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Items: 1 to 50 of 473

1.

CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.

Kristensen LK, Fröhlich C, Christensen C, Melander MC, Poulsen TT, Galler GR, Lantto J, Horak ID, Kragh M, Nielsen CH, Kjaer A.

Theranostics. 2019 Oct 18;9(26):8221-8238. doi: 10.7150/thno.37513. eCollection 2019.

2.

Ixodid ticks (Acari: Ixodidae) collected from African savanna elephants (Loxodonta africana) and African forest elephants (Loxodonta cyclotis).

Kariuki E, Kutima H, Kock M, Horak IG, Jooste R, Neves L.

Onderstepoort J Vet Res. 2019 Nov 6;86(1):e1-e5. doi: 10.4102/ojvr.v86i1.1781.

3.

Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform.

Gjetting T, Gad M, Fröhlich C, Lindsted T, Melander MC, Bhatia VK, Grandal MM, Dietrich N, Uhlenbrock F, Galler GR, Strandh M, Lantto J, Bouquin T, Horak ID, Kragh M, Pedersen MW, Koefoed K.

MAbs. 2019 May/Jun;11(4):666-680. doi: 10.1080/19420862.2019.1596514. Epub 2019 May 3.

4.

Toxicity of C60 fullerene-cisplatin nanocomplex against Lewis lung carcinoma cells.

Prylutska S, Grynyuk I, Skaterna T, Horak I, Grebinyk A, Drobot L, Matyshevska O, Senenko A, Prylutskyy Y, Naumovets A, Ritter U, Frohme M.

Arch Toxicol. 2019 May;93(5):1213-1226. doi: 10.1007/s00204-019-02441-6. Epub 2019 Apr 15.

PMID:
30989314
5.

Microbial metabolomics: essential definitions and the importance of cultivation conditions for utilizing Bacillus species as bionematicides.

Horak I, Engelbrecht G, van Rensburg PJJ, Claassens S.

J Appl Microbiol. 2019 Aug;127(2):326-343. doi: 10.1111/jam.14218. Epub 2019 May 23. Review.

PMID:
30739384
6.

Safety of early discharge in low risk patients after acute ST-segment elevation myocardial infarction, treated with primary percutaneous coronary intervention. Open label, randomized trial.

Novobilsky K, Stipal R, Cerny P, Horak I, Kaucak V, Mrozek J, Vaclavik J, Kryza R.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Feb;163(1):61-66. doi: 10.5507/bp.2018.041. Epub 2018 Aug 28.

7.
8.

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.

Keir ST, Chandramohan V, Hemphill CD, Grandal MM, Melander MC, Pedersen MW, Horak ID, Kragh M, Desjardins A, Friedman HS, Bigner DD.

J Neurooncol. 2018 Jul;138(3):489-498. doi: 10.1007/s11060-018-2832-6. Epub 2018 Mar 21.

9.

Acquired Resistance to a MET Antibody In Vivo Can Be Overcome by the MET Antibody Mixture Sym015.

Pollmann SE, Calvert VS, Rao S, Boca SM, Madhavan S, Horak ID, Kjaer A, Petricoin EF, Kragh M, Poulsen TT.

Mol Cancer Ther. 2018 Jun;17(6):1259-1270. doi: 10.1158/1535-7163.MCT-17-0787. Epub 2018 Mar 15.

10.

Corrigendum to Effects of tectonics and large scale climatic changes on the evolutionary history of Hyalomma ticks Molecular Phylogenetics and Evolution (2017) 114:153-165.

Sands AF, Apanaskevich DA, Matthee S, Horak IG, Harrison A, Karim S, Mohammad MK, Mumcuoglu KY, Rajakaruna RS, Santos-Silva MM, Kamani J, Matthee CA.

Mol Phylogenet Evol. 2018 Mar;120:390. doi: 10.1016/j.ympev.2018.01.010. No abstract available.

PMID:
29482872
11.

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kim HJ, Kang SK, Kwon WS, Kim TS, Jeong I, Jeung HC, Kragh M, Horak ID, Chung HC, Rha SY.

Int J Cancer. 2018 Jul 1;143(1):151-159. doi: 10.1002/ijc.31304. Epub 2018 Feb 23.

12.

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

Montagut C, Argilés G, Ciardiello F, Poulsen TT, Dienstmann R, Kragh M, Kopetz S, Lindsted T, Ding C, Vidal J, Clausell-Tormos J, Siravegna G, Sánchez-Martín FJ, Koefoed K, Pedersen MW, Grandal MM, Dvorkin M, Wyrwicz L, Rovira A, Cubillo A, Salazar R, Desseigne F, Nadal C, Albanell J, Zagonel V, Siena S, Fumi G, Rospo G, Nadler P, Horak ID, Bardelli A, Tabernero J.

