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AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

Bing SJ, Shemesh I, Chong WP, Horai R, Jittayasothorn Y, Silver PB, Sredni B, Caspi RR.

J Autoimmun. 2019 Jun;100:52-61. doi: 10.1016/j.jaut.2019.02.006. Epub 2019 Mar 8.


Microbiome and Autoimmune Uveitis.

Horai R, Caspi RR.

Front Immunol. 2019 Feb 19;10:232. doi: 10.3389/fimmu.2019.00232. eCollection 2019. Review.


Control-matched comparison of refractive and visual outcomes between small incision lenticule extraction and femtosecond laser-assisted LASIK.

Kataoka T, Nishida T, Murata A, Ito M, Isogai N, Horai R, Kojima T, Yoshida Y, Nakamura T.

Clin Ophthalmol. 2018 May 10;12:865-873. doi: 10.2147/OPTH.S161883. eCollection 2018.


New surgical approach for intrascleral fixation using an intraocular lens with hook-shaped haptics.

Yoshida N, Kojima T, Yokoyama S, Horai R, Ichikawa K.

J Cataract Refract Surg. 2018 Feb;44(2):129-133. doi: 10.1016/j.jcrs.2017.12.011. Epub 2018 Mar 2.


STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

St Leger AJ, Hansen AM, Karauzum H, Horai R, Yu CR, Laurence A, Mayer-Barber KD, Silver P, Villasmil R, Egwuagu C, Datta SK, Caspi RR.

J Exp Med. 2018 Apr 2;215(4):1079-1090. doi: 10.1084/jem.20170369. Epub 2018 Feb 28.


Clinical and ex vivo laboratory comparison of the self-sealing properties and dimensional stability between the femtosecond laser and manual clear corneal incisions.

Kojima T, Takagi M, Ichikawa K, Horai R, Sakai Y, Tanaka Y, Tamaoki A, Ichikawa K.

Acta Ophthalmol. 2018 Jun;96(4):e510-e514. doi: 10.1111/aos.13634. Epub 2017 Nov 30.


Effect of Background Luminance Level on the Assessment of Color Visual Acuity Using Colored Landolt Rings in Young Healthy Subjects.

Tanaka Y, Yokoyama S, Horai R, Kojima T, Hiroyuki S, Kato Y, Takagi M, Nakamura H, Tanaka K, Ichikawa K, Tanabe S.

Curr Eye Res. 2018 Mar;43(3):428-434. doi: 10.1080/02713683.2017.1405043. Epub 2017 Nov 22.


Gut microbiota linked to autoimmune uveitis.

Horai R.

Ann Eye Sci. 2017 Apr;2. pii: 19. doi: 10.21037/aes.2017.03.02. Epub 2017 Apr 7. No abstract available.


Comparison of Maximum Stretch Forces between Femtosecond Laser-Assisted Capsulotomy and Continuous Curvilinear Capsulorhexis.

Takagi M, Kojima T, Ichikawa K, Tanaka Y, Kato Y, Horai R, Tamaoki A, Ichikawa K.

J Ophthalmol. 2017;2017:3489373. doi: 10.1155/2017/3489373. Epub 2017 Jan 22.


Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents.

Dillenburg-Pilla P, Zárate-Bladés CR, Silver PB, Horai R, Caspi RR.

Bio Protoc. 2016 Sep 20;6(18). pii: e1936.


Commensal microbiota as a potential trigger of autoimmune uveitis.

Horai R, Sen HN, Caspi RR.

Expert Rev Clin Immunol. 2017 Apr;13(4):291-293. doi: 10.1080/1744666X.2017.1288098. Epub 2017 Feb 15. No abstract available.


Gut microbiota as a source of a surrogate antigen that triggers autoimmunity in an immune privileged site.

Zárate-Bladés CR, Horai R, Mattapallil MJ, Ajami NJ, Wong M, Petrosino JF, Itoh K, Chan CC, Caspi RR.

Gut Microbes. 2017 Jan 2;8(1):59-66. doi: 10.1080/19490976.2016.1273996. Epub 2017 Jan 3. Review.


Regulation of Autoimmunity by the Microbiome.

Zárate-Bladés CR, Horai R, Caspi RR.

DNA Cell Biol. 2016 Sep;35(9):455-8. doi: 10.1089/dna.2016.3432. Epub 2016 Jul 27.


Complete Genome Sequence of Turicibacter sp. Strain H121, Isolated from the Feces of a Contaminated Germ-Free Mouse.

Auchtung TA, Holder ME, Gesell JR, Ajami NJ, Duarte RT, Itoh K, Caspi RR, Petrosino JF, Horai R, Zárate-Bladés CR.

