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Items: 1 to 50 of 129

1.

Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability.

Vila Cuenca M, Ferrantelli E, Meinster E, Pouw SM, Kovačević I, de Menezes RX, Niessen HW, Beelen RHJ, Hordijk PL, Vervloet MG.

J Am Heart Assoc. 2018 Sep 4;7(17):e008776. doi: 10.1161/JAHA.118.008776. Erratum in: J Am Heart Assoc. 2018 Oct 2;7(19):e02709.

2.

A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability.

Amado-Azevedo J, de Menezes RX, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL.

PLoS One. 2018 Jul 26;13(7):e0201231. doi: 10.1371/journal.pone.0201231. eCollection 2018.

3.

Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study.

Bokslag A, Franssen C, Alma LJ, Kovacevic I, Kesteren FV, Teunissen PW, Kamp O, Ganzevoort W, Hordijk PL, Groot CJM, Paulus WJ.

PLoS One. 2018 Jun 12;13(6):e0198908. doi: 10.1371/journal.pone.0198908. eCollection 2018.

4.

Stabilization of cell-cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function.

Vila Cuenca M, van Bezu J, Beelen RHJ, Vervloet MG, Hordijk PL.

Nephrol Dial Transplant. 2018 Apr 30. doi: 10.1093/ndt/gfy111. [Epub ahead of print]

PMID:
29718431
5.

Endothelial dysfunction as a long-term effect of late onset hypertensive pregnancy disorders: High BMI is key.

Alma LJ, De Groot CJM, De Menezes RX, Hermes W, Hordijk PL, Kovačević I.

Eur J Obstet Gynecol Reprod Biol. 2018 Jun;225:62-69. doi: 10.1016/j.ejogrb.2018.04.003. Epub 2018 Apr 12.

PMID:
29677687
6.

Correction: Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.

Smeets MWJ, Bierings R, Meems H, Mul FPJ, Geerts D, Vlaar APJ, Voorberg J, Hordijk PL.

PLoS One. 2018 Mar 21;13(3):e0194958. doi: 10.1371/journal.pone.0194958. eCollection 2018.

7.

The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.

Kovačević I, Sakaue T, Majoleé J, Pronk MC, Maekawa M, Geerts D, Fernandez-Borja M, Higashiyama S, Hordijk PL.

J Cell Biol. 2018 Mar 5;217(3):1015-1032. doi: 10.1083/jcb.201606055. Epub 2018 Jan 22.

8.

The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity.

Amado-Azevedo J, Reinhard NR, van Bezu J, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL.

Vascul Pharmacol. 2018 Feb;101:38-47. doi: 10.1016/j.vph.2017.11.007. Epub 2017 Nov 21.

PMID:
29174013
9.

The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate.

Reinhard NR, Mastop M, Yin T, Wu Y, Bosma EK, Gadella TWJ Jr, Goedhart J, Hordijk PL.

Mol Biol Cell. 2017 Nov 7;28(23):3371-3382. doi: 10.1091/mbc.E17-03-0136. Epub 2017 Sep 27.

10.

RhoA, RhoB and RhoC differentially regulate endothelial barrier function.

Pronk MCA, van Bezu JSM, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL.

Small GTPases. 2017 Sep 26:1-19. doi: 10.1080/21541248.2017.1339767. [Epub ahead of print]

PMID:
28949796
11.

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.

Amado-Azevedo J, Reinhard NR, van Bezu J, de Menezes RX, van Beusechem VW, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL.

Sci Rep. 2017 Aug 31;7(1):10132. doi: 10.1038/s41598-017-10392-0.

12.

Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor.

Smeets MWJ, Mourik MJ, Niessen HWM, Hordijk PL.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1618-1627. doi: 10.1161/ATVBAHA.117.309885. Epub 2017 Aug 3.

PMID:
28775074
13.

Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro.

Schaefer A, van Duijn TJ, Majolee J, Burridge K, Hordijk PL.

J Immunol. 2017 Jun 15;198(12):4823-4836. doi: 10.4049/jimmunol.1601987. Epub 2017 May 8.

14.

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.

Smeets MW, Bierings R, Meems H, Mul FP, Geerts D, Vlaar AP, Voorberg J, Hordijk PL.

PLoS One. 2017 Mar 1;12(3):e0173077. doi: 10.1371/journal.pone.0173077. eCollection 2017. Erratum in: PLoS One. 2018 Mar 21;13(3):e0194958.

15.

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Nov 15;11(11):e0166809. doi: 10.1371/journal.pone.0166809. eCollection 2016.

16.

Traction force dynamics predict gap formation in activated endothelium.

Valent ET, van Nieuw Amerongen GP, van Hinsbergh VW, Hordijk PL.