JAMA Oncol. 2018 Apr 12;4(4):e175245. doi: 10.1001/jamaoncol.2017.5245. Epub 2018 Apr 12. Erratum in: JAMA Oncol. 2019 May 1;5(5):745.

13.

Ixodid tick diversity on wild mammals, birds, and reptiles in and around Etosha National Park, Namibia.

Turner WC, Küsters M, Versfeld W, Horak IG.

Afr J Ecol. 2017 Dec;55(4):714-721. doi: 10.1111/aje.12369. Epub 2017 Feb 27. No abstract available.

14.

Range expansion of the economically important Asiatic blue tick, <i>Rhipicephalus microplus</i>, in South Africa.

Nyangiwe N, Horak IG, Van der Mescht L, Matthee S.

J S Afr Vet Assoc. 2017 Dec 8;88(0):e1-e7. doi: 10.4102/jsava.v88i0.1482.

15.

An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.

Schwarz LJ, Hutchinson KE, Rexer BN, Estrada MV, Gonzalez Ericsson PI, Sanders ME, Dugger TC, Formisano L, Guerrero-Zotano A, Red-Brewer M, Young CD, Lantto J, Pedersen MW, Kragh M, Horak ID, Arteaga CL.

J Natl Cancer Inst. 2017 Nov 1;109(11). doi: 10.1093/jnci/djx065.

16.

Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms.

Grandal MM, Havrylov S, Poulsen TT, Koefoed K, Dahlman A, Galler GR, Conrotto P, Collins S, Eriksen KW, Kaufman D, Woude GFV, Jacobsen HJ, Horak ID, Kragh M, Lantto J, Bouquin T, Park M, Pedersen MW.

Mol Cancer Ther. 2017 Dec;16(12):2780-2791. doi: 10.1158/1535-7163.MCT-17-0374. Epub 2017 Aug 11.

17.

Sym015: A Highly Efficacious Antibody Mixture against MET-Amplified Tumors.

Poulsen TT, Grandal MM, Skartved NJØ, Hald R, Alifrangis L, Koefoed K, Lindsted T, Fröhlich C, Pollmann SE, Eriksen KW, Dahlman A, Jacobsen HJ, Bouquin T, Pedersen MW, Horak ID, Lantto J, Kragh M.

Clin Cancer Res. 2017 Oct 1;23(19):5923-5935. doi: 10.1158/1078-0432.CCR-17-0782. Epub 2017 Jul 5.

18.

Effects of tectonics and large scale climatic changes on the evolutionary history of Hyalomma ticks.

Sands AF, Apanaskevich DA, Matthee S, Horak IG, Harrison A, Karim S, Mohammad MK, Mumcuoglu KY, Rajakaruna RS, Santos-Silva MM, Matthee CA.

Mol Phylogenet Evol. 2017 Sep;114:153-165. doi: 10.1016/j.ympev.2017.06.002. Epub 2017 Jun 15. Erratum in: Mol Phylogenet Evol. 2018 Mar;120:390.

PMID:
28625763
20.

Parasites of domestic and wild animals in South Africa. L. Ixodid ticks infesting horses and donkeys.

Horak IG, Heyne H, Halajian A, Booysen S, Smit WJ.

Onderstepoort J Vet Res. 2017 Feb 28;84(1):e1-e6. doi: 10.4102/ojvr.v84i1.1302.

21.

Parasites of domestic and wild animals in South Africa. XLIX. Ticks (Acari: Ixodidae) infesting white and black rhinoceroses in southern Africa.

Horak IG, Boshoff CR, Cooper DV, Foggin CM, Govender D, Harrison A, Hausler G, Hofmeyr M, Kilian JW, MacFadyen DN, Nel PJ, Peinke D, Squarre D, Zimmermann D.

Onderstepoort J Vet Res. 2017 Jan 30;84(1):e1-e11. doi: 10.4102/ojvr.v84i1.1301.

22.

Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab.

Iida M, Bahrar H, Brand TM, Pearson HE, Coan JP, Orbuch RA, Flanigan BG, Swick AD, Prabakaran PJ, Lantto J, Horak ID, Kragh M, Salgia R, Kimple RJ, Wheeler DL.

