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Radiation-induced astrocyte senescence is rescued by Δ133p53.

Turnquist C, Beck JA, Horikawa I, Obiorah IE, Von Muhlinen N, Vojtesek B, Lane DP, Grunseich C, Chahine JJ, Ames HM, Smart DD, Harris BT, Harris CC.

Neuro Oncol. 2019 Mar 18;21(4):474-485. doi: 10.1093/neuonc/noz001.


Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells.

Mondal AM, Zhou H, Horikawa I, Suprynowicz FA, Li G, Dakic A, Rosenthal B, Ye L, Harris CC, Schlegel R, Liu X.

Cell Death Dis. 2018 Jul 3;9(7):750. doi: 10.1038/s41419-018-0767-7.


p53 isoforms regulate premature aging in human cells.

von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.

Oncogene. 2018 May;37(18):2379-2393. doi: 10.1038/s41388-017-0101-3. Epub 2018 Feb 12.


Δ133p53: A p53 isoform enriched in human pluripotent stem cells.

Horikawa I, Harris CC.

Cell Cycle. 2017 Sep 17;16(18):1631-1632. doi: 10.1080/15384101.2017.1345228. Epub 2017 Jul 20. No abstract available.


Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells.

Horikawa I, Park KY, Isogaya K, Hiyoshi Y, Li H, Anami K, Robles AI, Mondal AM, Fujita K, Serrano M, Harris CC.

Cell Death Differ. 2017 Jun;24(6):1017-1028. doi: 10.1038/cdd.2017.48. Epub 2017 Mar 31.


p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration.

Turnquist C, Horikawa I, Foran E, Major EO, Vojtesek B, Lane DP, Lu X, Harris BT, Harris CC.

Cell Death Differ. 2016 Sep 1;23(9):1515-28. doi: 10.1038/cdd.2016.37. Epub 2016 Apr 22.


Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer.

Hiyoshi Y, Schetter AJ, Okayama H, Inamura K, Anami K, Nguyen GH, Horikawa I, Hawkes JE, Bowman ED, Leung SY, Harris CC.

PLoS One. 2015 Apr 20;10(4):e0124899. doi: 10.1371/journal.pone.0124899. eCollection 2015.


Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

Horikawa I, Fujita K, Jenkins LM, Hiyoshi Y, Mondal AM, Vojtesek B, Lane DP, Appella E, Harris CC.

Nat Commun. 2014 Aug 21;5:4706. doi: 10.1038/ncomms5706.


p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.

Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.

J Clin Invest. 2013 Dec;123(12):5247-57. doi: 10.1172/JCI70355. Epub 2013 Nov 15.


Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.

PLoS One. 2012;7(9):e44156. doi: 10.1371/journal.pone.0044156. Epub 2012 Sep 6.


Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.

Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.

Oncogene. 2013 May 30;32(22):2792-8. doi: 10.1038/onc.2012.288. Epub 2012 Jul 9.


p53 governs telomere regulation feedback too, via TRF2.

Horikawa I, Fujita K, Harris CC.

Aging (Albany NY). 2011 Jan;3(1):26-32.


Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.

Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.

PLoS One. 2010 Nov 19;5(11):e15541. doi: 10.1371/journal.pone.0015541.


Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon JC, Lane DP, Harris CC.

Nat Cell Biol. 2010 Dec;12(12):1205-12. doi: 10.1038/ncb2123. Epub 2010 Nov 7.


Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.

Liu S, Qi Y, Ge Y, Duplessis T, Rowan BG, Ip C, Cheng H, Rennie PS, Horikawa I, Lustig AJ, Yu Q, Zhang H, Dong Y.

Mol Cancer Ther. 2010 Jul;9(7):2016-25. doi: 10.1158/1535-7163.MCT-09-0924. Epub 2010 Jun 22.


p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.

Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC.

Nat Cell Biol. 2009 Sep;11(9):1135-42. doi: 10.1038/ncb1928. Epub 2009 Aug 23.


MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.

Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90. doi: 10.1073/pnas.0905234106. Epub 2009 Jul 13.


Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.

Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.

Epigenetics Chromatin. 2008 Nov 3;1(1):6. doi: 10.1186/1756-8935-1-6.


Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis.

Horikawa I, Michishita E, Barrett JC.

Cytotechnology. 2004 Jun;45(1-2):23-32. doi: 10.1007/s10616-004-5122-4.


Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.

Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC.

Cancer Res. 2008 May 1;68(9):3193-203. doi: 10.1158/0008-5472.CAN-07-2780.


Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.

Yang Q, Zhang R, Horikawa I, Fujita K, Afshar Y, Kokko A, Laiho P, Aaltonen LA, Harris CC.

Cancer Res. 2007 Dec 15;67(24):11677-86.


Delayed kinetics of DNA double-strand break processing in normal and pathological aging.

Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM.

Aging Cell. 2008 Jan;7(1):89-100. Epub 2007 Dec 19.


Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.

Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18437-42. Epub 2005 Dec 12.


Upregulation of the KIAA1199 gene is associated with cellular mortality.

Michishita E, Garcés G, Barrett JC, Horikawa I.

Cancer Lett. 2006 Jul 28;239(1):71-7. Epub 2005 Sep 12.


Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I.