Exp Cell Res. 2016 Sep 10;347(1):161-70. doi: 10.1016/j.yexcr.2016.07.029. Epub 2016 Aug 3.

PMID:
27498166
17.

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions.

Dorland YL, Malinova TS, van Stalborch AM, Grieve AG, van Geemen D, Jansen NS, de Kreuk BJ, Nawaz K, Kole J, Geerts D, Musters RJ, de Rooij J, Hordijk PL, Huveneers S.

Nat Commun. 2016 Jul 15;7:12210. doi: 10.1038/ncomms12210.

18.

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw-Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Jul 8;11(7):e0157233. doi: 10.1371/journal.pone.0157233. eCollection 2016. Erratum in: PLoS One. 2016 Nov 15;11(11):e0166809.

19.

Intracellular pH steers vascular wall remodelling.

Hordijk PL.

Cardiovasc Res. 2016 Aug 1;111(3):165-6. doi: 10.1093/cvr/cvw164. Epub 2016 Jun 13. No abstract available.

PMID:
27297889
20.

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells.

Reinhard NR, van Helden SF, Anthony EC, Yin T, Wu YI, Goedhart J, Gadella TW, Hordijk PL.

Sci Rep. 2016 May 5;6:25502. doi: 10.1038/srep25502.

21.

A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells.

van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW Jr, Goedhart J.

PLoS One. 2016 Jan 22;11(1):e0146789. doi: 10.1371/journal.pone.0146789. eCollection 2016.

22.

Recent insights into endothelial control of leukocyte extravasation.

Hordijk PL.

Cell Mol Life Sci. 2016 Apr;73(8):1591-608. doi: 10.1007/s00018-016-2136-y. Epub 2016 Jan 21. Review.

PMID:
26794844
23.

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N.

J Biol Chem. 2016 Feb 26;291(9):4813-25. doi: 10.1074/jbc.M115.698688. Epub 2015 Dec 30.

24.

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking.

Daniel AE, Timmerman I, Kovacevic I, Hordijk PL, Adriaanse L, Paatero I, Belting HG, van Buul JD.

PLoS One. 2015 Dec 29;10(12):e0145684. doi: 10.1371/journal.pone.0145684. eCollection 2015.

25.

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia.

Woodfin A, Beyrau M, Voisin MB, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S.

Blood. 2016 Feb 18;127(7):898-907. doi: 10.1182/blood-2015-08-664995. Epub 2015 Dec 8.

26.

Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration.

Schaefer A, Hordijk PL.

J Cell Sci. 2015 Jul 1;128(13):2221-30. doi: 10.1242/jcs.163055. Epub 2015 Jun 19. Review.

27.

Between Rho(k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease.

Huveneers S, Daemen MJ, Hordijk PL.

Circ Res. 2015 Feb 27;116(5):895-908. doi: 10.1161/CIRCRESAHA.116.305720. Review.

PMID:
25722443
28.

Toward understanding RhoGTPase specificity: structure, function and local activation.

Schaefer A, Reinhard NR, Hordijk PL.

Small GTPases. 2014;5(2):6. doi: 10.4161/21541248.2014.968004. Review.

29.

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration.

Schaefer A, Te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FP, de Vries CJ, Daemen MJ, Figdor CG, van Buul JD, Hordijk PL.

J Cell Sci. 2014 Oct 15;127(Pt 20):4470-82. doi: 10.1242/jcs.154708. Epub 2014 Aug 8. Erratum in: J Cell Sci. 2014 Nov 15;127(22):4985. J Cell Sci. 2014 Oct 15;127(Pt 20):doi/10.1242/jcs.164814.

30.

F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins.

van Geemen D, Smeets MW, van Stalborch AM, Woerdeman LA, Daemen MJ, Hordijk PL, Huveneers S.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2059-67. doi: 10.1161/ATVBAHA.114.304180. Epub 2014 Jul 10.

PMID:
25012130
31.

BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells.

Klamer SE, Kuijk CG, Hordijk PL, van der Schoot CE, von Lindern M, van Hennik PB, Voermans C.

Cell Adh Migr. 2013 Sep-Oct;7(5):434-49. doi: 10.4161/cam.26596. Epub 2013 Oct 8.

32.

The human minor histocompatibility antigen 1 is a RhoGAP.

de Kreuk BJ, Schaefer A, Anthony EC, Tol S, Fernandez-Borja M, Geerts D, Pool J, Hambach L, Goulmy E, Hordijk PL.

PLoS One. 2013 Sep 23;8(9):e73962. doi: 10.1371/journal.pone.0073962. eCollection 2013.

33.

Nucleophosmin1 is a negative regulator of the small GTPase Rac1.

Zoughlami Y, van Stalborgh AM, van Hennik PB, Hordijk PL.