Mol Cancer Ther. 2016 Sep;15(9):2175-86. doi: 10.1158/1535-7163.MCT-16-0012. Epub 2016 Jul 15.

23.

Pan-HER-An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand-induced EGFR homo- and heterodimers.

Ellebaek S, Brix S, Grandal M, Lantto J, Horak ID, Kragh M, Poulsen TT.

Int J Cancer. 2016 Nov 1;139(9):2095-105. doi: 10.1002/ijc.30242. Epub 2016 Jul 19.

24.

Cetuximab Resistance in Squamous Carcinomas of the Upper Aerodigestive Tract Is Driven by Receptor Tyrosine Kinase Plasticity: Potential for mAb Mixtures.

Kjær I, Lindsted T, Fröhlich C, Olsen JV, Horak ID, Kragh M, Pedersen MW.

Mol Cancer Ther. 2016 Jul;15(7):1614-26. doi: 10.1158/1535-7163.MCT-15-0565. Epub 2016 May 11.

25.
26.

The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer.

Sánchez-Martín FJ, Bellosillo B, Gelabert-Baldrich M, Dalmases A, Cañadas I, Vidal J, Martinez A, Argilés G, Siravegna G, Arena S, Koefoed K, Visa L, Arpí O, Horak ID, Iglesias M, Stroh C, Kragh M, Rovira A, Albanell J, Tabernero J, Bardelli A, Montagut C.

Clin Cancer Res. 2016 Jul 1;22(13):3260-7. doi: 10.1158/1078-0432.CCR-15-2400. Epub 2016 Feb 17.

27.

Evidence for interspecific interactions in the ectoparasite infracommunity of a wild mammal.

Hoffmann S, Horak IG, Bennett NC, Lutermann H.

Parasit Vectors. 2016 Feb 2;9:58. doi: 10.1186/s13071-016-1342-7.

28.

Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85.

Bazalii AV, Horak IR, Pasi chn yk GV, Komisarenko SV, Drobot LB.

Ukr Biochem J. 2016 Jan-Feb;88(1):119-25. doi: 10.15407/ubj88.01.119.

PMID:
29227594
29.

Analysis of large new South African dataset using two host-specificity indices shows generalism in both adult and larval ticks of mammals.

Espinaze MP, Hellard E, Horak IG, Cumming GS.

Parasitology. 2016 Mar;143(3):366-73. doi: 10.1017/S0031182015001730. Epub 2015 Dec 22.

PMID:
26690251
30.

In vivo imaging of therapy response to a novel pan-HER antibody mixture using FDG and FLT positron emission tomography.

Nielsen CH, Jensen MM, Kristensen LK, Dahlman A, Fröhlich C, Jacobsen HJ, Poulsen TT, Lantto J, Horak ID, Kragh M, Kjaer A.

Oncotarget. 2015 Nov 10;6(35):37486-99. doi: 10.18632/oncotarget.6060.

31.

Questing ixodid ticks on the vegetation of sable antelope and multi-herbivore enclosures in Thabazimbi.

Uys AC, Horak IG, Harrison A.

J S Afr Vet Assoc. 2015 Jul 14;86(1):1243. doi: 10.4102/jsava.v86i1.1243.

32.

Distribution of endemic and introduced tick species in Free State Province, South Africa.

Horak IG, Jordaan AJ, Nel PJ, van Heerden J, Heyne H, van Dalen EM.

J S Afr Vet Assoc. 2015 Jun 9;86(1):1255. doi: 10.4102/jsava.v86i1.1255.

34.

The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis.

Fourie JJ, Horak I, Crafford D, Erasmus HL, Botha OJ.

J S Afr Vet Assoc. 2015 Mar 25;86(1):1193. doi: 10.4102/jsava.v86i1.1193.

35.

Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer.

Dienstmann R, Patnaik A, Garcia-Carbonero R, Cervantes A, Benavent M, Roselló S, Tops BB, van der Post RS, Argilés G, Skartved NJ, Hansen UH, Hald R, Pedersen MW, Kragh M, Horak ID, Braun S, Van Cutsem E, Tolcher AW, Tabernero J.

Cancer Discov. 2015 Jun;5(6):598-609. doi: 10.1158/2159-8290.CD-14-1432. Epub 2015 May 11.

36.

A proof of concept trial of the anti-EGFR antibody mixture Sym004 in patients with squamous cell carcinoma of the head and neck.

Machiels JP, Specenier P, Krauß J, Dietz A, Kaminsky MC, Lalami Y, Henke M, Keilholz U, Knecht R, Skartved NJ, Horak ID, Pamperin P, Braun S, Gauler TC.