Genome Announc. 2016 Mar 24;4(2). pii: e00114-16. doi: 10.1128/genomeA.00114-16.


Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function.

Kielczewski JL, Horai R, Jittayasothorn Y, Chan CC, Caspi RR.

J Immunol. 2016 Feb 1;196(3):1013-25. doi: 10.4049/jimmunol.1501570. Epub 2015 Dec 28.


Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site.

Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR.

Immunity. 2015 Aug 18;43(2):343-53. doi: 10.1016/j.immuni.2015.07.014.


Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis.

Horai R, Chong WP, Zhou R, Chen J, Silver PB, Agarwal RK, Caspi RR.

Curr Mol Med. 2015;15(6):511-6.


Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis.

Chen J, Qian H, Horai R, Chan CC, Caspi RR.

Curr Mol Med. 2015;15(6):550-7. Review.


Correction: Retina-Specific T Regulatory Cells Bring About Resolution and Maintain Remission of Autoimmune Uveitis.

Silver PB, Horai R, Chen J, Jittayasothorn Y, Chan CC, Villasmil R, Kesen MR, Caspi RR.

J Immunol. 2015 Jul 1;195(1):393. doi: 10.4049/jimmunol.1501038. No abstract available.


IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.

Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y.

J Immunol. 2015 Apr 1;194(7):3156-68. doi: 10.4049/jimmunol.1402155. Epub 2015 Feb 27.


Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.

Silver PB, Horai R, Chen J, Jittayasothorn Y, Chan CC, Villasmil R, Kesen MR, Caspi RR.

J Immunol. 2015 Apr 1;194(7):3011-9. doi: 10.4049/jimmunol.1402650. Epub 2015 Feb 25. Erratum in: J Immunol. 2015 Jul 1;195(1):393. Silver, Phyllis [Corrected to Silver, Phyllis B].


IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses.

Chong WP, Horai R, Mattapallil MJ, Silver PB, Chen J, Zhou R, Sergeev Y, Villasmil R, Chan CC, Caspi RR.

J Autoimmun. 2014 May;50:12-22. doi: 10.1016/j.jaut.2013.08.003. Epub 2013 Sep 7.


Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein.

Chen J, Qian H, Horai R, Chan CC, Falick Y, Caspi RR.

PLoS One. 2013 Aug 28;8(8):e72161. doi: 10.1371/journal.pone.0072161. eCollection 2013.


The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.

Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M.

Mol Biol Cell. 2013 Sep;24(17):2633-44. doi: 10.1091/mbc.E13-05-0234. Epub 2013 Jul 17.


Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen.

Horai R, Silver PB, Chen J, Agarwal RK, Chong WP, Jittayasothorn Y, Mattapallil MJ, Nguyen S, Natarajan K, Villasmil R, Wang P, Karabekian Z, Lytton SD, Chan CC, Caspi RR.

J Autoimmun. 2013 Aug;44:21-33. doi: 10.1016/j.jaut.2013.06.003. Epub 2013 Jun 28.


Use of optical coherence tomography and electroretinography to evaluate retinal pathology in a mouse model of autoimmune uveitis.

Chen J, Qian H, Horai R, Chan CC, Caspi RR.

PLoS One. 2013 May 14;8(5):e63904. doi: 10.1371/journal.pone.0063904. Print 2013.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Factors affecting rotation of a posterior chamber collagen copolymer toric phakic intraocular lens.

Mori T, Yokoyama S, Kojima T, Isogai N, Ito M, Horai R, Nakamura T, Ichikawa K.

J Cataract Refract Surg. 2012 Apr;38(4):568-73. doi: 10.1016/j.jcrs.2011.11.028. Epub 2012 Feb 18.


Optimization of an implantable collamer lens sizing method using high-frequency ultrasound biomicroscopy.

Kojima T, Yokoyama S, Ito M, Horai R, Hara S, Nakamura T, Ichikawa K.

Am J Ophthalmol. 2012 Apr;153(4):632-7, 637.e1. doi: 10.1016/j.ajo.2011.06.031. Epub 2012 Jan 14.


The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition.

Zhou R, Horai R, Silver PB, Mattapallil MJ, Zárate-Bladés CR, Chong WP, Chen J, Rigden RC, Villasmil R, Caspi RR.

J Immunol. 2012 Feb 15;188(4):1742-50. doi: 10.4049/jimmunol.1102415. Epub 2012 Jan 11.


A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.

Zhou R, Horai R, Mattapallil MJ, Caspi RR.

J Immunol. 2011 Oct 15;187(8):4170-7. doi: 10.4049/jimmunol.1101634. Epub 2011 Sep 14.


Cytokines in autoimmune uveitis.

Horai R, Caspi RR.