Mol Biol Cell. 2005 Oct;16(10):4623-35. Epub 2005 Aug 3.


Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers.

Tanaka H, Horikawa I, Barrett JC, Oshimura M.

Int J Cancer. 2005 Jul 1;115(4):653-7.


[Clinical usefulness of odor stick identification test for patients with olfactory disturbance].

Miwa T, Furukawa M, Tsukatani T, Ikeno S, Yata T, Horikawa I, Deguchi Y, Saito S.

Nihon Jibiinkoka Gakkai Kaiho. 2004 Oct;107(10):956-65. Japanese.


Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.

Sinha-Datta U, Horikawa I, Michishita E, Datta A, Sigler-Nicot JC, Brown M, Kazanji M, Barrett JC, Nicot C.

Blood. 2004 Oct 15;104(8):2523-31. Epub 2004 Jun 29.


HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE.

EMBO J. 2004 May 5;23(9):1949-56. Epub 2004 Apr 8.


Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.

Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC.

Nat Cell Biol. 2004 Feb;6(2):168-70.


Role of Ets/Id proteins for telomerase regulation in human cancer cells.

Xiao X, Athanasiou M, Sidorov IA, Horikawa I, Cremona G, Blair D, Barret JC, Dimitrov DS.

Exp Mol Pathol. 2003 Dec;75(3):238-47.


Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms.

Horikawa I, Barrett JC.

Carcinogenesis. 2003 Jul;24(7):1167-76. Epub 2003 May 22. Review.


Identification of a </= 600-kb region on human chromosome 1q42.3 inducing cellular senescence.

Yawata T, Kamino H, Kugoh H, Katoh M, Nomura N, Oishi M, Horikawa I, Barrett JC, Oshimura M.

Oncogene. 2003 Jan 16;22(2):281-90.


cDNA cloning of the human polybromo-1 gene on chromosome 3p21.

Horikawa I, Barrett JC.

DNA Seq. 2002 Aug;13(4):211-5.


Potential changes with gamma-band oscillation at the frontal scalp elicited by intravenous olfactory stimulation in humans.

Ishimaru T, Hatanaka S, Yata T, Horikawa I, Tsukatani T, Nishimura T, Miwa T, Furukawa M.

Chem Senses. 2002 Oct;27(8):711-7.


Role of nerve growth factor in the olfactory system.

Miwa T, Moriizumi T, Horikawa I, Uramoto N, Ishimaru T, Nishimura T, Furukawa M.

Microsc Res Tech. 2002 Aug 1;58(3):197-203. Review.


Identification and characterization of rapidly dividing U937 clones with differential telomerase activity and gene expression profiles: role of c-Myc/Mad1 and Id/Ets proteins.

Xiao X, Phogat SK, Sidorov IA, Yang J, Horikawa I, Prieto D, Adelesberger J, Lempicki R, Barrett JC, Dimitrov DS.

Leukemia. 2002 Sep;16(9):1877-80. No abstract available.


Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter.

Lee D, Kim HZ, Jeong KW, Shim YS, Horikawa I, Barrett JC, Choe J.

J Biol Chem. 2002 Aug 2;277(31):27748-56. Epub 2002 May 17.


The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.

Leem SH, Londoño-Vallejo JA, Kim JH, Bui H, Tubacher E, Solomon G, Park JE, Horikawa I, Kouprina N, Barrett JC, Larionov V.

Oncogene. 2002 Jan 24;21(5):769-77.


Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells.

Horikawa I, Parker ES, Solomon GG, Barrett JC.

J Cell Biochem. 2001;82(3):415-21.


Myofibrosarcoma of the nasal cavity and paranasal sinus.

Kondo S, Yoshizaki T, Minato H, Horikawa I, Tatsumi A, Furukawa M.

Histopathology. 2001 Aug;39(2):216-7. No abstract available.


cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome.

Horikawa I, Barrett JC.

J Natl Cancer Inst. 2001 Aug 1;93(15):1171-3. No abstract available.


Myofibrosarcoma of the nasal cavity and paranasal sinus.

Kondo S, Yoshizaki T, Minato H, Horikawa I, Tatsumi A, Furukawa M.

Histopathology. 2001 May;38(5):482-4. No abstract available.


Functional evidence for a telomerase repressor gene on human chromosome 10p15.1.

Nishimoto A, Miura N, Horikawa I, Kugoh H, Murakami Y, Hirohashi S, Kawasaki H, Gazdar AF, Shay JW, Barrett JC, Oshimura M.

Oncogene. 2001 Feb 15;20(7):828-35.


Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein.

Veldman T, Horikawa I, Barrett JC, Schlegel R.

J Virol. 2001 May;75(9):4467-72.


Cellular senescence of a human bladder carcinoma cell line (JTC-32) induced by a normal chromosome 11.

Kugoh H, Fujiwara M, Kihara K, Fukui I, Horikawa I, Schulz TC, Oshimura M.

Cancer Genet Cytogenet. 2000 Jan 15;116(2):158-63.


DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.

Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC.

Cancer Res. 1999 Dec 15;59(24):6087-90.


Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer.

Tanaka H, Horikawa I, Kugoh H, Shimizu M, Barrett JC, Oshimura M.

Mol Carcinog. 1999 Aug;25(4):249-55.


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