Cancer Chemother Pharmacol. 2015 Jul;76(1):13-20. doi: 10.1007/s00280-015-2761-4. Epub 2015 May 8.

PMID:
25952795
37.

Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.

Jacobsen HJ, Poulsen TT, Dahlman A, Kjær I, Koefoed K, Sen JW, Weilguny D, Bjerregaard B, Andersen CR, Horak ID, Pedersen MW, Kragh M, Lantto J.

Clin Cancer Res. 2015 Sep 15;21(18):4110-22. doi: 10.1158/1078-0432.CCR-14-3312. Epub 2015 Apr 23.

38.

Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs.

Fourie JJ, Liebenberg JE, Horak IG, Taenzler J, Heckeroth AR, Frénais R.

Parasit Vectors. 2015 Mar 28;8:187. doi: 10.1186/s13071-015-0775-8.

39.

History and development of research on wildlife parasites in southern Africa, with emphasis on terrestrial mammals, especially ungulates.

Junker K, Horak IG, Penzhorn B.

Int J Parasitol Parasites Wildl. 2014 Dec 24;4(1):50-70. doi: 10.1016/j.ijppaw.2014.12.003. eCollection 2015 Apr.

40.

Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance.

Pedersen MW, Jacobsen HJ, Koefoed K, Dahlman A, Kjær I, Poulsen TT, Meijer PJ, Nielsen LS, Horak ID, Lantto J, Kragh M.

Mol Cancer Ther. 2015 Mar;14(3):669-80. doi: 10.1158/1535-7163.MCT-14-0697. Epub 2015 Jan 22.

41.

The Namaqua rock mouse (Micaelamys namaquensis) as a potential reservoir and host of arthropod vectors of diseases of medical and veterinary importance in South Africa.

Fagir DM, Ueckermann EA, Horak IG, Bennett NC, Lutermann H.

Parasit Vectors. 2014 Aug 15;7:366. doi: 10.1186/1756-3305-7-366.

42.

Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab.

Iida M, Brand TM, Starr MM, Li C, Huppert EJ, Luthar N, Pedersen MW, Horak ID, Kragh M, Wheeler DL.

Neoplasia. 2013 Oct;15(10):1196-206.

43.

The influence of interspecific competition and host preference on the phylogeography of two African ixodid tick species.

Cangi N, Horak IG, Apanaskevich DA, Matthee S, das Neves LC, Estrada-Peña A, Matthee CA.

PLoS One. 2013 Oct 9;8(10):e76930. doi: 10.1371/journal.pone.0076930. eCollection 2013.

44.
45.

A new species of Rhipicephalus (Acari: Ixodidae), a parasite of giraffes in Kenya.

Horak IG, Apanaskevich DA, Kariuki EK.

J Med Entomol. 2013 Jul;50(4):685-90.

PMID:
23926765
46.

First record of the pantropical blue tick Rhipicephalus microplus in Namibia.

Nyangiwe N, Matthee C, Horak I, Matthee S.

Exp Appl Acarol. 2013 Dec;61(4):503-7. doi: 10.1007/s10493-013-9717-3. Epub 2013 Jul 13.

PMID:
23851930
47.
48.

Prophylactic treatment of flea-infested dogs with an imidacloprid / flumethrin collar (Seresto®, Bayer) to preempt infection with Dipylidium caninum.

Fourie JJ, Crafford D, Horak IG, Stanneck D.

Parasitol Res. 2013 Aug;112 Suppl 1:33-46. doi: 10.1007/s00436-013-3279-5.

PMID:
23771717
49.

Displacement of Rhipicephalus decoloratus by Rhipicephalus microplus (Acari: Ixodidae) in the Eastern Cape Province, South Africa.

Nyangiwe N, Harrison A, Horak IG.

Exp Appl Acarol. 2013 Nov;61(3):371-82. doi: 10.1007/s10493-013-9705-7. Epub 2013 Jun 16.

PMID:
23771510
50.

The effects of a pour-on formulation of fluazuron 2.5 % and flumethrin 1 % on populations of Rhipicephalus decoloratus and Rhipicephalus microplus both on and off bovine (Bonsmara breed) hosts.

Fourie JJ, Liebenberg JE, Nyangiwe N, Austin C, Horak IG, Bhushan C.

Parasitol Res. 2013 Aug;112 Suppl 1:67-79. doi: 10.1007/s00436-013-3282-x.

PMID:
23749085

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