eCollection 2018.

8.

Molecular and structural architecture of polyQ aggregates in yeast.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. Epub 2018 Mar 26.

9.

Authorship position should not serve as a proxy metric.

Hornburg D.

Nature. 2018 Feb 22;554(7693):423. doi: 10.1038/d41586-018-02204-w. No abstract available.

PMID:
29469129
10.

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.

Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ.

Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034.

11.

Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

Windeløv JA, Wewer Albrechtsen NJ, Kuhre RE, Jepsen SL, Hornburg D, Pedersen J, Jensen EP, Galsgaard KD, Winther-Sørensen M, Ørgaard A, Deacon CF, Mann M, Kissow H, Hartmann B, Holst JJ.

Diabetologia. 2017 Oct;60(10):2066-2075. doi: 10.1007/s00125-017-4347-7. Epub 2017 Jul 1.

PMID:
28669086
12.

Social network architecture of human immune cells unveiled by quantitative proteomics.

Rieckmann JC, Geiger R, Hornburg D, Wolf T, Kveler K, Jarrossay D, Sallusto F, Shen-Orr SS, Lanzavecchia A, Mann M, Meissner F.

Nat Immunol. 2017 May;18(5):583-593. doi: 10.1038/ni.3693. Epub 2017 Mar 6.

PMID:
28263321
13.

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D.

EMBO J. 2016 Nov 2;35(21):2350-2370. Epub 2016 Sep 12.

14.

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Sivadasan R, Hornburg D, Drepper C, Frank N, Jablonka S, Hansel A, Lojewski X, Sterneckert J, Hermann A, Shaw PJ, Ince PG, Mann M, Meissner F, Sendtner M.

Nat Neurosci. 2016 Dec;19(12):1610-1618. doi: 10.1038/nn.4407. Epub 2016 Oct 10.

15.

Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma.

Wewer Albrechtsen NJ, Hornburg D, Albrechtsen R, Svendsen B, Toräng S, Jepsen SL, Kuhre RE, Hansen M, Janus C, Floyd A, Lund A, Vilsbøll T, Knop FK, Vestergaard H, Deacon CF, Meissner F, Mann M, Holst JJ, Hartmann B.

EBioMedicine. 2016 May;7:112-20. doi: 10.1016/j.ebiom.2016.03.034. Epub 2016 Mar 31.

16.

Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585-597.

Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hartmann B, Mathiesen ER, Hansen CP, Storkholm JH, van Hall G, Rehfeld JF, Hornburg D, Meissner F, Mann M, Larsen S, Holst JJ, Vilsbøll T, Knop FK.

Diabetes. 2016 Jun;65(6):1752. doi: 10.2337/db16-er06. No abstract available.

17.

Evidence of Extrapancreatic Glucagon Secretion in Man.

Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hartmann B, Mathiesen ER, Hansen CP, Storkholm JH, van Hall G, Rehfeld JF, Hornburg D, Meissner F, Mann M, Larsen S, Holst JJ, Vilsbøll T, Knop FK.

Diabetes. 2016 Mar;65(3):585-97. doi: 10.2337/db15-1541. Epub 2015 Dec 15. Erratum in: Diabetes. 2016 Jun;65(6):1752.

18.

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS.

Science. 2016 Jan 8;351(6269):173-6. doi: 10.1126/science.aad2033. Epub 2015 Dec 3.

19.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

20.

The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics.

Beck S, Michalski A, Raether O, Lubeck M, Kaspar S, Goedecke N, Baessmann C, Hornburg D, Meier F, Paron I, Kulak NA, Cox J, Mann M.

Mol Cell Proteomics. 2015 Jul;14(7):2014-29. doi: 10.1074/mcp.M114.047407. Epub 2015 May 19.

21.

Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.

Ripaud L, Chumakova V, Antonin M, Hastie AR, Pinkert S, Körner R, Ruff KM, Pappu RV, Hornburg D, Mann M, Hartl FU, Hipp MS.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18219-24. doi: 10.1073/pnas.1421313111. Epub 2014 Dec 8.

22.

The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.

Scheltema RA, Hauschild JP, Lange O, Hornburg D, Denisov E, Damoc E, Kuehn A, Makarov A, Mann M.

Mol Cell Proteomics. 2014 Dec;13(12):3698-708. doi: 10.1074/mcp.M114.043489. Epub 2014 Oct 30.

23.

Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.

Hornburg D, Drepper C, Butter F, Meissner F, Sendtner M, Mann M.

Mol Cell Proteomics. 2014 Dec;13(12):3410-20. doi: 10.1074/mcp.M113.037291. Epub 2014 Sep 5.

24.

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.

May S, Hornburg D, Schludi MH, Arzberger T, Rentzsch K, Schwenk BM, Grässer FA, Mori K, Kremmer E, Banzhaf-Strathmann J, Mann M, Meissner F, Edbauer D.

Acta Neuropathol. 2014 Oct;128(4):485-503. doi: 10.1007/s00401-014-1329-4. Epub 2014 Aug 14.

25.

Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.

Scharnagl C, Pester O, Hornburg P, Hornburg D, Götz A, Langosch D.

Biophys J. 2014 Mar 18;106(6):1318-26. doi: 10.1016/j.bpj.2014.02.013.

26.

The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.

Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D.

J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16.

27.

Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices.

Quint S, Widmaier S, Minde D, Hornburg D, Langosch D, Scharnagl C.

Biophys J. 2010 Oct 20;99(8):2541-9. doi: 10.1016/j.bpj.2010.08.031.

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