J Interferon Cytokine Res. 2011 Oct;31(10):733-44. doi: 10.1089/jir.2011.0042. Epub 2011 Jul 25. Review.


Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.

Mattapallil MJ, Silver PB, Mattapallil JJ, Horai R, Karabekian Z, McDowell JH, Chan CC, James EA, Kwok WW, Sen HN, Nussenblatt RB, David CS, Caspi RR.

J Immunol. 2011 Aug 15;187(4):1977-85. doi: 10.4049/jimmunol.1101247. Epub 2011 Jul 15.


Repeatability of the ciliary sulcus-to-sulcus diameter measurement using wide-scanning-field ultrasound biomicroscopy.

Yokoyama S, Kojima T, Horai R, Ito M, Nakamura T, Ichikawa K.

J Cataract Refract Surg. 2011 Jul;37(7):1251-6. doi: 10.1016/j.jcrs.2011.01.024. Epub 2011 May 12.


Quantitative evaluation of night vision and correlation of refractive and topographical parameters with glare after orthokeratology.

Kojima T, Hasegawa A, Hara S, Horai R, Yoshida Y, Nakamura T, Dogru M, Ichikawa K.

Graefes Arch Clin Exp Ophthalmol. 2011 Oct;249(10):1519-26. doi: 10.1007/s00417-011-1696-7. Epub 2011 May 12.


TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice.

Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y.

J Immunol. 2010 Aug 1;185(3):1887-93. doi: 10.4049/jimmunol.1001227. Epub 2010 Jul 7.


Correction of residual refractive error in pseudophakic eyes with the use of a secondary piggyback toricImplantable Collamer Lens.

Kojima T, Horai R, Hara S, Nakamura H, Nakamura T, Satoh Y, Ichikawa K.

J Refract Surg. 2010 Oct;26(10):766-9. doi: 10.3928/1081597X-20100512-02. Epub 2010 May 17.


Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL.

Immunol Rev. 2009 Mar;228(1):93-114. doi: 10.1111/j.1600-065X.2008.00757.x. Review.


Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.

Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ.

J Biol Chem. 2009 Feb 13;284(7):4429-38. doi: 10.1074/jbc.M808679200. Epub 2008 Dec 11.


Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms.

Agarwal RK, Horai R, Viley AM, Silver PB, Grajewski RS, Su SB, Yazdani AT, Zhu W, Kronenberg M, Murray PJ, Rutschman RL, Chan CC, Caspi RR.

J Immunol. 2008 Apr 15;180(8):5423-9.


Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion.

Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR.

J Immunol. 2008 Apr 15;180(8):5167-71.


Kid-mediated chromosome compaction ensures proper nuclear envelope formation.

Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, Yamamoto T.

Cell. 2008 Mar 7;132(5):771-82. doi: 10.1016/j.cell.2008.01.029.


Requirements for selection of conventional and innate T lymphocyte lineages.

Horai R, Mueller KL, Handon RA, Cannons JL, Anderson SM, Kirby MR, Schwartzberg PL.

Immunity. 2007 Nov;27(5):775-85.


Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

Kina S, Tezuka T, Kusakawa S, Kishimoto Y, Kakizawa S, Hashimoto K, Ohsugi M, Kiyama Y, Horai R, Sudo K, Kakuta S, Iwakura Y, Iino M, Kano M, Manabe T, Yamamoto T.

Eur J Neurosci. 2007 Oct;26(8):2269-78.


Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.

Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, Kotaki H, Horai R, Iwakura Y, Nishihara M.

Behav Brain Res. 2007 Dec 28;185(2):110-8. Epub 2007 Jul 20.


Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.

Adriani M, Aoki J, Horai R, Thornton AM, Konno A, Kirby M, Anderson SM, Siegel RM, Candotti F, Schwartzberg PL.

Clin Immunol. 2007 Jul;124(1):41-8. Epub 2007 May 18.


Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

Ishida M, Choi JH, Hirabayashi K, Matsuwaki T, Suzuki M, Yamanouchi K, Horai R, Sudo K, Iwakura Y, Nishihara M.

J Reprod Dev. 2007 Jun;53(3):499-508. Epub 2007 Feb 2.


Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

Broussard C, Fleischacker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ, Schwartzberg PL.

Immunity. 2006 Jul;25(1):93-104. Erratum in: Immunity. 2006 Nov;25(5):849. Fleischecker, Christine [corrected to Fleischacker, Christine].


SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.

Cannons JL, Yu LJ, Jankovic D, Crotty S, Horai R, Kirby M, Anderson S, Cheever AW, Sher A, Schwartzberg PL.

J Exp Med. 2006 Jun 12;203(6):1551-65. Epub 2006 Jun 5.

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