PLoS One. 2013 Jul 16;8(7):e68477. doi: 10.1371/journal.pone.0068477. Print 2013.

34.

The Rac1 hypervariable region in targeting and signaling: a tail of many stories.

Lam BD, Hordijk PL.

Small GTPases. 2013 Apr-Jun;4(2):78-89. doi: 10.4161/sgtp.23310. Epub 2013 Jan 25. Review.

35.

Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration.

Lam BD, Anthony EC, Hordijk PL.

FEBS Lett. 2013 Jan 16;587(2):111-9. doi: 10.1016/j.febslet.2012.11.013. Epub 2012 Nov 26.

36.

The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.

de Kreuk BJ, Anthony EC, Geerts D, Hordijk PL.

J Biol Chem. 2012 Dec 21;287(52):43438-53. doi: 10.1074/jbc.M112.391078. Epub 2012 Nov 5.

37.

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.

Timmerman I, Hoogenboezem M, Bennett AM, Geerts D, Hordijk PL, van Buul JD.

Mol Biol Cell. 2012 Nov;23(21):4212-25. doi: 10.1091/mbc.E12-01-0038. Epub 2012 Sep 5.

38.

Rho GTPase expression in human myeloid cells.

van Helden SF, Anthony EC, Dee R, Hordijk PL.

PLoS One. 2012;7(8):e42563. doi: 10.1371/journal.pone.0042563. Epub 2012 Aug 16.

39.

Control of Rho GTPase function by BAR-domains.

de Kreuk BJ, Hordijk PL.

Small GTPases. 2012 Jan-Mar;3(1):45-52. doi: 10.4161/sgtp.18960.

40.

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.

van Rijssel J, Kroon J, Hoogenboezem M, van Alphen FP, de Jong RJ, Kostadinova E, Geerts D, Hordijk PL, van Buul JD.

Mol Biol Cell. 2012 Aug;23(15):2831-44. doi: 10.1091/mbc.E11-11-0907. Epub 2012 Jun 13.

41.

Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3.

Geutskens SB, Andrews WD, van Stalborch AM, Brussen K, Holtrop-de Haan SE, Parnavelas JG, Hordijk PL, van Hennik PB.

Lab Invest. 2012 Aug;92(8):1129-39. doi: 10.1038/labinvest.2012.81. Epub 2012 May 21.

42.

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.

Nethe M, de Kreuk BJ, Tauriello DV, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL.

J Cell Sci. 2012 Jul 15;125(Pt 14):3430-42. doi: 10.1242/jcs.100925. Epub 2012 Mar 30.

43.

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration.

Schaefer A, Nethe M, Hordijk PL.

Biochem J. 2012 Feb 15;442(1):13-25. doi: 10.1042/BJ20111815. Review.

PMID:
22280013
44.

The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.

van Rijssel J, Hoogenboezem M, Wester L, Hordijk PL, Van Buul JD.

PLoS One. 2012;7(1):e29912. doi: 10.1371/journal.pone.0029912. Epub 2012 Jan 6.

45.

Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.

Zoughlami Y, Voermans C, Brussen K, van Dort KA, Kootstra NA, Maussang D, Smit MJ, Hordijk PL, van Hennik PB.

Blood. 2012 Mar 1;119(9):2024-32. doi: 10.1182/blood-2011-06-364828. Epub 2012 Jan 11.

46.

Analysis of nucleo-cytoplasmic shuttling of the proto-oncogene SET/I2PP2A.

Lam BD, Anthony EC, Hordijk PL.

Cytometry A. 2012 Jan;81(1):81-9. doi: 10.1002/cyto.a.21153. Epub 2011 Oct 11.

47.

Localizing cellular housekeeping.

Hordijk PL.

Nat Rev Mol Cell Biol. 2011 Dec;12(12):771. doi: 10.1038/nrm3206. No abstract available.

PMID:
21971042
48.

Altered intracellular localization and mobility of SBDS protein upon mutation in Shwachman-Diamond syndrome.

Orelio C, van der Sluis RM, Verkuijlen P, Nethe M, Hordijk PL, van den Berg TK, Kuijpers TW.

PLoS One. 2011;6(6):e20727. doi: 10.1371/journal.pone.0020727. Epub 2011 Jun 13.

49.

The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration.

de Kreuk BJ, Nethe M, Fernandez-Borja M, Anthony EC, Hensbergen PJ, Deelder AM, Plomann M, Hordijk PL.

J Cell Sci. 2011 Jul 15;124(Pt 14):2375-88. doi: 10.1242/jcs.080630. Epub 2011 Jun 21.

50.

The role of ubiquitylation and degradation in RhoGTPase signalling.

Nethe M, Hordijk PL.

J Cell Sci. 2010 Dec 1;123(Pt 23):4011-8. doi: 10.1242/jcs.078360. Review.

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