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Items: 22


Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.

Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS.

Nat Biotechnol. 2020 Jan 13. doi: 10.1038/s41587-019-0387-5. [Epub ahead of print]


Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.

Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS.

Science. 2019 Aug 23;365(6455):786-793. doi: 10.1126/science.aax4438. Epub 2019 Aug 8.


Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD.

PLoS Genet. 2019 Mar 15;15(3):e1008057. doi: 10.1371/journal.pgen.1008057. eCollection 2019 Mar.


A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure.

Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K.

PLoS Biol. 2018 Aug 27;16(8):e2004624. doi: 10.1371/journal.pbio.2004624. eCollection 2018 Aug.


Mapping the Genetic Landscape of Human Cells.

Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA.

Cell. 2018 Aug 9;174(4):953-967.e22. doi: 10.1016/j.cell.2018.06.010. Epub 2018 Jul 19.


Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK.

Elife. 2018 May 10;7. pii: e36620. doi: 10.7554/eLife.36620.


Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY.

Cell. 2018 May 31;173(6):1398-1412.e22. doi: 10.1016/j.cell.2018.03.068. Epub 2018 May 3.


Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.

Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA.

Elife. 2018 Jan 23;7. pii: e31098. doi: 10.7554/eLife.31098.


Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.

Hepatology. 2018 Aug;68(2):663-676. doi: 10.1002/hep.29626. Epub 2018 May 14.


Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS.

Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012.


A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS.

Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048.


CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA.

Science. 2017 Jan 6;355(6320). pii: aah7111. doi: 10.1126/science.aah7111. Epub 2016 Dec 15.


Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS.

Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760.


Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3892-900. doi: 10.1073/pnas.1600582113. Epub 2016 Jun 20.


Single-cell analysis of long non-coding RNAs in the developing human neocortex.

Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA.

Genome Biol. 2016 Apr 14;17:67. doi: 10.1186/s13059-016-0932-1.


Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.

Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC.

Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28.


Nucleosomes impede Cas9 access to DNA in vivo and in vitro.

Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS.

Elife. 2016 Mar 17;5. pii: e12677. doi: 10.7554/eLife.12677.


CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR.

Cell Stem Cell. 2016 Apr 7;18(4):541-53. doi: 10.1016/j.stem.2016.01.022. Epub 2016 Mar 10.


Next-generation libraries for robust RNA interference-based genome-wide screens.

Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3384-91. doi: 10.1073/pnas.1508821112. Epub 2015 Jun 15.


Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS.

Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9.


A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.

Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS.

Cell. 2013 Feb 14;152(4):909-22. doi: 10.1016/j.cell.2013.01.030. Epub 2013 Feb 8.


ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p.

Copic A, Latham CF, Horlbeck MA, D'Arcangelo JG, Miller EA.

Science. 2012 Mar 16;335(6074):1359-62. doi: 10.1126/science.1215909. Epub 2012 Feb 2.

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